Shan Siddiqi
@shansiddiqi.bsky.social
Psychiatric neuroscientist (with capital Ψ, lowercase n)
| Causal mapper of @braincircuits.bsky.social
| Neuropsychiatrist
| Asst Prof @harvard.edu
| husband, father of a pure-bred Bengal cat and a 37.5% Bengal human
| Causal mapper of @braincircuits.bsky.social
| Neuropsychiatrist
| Asst Prof @harvard.edu
| husband, father of a pure-bred Bengal cat and a 37.5% Bengal human
Reposted by Shan Siddiqi
When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/
DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC
Transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) is hypothesized to relieve symptoms of depression by inhibiting activity in the subgenual anterior cingulate corte...
www.biorxiv.org
April 3, 2025 at 6:15 PM
When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/
Reposted by Shan Siddiqi
Is generalized epilepsy a seizure of the whole brain or a specific brain network?
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications
Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...
nature.com
March 24, 2025 at 4:01 PM
Is generalized epilepsy a seizure of the whole brain or a specific brain network?
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
Out now in Brain
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
March 23, 2025 at 3:05 AM
Out now in Brain
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
Reposted by Shan Siddiqi
Looking toward to our ANPA symposium on interventional neuropsychiatry - kicked off w a brilliant talk & overview on TMS by Nick Trapp.
March 14, 2025 at 1:44 PM
Looking toward to our ANPA symposium on interventional neuropsychiatry - kicked off w a brilliant talk & overview on TMS by Nick Trapp.
I think the theoretical limit of explainable variance in a model should be less than the product of the test-retest reliabilities of the input variables. If the explained variance in a study exceeds that value (as it often does in the psychiatric literature), the model must be overfit.
March 2, 2025 at 6:33 AM
I think the theoretical limit of explainable variance in a model should be less than the product of the test-retest reliabilities of the input variables. If the explained variance in a study exceeds that value (as it often does in the psychiatric literature), the model must be overfit.
Out now in Brain Stimulation
Towards accredited training in brain stimulation: proceedings from the Brain Stimulation Subspecialty Summits (BraSSS)
with co-host Nolan Williams and 23 other awesome co-authors including some from @braincircuits.bsky.social
www.brainstimjrnl.com/article/S193...
Towards accredited training in brain stimulation: proceedings from the Brain Stimulation Subspecialty Summits (BraSSS)
with co-host Nolan Williams and 23 other awesome co-authors including some from @braincircuits.bsky.social
www.brainstimjrnl.com/article/S193...
February 22, 2025 at 12:31 AM
Out now in Brain Stimulation
Towards accredited training in brain stimulation: proceedings from the Brain Stimulation Subspecialty Summits (BraSSS)
with co-host Nolan Williams and 23 other awesome co-authors including some from @braincircuits.bsky.social
www.brainstimjrnl.com/article/S193...
Towards accredited training in brain stimulation: proceedings from the Brain Stimulation Subspecialty Summits (BraSSS)
with co-host Nolan Williams and 23 other awesome co-authors including some from @braincircuits.bsky.social
www.brainstimjrnl.com/article/S193...
Reposted by Shan Siddiqi
Finally … this also means I am recruiting – big time!
Please email me in case you know somebody that might be interested (PhD/Postdoc positions). Please RT for reach! 🙏🙏
Please email me in case you know somebody that might be interested (PhD/Postdoc positions). Please RT for reach! 🙏🙏
a yellow sign that says we 're hiring
ALT: a yellow sign that says we 're hiring
media.tenor.com
February 17, 2025 at 1:49 AM
Finally … this also means I am recruiting – big time!
Please email me in case you know somebody that might be interested (PhD/Postdoc positions). Please RT for reach! 🙏🙏
Please email me in case you know somebody that might be interested (PhD/Postdoc positions). Please RT for reach! 🙏🙏
My cat has developed a penchant for Kraepelin. Last couple of days she just sits next to this old book (first edition English translation) and tries to read it.
February 16, 2025 at 7:15 PM
My cat has developed a penchant for Kraepelin. Last couple of days she just sits next to this old book (first edition English translation) and tries to read it.
Reposted by Shan Siddiqi
jamanetwork.com/journals/jam...
Thread below👇
Thread below👇
Mapping Lesions That Cause Psychosis
This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit
jamanetwork.com
February 12, 2025 at 9:47 PM
jamanetwork.com/journals/jam...
Thread below👇
Thread below👇
Reposted by Shan Siddiqi
Can damage to a specific brain circuit cause psychosis? New paper out today by @andrewpines.bsky.social @shansiddiqi.bsky.social says Yes! Hub of the circuit is in the hippocampus - great alignment with NMDA encephalitis. @braincircuits.bsky.social
What brain regions are involved in causing psychotic symptoms?
Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients!
1/n🧵
Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients!
1/n🧵
February 13, 2025 at 1:34 AM
Can damage to a specific brain circuit cause psychosis? New paper out today by @andrewpines.bsky.social @shansiddiqi.bsky.social says Yes! Hub of the circuit is in the hippocampus - great alignment with NMDA encephalitis. @braincircuits.bsky.social
Reposted by Shan Siddiqi
Do lesions that cause psychosis fall into a common brain network?
Exciting new work by @andrewpines.bsky.social, @shansiddiqi.bsky.social and colleagues – tweetorial below by the first author, paper here:
jamanetwork.com/journals/jam...
Exciting new work by @andrewpines.bsky.social, @shansiddiqi.bsky.social and colleagues – tweetorial below by the first author, paper here:
jamanetwork.com/journals/jam...
February 12, 2025 at 9:01 PM
Do lesions that cause psychosis fall into a common brain network?
Exciting new work by @andrewpines.bsky.social, @shansiddiqi.bsky.social and colleagues – tweetorial below by the first author, paper here:
jamanetwork.com/journals/jam...
Exciting new work by @andrewpines.bsky.social, @shansiddiqi.bsky.social and colleagues – tweetorial below by the first author, paper here:
jamanetwork.com/journals/jam...
Reposted by Shan Siddiqi
What brain regions are involved in causing psychotic symptoms?
Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients!
1/n🧵
Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients!
1/n🧵
February 12, 2025 at 8:23 PM
What brain regions are involved in causing psychotic symptoms?
Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients!
1/n🧵
Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients!
1/n🧵
When the Nazis took power, I've of their most effective actions was to destroy the universities.
1. Today the NIH director issued a new directive slashing overhead rates to 15%.
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
I want to provide some context on what that means and why it matters.
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:49 AM
When the Nazis took power, I've of their most effective actions was to destroy the universities.
Reposted by Shan Siddiqi
Super cool to finally meet @shansiddiqi.bsky.social this morning and hear about his lesion network mapping data for schizophrenia - and their consilience with our computational work in primates and paranoia!
#MDThalamus
#MDThalamus
Early start (7:30am symposium) in Grand Ballroom C, for WinterBrain
❄️🧠
I’ll be talking about translational approaches to paranoia, and consilience across rodents, primates, and humans
❄️🧠
I’ll be talking about translational approaches to paranoia, and consilience across rodents, primates, and humans
January 27, 2025 at 8:14 PM
Super cool to finally meet @shansiddiqi.bsky.social this morning and hear about his lesion network mapping data for schizophrenia - and their consilience with our computational work in primates and paranoia!
#MDThalamus
#MDThalamus
I get it, bsky is great, but I find it harder to get motivated when there’s no vitriol to fight.
I need a troll.
I need a troll.
January 24, 2025 at 12:29 AM
I get it, bsky is great, but I find it harder to get motivated when there’s no vitriol to fight.
I need a troll.
I need a troll.
Anybody have experience with a successful R33 application?
There's no budget limit, so I'm trying to figure out what kind of budget might be perceived as excessive.
There's no budget limit, so I'm trying to figure out what kind of budget might be perceived as excessive.
January 21, 2025 at 7:39 PM
Anybody have experience with a successful R33 application?
There's no budget limit, so I'm trying to figure out what kind of budget might be perceived as excessive.
There's no budget limit, so I'm trying to figure out what kind of budget might be perceived as excessive.
ECT, TMS, and ketamine outperform other options for treatment resistant depression.
Should we be offering these options to patients earlier in the course of illness?
www.nature.com/articles/s41...
Should we be offering these options to patients earlier in the course of illness?
www.nature.com/articles/s41...
Relative effectiveness of antidepressant treatments in treatment-resistant depression: a systematic review and network meta-analysis of randomized controlled trials - Neuropsychopharmacology
Neuropsychopharmacology - Relative effectiveness of antidepressant treatments in treatment-resistant depression: a systematic review and network meta-analysis of randomized controlled trials
www.nature.com
January 12, 2025 at 7:27 AM
ECT, TMS, and ketamine outperform other options for treatment resistant depression.
Should we be offering these options to patients earlier in the course of illness?
www.nature.com/articles/s41...
Should we be offering these options to patients earlier in the course of illness?
www.nature.com/articles/s41...
Reposted by Shan Siddiqi
We are launching a new Harvard Medical School Continuing Medical Education Course
Brain Medicine: Integrating the Clinical Neurosciences
Live Virtual Course w On Demand Viewing for 30 days
February 7th, 2025
Registration Details Below (Join Us!):
cmecatalog.hms.harvard.edu/brain-medici...
Brain Medicine: Integrating the Clinical Neurosciences
Live Virtual Course w On Demand Viewing for 30 days
February 7th, 2025
Registration Details Below (Join Us!):
cmecatalog.hms.harvard.edu/brain-medici...
January 8, 2025 at 2:31 PM
We are launching a new Harvard Medical School Continuing Medical Education Course
Brain Medicine: Integrating the Clinical Neurosciences
Live Virtual Course w On Demand Viewing for 30 days
February 7th, 2025
Registration Details Below (Join Us!):
cmecatalog.hms.harvard.edu/brain-medici...
Brain Medicine: Integrating the Clinical Neurosciences
Live Virtual Course w On Demand Viewing for 30 days
February 7th, 2025
Registration Details Below (Join Us!):
cmecatalog.hms.harvard.edu/brain-medici...
Reposted by Shan Siddiqi
🚨Interested in Dystonia?🚨
@braincircuits.bsky.social
GPi DBS for dystonia is effective.
More recently, STN DBS has been investigated, as an alternative.
In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks…
www.pnas.org/doi/10.1073/...
@braincircuits.bsky.social
GPi DBS for dystonia is effective.
More recently, STN DBS has been investigated, as an alternative.
In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks…
www.pnas.org/doi/10.1073/...
January 8, 2025 at 8:03 PM
🚨Interested in Dystonia?🚨
@braincircuits.bsky.social
GPi DBS for dystonia is effective.
More recently, STN DBS has been investigated, as an alternative.
In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks…
www.pnas.org/doi/10.1073/...
@braincircuits.bsky.social
GPi DBS for dystonia is effective.
More recently, STN DBS has been investigated, as an alternative.
In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks…
www.pnas.org/doi/10.1073/...
New use for ChatGPT: help me figure out how to respond to this reviewer comment without throwing off the overall flow of the paper.
January 5, 2025 at 3:33 AM
New use for ChatGPT: help me figure out how to respond to this reviewer comment without throwing off the overall flow of the paper.
Reposted by Shan Siddiqi
Happy to share Bryan Jenkins' latest work published in @psychopharmacology.bsky.social: Cannabidiol potentiates physiological and behavioral markers of hypothalamic–pituitary–adrenal (HPA) axis responsivity in female and male mice link.springer.com/article/10.1.... Bryan truly led this project!
Cannabidiol (CBD) potentiates physiological and behavioral markers of hypothalamic–pituitary–adrenal (HPA) axis responsivity in female and male mice - Psychopharmacology
Rationale Clinical literature indicates there may be a therapeutic use of cannabidiol (CBD) for stress-related disorders. Preclinical literature remains conflicted regarding the underlying neurobehavi...
link.springer.com
January 4, 2025 at 4:56 PM
Happy to share Bryan Jenkins' latest work published in @psychopharmacology.bsky.social: Cannabidiol potentiates physiological and behavioral markers of hypothalamic–pituitary–adrenal (HPA) axis responsivity in female and male mice link.springer.com/article/10.1.... Bryan truly led this project!
Reposted by Shan Siddiqi
Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.
December 20, 2024 at 11:18 AM
Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.
Don't miss out on "Neuropsychiatry of Magic," the 1075th meeting of the Boston Society of Neurology, Neurosurgery, and Psychiatry, featuring Daniel Roy's neuroscience-inspired magic performance!
Join us Thurs, Jan 16 at 6pm for an unforgettable evening.
RSVP:
www.eventbrite.com/e/neuropsych...
Join us Thurs, Jan 16 at 6pm for an unforgettable evening.
RSVP:
www.eventbrite.com/e/neuropsych...
December 28, 2024 at 1:06 AM
Don't miss out on "Neuropsychiatry of Magic," the 1075th meeting of the Boston Society of Neurology, Neurosurgery, and Psychiatry, featuring Daniel Roy's neuroscience-inspired magic performance!
Join us Thurs, Jan 16 at 6pm for an unforgettable evening.
RSVP:
www.eventbrite.com/e/neuropsych...
Join us Thurs, Jan 16 at 6pm for an unforgettable evening.
RSVP:
www.eventbrite.com/e/neuropsych...
Reposted by Shan Siddiqi
The effect of spherical projections on spin tests for brain maps | biorxiv.org/content/10.1...
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
December 20, 2024 at 2:39 PM
The effect of spherical projections on spin tests for brain maps | biorxiv.org/content/10.1...
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
Reposted by Shan Siddiqi
Happy for this to arrive just in time to add to my holiday book pile: Conversations in Critical Psychiatry by @awaisaftab.bsky.social. I'm looking forward to this one.
December 19, 2024 at 9:17 PM
Happy for this to arrive just in time to add to my holiday book pile: Conversations in Critical Psychiatry by @awaisaftab.bsky.social. I'm looking forward to this one.