Lukas Goede
@lukasgoede.bsky.social
Neuroscientist @ Brigham & Women's Hospital, Harvard Medical School | @netstim.org | Neurology resident | Interested in deep brain stimulation, non-invasive brain stimulation and movement disorders
What might the future of deep brain stimulation look like?
Not just continuous stimulation, but decoding symptoms in real time and directing stimulation to the right brain circuits.
Fascinating perspective article by @andreashorn.org & @julianneumann.bsky.social in @natrevneurol.nature.com:
Not just continuous stimulation, but decoding symptoms in real time and directing stimulation to the right brain circuits.
Fascinating perspective article by @andreashorn.org & @julianneumann.bsky.social in @natrevneurol.nature.com:
In #DeepBrainStimulation
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
September 4, 2025 at 4:09 PM
What might the future of deep brain stimulation look like?
Not just continuous stimulation, but decoding symptoms in real time and directing stimulation to the right brain circuits.
Fascinating perspective article by @andreashorn.org & @julianneumann.bsky.social in @natrevneurol.nature.com:
Not just continuous stimulation, but decoding symptoms in real time and directing stimulation to the right brain circuits.
Fascinating perspective article by @andreashorn.org & @julianneumann.bsky.social in @natrevneurol.nature.com:
Reposted by Lukas Goede
Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES
Tremor is a common symptom across many neurological disorders.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
May 24, 2025 at 2:30 PM
Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES
Tremor is a common symptom across many neurological disorders.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
May 22, 2025 at 8:41 PM
Tremor is a common symptom across many neurological disorders.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
Patient selection for Deep Brain Stimulation (DBS) is crucial.
Are there ways to improve it?
In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.
doi.org/10.1002/acn3...
A thread. 🧵
Are there ways to improve it?
In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.
doi.org/10.1002/acn3...
A thread. 🧵
Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?
Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 P...
doi.org
May 19, 2025 at 7:14 PM
Patient selection for Deep Brain Stimulation (DBS) is crucial.
Are there ways to improve it?
In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.
doi.org/10.1002/acn3...
A thread. 🧵
Are there ways to improve it?
In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response
- and serve as an additional marker for DBS outcomes.
doi.org/10.1002/acn3...
A thread. 🧵
Reposted by Lukas Goede
When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal:
doi.org/10.1016/j.br...
doi.org/10.1016/j.br...
May 12, 2025 at 11:18 AM
When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal:
doi.org/10.1016/j.br...
doi.org/10.1016/j.br...
Follow this interesting study led by @bahnebahners.bsky.social and @andreashorn.org using MEG‑LFP data to investigate cortico‑subthalamic coupling in Parkinson’s disease. The study showed that the optimal DBS response network defined by fMRI operates in the high‑beta band.
Happy to be part of it!
Happy to be part of it!
🚨 🥁 Preprint alert:
The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band
->> www.researchgate.net/publication/... <<--
The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band
->> www.researchgate.net/publication/... <<--
April 9, 2025 at 7:28 PM
Follow this interesting study led by @bahnebahners.bsky.social and @andreashorn.org using MEG‑LFP data to investigate cortico‑subthalamic coupling in Parkinson’s disease. The study showed that the optimal DBS response network defined by fMRI operates in the high‑beta band.
Happy to be part of it!
Happy to be part of it!
Reposted by Lukas Goede
Is generalized epilepsy a seizure of the whole brain or a specific brain network?
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications
Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...
nature.com
March 24, 2025 at 4:01 PM
Is generalized epilepsy a seizure of the whole brain or a specific brain network?
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
Reposted by Lukas Goede
Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder?
Take a look at our summary of this exciting field and how things could be brought together out now in BPS:
www.biologicalpsychiatryjournal.com/article/S000...
A brief 🧵
Take a look at our summary of this exciting field and how things could be brought together out now in BPS:
www.biologicalpsychiatryjournal.com/article/S000...
A brief 🧵
Deep Brain Stimulation response circuits in Obsessive Compulsive Disorder
In the field of deep brain stimulation (DBS), two major themes are currently making
significant progress. First, the framework of connectomic DBS, in which circuits that
are associated with improvemen...
www.biologicalpsychiatryjournal.com
March 21, 2025 at 4:13 PM
Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder?
Take a look at our summary of this exciting field and how things could be brought together out now in BPS:
www.biologicalpsychiatryjournal.com/article/S000...
A brief 🧵
Take a look at our summary of this exciting field and how things could be brought together out now in BPS:
www.biologicalpsychiatryjournal.com/article/S000...
A brief 🧵
Want to learn DBS electrode localization with @lead-dbs.org while being able to verify your results?
This new tool from the @netstim.org lab lets you compare your performance against experts.
Spearheaded by Savir Madan & @laurenahart.bsky.social
This new tool from the @netstim.org lab lets you compare your performance against experts.
Spearheaded by Savir Madan & @laurenahart.bsky.social
Madan and Hart et al. introduce Lead-Tutor, an open-access educational resource that combines an imaging dataset of anonymized DBS cases with a software tool for self-teaching: doi.org/10.52294/001...
@laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social
@laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social
March 1, 2025 at 7:37 AM
Want to learn DBS electrode localization with @lead-dbs.org while being able to verify your results?
This new tool from the @netstim.org lab lets you compare your performance against experts.
Spearheaded by Savir Madan & @laurenahart.bsky.social
This new tool from the @netstim.org lab lets you compare your performance against experts.
Spearheaded by Savir Madan & @laurenahart.bsky.social
A fantastic resource for science communication: Openly available icons illustrating different Parkinson’s disease symptoms, created by @patriciazvarova.bsky.social with patient feedback.
Explore them here: osf.io/ybcah/
Explore them here: osf.io/ybcah/
February 15, 2025 at 2:36 AM
A fantastic resource for science communication: Openly available icons illustrating different Parkinson’s disease symptoms, created by @patriciazvarova.bsky.social with patient feedback.
Explore them here: osf.io/ybcah/
Explore them here: osf.io/ybcah/
Reposted by Lukas Goede
jamanetwork.com/journals/jam...
Thread below👇
Thread below👇
Mapping Lesions That Cause Psychosis
This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit
jamanetwork.com
February 12, 2025 at 9:47 PM
jamanetwork.com/journals/jam...
Thread below👇
Thread below👇
Reposted by Lukas Goede
Interested in modeling DBS induced white matter activations?
Konstantin Butenko has a new preprint on all the options available within OSS-DBS / @lead-dbs.org including Electric Field Projections and probabilistic Pathway Activation Modeling:
www.medrxiv.org/content/10.1...
Konstantin Butenko has a new preprint on all the options available within OSS-DBS / @lead-dbs.org including Electric Field Projections and probabilistic Pathway Activation Modeling:
www.medrxiv.org/content/10.1...
January 19, 2025 at 12:49 AM
Interested in modeling DBS induced white matter activations?
Konstantin Butenko has a new preprint on all the options available within OSS-DBS / @lead-dbs.org including Electric Field Projections and probabilistic Pathway Activation Modeling:
www.medrxiv.org/content/10.1...
Konstantin Butenko has a new preprint on all the options available within OSS-DBS / @lead-dbs.org including Electric Field Projections and probabilistic Pathway Activation Modeling:
www.medrxiv.org/content/10.1...
Reposted by Lukas Goede
🚨Interested in Dystonia?🚨
@braincircuits.bsky.social
GPi DBS for dystonia is effective.
More recently, STN DBS has been investigated, as an alternative.
In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks…
www.pnas.org/doi/10.1073/...
@braincircuits.bsky.social
GPi DBS for dystonia is effective.
More recently, STN DBS has been investigated, as an alternative.
In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks…
www.pnas.org/doi/10.1073/...
January 8, 2025 at 8:03 PM
🚨Interested in Dystonia?🚨
@braincircuits.bsky.social
GPi DBS for dystonia is effective.
More recently, STN DBS has been investigated, as an alternative.
In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks…
www.pnas.org/doi/10.1073/...
@braincircuits.bsky.social
GPi DBS for dystonia is effective.
More recently, STN DBS has been investigated, as an alternative.
In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks…
www.pnas.org/doi/10.1073/...
We report an interesting case of late-onset Pelizaeus-Merzbacher-like disease 1, diagnosed via genetic testing in a patient with decades-long progressive spasticity and tremor.
Explore it now in Movement Disorders Clinical Practice!
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Explore it now in Movement Disorders Clinical Practice!
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com
January 6, 2025 at 4:07 PM
We report an interesting case of late-onset Pelizaeus-Merzbacher-like disease 1, diagnosed via genetic testing in a patient with decades-long progressive spasticity and tremor.
Explore it now in Movement Disorders Clinical Practice!
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Explore it now in Movement Disorders Clinical Practice!
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Lukas Goede
The brain’s action-mode is created by a dedicated action-mode network (AMN) rdcu.be/d5odm. In the brain’s mode continuum, AMN sits opposite DMN’s default-mode, as yin-yang. AMN might be key in pain, apathy, Parkinson’s. New @natrevneurosci.bsky.social w/ Marc Raichle & @gordonneuro.bsky.social 🧵 ⬇️
January 2, 2025 at 4:48 PM
The brain’s action-mode is created by a dedicated action-mode network (AMN) rdcu.be/d5odm. In the brain’s mode continuum, AMN sits opposite DMN’s default-mode, as yin-yang. AMN might be key in pain, apathy, Parkinson’s. New @natrevneurosci.bsky.social w/ Marc Raichle & @gordonneuro.bsky.social 🧵 ⬇️
Reposted by Lukas Goede
New landmark TMS trial dropped by Jonathan Downar's team, which will revolutionize care for depression even more than the SAINT trial did – extensive (10 hour!) sessions of TMS in a single day, enhanced by single dose of cycloserine. 90% response, 70% remission!
www.researchgate.net/publication/...
www.researchgate.net/publication/...
(PDF) Real-world effectiveness of a single-day regimen for transcranial magnetic stimulation using Optimized, Neuroplastogen-Enhanced techniques in Depression (ONE-D)
PDF | Background: Conventional transcranial magnetic stimulation (TMS) regimens are logistically burdensome, requiring days or weeks of clinic visits.... | Find, read and cite all the research you nee...
www.researchgate.net
December 27, 2024 at 2:35 PM
New landmark TMS trial dropped by Jonathan Downar's team, which will revolutionize care for depression even more than the SAINT trial did – extensive (10 hour!) sessions of TMS in a single day, enhanced by single dose of cycloserine. 90% response, 70% remission!
www.researchgate.net/publication/...
www.researchgate.net/publication/...
Today at noon ET - make sure not to miss these talks about evoked potentials in neuromodulation.
Registration is free.
Registration is free.
The final (& an amazing!) installment of the 2024 talk series is here! Join us on Thursday, Dec 19 to hear @bahnebahners.bsky.social and @allisonwatersphd.bsky.social discuss bridging the gap between electrophysiology and neuromodulation! Register for free here: stimulatingbrains.org/talk-series/
December 19, 2024 at 2:17 PM
Today at noon ET - make sure not to miss these talks about evoked potentials in neuromodulation.
Registration is free.
Registration is free.
Reposted by Lukas Goede
Today we say goodbye to @bahnebahners.bsky.social who spent the last year with us as a Thiemann visiting fellow – safe travels, don't be a stranger & thank you so much for bringing so much fun, joy and science into the lab & the @braincircuits.bsky.social!
December 13, 2024 at 3:02 AM
Today we say goodbye to @bahnebahners.bsky.social who spent the last year with us as a Thiemann visiting fellow – safe travels, don't be a stranger & thank you so much for bringing so much fun, joy and science into the lab & the @braincircuits.bsky.social!
Reposted by Lukas Goede
First paper to ever use a 12-year-old feature of Lead-DBS which is to visualize graph networks, implemented still during the PhD of @andreashorn.org and pretty obscure in a tool called lead groupconnectome.
Achtzehn et al. on STN-DBS ➔ Cognitive Control:
onlinelibrary.wiley.com/doi/10.1002/...
Achtzehn et al. on STN-DBS ➔ Cognitive Control:
onlinelibrary.wiley.com/doi/10.1002/...
December 10, 2024 at 4:22 PM
First paper to ever use a 12-year-old feature of Lead-DBS which is to visualize graph networks, implemented still during the PhD of @andreashorn.org and pretty obscure in a tool called lead groupconnectome.
Achtzehn et al. on STN-DBS ➔ Cognitive Control:
onlinelibrary.wiley.com/doi/10.1002/...
Achtzehn et al. on STN-DBS ➔ Cognitive Control:
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Lukas Goede
Showed a glimpse of a new atlas that we're building in Paris yesterday. Pretty excited about it and implications for network modeling.
December 5, 2024 at 11:50 AM
Showed a glimpse of a new atlas that we're building in Paris yesterday. Pretty excited about it and implications for network modeling.
Reposted by Lukas Goede
Updated DBS starter pack including numerous new folks – @raynorproject.bsky.social @parkinsondotorg.bsky.social welcome to @bsky.app!
go.bsky.app/B9A9Cho
go.bsky.app/B9A9Cho
November 21, 2024 at 8:41 PM
Updated DBS starter pack including numerous new folks – @raynorproject.bsky.social @parkinsondotorg.bsky.social welcome to @bsky.app!
go.bsky.app/B9A9Cho
go.bsky.app/B9A9Cho
Reposted by Lukas Goede
New to #BlueSky and interested in following people who treat and study movement disorders?
#NeuroSky #MedSky #AcademicSky
Link (not exhaustive): go.bsky.app/F4ZDiMh
#NeuroSky #MedSky #AcademicSky
Link (not exhaustive): go.bsky.app/F4ZDiMh
November 21, 2024 at 1:09 AM
New to #BlueSky and interested in following people who treat and study movement disorders?
#NeuroSky #MedSky #AcademicSky
Link (not exhaustive): go.bsky.app/F4ZDiMh
#NeuroSky #MedSky #AcademicSky
Link (not exhaustive): go.bsky.app/F4ZDiMh
November 21, 2024 at 1:59 PM
Reposted by Lukas Goede
What an incredible episode of Stimulating Brains from Prof. @andreashorn.org with guests Prof. Susan Boehnke and astronomy CEO Mark McAuley. They covered a lot of important ground from Mark's Parkinson's diagnosis to the challenges he faced getting DBS to..
stimulatingbrains.org/63-mark-mcau...
stimulatingbrains.org/63-mark-mcau...
#63: Mark McAuley & Susan Boehnke – Patient-led Research, Patient-Centered Care and Neuroscience Education – Stimulating Brains
stimulatingbrains.org
November 20, 2024 at 1:35 PM
What an incredible episode of Stimulating Brains from Prof. @andreashorn.org with guests Prof. Susan Boehnke and astronomy CEO Mark McAuley. They covered a lot of important ground from Mark's Parkinson's diagnosis to the challenges he faced getting DBS to..
stimulatingbrains.org/63-mark-mcau...
stimulatingbrains.org/63-mark-mcau...
Make sure not to miss this session of @stimbrains.bsky.social next Thursday! Free registration link attached.
If you are curious about neuromodlation for clinicians, lesion network mapping in Epilepsy OR how to get a job in academia, join us for a very exciting session on Nov. 21st at 12 PM ET/6 PM CET ft our very own @fredschaper.bsky.social & Robert Fisher. Register here! partners.zoom.us/webinar/regi...
Welcome! You are invited to join a webinar: Stimulating brains talk series. After registering, you will receive a confirmation email about joining the webinar.
On Thursday 11/21 we will host Fred Schaper and Robert Fisher.
partners.zoom.us
November 14, 2024 at 7:54 PM
Make sure not to miss this session of @stimbrains.bsky.social next Thursday! Free registration link attached.