Andrew Pines
@andrewpines.bsky.social
Postdoctoral Research Fellow at Brigham and Women’s Hospital.
Interested in psychosis, causality, neuroimaging, neuromodulation
Interested in psychosis, causality, neuroimaging, neuromodulation
Pinned
Andrew Pines
@andrewpines.bsky.social
· Feb 12
Mapping Lesions That Cause Psychosis
This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit
jamanetwork.com
jamanetwork.com/journals/jam...
Thread below👇
Thread below👇
Reposted by Andrew Pines
🧠⚡ New year, fresh StimBrains talks!
Join us when we explore the brain networks driving schizophrenia & how we can treat them via DBS.
January session (Thurs, Jan 29, noon ET / 6pm CET)
feat. the amazing @andrewpines.bsky.social & Nicola Cascella
✨ Get Zoom link here: talks.stimulatingbrains.org
Join us when we explore the brain networks driving schizophrenia & how we can treat them via DBS.
January session (Thurs, Jan 29, noon ET / 6pm CET)
feat. the amazing @andrewpines.bsky.social & Nicola Cascella
✨ Get Zoom link here: talks.stimulatingbrains.org
January 20, 2026 at 9:01 PM
🧠⚡ New year, fresh StimBrains talks!
Join us when we explore the brain networks driving schizophrenia & how we can treat them via DBS.
January session (Thurs, Jan 29, noon ET / 6pm CET)
feat. the amazing @andrewpines.bsky.social & Nicola Cascella
✨ Get Zoom link here: talks.stimulatingbrains.org
Join us when we explore the brain networks driving schizophrenia & how we can treat them via DBS.
January session (Thurs, Jan 29, noon ET / 6pm CET)
feat. the amazing @andrewpines.bsky.social & Nicola Cascella
✨ Get Zoom link here: talks.stimulatingbrains.org
Reposted by Andrew Pines
What is the status of DBS for epilepsy?
Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/
A 🧵 — please RT for reach! 🙏
Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/
A 🧵 — please RT for reach! 🙏
December 19, 2025 at 10:19 PM
What is the status of DBS for epilepsy?
Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/
A 🧵 — please RT for reach! 🙏
Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/
A 🧵 — please RT for reach! 🙏
Super excited about this!
🧠⚡ New year, fresh StimBrains talks!
Join us when we explore the brain networks driving schizophrenia & how we can treat them via DBS.
January session (Thurs, Jan 29, noon ET / 6pm CET)
feat. the amazing @andrewpines.bsky.social & Nicola Cascella
✨ Get Zoom link here: talks.stimulatingbrains.org
Join us when we explore the brain networks driving schizophrenia & how we can treat them via DBS.
January session (Thurs, Jan 29, noon ET / 6pm CET)
feat. the amazing @andrewpines.bsky.social & Nicola Cascella
✨ Get Zoom link here: talks.stimulatingbrains.org
January 20, 2026 at 11:17 PM
Super excited about this!
Reposted by Andrew Pines
Activating brain regions linked to reward and positive expectations may be associated with increased antibody responses following vaccination, suggesting a connection between mental states and immune function. doi.org/hbkjfq
Can training your brain boost immune response? Vaccination study highlights power of positive thinking
Training people to activate a part of the brain linked to reward and positive expectations may be associated with an increase in the body's immune response to a vaccine.
medicalxpress.com
January 19, 2026 at 7:14 PM
Activating brain regions linked to reward and positive expectations may be associated with increased antibody responses following vaccination, suggesting a connection between mental states and immune function. doi.org/hbkjfq
Reposted by Andrew Pines
Are connectome-based network mapping methods and the >200 papers that have used it invalid?
New paper out in
@NatureNeuro
says YES. nature.com/articles/s41...
I have concerns about this new paper's methods and conclusions, but am biased. What do others think?
New paper out in
@NatureNeuro
says YES. nature.com/articles/s41...
I have concerns about this new paper's methods and conclusions, but am biased. What do others think?
Investigating the methodological foundation of lesion network mapping - Nature Neuroscience
The lesion network mapping method links diverse brain lesions to similar functional brain networks, reflecting general brain organization rather than disorder-specific circuits.
nature.com
January 18, 2026 at 1:59 AM
Are connectome-based network mapping methods and the >200 papers that have used it invalid?
New paper out in
@NatureNeuro
says YES. nature.com/articles/s41...
I have concerns about this new paper's methods and conclusions, but am biased. What do others think?
New paper out in
@NatureNeuro
says YES. nature.com/articles/s41...
I have concerns about this new paper's methods and conclusions, but am biased. What do others think?
Reposted by Andrew Pines
New Perspective from myself, Sarah Heilbronner and @myoo.bsky.social . “Rethinking the centrality of brain areas in understanding functional organization” in Nature Neuroscience. 🧵
rdcu.be/eVZ1A
rdcu.be/eVZ1A
Rethinking the centrality of brain areas in understanding functional organization
Nature Neuroscience - Parcellation of the cortex into functionally modular brain areas is foundational to neuroscience. Here, Hayden, Heilbronner and Yoo question the central status of brain areas...
rdcu.be
December 23, 2025 at 1:02 PM
New Perspective from myself, Sarah Heilbronner and @myoo.bsky.social . “Rethinking the centrality of brain areas in understanding functional organization” in Nature Neuroscience. 🧵
rdcu.be/eVZ1A
rdcu.be/eVZ1A
Reposted by Andrew Pines
The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more!
Please rt and reach out if you’re interested 👀
Find out more holmeslab.rutgers.edu
Please rt and reach out if you’re interested 👀
Find out more holmeslab.rutgers.edu
November 11, 2025 at 4:50 PM
The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more!
Please rt and reach out if you’re interested 👀
Find out more holmeslab.rutgers.edu
Please rt and reach out if you’re interested 👀
Find out more holmeslab.rutgers.edu
Reposted by Andrew Pines
🚨 New preprint out! 🚨
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
August 22, 2025 at 2:21 PM
🚨 New preprint out! 🚨
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
“Translating the Transcriptome: A Connectomics Approach for Gene-Network Mapping and Clinical Application”
🔗 doi.org/10.1101/2025... 
🧵 A short thread:
Reposted by Andrew Pines
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
July 17, 2025 at 1:36 AM
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...
doi.org/10.1038/s415...
Reposted by Andrew Pines
Alert!!!!
“An Action Networks Model for Pain”
We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.
👉 thread below 🧵
osf.io/preprints/ps...
“An Action Networks Model for Pain”
We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.
👉 thread below 🧵
osf.io/preprints/ps...
June 26, 2025 at 1:29 PM
Alert!!!!
“An Action Networks Model for Pain”
We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.
👉 thread below 🧵
osf.io/preprints/ps...
“An Action Networks Model for Pain”
We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it.
👉 thread below 🧵
osf.io/preprints/ps...
Reposted by Andrew Pines
Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover!
🔗 Full article: onlinelibrary.wiley.com/doi/full/10....
@childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social
🔗 Full article: onlinelibrary.wiley.com/doi/full/10....
@childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social
Coordinate Network Mapping of Focal Brain Volume Differences in ADHD Reveals Common Patterns That Lack Specificity: A Systematic Review
Objective Attention-deficit/hyperactivity disorder (ADHD) has been associated with decreased regional brain volume, yet no consistent localization has emerged across studies. This discrepancy has be...
onlinelibrary.wiley.com
June 17, 2025 at 12:30 PM
Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover!
🔗 Full article: onlinelibrary.wiley.com/doi/full/10....
@childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social
🔗 Full article: onlinelibrary.wiley.com/doi/full/10....
@childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social
Reposted by Andrew Pines
Out now in Brain
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
March 23, 2025 at 3:05 AM
Out now in Brain
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
Reposted by Andrew Pines
Mixed Bag #22: Nils Wendel on Learning Psychopharmacology
Wendel explores the topic using a book, a concept, a person, an article, and a surprise item
www.psychiatrymargins.com/p/mixed-bag-...
Wendel explores the topic using a book, a concept, a person, an article, and a surprise item
www.psychiatrymargins.com/p/mixed-bag-...
Mixed Bag #22: Nils Wendel on Learning Psychopharmacology
A book, a concept, a person, an article, and a surprise item
www.psychiatrymargins.com
May 23, 2025 at 2:39 PM
Mixed Bag #22: Nils Wendel on Learning Psychopharmacology
Wendel explores the topic using a book, a concept, a person, an article, and a surprise item
www.psychiatrymargins.com/p/mixed-bag-...
Wendel explores the topic using a book, a concept, a person, an article, and a surprise item
www.psychiatrymargins.com/p/mixed-bag-...
Reposted by Andrew Pines
MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects?
@science.org @braincircuits.bsky.social @netstim.org
– a thread🧵!
www.science.org/doi/10.1126/...
@science.org @braincircuits.bsky.social @netstim.org
– a thread🧵!
www.science.org/doi/10.1126/...
May 14, 2025 at 7:24 PM
MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects?
@science.org @braincircuits.bsky.social @netstim.org
– a thread🧵!
www.science.org/doi/10.1126/...
@science.org @braincircuits.bsky.social @netstim.org
– a thread🧵!
www.science.org/doi/10.1126/...
Reposted by Andrew Pines
The brainstem’s red nucleus is an evolutionarily old structure that emerged as animals began to use limbs for walking, but its function in humans reaches beyond motor control, a new study suggests.
By @sydneywyatt.bsky.social
#neuroskyence
www.thetransmitter.org/brain-imagin...
By @sydneywyatt.bsky.social
#neuroskyence
www.thetransmitter.org/brain-imagin...
‘Old’ brainstem structure evolved beyond basic motor control
The human red nucleus may also help coordinate action, reward and motivated behavior, a new study suggests.
www.thetransmitter.org
May 16, 2025 at 4:55 PM
The brainstem’s red nucleus is an evolutionarily old structure that emerged as animals began to use limbs for walking, but its function in humans reaches beyond motor control, a new study suggests.
By @sydneywyatt.bsky.social
#neuroskyence
www.thetransmitter.org/brain-imagin...
By @sydneywyatt.bsky.social
#neuroskyence
www.thetransmitter.org/brain-imagin...
Reposted by Andrew Pines
When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal:
doi.org/10.1016/j.br...
doi.org/10.1016/j.br...
May 12, 2025 at 11:18 AM
When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal:
doi.org/10.1016/j.br...
doi.org/10.1016/j.br...
Reposted by Andrew Pines
🧠💊New preprint differentiating antipsychotic medication vs. illness effects on cortical thickness in people w/ psychosis.
Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3
www.medrxiv.org/content/10.1...
Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3
www.medrxiv.org/content/10.1...
May 12, 2025 at 1:09 AM
🧠💊New preprint differentiating antipsychotic medication vs. illness effects on cortical thickness in people w/ psychosis.
Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3
www.medrxiv.org/content/10.1...
Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3
www.medrxiv.org/content/10.1...
Reposted by Andrew Pines
We’re hiring a clinical research coordinator to lead a neuroimaging study on brain changes across pregnancy and perinatal depression.
wd1.myworkdaysite.com/en-US/recrui...
Please RT.
wd1.myworkdaysite.com/en-US/recrui...
Please RT.
April 28, 2025 at 4:47 PM
We’re hiring a clinical research coordinator to lead a neuroimaging study on brain changes across pregnancy and perinatal depression.
wd1.myworkdaysite.com/en-US/recrui...
Please RT.
wd1.myworkdaysite.com/en-US/recrui...
Please RT.
Reposted by Andrew Pines
It was a great honor to talk with the founding editor of Brain Stimulation, Dr. Harold Sackeim!
Beyond the past, present and future of ECT, we covered the entire field of neuromodulation.
Priceless insights from a key leader in the field!
Tune in here 👇
stimulatingbrains.org/71-harold-sa...
Beyond the past, present and future of ECT, we covered the entire field of neuromodulation.
Priceless insights from a key leader in the field!
Tune in here 👇
stimulatingbrains.org/71-harold-sa...
April 25, 2025 at 2:12 AM
It was a great honor to talk with the founding editor of Brain Stimulation, Dr. Harold Sackeim!
Beyond the past, present and future of ECT, we covered the entire field of neuromodulation.
Priceless insights from a key leader in the field!
Tune in here 👇
stimulatingbrains.org/71-harold-sa...
Beyond the past, present and future of ECT, we covered the entire field of neuromodulation.
Priceless insights from a key leader in the field!
Tune in here 👇
stimulatingbrains.org/71-harold-sa...
Reposted by Andrew Pines
We had a truly inspiring and insightful conversation with Dr. Rees Cosgrove, Director of Epilepsy and Functional Neurosurgery at @brighamandwomens.bsky.social & Professor of Neurosurgery @harvardmed.bsky.social
Rediscovering the lost art of brain lesions…!
stimulatingbrains.org/70-rees-cosg...
Rediscovering the lost art of brain lesions…!
stimulatingbrains.org/70-rees-cosg...
April 22, 2025 at 8:31 PM
We had a truly inspiring and insightful conversation with Dr. Rees Cosgrove, Director of Epilepsy and Functional Neurosurgery at @brighamandwomens.bsky.social & Professor of Neurosurgery @harvardmed.bsky.social
Rediscovering the lost art of brain lesions…!
stimulatingbrains.org/70-rees-cosg...
Rediscovering the lost art of brain lesions…!
stimulatingbrains.org/70-rees-cosg...
Reposted by Andrew Pines
A postdoc in my lab contacted a fellow scientist to get some advice and was told that, because he's currently working on the topic, he "can't give away all his secrets." I find this extremely lame, and yet I keep encountering it. Science is not a zero-sum game!!
April 16, 2025 at 9:14 PM
A postdoc in my lab contacted a fellow scientist to get some advice and was told that, because he's currently working on the topic, he "can't give away all his secrets." I find this extremely lame, and yet I keep encountering it. Science is not a zero-sum game!!
Reposted by Andrew Pines
Probably the most insightful and most important paper on physiomarkers of subthalamic DBS in a long while. Bravo @julianneumann.bsky.social @tsbinns.com and team!!
Out at @natcomms.nature.com:
www.nature.com/articles/s41...
Out at @natcomms.nature.com:
www.nature.com/articles/s41...
April 16, 2025 at 12:50 AM
Probably the most insightful and most important paper on physiomarkers of subthalamic DBS in a long while. Bravo @julianneumann.bsky.social @tsbinns.com and team!!
Out at @natcomms.nature.com:
www.nature.com/articles/s41...
Out at @natcomms.nature.com:
www.nature.com/articles/s41...
Reposted by Andrew Pines
When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/
DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC
Transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) is hypothesized to relieve symptoms of depression by inhibiting activity in the subgenual anterior cingulate corte...
www.biorxiv.org
April 9, 2025 at 11:12 PM
When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/
Reposted by Andrew Pines
It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠
A network correspondence toolbox for quantitative evaluation of novel neuroimaging results - Nature Communications
Here, the authors present the Network Correspondence Toolbox, which enables researchers to examine and report spatial correspondence between their neuroimaging results and widely used brain atlases.
www.nature.com
March 26, 2025 at 1:54 AM
It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠
Reposted by Andrew Pines
Cool talk by Aaron Boes on clinical applications and cognitive prognosis from network neuroimaging @bostonchildrens.bsky.social @harvardmed.bsky.social
March 26, 2025 at 6:21 PM
Cool talk by Aaron Boes on clinical applications and cognitive prognosis from network neuroimaging @bostonchildrens.bsky.social @harvardmed.bsky.social