Can Sarica
@cansarica.bsky.social
🇹🇷 🇨🇦 Neurosurgeon, Current PhD candidate @KBI_UHN & former clinical fellow @UofT studying focused ultrasound w Andres M. Lozano and Robert Chen
Reposted by Can Sarica
Which is best, one side or two? A Systematic Review of Deep Brain Stimulation Approaches in PD and Essential Tremor. https://loom.ly/dT7cWGA
September 19, 2025 at 10:16 PM
Which is best, one side or two? A Systematic Review of Deep Brain Stimulation Approaches in PD and Essential Tremor. https://loom.ly/dT7cWGA
Reposted by Can Sarica
Deep Brain Ultrasound Augments Human Attention https://www.biorxiv.org/content/10.1101/2025.09.28.678996v1
September 29, 2025 at 6:15 PM
Deep Brain Ultrasound Augments Human Attention https://www.biorxiv.org/content/10.1101/2025.09.28.678996v1
Honored to be selected as one of the finalists for the DBS Think Tank Rising Stars Challenge. Grateful to the
@dbsthinktank.bsky.social community for this opportunity and for fostering such an inspiring platform for advancing #DBS research. Excited to share my work on Aug 29! Links below 👇
@dbsthinktank.bsky.social community for this opportunity and for fostering such an inspiring platform for advancing #DBS research. Excited to share my work on Aug 29! Links below 👇
August 19, 2025 at 6:45 PM
Honored to be selected as one of the finalists for the DBS Think Tank Rising Stars Challenge. Grateful to the
@dbsthinktank.bsky.social community for this opportunity and for fostering such an inspiring platform for advancing #DBS research. Excited to share my work on Aug 29! Links below 👇
@dbsthinktank.bsky.social community for this opportunity and for fostering such an inspiring platform for advancing #DBS research. Excited to share my work on Aug 29! Links below 👇
Reposted by Can Sarica
Should you have DBS on one side or two sides of your brain? Do you know why the answer isn’t in the averages? A paper by Vetkas and colleagues presents pooled data and we should be cautious how we interpret. @parkinsondotorg.bsky.social
August 15, 2025 at 12:18 PM
Should you have DBS on one side or two sides of your brain? Do you know why the answer isn’t in the averages? A paper by Vetkas and colleagues presents pooled data and we should be cautious how we interpret. @parkinsondotorg.bsky.social
www.nature.com/articles/s41...
New study out! Is bilateral STN #DBS for #PD merely 2 × unilateral—or something more? We scanned 22 pts with #BOLD #fMRI: half with one lead on, half with both. Bilateral stimulation showed a synergistic suppression of sensorimotor cortex @alfonsofasano.bsky.social
New study out! Is bilateral STN #DBS for #PD merely 2 × unilateral—or something more? We scanned 22 pts with #BOLD #fMRI: half with one lead on, half with both. Bilateral stimulation showed a synergistic suppression of sensorimotor cortex @alfonsofasano.bsky.social
Functional network differences between unilateral and bilateral deep brain stimulation of the subthalamic nucleus - npj Parkinson's Disease
npj Parkinson's Disease - Functional network differences between unilateral and bilateral deep brain stimulation of the subthalamic nucleus
www.nature.com
July 19, 2025 at 10:54 AM
www.nature.com/articles/s41...
New study out! Is bilateral STN #DBS for #PD merely 2 × unilateral—or something more? We scanned 22 pts with #BOLD #fMRI: half with one lead on, half with both. Bilateral stimulation showed a synergistic suppression of sensorimotor cortex @alfonsofasano.bsky.social
New study out! Is bilateral STN #DBS for #PD merely 2 × unilateral—or something more? We scanned 22 pts with #BOLD #fMRI: half with one lead on, half with both. Bilateral stimulation showed a synergistic suppression of sensorimotor cortex @alfonsofasano.bsky.social
Excited to share our latest paper in @thejournalofpain.bsky.social, led by my dear friend Oliver Flouty!
Using #ECoG in 4 sheep, we explored supraspinal effects of high-frequency #spinalcordstimulation— revealing region- and frequency-specific modulatory patterns.
www.jpain.org/article/S152...
Using #ECoG in 4 sheep, we explored supraspinal effects of high-frequency #spinalcordstimulation— revealing region- and frequency-specific modulatory patterns.
www.jpain.org/article/S152...
Neurophysiological effects of high-frequency spinal cord stimulation on cortico-sensory areas in large ovine animal model
Spinal Cord Stimulation (SCS) has been a cornerstone in managing chronic pain since
the late 1960s. However, traditional SCS is often associated with variable efficacy
and side effects, driving the de...
www.jpain.org
July 9, 2025 at 7:52 AM
Excited to share our latest paper in @thejournalofpain.bsky.social, led by my dear friend Oliver Flouty!
Using #ECoG in 4 sheep, we explored supraspinal effects of high-frequency #spinalcordstimulation— revealing region- and frequency-specific modulatory patterns.
www.jpain.org/article/S152...
Using #ECoG in 4 sheep, we explored supraspinal effects of high-frequency #spinalcordstimulation— revealing region- and frequency-specific modulatory patterns.
www.jpain.org/article/S152...
Thrilled to join the 24th International Symposium for Therapeutic Ultrasound #ISTU2025 in Banff! We shared our latest work on ultrasound in movement disorders with 4 oral presentations. Great to reconnect with colleagues worldwide—huge thanks to Samuel Pichardo & Laura Curiel, for organization.
June 24, 2025 at 7:39 PM
Thrilled to join the 24th International Symposium for Therapeutic Ultrasound #ISTU2025 in Banff! We shared our latest work on ultrasound in movement disorders with 4 oral presentations. Great to reconnect with colleagues worldwide—huge thanks to Samuel Pichardo & Laura Curiel, for organization.
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Happy to share our work in @movedisorder.bsky.social We compared outcomes of bilateral #HIFU and #DBS in essential tremor, identified thalamic hotspots using probabilistic mapping.
@fusfoundation.bsky.social @alfonsofasano.bsky.social
Happy to share our work in @movedisorder.bsky.social We compared outcomes of bilateral #HIFU and #DBS in essential tremor, identified thalamic hotspots using probabilistic mapping.
@fusfoundation.bsky.social @alfonsofasano.bsky.social
May 10, 2025 at 2:45 PM
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Happy to share our work in @movedisorder.bsky.social We compared outcomes of bilateral #HIFU and #DBS in essential tremor, identified thalamic hotspots using probabilistic mapping.
@fusfoundation.bsky.social @alfonsofasano.bsky.social
Happy to share our work in @movedisorder.bsky.social We compared outcomes of bilateral #HIFU and #DBS in essential tremor, identified thalamic hotspots using probabilistic mapping.
@fusfoundation.bsky.social @alfonsofasano.bsky.social
Reposted by Can Sarica
Invasive Deep Brain Stimulation is often a last resort for people with Parkinson's disease & other conditions.
Here, Darmani et al show direct electrophysiological evidence that *non-invasive* ultrasound stimulation is effective even in deep brain structures. Amazing! www.nature.com/articles/s41...
Here, Darmani et al show direct electrophysiological evidence that *non-invasive* ultrasound stimulation is effective even in deep brain structures. Amazing! www.nature.com/articles/s41...
Individualized non-invasive deep brain stimulation of the basal ganglia using transcranial ultrasound stimulation - Nature Communications
Transcranial ultrasound stimulation (TUS) is a non-invasive method to modulate deep brain activity. Using direct recordings from implanted electrodes, we showed that TUS engages the human globus palli...
www.nature.com
April 1, 2025 at 8:01 AM
Invasive Deep Brain Stimulation is often a last resort for people with Parkinson's disease & other conditions.
Here, Darmani et al show direct electrophysiological evidence that *non-invasive* ultrasound stimulation is effective even in deep brain structures. Amazing! www.nature.com/articles/s41...
Here, Darmani et al show direct electrophysiological evidence that *non-invasive* ultrasound stimulation is effective even in deep brain structures. Amazing! www.nature.com/articles/s41...
Reposted by Can Sarica
Wouldn't it be cool to be able to stimulate deep w/in the brain w/o the need for brain surgery, and without actually making a physical lesion in the brain (i.e. FUS or pallidotomy)? This paper provides 'proof of concept' that a transcranial ultrasound stimulation (TUS) approach may be achievable.
March 30, 2025 at 3:25 PM
Wouldn't it be cool to be able to stimulate deep w/in the brain w/o the need for brain surgery, and without actually making a physical lesion in the brain (i.e. FUS or pallidotomy)? This paper provides 'proof of concept' that a transcranial ultrasound stimulation (TUS) approach may be achievable.
Proud to share the first of our two-part sequel papers on the #TUS-#DBS project! t.co/yrGRcdpjXn
We recorded local field potentials using #PerceptPc #DBS systems in #Parkinsons patients while applying transcranial ultrasound stimulation (#TUS) — aiming to better understand its effects & mechanisms.
We recorded local field potentials using #PerceptPc #DBS systems in #Parkinsons patients while applying transcranial ultrasound stimulation (#TUS) — aiming to better understand its effects & mechanisms.
March 22, 2025 at 6:10 PM
Proud to share the first of our two-part sequel papers on the #TUS-#DBS project! t.co/yrGRcdpjXn
We recorded local field potentials using #PerceptPc #DBS systems in #Parkinsons patients while applying transcranial ultrasound stimulation (#TUS) — aiming to better understand its effects & mechanisms.
We recorded local field potentials using #PerceptPc #DBS systems in #Parkinsons patients while applying transcranial ultrasound stimulation (#TUS) — aiming to better understand its effects & mechanisms.
Our paper on the safety of transcranial ultrasound stimulation in #Parkinson patients, published in @movedisorder.bsky.social, has been recognized as one of the #TopCitedArticles! Huge thanks to my incredible co-first authors Drs. Samuel and Ding.
onlinelibrary.wiley.com/doi/full/10.... @wiley.com
onlinelibrary.wiley.com/doi/full/10.... @wiley.com
March 19, 2025 at 2:19 PM
Our paper on the safety of transcranial ultrasound stimulation in #Parkinson patients, published in @movedisorder.bsky.social, has been recognized as one of the #TopCitedArticles! Huge thanks to my incredible co-first authors Drs. Samuel and Ding.
onlinelibrary.wiley.com/doi/full/10.... @wiley.com
onlinelibrary.wiley.com/doi/full/10.... @wiley.com
Brain Stimulation Conference 2025 wraps up today! Grateful for the opportunity to present my latest work as a poster and to receive valuable feedback from some of the leading experts in the field. Already looking forward to next one! #BrainStim2025 #BrainStimConf @braistimjournal.bsky.social
February 26, 2025 at 2:12 PM
Brain Stimulation Conference 2025 wraps up today! Grateful for the opportunity to present my latest work as a poster and to receive valuable feedback from some of the leading experts in the field. Already looking forward to next one! #BrainStim2025 #BrainStimConf @braistimjournal.bsky.social
We’re thrilled to hear from Dr. Andreas Horn, this year’s Brain Stimulation Early Career Award winner, at #BrainStimConf today! Congratulations on this well-deserved recognition @andreashorn.org #BrainStim2025 @braistimjournal.bsky.social @braincircuits.bsky.social
February 25, 2025 at 5:20 AM
We’re thrilled to hear from Dr. Andreas Horn, this year’s Brain Stimulation Early Career Award winner, at #BrainStimConf today! Congratulations on this well-deserved recognition @andreashorn.org #BrainStim2025 @braistimjournal.bsky.social @braincircuits.bsky.social
Thank you! It was wonderful to be in Boston and to have the opportunity to connect with you and the team.
It was great to have you here in Boston!
February 9, 2025 at 3:54 AM
Thank you! It was wonderful to be in Boston and to have the opportunity to connect with you and the team.
Honored to be invited by @foxmdphd.bsky.social to give a talk on mapping tremor response zones in thalamus @harvardmed.beky.social this Friday. It was a privilege to discuss with brilliant scientists like Dr. Cosgrove, Dr. Horn @andreashorn.org, Dr. Bubrick, and Dr. Siddiqi @shansiddiqi.bsky.social.
February 8, 2025 at 7:22 PM
Honored to be invited by @foxmdphd.bsky.social to give a talk on mapping tremor response zones in thalamus @harvardmed.beky.social this Friday. It was a privilege to discuss with brilliant scientists like Dr. Cosgrove, Dr. Horn @andreashorn.org, Dr. Bubrick, and Dr. Siddiqi @shansiddiqi.bsky.social.
Thrilled to share the final version of our paper on the #fMRI correlates of #spinalcordstimulation for chronic #backpain! Check it out in the latest issue of Brain Stimulation!
www.brainstimjrnl.com/article/S193...
www.brainstimjrnl.com/article/S193...
Functional MRI reveals brain activation patterns associated with optimization of spinal cord stimulation parameters in treating chronic pain
Spinal cord stimulation (SCS) is widely used to manage chronic pain, yet its supraspinal
mechanisms remain incompletely understood [1]. Chronic pain affects up to 20 % of
individuals globally and is a...
www.brainstimjrnl.com
January 24, 2025 at 5:06 PM
Thrilled to share the final version of our paper on the #fMRI correlates of #spinalcordstimulation for chronic #backpain! Check it out in the latest issue of Brain Stimulation!
www.brainstimjrnl.com/article/S193...
www.brainstimjrnl.com/article/S193...
doi.org/10.3171/2024...
Thrilled to unveil our multicenter study—featuring Bern, Hannover, Innsbruck, Milan, Oxford, & Toronto—mapping thalamic #DBS response regions for central post- #stroke #pain. A step forward in understanding and treating this challenging condition! @lead-dbs.org
Thrilled to unveil our multicenter study—featuring Bern, Hannover, Innsbruck, Milan, Oxford, & Toronto—mapping thalamic #DBS response regions for central post- #stroke #pain. A step forward in understanding and treating this challenging condition! @lead-dbs.org
January 5, 2025 at 2:22 PM
doi.org/10.3171/2024...
Thrilled to unveil our multicenter study—featuring Bern, Hannover, Innsbruck, Milan, Oxford, & Toronto—mapping thalamic #DBS response regions for central post- #stroke #pain. A step forward in understanding and treating this challenging condition! @lead-dbs.org
Thrilled to unveil our multicenter study—featuring Bern, Hannover, Innsbruck, Milan, Oxford, & Toronto—mapping thalamic #DBS response regions for central post- #stroke #pain. A step forward in understanding and treating this challenging condition! @lead-dbs.org
Check out our new book chapter on ethical challenges in the future of #DBS, authored by Cletus Cheyuo! It's featured in "Ethical Challenges for the Future of Neurosurgery," @springernature.bsky.social edited by Mark Bernstein and Ahmed Ammar. 📚
rdcu.be/d24nd
rdcu.be/d24nd
December 11, 2024 at 4:05 AM
Check out our new book chapter on ethical challenges in the future of #DBS, authored by Cletus Cheyuo! It's featured in "Ethical Challenges for the Future of Neurosurgery," @springernature.bsky.social edited by Mark Bernstein and Ahmed Ammar. 📚
rdcu.be/d24nd
rdcu.be/d24nd
t.co/SnttfVdhTF
In our latest study, we explored metaplastic effects on TUS-induced plasticity. We found that priming theta burst #TUS (tbTUS) with #TMS extends plasticity duration, while delivering #TMS immediately after #tbTUS abolishes its induction. Check it out at
@sfnjournals.bsky.social!
In our latest study, we explored metaplastic effects on TUS-induced plasticity. We found that priming theta burst #TUS (tbTUS) with #TMS extends plasticity duration, while delivering #TMS immediately after #tbTUS abolishes its induction. Check it out at
@sfnjournals.bsky.social!
https://www.jneurosci.org/content/44/44/e2438232024
t.co
December 4, 2024 at 5:50 AM
t.co/SnttfVdhTF
In our latest study, we explored metaplastic effects on TUS-induced plasticity. We found that priming theta burst #TUS (tbTUS) with #TMS extends plasticity duration, while delivering #TMS immediately after #tbTUS abolishes its induction. Check it out at
@sfnjournals.bsky.social!
In our latest study, we explored metaplastic effects on TUS-induced plasticity. We found that priming theta burst #TUS (tbTUS) with #TMS extends plasticity duration, while delivering #TMS immediately after #tbTUS abolishes its induction. Check it out at
@sfnjournals.bsky.social!
My close friends know I’ve been systematically visiting #UNESCO #WorldHeritageSites (WHS) and have now reached #277! Instead of sharing all my travel photos here, I’ll be updating my banner with WHS photos I’ve personally taken—starting with 🇺🇸 #Cahokia Mounds State Historic
November 23, 2024 at 1:29 PM
My close friends know I’ve been systematically visiting #UNESCO #WorldHeritageSites (WHS) and have now reached #277! Instead of sharing all my travel photos here, I’ll be updating my banner with WHS photos I’ve personally taken—starting with 🇺🇸 #Cahokia Mounds State Historic
Thrilled that the best time of the year is here: the #GairdnerScienceWeek Laureate Lectures! It was a privilege to hear from the 2024 @GairdnerAwards laureates Shankar Balasubramanian, David Klenerman, Pascal Mayer @PascalMAYER16, and Michel Sadelain. Their presentations were
November 23, 2024 at 1:29 PM
Thrilled that the best time of the year is here: the #GairdnerScienceWeek Laureate Lectures! It was a privilege to hear from the 2024 @GairdnerAwards laureates Shankar Balasubramanian, David Klenerman, Pascal Mayer @PascalMAYER16, and Michel Sadelain. Their presentations were
After a long break, my running mate Gozde and I got back into it with a 10k night run—double the fun compared to a day run, and triple the fun with the after-party DJ! #britanightrun
November 23, 2024 at 1:29 PM
After a long break, my running mate Gozde and I got back into it with a 10k night run—double the fun compared to a day run, and triple the fun with the after-party DJ! #britanightrun
The #WSSFN2024 Congress in Chicago was a huge success! Grateful to the organizers for making this incredible event happen @mhodaie. It was fantastic to see current and former Toronto fellows throughout the venue. Thrilled to present our latest research and excited for the
November 23, 2024 at 1:29 PM
The #WSSFN2024 Congress in Chicago was a huge success! Grateful to the organizers for making this incredible event happen @mhodaie. It was fantastic to see current and former Toronto fellows throughout the venue. Thrilled to present our latest research and excited for the