Frederic Schaper
@fredschaper.bsky.social
Instructor in Neurology, MD PhD | Neuroscientist at @braincircuits.bsky.social at Brigham and Women’s Hospital of MGB, Harvard Medical School | I’m Interested in neuromodulation, brain networks, and epilepsy
Pinned
Frederic Schaper
@fredschaper.bsky.social
· Mar 24
A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications
Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...
nature.com
Is generalized epilepsy a seizure of the whole brain or a specific brain network?
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
Reposted by Frederic Schaper
Honored to moderate a panel on noninvasive mapping of human brain circuits at MGB Neuroscience Day.
Great insights from @anastasiayendiki.bsky.social
@mghmartinos.bsky.social, @fredschaper.bsky.social
@braincircuits.bsky.social, Alex Golby and Pravan Nanda @mgbneurosurgres.bsky.social.
Great insights from @anastasiayendiki.bsky.social
@mghmartinos.bsky.social, @fredschaper.bsky.social
@braincircuits.bsky.social, Alex Golby and Pravan Nanda @mgbneurosurgres.bsky.social.
September 25, 2025 at 8:16 PM
Honored to moderate a panel on noninvasive mapping of human brain circuits at MGB Neuroscience Day.
Great insights from @anastasiayendiki.bsky.social
@mghmartinos.bsky.social, @fredschaper.bsky.social
@braincircuits.bsky.social, Alex Golby and Pravan Nanda @mgbneurosurgres.bsky.social.
Great insights from @anastasiayendiki.bsky.social
@mghmartinos.bsky.social, @fredschaper.bsky.social
@braincircuits.bsky.social, Alex Golby and Pravan Nanda @mgbneurosurgres.bsky.social.
Reposted by Frederic Schaper
Honored to highlight our work @braincircuits.bsky.social @massgenbrigham.bsky.social Neuro Research Day. Thank you @shansiddiqi.bsky.social @fredschaper.bsky.social Sheena Baratano and Sam Snider for sharing your experience.
July 21, 2025 at 5:31 PM
Honored to highlight our work @braincircuits.bsky.social @massgenbrigham.bsky.social Neuro Research Day. Thank you @shansiddiqi.bsky.social @fredschaper.bsky.social Sheena Baratano and Sam Snider for sharing your experience.
Reposted by Frederic Schaper
Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇
🧠 ⚡️ Preprint alert ⚡️ 🧠
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
June 24, 2025 at 7:33 PM
Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇
Reposted by Frederic Schaper
🧠 ⚡️ Preprint alert ⚡️ 🧠
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
June 24, 2025 at 7:24 PM
🧠 ⚡️ Preprint alert ⚡️ 🧠
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
Reposted by Frederic Schaper
Very hard to say goodbye to these fantastic people.
I will miss you guys! @braincircuits.bsky.social!
I will miss you guys! @braincircuits.bsky.social!
April 16, 2025 at 12:54 AM
Very hard to say goodbye to these fantastic people.
I will miss you guys! @braincircuits.bsky.social!
I will miss you guys! @braincircuits.bsky.social!
Reposted by Frederic Schaper
🚨 🥁 Preprint alert:
The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band
->> www.researchgate.net/publication/... <<--
The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band
->> www.researchgate.net/publication/... <<--
April 9, 2025 at 6:19 PM
🚨 🥁 Preprint alert:
The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band
->> www.researchgate.net/publication/... <<--
The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band
->> www.researchgate.net/publication/... <<--
Reposted by Frederic Schaper
How does early life adversity impact white matter brain connections and subsequent cognitive abilities?
Adversity was associated with lower white matter integrity and later difficulty with arithmetic & receptive language yet interpersonal resilience was protective.
www.pnas.org/doi/epub/10....
Adversity was associated with lower white matter integrity and later difficulty with arithmetic & receptive language yet interpersonal resilience was protective.
www.pnas.org/doi/epub/10....
www.pnas.org
April 7, 2025 at 8:52 PM
How does early life adversity impact white matter brain connections and subsequent cognitive abilities?
Adversity was associated with lower white matter integrity and later difficulty with arithmetic & receptive language yet interpersonal resilience was protective.
www.pnas.org/doi/epub/10....
Adversity was associated with lower white matter integrity and later difficulty with arithmetic & receptive language yet interpersonal resilience was protective.
www.pnas.org/doi/epub/10....
Reposted by Frederic Schaper
Was fun to do a podcast about our recent paper on creativity and brain disease with Dr Norman Swan @abcnewsbot.bsky.social @braincircuits.bsky.social @foxmdphd.bsky.social @harvardmed.bsky.social www.abc.net.au/listen/progr...
What brain damage tells us about creativity - ABC listen
Scientists have long been aware of a paradox of neurodegenerative disease – that as the brain deteriorates, in some patients creativity flourishes.
Researchers have used imaging techniques to map cre...
www.abc.net.au
March 30, 2025 at 1:02 PM
Was fun to do a podcast about our recent paper on creativity and brain disease with Dr Norman Swan @abcnewsbot.bsky.social @braincircuits.bsky.social @foxmdphd.bsky.social @harvardmed.bsky.social www.abc.net.au/listen/progr...
Reposted by Frederic Schaper
Is generalized epilepsy a seizure of the whole brain or a specific brain network?
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications
Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...
nature.com
March 25, 2025 at 1:38 AM
Reposted by Frederic Schaper
An amazing read and what a concise thread !!
Is generalized epilepsy a seizure of the whole brain or a specific brain network?
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications
Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...
nature.com
March 25, 2025 at 1:31 AM
An amazing read and what a concise thread !!
Reposted by Frederic Schaper
This is amazing work!
Is generalized epilepsy a seizure of the whole brain or a specific brain network?
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications
Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...
nature.com
March 25, 2025 at 12:55 AM
This is amazing work!
Reposted by Frederic Schaper
Lesions causing epilepsy map to a brain circuit, but what about generalized epilepsy? Great new paper (and thread) by @fredschaper.bsky.social identifies this circuit with implications for #DBS. @braincircuits.bsky.social
Is generalized epilepsy a seizure of the whole brain or a specific brain network?
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications
Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...
nature.com
March 25, 2025 at 1:15 AM
Lesions causing epilepsy map to a brain circuit, but what about generalized epilepsy? Great new paper (and thread) by @fredschaper.bsky.social identifies this circuit with implications for #DBS. @braincircuits.bsky.social
Reposted by Frederic Schaper
New @braincircuits.bsky.social paper out at @naturecomms.bsky.social 👇👇
Is generalized epilepsy a seizure of the whole brain or a specific brain network?
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications
Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...
nature.com
March 24, 2025 at 4:49 PM
New @braincircuits.bsky.social paper out at @naturecomms.bsky.social 👇👇
Reposted by Frederic Schaper
Fantastic new work by @fredschaper.bsky.social on mapping epilepsy onto brain networks! Congratulations Fred & team!
Is generalized epilepsy a seizure of the whole brain or a specific brain network?
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications
Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...
nature.com
March 24, 2025 at 4:48 PM
Fantastic new work by @fredschaper.bsky.social on mapping epilepsy onto brain networks! Congratulations Fred & team!
Is generalized epilepsy a seizure of the whole brain or a specific brain network?
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications
Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...
nature.com
March 24, 2025 at 4:01 PM
Is generalized epilepsy a seizure of the whole brain or a specific brain network?
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.
Paper: nature.com/articles/s41...
A 🧵 below:
Reposted by Frederic Schaper
Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder?
Take a look at our summary of this exciting field and how things could be brought together out now in BPS:
www.biologicalpsychiatryjournal.com/article/S000...
A brief 🧵
Take a look at our summary of this exciting field and how things could be brought together out now in BPS:
www.biologicalpsychiatryjournal.com/article/S000...
A brief 🧵
Deep Brain Stimulation response circuits in Obsessive Compulsive Disorder
In the field of deep brain stimulation (DBS), two major themes are currently making
significant progress. First, the framework of connectomic DBS, in which circuits that
are associated with improvemen...
www.biologicalpsychiatryjournal.com
March 21, 2025 at 4:13 PM
Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder?
Take a look at our summary of this exciting field and how things could be brought together out now in BPS:
www.biologicalpsychiatryjournal.com/article/S000...
A brief 🧵
Take a look at our summary of this exciting field and how things could be brought together out now in BPS:
www.biologicalpsychiatryjournal.com/article/S000...
A brief 🧵
Reposted by Frederic Schaper
Out now in Brain
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
March 23, 2025 at 3:05 AM
Out now in Brain
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
Reposted by Frederic Schaper
Can brain damage change your political opinions? “No significant neuroanatomical circuit was associated with political ideology or party affiliation, but a distinct circuit was associated with intensity of political involvement” Work by @shansiddiqi.bsky.social @braincircuits.bsky.social
Out now in Brain
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.
With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman
academic.oup.com/brain/advanc...
@braincircuits.bsky.social
March 23, 2025 at 1:45 PM
Can brain damage change your political opinions? “No significant neuroanatomical circuit was associated with political ideology or party affiliation, but a distinct circuit was associated with intensity of political involvement” Work by @shansiddiqi.bsky.social @braincircuits.bsky.social
Reposted by Frederic Schaper
Reposted by Frederic Schaper
Ever wondered how well your Lead-DBS electrode localizations compare to expert solutions on the same data? Now, with Lead-Tutor, you can self-assess!
Madan and Hart et al. introduce Lead-Tutor, an open-access educational resource that combines an imaging dataset of anonymized DBS cases with a software tool for self-teaching: doi.org/10.52294/001...
@laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social
@laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social
March 2, 2025 at 2:36 PM
Ever wondered how well your Lead-DBS electrode localizations compare to expert solutions on the same data? Now, with Lead-Tutor, you can self-assess!
Reposted by Frederic Schaper
A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪
Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine
Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range of age-related diseases were compared, highlighting the potential beneficial effects of environment-focused interventions.
go.nature.com
March 1, 2025 at 2:34 AM
A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪
Reposted by Frederic Schaper
The 12th Annual Deep Brain Stimulation Think Tank Proceedings are out and free to download. Check out Nico Dosenbach as he brings us up to speed on changes in the way we are thinking about the somato-cognitive action network (SCAN) functional connectivity to subcortex.
February 27, 2025 at 12:46 PM
The 12th Annual Deep Brain Stimulation Think Tank Proceedings are out and free to download. Check out Nico Dosenbach as he brings us up to speed on changes in the way we are thinking about the somato-cognitive action network (SCAN) functional connectivity to subcortex.
Reposted by Frederic Schaper
Reposted by Frederic Schaper
@andreashorn.org giving his Early Career Researcher Award Plenary lecture showing his imaging pipeline connectomics.
February 25, 2025 at 2:14 AM
@andreashorn.org giving his Early Career Researcher Award Plenary lecture showing his imaging pipeline connectomics.