Center for Brain Circuit Therapeutics
@braincircuits.bsky.social
Center For Brain Circuit Therapeutics at Mass General Brigham / Harvard Medical School
Reposted by Center for Brain Circuit Therapeutics
In #DeepBrainStimulation
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
September 3, 2025 at 7:59 PM
In #DeepBrainStimulation
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
Reposted by Center for Brain Circuit Therapeutics
From Adaptive DBS to Adaptive Circuit Targeting 👇👇
In #DeepBrainStimulation
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
September 3, 2025 at 8:09 PM
From Adaptive DBS to Adaptive Circuit Targeting 👇👇
Reposted by Center for Brain Circuit Therapeutics
Next steps ahead for DBS! 👇👇
In #DeepBrainStimulation
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
September 3, 2025 at 8:08 PM
Next steps ahead for DBS! 👇👇
Reposted by Center for Brain Circuit Therapeutics
One of our "bigger visions" for the next years summarized in a neat perspective paper out now 👇👇
In #DeepBrainStimulation
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
the two major developments across the last decade have been
1. Adaptive DBS and
2. Connectomic DBS
In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask:
Could the two be united into a common framework?
www.nature.com/articles/s41...
A 🧵
September 3, 2025 at 8:11 PM
One of our "bigger visions" for the next years summarized in a neat perspective paper out now 👇👇
Reposted by Center for Brain Circuit Therapeutics
How should we best model recruitment of axons by deep brain stimulation?
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:
academic.oup.com/braincomms/a...
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:
academic.oup.com/braincomms/a...
August 22, 2025 at 8:15 AM
How should we best model recruitment of axons by deep brain stimulation?
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:
academic.oup.com/braincomms/a...
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:
academic.oup.com/braincomms/a...
Reposted by Center for Brain Circuit Therapeutics
Konstantin Butenko compares four methods for mapping structural network activations in deep brain stimulation—two simple, two complex; some deterministic, some probabilistic—into @lead-dbs.org for direct use in the Fiber Filtering Explorer. See the methods paper below 👇👇
How should we best model recruitment of axons by deep brain stimulation?
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:
academic.oup.com/braincomms/a...
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:
academic.oup.com/braincomms/a...
August 22, 2025 at 8:17 AM
Konstantin Butenko compares four methods for mapping structural network activations in deep brain stimulation—two simple, two complex; some deterministic, some probabilistic—into @lead-dbs.org for direct use in the Fiber Filtering Explorer. See the methods paper below 👇👇
Reposted by Center for Brain Circuit Therapeutics
Sending off 2 of our best research assistants to graduate programs that are lucky to have them. Congrats Grace and Jessy and we look forward to your ongoing success! @braincircuits.bsky.social
August 19, 2025 at 11:09 PM
Sending off 2 of our best research assistants to graduate programs that are lucky to have them. Congrats Grace and Jessy and we look forward to your ongoing success! @braincircuits.bsky.social
Reposted by Center for Brain Circuit Therapeutics
Honored to highlight our work @braincircuits.bsky.social @massgenbrigham.bsky.social Neuro Research Day. Thank you @shansiddiqi.bsky.social @fredschaper.bsky.social Sheena Baratano and Sam Snider for sharing your experience.
July 21, 2025 at 5:31 PM
Honored to highlight our work @braincircuits.bsky.social @massgenbrigham.bsky.social Neuro Research Day. Thank you @shansiddiqi.bsky.social @fredschaper.bsky.social Sheena Baratano and Sam Snider for sharing your experience.
Reposted by Center for Brain Circuit Therapeutics
Is there a brain circuit target for restoring consciousness after brain injury? New work by @rolstonjohn.bsky.social @braincircuits.bsky.social says yes!
Just dropped in @natcomms.nature.com: we show that re-engaging a thalamic–ventral tegmental circuit with deep brain stimulation can reignite consciousness in patients with severe brain injury. Work led by Aaron Warren, with @andreashorn.org @foxmdphd.bsky.social @ others! tinyurl.com/4kz8j89b
A human brain network linked to restoration of consciousness after deep brain stimulation - Nature Communications
In people with severe brain injuries, stimulation restored consciousness by engaging a deep brain circuit for wakefulness—revealing a target that may also guide treatment in stroke and epilepsy.
www.nature.com
July 21, 2025 at 11:26 PM
Is there a brain circuit target for restoring consciousness after brain injury? New work by @rolstonjohn.bsky.social @braincircuits.bsky.social says yes!
Reposted by Center for Brain Circuit Therapeutics
How may traveling waves in the brain impact seizure focus detection in functional neurosurgery?
How does RNS for epilepsy really work?
Are we ready for stem cell therapy in PD?
DBS for disorders of consciousness?
Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇
How does RNS for epilepsy really work?
Are we ready for stem cell therapy in PD?
DBS for disorders of consciousness?
Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇
We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇
stimulatingbrains.org/72-john-rols...
stimulatingbrains.org/72-john-rols...
August 1, 2025 at 8:26 PM
How may traveling waves in the brain impact seizure focus detection in functional neurosurgery?
How does RNS for epilepsy really work?
Are we ready for stem cell therapy in PD?
DBS for disorders of consciousness?
Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇
How does RNS for epilepsy really work?
Are we ready for stem cell therapy in PD?
DBS for disorders of consciousness?
Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇
Reposted by Center for Brain Circuit Therapeutics
We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇
stimulatingbrains.org/72-john-rols...
stimulatingbrains.org/72-john-rols...
August 1, 2025 at 8:25 PM
We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇
stimulatingbrains.org/72-john-rols...
stimulatingbrains.org/72-john-rols...
Reposted by Center for Brain Circuit Therapeutics
Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇
🧠 ⚡️ Preprint alert ⚡️ 🧠
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
June 24, 2025 at 7:33 PM
Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇
Reposted by Center for Brain Circuit Therapeutics
🧠 ⚡️ Preprint alert ⚡️ 🧠
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
June 24, 2025 at 7:24 PM
🧠 ⚡️ Preprint alert ⚡️ 🧠
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.
Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...
Reposted by Center for Brain Circuit Therapeutics
Can a brain injury lead someone to commit a crime?
Brain imaging is increasingly introduced as evidence in criminal trials but it remains unclear which structural injuries play a causal role in criminal behavior. @braincircuits.bsky.social @foxmdphd.bsky.social
www.nature.com/articles/s41...
Brain imaging is increasingly introduced as evidence in criminal trials but it remains unclear which structural injuries play a causal role in criminal behavior. @braincircuits.bsky.social @foxmdphd.bsky.social
www.nature.com/articles/s41...
White matter disconnection in acquired criminality - Molecular Psychiatry
Molecular Psychiatry - White matter disconnection in acquired criminality
www.nature.com
June 11, 2025 at 4:37 PM
Can a brain injury lead someone to commit a crime?
Brain imaging is increasingly introduced as evidence in criminal trials but it remains unclear which structural injuries play a causal role in criminal behavior. @braincircuits.bsky.social @foxmdphd.bsky.social
www.nature.com/articles/s41...
Brain imaging is increasingly introduced as evidence in criminal trials but it remains unclear which structural injuries play a causal role in criminal behavior. @braincircuits.bsky.social @foxmdphd.bsky.social
www.nature.com/articles/s41...
Reposted by Center for Brain Circuit Therapeutics
Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover!
🔗 Full article: onlinelibrary.wiley.com/doi/full/10....
@childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social
🔗 Full article: onlinelibrary.wiley.com/doi/full/10....
@childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social
Coordinate Network Mapping of Focal Brain Volume Differences in ADHD Reveals Common Patterns That Lack Specificity: A Systematic Review
Objective Attention-deficit/hyperactivity disorder (ADHD) has been associated with decreased regional brain volume, yet no consistent localization has emerged across studies. This discrepancy has be...
onlinelibrary.wiley.com
June 17, 2025 at 12:30 PM
Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover!
🔗 Full article: onlinelibrary.wiley.com/doi/full/10....
@childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social
🔗 Full article: onlinelibrary.wiley.com/doi/full/10....
@childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social
Reposted by Center for Brain Circuit Therapeutics
We are actively looking for an administrative position to help lead the newly founded @netstim.org at the University of Cologne – please spread the word and/or let us know if you know somebody that could be interested!
lnkd.in/eEbnXByJ
lnkd.in/eEbnXByJ
June 20, 2025 at 7:52 AM
We are actively looking for an administrative position to help lead the newly founded @netstim.org at the University of Cologne – please spread the word and/or let us know if you know somebody that could be interested!
lnkd.in/eEbnXByJ
lnkd.in/eEbnXByJ
10,000! 🎂🍰 💯x💯!
@foxmdphd.bsky.social's legendary anticorrelation paper has now been cited over 10.000 times and this was reason for a dedicated PNAS cake. Congratulations again, Mike, for this unbelievable pioneering effort that opened up the then novel field of resting-state fMRI!
@braincircuits.bsky.social
@braincircuits.bsky.social
June 2, 2025 at 9:50 AM
10,000! 🎂🍰 💯x💯!
Reposted by Center for Brain Circuit Therapeutics
May 30, 2025 at 3:59 PM
Reposted by Center for Brain Circuit Therapeutics
Hard to keep track about all the great things our labmembers have achieved recently:
May 29, 2025 at 4:16 PM
Hard to keep track about all the great things our labmembers have achieved recently:
Reposted by Center for Brain Circuit Therapeutics
Happening today! We have two amazing speakers, Nicole Provenza and Martijn Figee who will share their thoughts on engineering for Neuromodulation and circuit based DBS for OCD respectively.
Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET
Register here: partners.zoom.us/webinar/regi...
Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET
Register here: partners.zoom.us/webinar/regi...
May 29, 2025 at 6:27 AM
Happening today! We have two amazing speakers, Nicole Provenza and Martijn Figee who will share their thoughts on engineering for Neuromodulation and circuit based DBS for OCD respectively.
Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET
Register here: partners.zoom.us/webinar/regi...
Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET
Register here: partners.zoom.us/webinar/regi...
Reposted by Center for Brain Circuit Therapeutics
Join us today! 👇👇
Happening today! We have two amazing speakers, Nicole Provenza and Martijn Figee who will share their thoughts on engineering for Neuromodulation and circuit based DBS for OCD respectively.
Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET
Register here: partners.zoom.us/webinar/regi...
Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET
Register here: partners.zoom.us/webinar/regi...
May 29, 2025 at 6:29 AM
Join us today! 👇👇
Reposted by Center for Brain Circuit Therapeutics
Are we on the cusp of moving beyond the levodopa challenge test to predict the best candidates and response to DBS in Parkinson's disease? We’ve long relied on the levodopa challenge to decide who’s a good candidate for deep brain stimulation but what if that test is only part of the story?
May 24, 2025 at 1:09 PM
Are we on the cusp of moving beyond the levodopa challenge test to predict the best candidates and response to DBS in Parkinson's disease? We’ve long relied on the levodopa challenge to decide who’s a good candidate for deep brain stimulation but what if that test is only part of the story?
Reposted by Center for Brain Circuit Therapeutics
Can brain injury cause the loss of visual imagination?
We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social
www.medrxiv.org/content/10.1...
We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social
www.medrxiv.org/content/10.1...
May 23, 2025 at 10:02 PM
Can brain injury cause the loss of visual imagination?
We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social
www.medrxiv.org/content/10.1...
We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social
www.medrxiv.org/content/10.1...
Reposted by Center for Brain Circuit Therapeutics
Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES
Tremor is a common symptom across many neurological disorders.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis?
We think: yes.
Our study is out now in @natcomms.nature.com:
🔗 www.nature.com/articles/s41...
🧵 A thread.
May 24, 2025 at 2:30 PM
Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES
Reposted by Center for Brain Circuit Therapeutics
New research from @lukasgoede.bsky.social @andreashorn.org & colleagues provides a robust, cross-condition tremor network that may guide both invasive & noninvasive neuromodulation strategies for #Parkinsons & essential tremor
www.nature.com/articles/s41...
www.nature.com/articles/s41...
May 23, 2025 at 8:32 AM
New research from @lukasgoede.bsky.social @andreashorn.org & colleagues provides a robust, cross-condition tremor network that may guide both invasive & noninvasive neuromodulation strategies for #Parkinsons & essential tremor
www.nature.com/articles/s41...
www.nature.com/articles/s41...