Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.

The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggesting its potential as a therapeutic target in lung cancer.

The famous physicist's legacy looms large 150 years after her birth

In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

Treatment resistance limits long-term effectiveness in cancer therapy. Conventional biomarkers typically rely on static gene expression levels. In this issue of Cancer Cell, Jassim et al. report a new approach, RECODR, which captures how gene relationships shift over time, uncovering hidden drivers of resistance and suggesting effective combination treatments.

17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Nguyen and Corvera review distinct changes that occur in adipose tissue during ageing, discuss potential mechanisms by which these changes impact whole-body metabolism, immunity and longevity, and highlight therapeutic opportunities.

The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing treatments.

Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.

Nature - Repeated damage from extreme heat over time seems to be a leading factor causing kidneys to fail.

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early events during cancer development.

These scientists are coming at cancer from all angles.

Nature Reviews Molecular Cell Biology, Published online: 09 April 2025; doi:10.1038/s41580-025-00843-2Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in disease. This Expert Recommendation article summarizes ferroptosis regulation and mechanisms and provides recommendations to increase the reproducibility and robustness of ferroptosis research.

As presented at the 2025 ASCO GI Cancers Symposium: in the phase 3 BREAKWATER trial, patients with previously untreated BRAF V600E metastatic colorectal cancer received the BRAF inhibitor encorafenib,...

Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.