Trentini Lab
@trentini-lab.bsky.social
Protein quality control and stress response lab at the Center for Molecular Medicine Cologne (CMMC) and CECAD research center
https://www.trentini-lab.cmmc-uni-koeln.de/
(Icon made by Freepik from www.flaticon.com)
https://www.trentini-lab.cmmc-uni-koeln.de/
(Icon made by Freepik from www.flaticon.com)
Pinned
Principles of ribosome-associated protein quality control during the synthesis of CFTR
Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...
www.biorxiv.org
🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins.
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
We had a fantastic time at the Ribo-Seq workshop in Bonn. Thanks so much, Kathrin @katleppek.bsky.social and Ranen, for organizing! We learned a lot, and we're excited to use Ribo-Seq in future projects.
We are well into our 5-day Cluster Workshop on Ribosome Profiling (Ribo-seq) run by sabbatical scientist Ranen Aviner @czbiohub.bsky.social. We welcome PhDs and PIs from Bonn/Cologne for a hands-on and analysis course sponsored by the Cluster @immunosens.bsky.social @unibonn.bsky.social UKB.
November 26, 2025 at 5:19 PM
We had a fantastic time at the Ribo-Seq workshop in Bonn. Thanks so much, Kathrin @katleppek.bsky.social and Ranen, for organizing! We learned a lot, and we're excited to use Ribo-Seq in future projects.
Reposted by Trentini Lab
We would like to invite all Rhineland RNA enthusiasts to attend our next series of in-person talks, featuring local and invited speakers. Highlights include the external talks by Didier Stainier, Simon Bekker-Jensen and Ranen Aviner. Please, register: tinyurl.com/RhinelandRNA
October 21, 2025 at 10:15 AM
We would like to invite all Rhineland RNA enthusiasts to attend our next series of in-person talks, featuring local and invited speakers. Highlights include the external talks by Didier Stainier, Simon Bekker-Jensen and Ranen Aviner. Please, register: tinyurl.com/RhinelandRNA
Reposted by Trentini Lab
⏰🔬⏳What if we could prevent age-related diseases before they even start? At #CECAD Cologne, that’s exactly our #mission! In this new video, Prof. Dr. Carien Niessen shares our vision uncovering the biology of #aging to improve #health.
#HealthyAging @unicologne.bsky.social
youtu.be/9ALNLpG3oYc
#HealthyAging @unicologne.bsky.social
youtu.be/9ALNLpG3oYc
CECAD: Our Scientific Mission
YouTube video by CECAD Cologne
youtu.be
September 16, 2025 at 9:54 AM
⏰🔬⏳What if we could prevent age-related diseases before they even start? At #CECAD Cologne, that’s exactly our #mission! In this new video, Prof. Dr. Carien Niessen shares our vision uncovering the biology of #aging to improve #health.
#HealthyAging @unicologne.bsky.social
youtu.be/9ALNLpG3oYc
#HealthyAging @unicologne.bsky.social
youtu.be/9ALNLpG3oYc
Reposted by Trentini Lab
🚨 Speaker Alert! 🚨
We’re thrilled to announce the next #CRC1678 Seminar featuring @christinemayr.bsky.social !
Join us to dive into the fascinating role of mRNA 3′UTRs in chaperoning intrinsically disordered regions to regulate protein activity.
📅 September 16
📍 CECAD Lecture Hall
⏰ 2:00 PM
We’re thrilled to announce the next #CRC1678 Seminar featuring @christinemayr.bsky.social !
Join us to dive into the fascinating role of mRNA 3′UTRs in chaperoning intrinsically disordered regions to regulate protein activity.
📅 September 16
📍 CECAD Lecture Hall
⏰ 2:00 PM
September 10, 2025 at 2:08 PM
🚨 Speaker Alert! 🚨
We’re thrilled to announce the next #CRC1678 Seminar featuring @christinemayr.bsky.social !
Join us to dive into the fascinating role of mRNA 3′UTRs in chaperoning intrinsically disordered regions to regulate protein activity.
📅 September 16
📍 CECAD Lecture Hall
⏰ 2:00 PM
We’re thrilled to announce the next #CRC1678 Seminar featuring @christinemayr.bsky.social !
Join us to dive into the fascinating role of mRNA 3′UTRs in chaperoning intrinsically disordered regions to regulate protein activity.
📅 September 16
📍 CECAD Lecture Hall
⏰ 2:00 PM
Reposted by Trentini Lab
I supervise an excellent postdoc who's looking for a postdoc or associate position in < 1 yr. Highly skilled in chem biol and biochem (peptide synthesis, native chem ligation, bacterial expression, purification, intein-based splicing, crystallography, interaction assays). Contact me if interested.
September 5, 2025 at 5:41 AM
I supervise an excellent postdoc who's looking for a postdoc or associate position in < 1 yr. Highly skilled in chem biol and biochem (peptide synthesis, native chem ligation, bacterial expression, purification, intein-based splicing, crystallography, interaction assays). Contact me if interested.
Reposted by Trentini Lab
🚨Check out this brand new publication from the lab of our CRC 1678 project leader @thevilchezlab.bsky.social about how C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules! Congrationlations to this achievement!🥳
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...
febs.onlinelibrary.wiley.com
September 2, 2025 at 2:20 PM
🚨Check out this brand new publication from the lab of our CRC 1678 project leader @thevilchezlab.bsky.social about how C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules! Congrationlations to this achievement!🥳
Reposted by Trentini Lab
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells
Pluripotent stem cells (SCs) rely on metabolic rewiring to regulate self-renewal and differentiation. The hexosamine biosynthetic pathway (HBP) integrates multiple metabolic inputs to produce uridine ...
doi.org
August 24, 2025 at 11:29 AM
🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...
#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience
🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins.
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
Principles of ribosome-associated protein quality control during the synthesis of CFTR
Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...
www.biorxiv.org
August 1, 2025 at 10:36 AM
🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins.
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇
www.biorxiv.org/content/10.1...
Reposted by Trentini Lab
Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social
New online: Conformational plasticity of a BiP–GRP94 chaperone complex
Conformational plasticity of a BiP–GRP94 chaperone complex
Nature Structural & Molecular Biology, Published online: 14 July 2025; doi:10.1038/s41594-025-01619-0BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mechanism of chaperone cooperation underlying this quality control process.
go.nature.com
July 15, 2025 at 6:06 AM
Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social
Reposted by Trentini Lab
Today marks the first day of our very first CRC 1678 Early Career Researcher Retreat! We’re proud to have such an amazing group of scientists with us—full of curiosity, energy, and team spirit. 💥🧠 🥳💪 #CRC1678 #ECRetreat #ScienceCommunity
July 14, 2025 at 6:38 PM
Today marks the first day of our very first CRC 1678 Early Career Researcher Retreat! We’re proud to have such an amazing group of scientists with us—full of curiosity, energy, and team spirit. 💥🧠 🥳💪 #CRC1678 #ECRetreat #ScienceCommunity
Reposted by Trentini Lab
Freshly launched! 🚀 Check out the new CRC 1678 website 🌐
👉 crc1678.uni-koeln.de
👉 crc1678.uni-koeln.de
About CRC 1678 - CRC1678 - Collaborative Research Center
CRC 1678 investigates how age and stress-driven declines in the accuracy of mRNA and protein production affect cellular and organismal health. By taking an
crc1678.uni-koeln.de
July 11, 2025 at 3:48 PM
Freshly launched! 🚀 Check out the new CRC 1678 website 🌐
👉 crc1678.uni-koeln.de
👉 crc1678.uni-koeln.de
Reposted by Trentini Lab
New from our lab @crick.ac.uk, in collaboration with the Enchev and Bukau labs.
By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis.
www.biorxiv.org/content/10.1...
By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis.
www.biorxiv.org/content/10.1...
June 2, 2025 at 4:12 PM
New from our lab @crick.ac.uk, in collaboration with the Enchev and Bukau labs.
By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis.
www.biorxiv.org/content/10.1...
By studying a protein that is difficult to fold, we discover fascinating new mechanisms by which the ribosome supports protein biogenesis.
www.biorxiv.org/content/10.1...
Congratulations to PhD student Tom Eisenack for winning a poster prize at the #ubfriends2025 symposium! Many thanks to the organizers for putting together such a fantastic meeting!
...AND THE #ubfriends2025 WINNERS ARE 👏
Best Short Talk:
@leokiss.bsky.social (@mpibiochem.bsky.social)
Best Posters:
Irene Schwartz (lab of @versteegga.bsky.social),
@julianvangerwen.bsky.social (@imsb-eth.bsky.social),
Tom Eisenack (lab @trentini-lab.bsky.social), and
@berndbauer.bsky.social!
Best Short Talk:
@leokiss.bsky.social (@mpibiochem.bsky.social)
Best Posters:
Irene Schwartz (lab of @versteegga.bsky.social),
@julianvangerwen.bsky.social (@imsb-eth.bsky.social),
Tom Eisenack (lab @trentini-lab.bsky.social), and
@berndbauer.bsky.social!
May 15, 2025 at 9:59 AM
Congratulations to PhD student Tom Eisenack for winning a poster prize at the #ubfriends2025 symposium! Many thanks to the organizers for putting together such a fantastic meeting!
Reposted by Trentini Lab
This week, the @crc1678 kick-off retreat brought all the project leaders together! 🚀 A fantastic opportunity to dive into projects, spark collaborations, and lay the groundwork for an exciting journey ahead. On our way to innovation, teamwork and impactful discoveries! 💡👩🔬🧑🔬 #Research #Collaboration
November 28, 2024 at 9:43 AM
This week, the @crc1678 kick-off retreat brought all the project leaders together! 🚀 A fantastic opportunity to dive into projects, spark collaborations, and lay the groundwork for an exciting journey ahead. On our way to innovation, teamwork and impactful discoveries! 💡👩🔬🧑🔬 #Research #Collaboration