Topher Hübel
@topherhuebel.bsky.social
MD PhD. DRK Kliniken Berlin & Århus Uni trained Charité & King‘s IoPPN & Karolinska & Uni Mainz. Eating. Behaviour. Genetics. Psychiatry. Analysis
Reposted by Topher Hübel
Online stings to catch sexual predators are on the rise. A growing number are targeting ageplay kink communities, in which adults engage in role play as children. David J. Ley Ph.D.https://www.psychologytoday.com/us/blog/women-who-stray/202511/could-your-kink-be-misunderstood-by-law-enforcement
Could Your Kink Be Misunderstood by Law Enforcement?
Online stings by law enforcement effectively detect potential sexual offenders. However, they may also pose a potential risk to people who engage in fantasy online roleplay.
www.psychologytoday.com
November 4, 2025 at 9:15 PM
Online stings to catch sexual predators are on the rise. A growing number are targeting ageplay kink communities, in which adults engage in role play as children. David J. Ley Ph.D.https://www.psychologytoday.com/us/blog/women-who-stray/202511/could-your-kink-be-misunderstood-by-law-enforcement
Reposted by Topher Hübel
5/ One of the key findings is that prematurity and diagnostic genetic variants act additively and independently to influence phenotypic severity in developmental disorders. Premature probands have more affected organ systems and delayed developmental milestone attainment compared to term probands.
March 24, 2025 at 8:59 AM
5/ One of the key findings is that prematurity and diagnostic genetic variants act additively and independently to influence phenotypic severity in developmental disorders. Premature probands have more affected organ systems and delayed developmental milestone attainment compared to term probands.
Reposted by Topher Hübel
9/ The presence of a diagnostic genetic variant modifies the relationship between polygenic predisposition to education-related traits and gestational duration, suggesting that the nature of the diagnostic variant has the largest impact on risk of preterm delivery.
March 24, 2025 at 9:01 AM
9/ The presence of a diagnostic genetic variant modifies the relationship between polygenic predisposition to education-related traits and gestational duration, suggesting that the nature of the diagnostic variant has the largest impact on risk of preterm delivery.
Reposted by Topher Hübel
1/ Thrilled to share our new preprint now out on medRxiv, where we explore genetic factors contributing to prematurity in developmental disorders and examine how prematurity influences clinical presentations: www.medrxiv.org/content/10.1...
Investigating the Interplay Between Prematurity and Genetic Variation in the Context of Rare Developmental Disorders
Rare damaging genetic variation accounts for a substantial proportion of the risk of rare developmental disorders (DDs), but common genetic variants as well as environmental factors, including prematu...
www.medrxiv.org
March 24, 2025 at 8:56 AM
1/ Thrilled to share our new preprint now out on medRxiv, where we explore genetic factors contributing to prematurity in developmental disorders and examine how prematurity influences clinical presentations: www.medrxiv.org/content/10.1...
Reposted by Topher Hübel
Pleased that our work on prematurity in developmental disorders is out in Genome Medicine 🎉
urldefense.proofpoint.com/v2/url?u=htt...
A big thank you to Patrick Campbell, @hilarycmartin.bsky.social, Elizabeth Radford, and all involved.
More in this thread ⬇️
bsky.app/profile/oliv...
urldefense.proofpoint.com/v2/url?u=htt...
A big thank you to Patrick Campbell, @hilarycmartin.bsky.social, Elizabeth Radford, and all involved.
More in this thread ⬇️
bsky.app/profile/oliv...
October 31, 2025 at 8:22 AM
Pleased that our work on prematurity in developmental disorders is out in Genome Medicine 🎉
urldefense.proofpoint.com/v2/url?u=htt...
A big thank you to Patrick Campbell, @hilarycmartin.bsky.social, Elizabeth Radford, and all involved.
More in this thread ⬇️
bsky.app/profile/oliv...
urldefense.proofpoint.com/v2/url?u=htt...
A big thank you to Patrick Campbell, @hilarycmartin.bsky.social, Elizabeth Radford, and all involved.
More in this thread ⬇️
bsky.app/profile/oliv...
Reposted by Topher Hübel
We wrote an article explaining why you shouldn't put several variables into a regression model and report which are statistically significant - even as exploratory research. bmjmedicine.bmj.com/content/4/1/.... How did we do?
October 27, 2025 at 5:39 PM
We wrote an article explaining why you shouldn't put several variables into a regression model and report which are statistically significant - even as exploratory research. bmjmedicine.bmj.com/content/4/1/.... How did we do?
Reposted by Topher Hübel
🧪🍎📃
Vitamin B12 is a rather unique vitamin.
Only certain bacteria and archaea can make it, not plants or animals.
Animals require B12 and can obtain and store it, which is why meat and fish are well-known sources for humans.
But what about non-animal foods? Can they provide any B12 at all?🧵⤵️
Vitamin B12 is a rather unique vitamin.
Only certain bacteria and archaea can make it, not plants or animals.
Animals require B12 and can obtain and store it, which is why meat and fish are well-known sources for humans.
But what about non-animal foods? Can they provide any B12 at all?🧵⤵️
October 25, 2025 at 5:30 PM
🧪🍎📃
Vitamin B12 is a rather unique vitamin.
Only certain bacteria and archaea can make it, not plants or animals.
Animals require B12 and can obtain and store it, which is why meat and fish are well-known sources for humans.
But what about non-animal foods? Can they provide any B12 at all?🧵⤵️
Vitamin B12 is a rather unique vitamin.
Only certain bacteria and archaea can make it, not plants or animals.
Animals require B12 and can obtain and store it, which is why meat and fish are well-known sources for humans.
But what about non-animal foods? Can they provide any B12 at all?🧵⤵️
Reposted by Topher Hübel
That merely being “under review” by a Nature family journal is offered as a quality proxy for a paper is a tragic illustration of the extent to which academia is addicted to brands and outsources evaluation
October 25, 2025 at 6:37 PM
That merely being “under review” by a Nature family journal is offered as a quality proxy for a paper is a tragic illustration of the extent to which academia is addicted to brands and outsources evaluation
Reposted by Topher Hübel
1. We ( @jbakcoleman.bsky.social, @cailinmeister.bsky.social, @jevinwest.bsky.social, and I) have a new preprint up on the arXiv.
There we explore how social media companies and other online information technology firms are able to manipulate scientific research about the effects of their products.
There we explore how social media companies and other online information technology firms are able to manipulate scientific research about the effects of their products.
October 24, 2025 at 12:47 AM
1. We ( @jbakcoleman.bsky.social, @cailinmeister.bsky.social, @jevinwest.bsky.social, and I) have a new preprint up on the arXiv.
There we explore how social media companies and other online information technology firms are able to manipulate scientific research about the effects of their products.
There we explore how social media companies and other online information technology firms are able to manipulate scientific research about the effects of their products.
Reposted by Topher Hübel
People sometimes ask why we want to rate DAGs. Couldn't we just rate statistical models instead?
We like to explain it with capybaras and bicycles.
We like to explain it with capybaras and bicycles.
October 17, 2025 at 12:52 PM
People sometimes ask why we want to rate DAGs. Couldn't we just rate statistical models instead?
We like to explain it with capybaras and bicycles.
We like to explain it with capybaras and bicycles.
Reposted by Topher Hübel
We built the openESM database:
▶️60 openly available experience sampling datasets (16K+ participants, 740K+ obs.) in one place
▶️Harmonized (meta-)data, fully open-source software
▶️Filter & search all data, simply download via R/Python
Find out more:
🌐 openesmdata.org
📝 doi.org/10.31234/osf...
▶️60 openly available experience sampling datasets (16K+ participants, 740K+ obs.) in one place
▶️Harmonized (meta-)data, fully open-source software
▶️Filter & search all data, simply download via R/Python
Find out more:
🌐 openesmdata.org
📝 doi.org/10.31234/osf...
October 22, 2025 at 7:34 PM
We built the openESM database:
▶️60 openly available experience sampling datasets (16K+ participants, 740K+ obs.) in one place
▶️Harmonized (meta-)data, fully open-source software
▶️Filter & search all data, simply download via R/Python
Find out more:
🌐 openesmdata.org
📝 doi.org/10.31234/osf...
▶️60 openly available experience sampling datasets (16K+ participants, 740K+ obs.) in one place
▶️Harmonized (meta-)data, fully open-source software
▶️Filter & search all data, simply download via R/Python
Find out more:
🌐 openesmdata.org
📝 doi.org/10.31234/osf...
Reposted by Topher Hübel
I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Staff Scientist
About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...
embl.wd103.myworkdayjobs.com
October 10, 2025 at 7:30 AM
I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Topher Hübel
The real harm to #LongCovid patients isn’t coming from most doctors or scientists; it’s coming from activists spreading false claims about COVID-19, twisting science, and vilifying experts. Misrepresentation doesn’t help patients; it isolates them from real care.
1/10
1/10
October 20, 2025 at 4:44 PM
The real harm to #LongCovid patients isn’t coming from most doctors or scientists; it’s coming from activists spreading false claims about COVID-19, twisting science, and vilifying experts. Misrepresentation doesn’t help patients; it isolates them from real care.
1/10
1/10
Reposted by Topher Hübel
They are formed in the early phase of acute infections. The exhausted precursors are at first found frequently, they decline without being completely lost in infections that the immune system resolves. This is the physiological response.
www.nature.com/artic...
7/8
www.nature.com/artic...
7/8
Precursors of exhausted T cells are pre-emptively formed in acute infection
Nature - T cell exhaustion was thought to be strictly associated only with chronic infections and tumours, but it turns out that acute infections also generate a subset of precursor T cells with...
www.nature.com
October 20, 2025 at 8:50 PM
They are formed in the early phase of acute infections. The exhausted precursors are at first found frequently, they decline without being completely lost in infections that the immune system resolves. This is the physiological response.
www.nature.com/artic...
7/8
www.nature.com/artic...
7/8
Reposted by Topher Hübel
T-CELL EXHAUSTION IN COVID-19: WHAT DO WE KNOW?
Why @frontiersin.bsky.social? These authors have not understood what T cell "exhaustion" is! "T-cell exhaustion is a terminal state of immune dysfunction" No!
www.frontiersin.org/...
1/8
Why @frontiersin.bsky.social? These authors have not understood what T cell "exhaustion" is! "T-cell exhaustion is a terminal state of immune dysfunction" No!
www.frontiersin.org/...
1/8
Frontiers | T-CELL EXHAUSTION IN COVID-19: WHAT DO WE KNOW?
ABSTRACT T-cell exhaustion is a terminal state of immune dysfunction characterized by impaired proliferation and effector functions, diminished cytokine secr...
www.frontiersin.org
October 20, 2025 at 8:50 PM
T-CELL EXHAUSTION IN COVID-19: WHAT DO WE KNOW?
Why @frontiersin.bsky.social? These authors have not understood what T cell "exhaustion" is! "T-cell exhaustion is a terminal state of immune dysfunction" No!
www.frontiersin.org/...
1/8
Why @frontiersin.bsky.social? These authors have not understood what T cell "exhaustion" is! "T-cell exhaustion is a terminal state of immune dysfunction" No!
www.frontiersin.org/...
1/8
Reposted by Topher Hübel
𝗘𝗻𝗱 𝗼𝗳 𝘁𝗵𝗲 𝗲𝗺𝗽𝗶𝗿𝗲 𝗼𝗳 𝗻𝗲𝘂𝗿𝗼𝗻𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻??
Astrocytes in the regulation of fear memories!
www.nature.com/articles/s41...
#neuroskyence
h/t @claeneuro.bsky.social
Astrocytes in the regulation of fear memories!
www.nature.com/articles/s41...
#neuroskyence
h/t @claeneuro.bsky.social
The astrocytic ensemble acts as a multiday trace to stabilize memory - Nature
Emotional experience evokes signalling in astrocytes, which form an ensemble that is reinforced by secondary astrocytic state changes resulting from repeated experience, leading to memory stabilizatio...
www.nature.com
October 21, 2025 at 5:57 PM
𝗘𝗻𝗱 𝗼𝗳 𝘁𝗵𝗲 𝗲𝗺𝗽𝗶𝗿𝗲 𝗼𝗳 𝗻𝗲𝘂𝗿𝗼𝗻𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻??
Astrocytes in the regulation of fear memories!
www.nature.com/articles/s41...
#neuroskyence
h/t @claeneuro.bsky.social
Astrocytes in the regulation of fear memories!
www.nature.com/articles/s41...
#neuroskyence
h/t @claeneuro.bsky.social
Reposted by Topher Hübel
💥The shingles vaccine might be one of the most underrated health moves after 50.💥
New large study(174K pts):
▪️ 50% lower risk of vascular dementia
▪️ 27% fewer blood clots
▪️ 25% lower risk of heart attack or stroke
▪️ 21% lower risk of dying early
#BlueSky #MedSky #NewsSky #SciSky 🧪 #NurseSky #IDSky
New large study(174K pts):
▪️ 50% lower risk of vascular dementia
▪️ 27% fewer blood clots
▪️ 25% lower risk of heart attack or stroke
▪️ 21% lower risk of dying early
#BlueSky #MedSky #NewsSky #SciSky 🧪 #NurseSky #IDSky
October 21, 2025 at 11:02 PM
Reposted by Topher Hübel
In a cohort of over 13,500 women with mean age ~72 years, >4,000 steps per day, at least 1-2 days per week, was associated with reduction in all-cause mortality and lower risk of cardiovascular disease
bjsm.bmj.com/content/earl...
bjsm.bmj.com/content/earl...
October 22, 2025 at 12:22 AM
In a cohort of over 13,500 women with mean age ~72 years, >4,000 steps per day, at least 1-2 days per week, was associated with reduction in all-cause mortality and lower risk of cardiovascular disease
bjsm.bmj.com/content/earl...
bjsm.bmj.com/content/earl...
Reposted by Topher Hübel
🚨 Please RT!
We’re recruiting a motivated postdoc to dissect the neurocircuits of affective pain.
Expertise in behavioral models of pain/SUDs, stereotaxy, microscopy, opto/chemogenetics, or fiber photometry encouraged.
Apply 👉 recruit.apo.ucla.edu/JPF10647
#Neuroscience #Postdoc
We’re recruiting a motivated postdoc to dissect the neurocircuits of affective pain.
Expertise in behavioral models of pain/SUDs, stereotaxy, microscopy, opto/chemogenetics, or fiber photometry encouraged.
Apply 👉 recruit.apo.ucla.edu/JPF10647
#Neuroscience #Postdoc
Postdoctoral Research Position
University of California, Los Angeles is hiring. Apply now!
recruit.apo.ucla.edu
October 21, 2025 at 11:44 PM
🚨 Please RT!
We’re recruiting a motivated postdoc to dissect the neurocircuits of affective pain.
Expertise in behavioral models of pain/SUDs, stereotaxy, microscopy, opto/chemogenetics, or fiber photometry encouraged.
Apply 👉 recruit.apo.ucla.edu/JPF10647
#Neuroscience #Postdoc
We’re recruiting a motivated postdoc to dissect the neurocircuits of affective pain.
Expertise in behavioral models of pain/SUDs, stereotaxy, microscopy, opto/chemogenetics, or fiber photometry encouraged.
Apply 👉 recruit.apo.ucla.edu/JPF10647
#Neuroscience #Postdoc
Reposted by Topher Hübel
Amid this week’s huge milestone in #HD treatment, I’m excited to share part of my PhD thesis + our paper published today in @movedisorder.bsky.social on CSF #PENK predicting striatal atrophy decades before clinical motor diagnosis 🔗 movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease
Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abu...
movementdisorders.onlinelibrary.wiley.com
September 26, 2025 at 10:44 AM
Amid this week’s huge milestone in #HD treatment, I’m excited to share part of my PhD thesis + our paper published today in @movedisorder.bsky.social on CSF #PENK predicting striatal atrophy decades before clinical motor diagnosis 🔗 movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Topher Hübel
📢 Have you registered yet?
Enhance your research impact with expert guidance from Lancet Group editors. Learn how SAGER guidelines for sex- and gender-based analyses can strengthen your work, with real examples and actionable insights.
👉 Register: hubs.li/Q03FQ_6l0
Enhance your research impact with expert guidance from Lancet Group editors. Learn how SAGER guidelines for sex- and gender-based analyses can strengthen your work, with real examples and actionable insights.
👉 Register: hubs.li/Q03FQ_6l0
October 20, 2025 at 11:32 AM
📢 Have you registered yet?
Enhance your research impact with expert guidance from Lancet Group editors. Learn how SAGER guidelines for sex- and gender-based analyses can strengthen your work, with real examples and actionable insights.
👉 Register: hubs.li/Q03FQ_6l0
Enhance your research impact with expert guidance from Lancet Group editors. Learn how SAGER guidelines for sex- and gender-based analyses can strengthen your work, with real examples and actionable insights.
👉 Register: hubs.li/Q03FQ_6l0
Reposted by Topher Hübel
“Food allergies in children dropped sharply in the years after new guidelines encouraged parents to introduce infants to peanuts, a study has found… a 36 percent reduction in all food allergies, driven largely by a 43 percent drop in peanut allergies” in children under 3 years old.
Peanut Allergies Have Plummeted in Children, Study Shows
www.nytimes.com
October 20, 2025 at 11:43 AM
“Food allergies in children dropped sharply in the years after new guidelines encouraged parents to introduce infants to peanuts, a study has found… a 36 percent reduction in all food allergies, driven largely by a 43 percent drop in peanut allergies” in children under 3 years old.
Reposted by Topher Hübel
One of the adaptive designs we are seeing more frequently is the Sequential Multiple Assignment Randomised Trial (or SMART trial) 1/7
#MethodologyMonday #126
#MethodologyMonday #126
October 20, 2025 at 6:39 AM
One of the adaptive designs we are seeing more frequently is the Sequential Multiple Assignment Randomised Trial (or SMART trial) 1/7
#MethodologyMonday #126
#MethodologyMonday #126
Reposted by Topher Hübel
A common med hair-loss med (finasteride) causes #depression and #suicide, concludes 8 studies in this report that examines why this signal was suppressed for 20 years
Likely mechanism = lowers allopregnanolone, neurosteroid that modulates GABA (benzo) receptors
pubmed.ncbi.nlm.nih.gov/41004169
Likely mechanism = lowers allopregnanolone, neurosteroid that modulates GABA (benzo) receptors
pubmed.ncbi.nlm.nih.gov/41004169
October 20, 2025 at 12:02 PM
A common med hair-loss med (finasteride) causes #depression and #suicide, concludes 8 studies in this report that examines why this signal was suppressed for 20 years
Likely mechanism = lowers allopregnanolone, neurosteroid that modulates GABA (benzo) receptors
pubmed.ncbi.nlm.nih.gov/41004169
Likely mechanism = lowers allopregnanolone, neurosteroid that modulates GABA (benzo) receptors
pubmed.ncbi.nlm.nih.gov/41004169