Mena Farag
@drmfarag.bsky.social
Neurology south London trainee 🧠 (OOP-R; ST6) ⋅ Clinical Research Fellow & PhD candidate based at UCL Queen Square Institute of Neurology — #HD-YAS https://orcid.org/0000-0002-0679-0117
Pinned
Mena Farag
@drmfarag.bsky.social
· Sep 26
Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease
Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abu...
movementdisorders.onlinelibrary.wiley.com
Amid this week’s huge milestone in #HD treatment, I’m excited to share part of my PhD thesis + our paper published today in @movedisorder.bsky.social on CSF #PENK predicting striatal atrophy decades before clinical motor diagnosis 🔗 movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Mena Farag
Discovery of disrupted sustained attention and altered functional connectivity in far‐from‐onset Huntington's disease gene‐expanded young adults alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Discovery of disrupted sustained attention and altered functional connectivity in far‐from‐onset Huntington's disease gene‐expanded young adults
BACKGROUND Cognitive impairments are a hallmark of Huntington's disease (HD). METHODS Seventy-one participants (43 HD gene-expanded [HDGE], 28 healthy controls) from the HD-Young Adult Study at tw...
alz-journals.onlinelibrary.wiley.com
January 15, 2026 at 10:06 AM
Discovery of disrupted sustained attention and altered functional connectivity in far‐from‐onset Huntington's disease gene‐expanded young adults alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Mena Farag
Congratulations @drmfarag.bsky.social from @ucl-hd.bsky.social! 👏 @ukdri.ac.uk @uclqsion.bsky.social @uclbrainscience.bsky.social @uclnews.bsky.social @ucl.ac.uk 🔗 www.ucl.ac.uk/brain-scienc...
Dr Mena Farag awarded a UK DRI Recognition Prize 2025
We're delighted that Dr Mena Farag (UCL Queen Square Institute of Neurology) was awarded the UK DRI PhD Prize on 9th December 2025 at Connectome 2025.
www.ucl.ac.uk
December 17, 2025 at 3:50 PM
I am incredibly honoured to share that I have been awarded the @ukdri.ac.uk PhD Prize at #Connectome 2025! @ucl-hd.bsky.social @uclqsion.bsky.social @uclbrainscience.bsky.social
December 9, 2025 at 1:04 PM
I am incredibly honoured to share that I have been awarded the @ukdri.ac.uk PhD Prize at #Connectome 2025! @ucl-hd.bsky.social @uclqsion.bsky.social @uclbrainscience.bsky.social
Reposted by Mena Farag
Open Access UCL Research: Huntington's disease clinical trials update: October 2025
discovery.ucl.ac.uk/id/eprint/10...
discovery.ucl.ac.uk/id/eprint/10...
Huntington's disease clinical trials update: October 2025
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UCL Discovery
UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
discovery.ucl.ac.uk
November 28, 2025 at 9:22 AM
Open Access UCL Research: Huntington's disease clinical trials update: October 2025
discovery.ucl.ac.uk/id/eprint/10...
discovery.ucl.ac.uk/id/eprint/10...
Check out the October 2025 edition of the #HD Clinical Trials Update, now published in the Journal of Huntington's Disease and available online! 🔗 journals.sagepub.com/doi/10.1177/... @profwild.bsky.social @ucl-hd.bsky.social @uclqsion.bsky.social @uclbrainscience.bsky.social
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
November 26, 2025 at 4:45 PM
Check out the October 2025 edition of the #HD Clinical Trials Update, now published in the Journal of Huntington's Disease and available online! 🔗 journals.sagepub.com/doi/10.1177/... @profwild.bsky.social @ucl-hd.bsky.social @uclqsion.bsky.social @uclbrainscience.bsky.social
Reposted by Mena Farag
🎉 Congratulations to Prof. Sarah Tabrizi ( @ucl-hd.bsky.social, @uclqsion.bsky.social) who has won the prestigious @britishneuro.bsky.social prize for her outstanding contributions to neuroscience!
www.ucl.ac.uk/news/2025/no...
www.ucl.ac.uk/news/2025/no...
November 18, 2025 at 11:08 AM
🎉 Congratulations to Prof. Sarah Tabrizi ( @ucl-hd.bsky.social, @uclqsion.bsky.social) who has won the prestigious @britishneuro.bsky.social prize for her outstanding contributions to neuroscience!
www.ucl.ac.uk/news/2025/no...
www.ucl.ac.uk/news/2025/no...
Reposted by Mena Farag
A secondary analysis of the TEMPO-2 RCT found no significant improvement in outcomes for minor ischemic stroke patients treated with intravenous tenecteplase, regardless of the presence of disabling deficits. ja.ma/3WT9IHi
October 27, 2025 at 3:30 PM
A secondary analysis of the TEMPO-2 RCT found no significant improvement in outcomes for minor ischemic stroke patients treated with intravenous tenecteplase, regardless of the presence of disabling deficits. ja.ma/3WT9IHi
Reposted by Mena Farag
Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com
October 1, 2025 at 9:09 AM
Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Amid this week’s huge milestone in #HD treatment, I’m excited to share part of my PhD thesis + our paper published today in @movedisorder.bsky.social on CSF #PENK predicting striatal atrophy decades before clinical motor diagnosis 🔗 movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease
Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abu...
movementdisorders.onlinelibrary.wiley.com
September 26, 2025 at 10:44 AM
Amid this week’s huge milestone in #HD treatment, I’m excited to share part of my PhD thesis + our paper published today in @movedisorder.bsky.social on CSF #PENK predicting striatal atrophy decades before clinical motor diagnosis 🔗 movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Mena Farag
A major milestone was reached yesterday in neurodegenerative medicine, advancing hope for those affected by Huntington’s disease🧵
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
eur01.safelinks.protection.outlook.com
September 25, 2025 at 9:49 AM
A major milestone was reached yesterday in neurodegenerative medicine, advancing hope for those affected by Huntington’s disease🧵
Reposted by Mena Farag
🧵 BREAKING: Gene therapy shows promise in slowing Huntington’s disease progression. A major milestone in neurodegenerative disease research. @uclqsion.bsky.social @ucl-hd.bsky.social
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.co.uk
September 24, 2025 at 2:25 PM
🧵 BREAKING: Gene therapy shows promise in slowing Huntington’s disease progression. A major milestone in neurodegenerative disease research. @uclqsion.bsky.social @ucl-hd.bsky.social
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Reposted by Mena Farag
Open Access UCL Research: Bias in HD-ISS staging introduced by the FreeSurfer cross-sectional stream: Insights from the Huntington's Disease Young Adult Study (HD-YAS) discovery.ucl.ac.uk/id/eprint/10...
Bias in HD-ISS staging introduced by the FreeSurfer cross-sectional stream: Insights from the Huntington's Disease Young Adult Study (HD-YAS)
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UCL Discovery
UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
discovery.ucl.ac.uk
August 22, 2025 at 9:04 AM
Open Access UCL Research: Bias in HD-ISS staging introduced by the FreeSurfer cross-sectional stream: Insights from the Huntington's Disease Young Adult Study (HD-YAS) discovery.ucl.ac.uk/id/eprint/10...
Reposted by Mena Farag
The oncogenic KRAS mutation has been the subject of intense investigation. In The Lancet, a new phase 3 trial reports on adagrasib versus docetaxel in KRASG12C-mutated non-small-cell lung cancer.
This and more in our latest issue 👉 bit.ly/4mi7T1y
This and more in our latest issue 👉 bit.ly/4mi7T1y
August 8, 2025 at 7:51 AM
The oncogenic KRAS mutation has been the subject of intense investigation. In The Lancet, a new phase 3 trial reports on adagrasib versus docetaxel in KRASG12C-mutated non-small-cell lung cancer.
This and more in our latest issue 👉 bit.ly/4mi7T1y
This and more in our latest issue 👉 bit.ly/4mi7T1y
In 2015, just out of medical school, I’d never have imagined seeing my name in @thelancet.com! Our review on vesicular monoamine transport (#VMAT) inhibitors is published today. @uclqsion.bsky.social @uclbrainscience.bsky.social
🔗 Read the full article here: www.thelancet.com/journals/lan...
🔗 Read the full article here: www.thelancet.com/journals/lan...
Vesicular monoamine transport inhibitors: current uses and future directions
Advancements over the past decade in understanding vesicular monoamine transporter
2 (VMAT2) inhibitors highlight their key role in the treatment of movement and neuropsychiatric
disorders. VMAT2 is c...
www.thelancet.com
August 8, 2025 at 7:30 AM
In 2015, just out of medical school, I’d never have imagined seeing my name in @thelancet.com! Our review on vesicular monoamine transport (#VMAT) inhibitors is published today. @uclqsion.bsky.social @uclbrainscience.bsky.social
🔗 Read the full article here: www.thelancet.com/journals/lan...
🔗 Read the full article here: www.thelancet.com/journals/lan...
Reposted by Mena Farag
Here's an open access link to full text of our paper shared last week! rdcu.be/evKF9
Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases
rdcu.be
July 14, 2025 at 3:21 PM
Here's an open access link to full text of our paper shared last week! rdcu.be/evKF9
Reposted by Mena Farag
Important paper on accessible biomarkers from @hob-lab.bsky.social. Well done Annabelle Coleman @drl-bo.bsky.social and all.
New paper from the @hob-lab.bsky.social just published in Journal of Neurology. A step toward more accessible biomarker testing 🩸 link.springer.com/article/10.1... @drl-bo.bsky.social @uclbrainscience.bsky.social @uclqsion.bsky.social
Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases - Journal of Neurology
Promising blood-based biomarkers of neuropathology have emerged with potential for therapeutic development and disease monitoring. However, these tools will require specialist tertiary services for in...
link.springer.com
July 11, 2025 at 8:31 AM
Important paper on accessible biomarkers from @hob-lab.bsky.social. Well done Annabelle Coleman @drl-bo.bsky.social and all.
Reposted by Mena Farag
I am unbelievably proud to have my first senior author paper published today! It was a long slog through multiple review cycles but we got there!
A big thank you to my lab members and all the collaborators and participants who contributed to this work! 🥲
A big thank you to my lab members and all the collaborators and participants who contributed to this work! 🥲
We are delighted to present the first publication out of the lab, available online today, titled ‘Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases’ link.springer.com/article/10.1...
Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases - Journal of Neurology
Promising blood-based biomarkers of neuropathology have emerged with potential for therapeutic development and disease monitoring. However, these tools will require specialist tertiary services for in...
link.springer.com
July 10, 2025 at 4:46 PM
I am unbelievably proud to have my first senior author paper published today! It was a long slog through multiple review cycles but we got there!
A big thank you to my lab members and all the collaborators and participants who contributed to this work! 🥲
A big thank you to my lab members and all the collaborators and participants who contributed to this work! 🥲
Reposted by Mena Farag
We are delighted to present the first publication out of the lab, available online today, titled ‘Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases’ link.springer.com/article/10.1...
Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases - Journal of Neurology
Promising blood-based biomarkers of neuropathology have emerged with potential for therapeutic development and disease monitoring. However, these tools will require specialist tertiary services for in...
link.springer.com
July 10, 2025 at 4:42 PM
We are delighted to present the first publication out of the lab, available online today, titled ‘Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases’ link.springer.com/article/10.1...
Reposted by Mena Farag
New paper from the @hob-lab.bsky.social just published in Journal of Neurology. A step toward more accessible biomarker testing 🩸 link.springer.com/article/10.1... @drl-bo.bsky.social @uclbrainscience.bsky.social @uclqsion.bsky.social
Evaluating finger-prick blood collection for remote quantification of neurofilament light in neurological diseases - Journal of Neurology
Promising blood-based biomarkers of neuropathology have emerged with potential for therapeutic development and disease monitoring. However, these tools will require specialist tertiary services for in...
link.springer.com
July 10, 2025 at 3:14 PM
New paper from the @hob-lab.bsky.social just published in Journal of Neurology. A step toward more accessible biomarker testing 🩸 link.springer.com/article/10.1... @drl-bo.bsky.social @uclbrainscience.bsky.social @uclqsion.bsky.social
Super fun first 5K #RUN4HDYO! 🏃 💨 🏃♀️
Over £2500 raised for the Olivia (Liv) Martinez Scholarship Fund for HDYO - honouring an amazing ambassador I met at #HDYO Congress in Glasgow in 2023. Liv's kindness and passion touched so many. @ucl-hd.bsky.social @uclqsion.bsky.social
Over £2500 raised for the Olivia (Liv) Martinez Scholarship Fund for HDYO - honouring an amazing ambassador I met at #HDYO Congress in Glasgow in 2023. Liv's kindness and passion touched so many. @ucl-hd.bsky.social @uclqsion.bsky.social
June 28, 2025 at 5:04 PM
Super fun first 5K #RUN4HDYO! 🏃 💨 🏃♀️
Over £2500 raised for the Olivia (Liv) Martinez Scholarship Fund for HDYO - honouring an amazing ambassador I met at #HDYO Congress in Glasgow in 2023. Liv's kindness and passion touched so many. @ucl-hd.bsky.social @uclqsion.bsky.social
Over £2500 raised for the Olivia (Liv) Martinez Scholarship Fund for HDYO - honouring an amazing ambassador I met at #HDYO Congress in Glasgow in 2023. Liv's kindness and passion touched so many. @ucl-hd.bsky.social @uclqsion.bsky.social
Reposted by Mena Farag
A series of digital tests carried out via a smartphone app could enhance the detection of disease progression in #HuntingtonsDisease and improve the efficiency of clinical trials, finds research led by scientists at @uclqsion.bsky.social @ucl-hd.bsky.social and Roche including @profwild.bsky.social
Smartphone tests could accelerate drug development for Huntington’s disease
A series of digital tests, carried out via a smartphone app, could enhance the detection of disease progression in Huntington’s disease and improve the efficiency of clinical trials, finds research le...
www.ucl.ac.uk
June 10, 2025 at 3:25 PM
A series of digital tests carried out via a smartphone app could enhance the detection of disease progression in #HuntingtonsDisease and improve the efficiency of clinical trials, finds research led by scientists at @uclqsion.bsky.social @ucl-hd.bsky.social and Roche including @profwild.bsky.social
Reposted by Mena Farag
New paper in BRAIN from Team Wild and Roche: A digital motor score for sensitive detection of progression in Huntington’s disease (open access)
doi.org/10.1093/brai...
doi.org/10.1093/brai...
A digital motor score for sensitive detection of progression in Huntington’s disease
Giboin et al. introduce a new motor score that can be used to monitor Huntington’s disease progression. Co-designed by people with Huntington’s disease and
doi.org
June 10, 2025 at 5:06 AM
New paper in BRAIN from Team Wild and Roche: A digital motor score for sensitive detection of progression in Huntington’s disease (open access)
doi.org/10.1093/brai...
doi.org/10.1093/brai...
Check out the March 2025 edition of the #HD Clinical Trials Update, now available online in the Journal of Huntington's Disease @profwild.bsky.social 🔓 Open access link: journals.sagepub.com/doi/10.1177/... @ucl-hd.bsky.social @uclbrainscience.bsky.social @uclqsion.bsky.social
April 30, 2025 at 2:30 PM
Check out the March 2025 edition of the #HD Clinical Trials Update, now available online in the Journal of Huntington's Disease @profwild.bsky.social 🔓 Open access link: journals.sagepub.com/doi/10.1177/... @ucl-hd.bsky.social @uclbrainscience.bsky.social @uclqsion.bsky.social