Chris Aiken, MD
@chrisaikenmd.bsky.social
Editor, Carlat Psychiatry Report.
Assist Prof, NYU & WFU medical schools.
www.chrisaikenmd.com
Posting daily updates on all things psychiatric
Assist Prof, NYU & WFU medical schools.
www.chrisaikenmd.com
Posting daily updates on all things psychiatric
Psychiatry's future challenges:
▪ Aging population = med-psych disorders
▪ Commodification of health favors the healthy
▪ Immigration, loneliness (& social fatigue), addiction, violence, burnout
▪ EMRs and specialization = dehumanization and fragmentation
From:
pubmed.ncbi.nlm.nih.gov/41619790
▪ Aging population = med-psych disorders
▪ Commodification of health favors the healthy
▪ Immigration, loneliness (& social fatigue), addiction, violence, burnout
▪ EMRs and specialization = dehumanization and fragmentation
From:
pubmed.ncbi.nlm.nih.gov/41619790
February 8, 2026 at 1:00 PM
Psychiatry's future challenges:
▪ Aging population = med-psych disorders
▪ Commodification of health favors the healthy
▪ Immigration, loneliness (& social fatigue), addiction, violence, burnout
▪ EMRs and specialization = dehumanization and fragmentation
From:
pubmed.ncbi.nlm.nih.gov/41619790
▪ Aging population = med-psych disorders
▪ Commodification of health favors the healthy
▪ Immigration, loneliness (& social fatigue), addiction, violence, burnout
▪ EMRs and specialization = dehumanization and fragmentation
From:
pubmed.ncbi.nlm.nih.gov/41619790
First #Keto trial in treatment resistant #depression (n=88)
▪ Compared it to adding fruit/veg
▪ Barely positive at 6 wk (0.05), not 12 wk
pubmed.ncbi.nlm.nih.gov/41637092
Evidence Moderate (6/10)
In contrast, Medi diet has large effect in 3 RCTs:
chrisaikenmd.com/antidepressa...
▪ Compared it to adding fruit/veg
▪ Barely positive at 6 wk (0.05), not 12 wk
pubmed.ncbi.nlm.nih.gov/41637092
Evidence Moderate (6/10)
In contrast, Medi diet has large effect in 3 RCTs:
chrisaikenmd.com/antidepressa...
February 7, 2026 at 1:00 PM
First #Keto trial in treatment resistant #depression (n=88)
▪ Compared it to adding fruit/veg
▪ Barely positive at 6 wk (0.05), not 12 wk
pubmed.ncbi.nlm.nih.gov/41637092
Evidence Moderate (6/10)
In contrast, Medi diet has large effect in 3 RCTs:
chrisaikenmd.com/antidepressa...
▪ Compared it to adding fruit/veg
▪ Barely positive at 6 wk (0.05), not 12 wk
pubmed.ncbi.nlm.nih.gov/41637092
Evidence Moderate (6/10)
In contrast, Medi diet has large effect in 3 RCTs:
chrisaikenmd.com/antidepressa...
Alice in Wonderland Syndrome:
▪ Distortions of visual perception, body image, and time perception
▪ Causes = infections, migraines, epilepsy, meds
New paper links it to
▪ Aripiprazole, sertraline, methylphenidate, topiramate
However, linking is not causation:
pubmed.ncbi.nlm.nih.gov/41448101
▪ Distortions of visual perception, body image, and time perception
▪ Causes = infections, migraines, epilepsy, meds
New paper links it to
▪ Aripiprazole, sertraline, methylphenidate, topiramate
However, linking is not causation:
pubmed.ncbi.nlm.nih.gov/41448101
February 6, 2026 at 1:01 PM
Alice in Wonderland Syndrome:
▪ Distortions of visual perception, body image, and time perception
▪ Causes = infections, migraines, epilepsy, meds
New paper links it to
▪ Aripiprazole, sertraline, methylphenidate, topiramate
However, linking is not causation:
pubmed.ncbi.nlm.nih.gov/41448101
▪ Distortions of visual perception, body image, and time perception
▪ Causes = infections, migraines, epilepsy, meds
New paper links it to
▪ Aripiprazole, sertraline, methylphenidate, topiramate
However, linking is not causation:
pubmed.ncbi.nlm.nih.gov/41448101
Genetic tests did not reduce #depression in new trial:
pubmed.ncbi.nlm.nih.gov/41277612
Some secondary outcomes positive, but that is common by chance alone.
Secondary outcomes help personalize treatment, but only when primary outcome is positive. Otherwise, ignore them.
pubmed.ncbi.nlm.nih.gov/41277612
Some secondary outcomes positive, but that is common by chance alone.
Secondary outcomes help personalize treatment, but only when primary outcome is positive. Otherwise, ignore them.
February 5, 2026 at 1:02 PM
Genetic tests did not reduce #depression in new trial:
pubmed.ncbi.nlm.nih.gov/41277612
Some secondary outcomes positive, but that is common by chance alone.
Secondary outcomes help personalize treatment, but only when primary outcome is positive. Otherwise, ignore them.
pubmed.ncbi.nlm.nih.gov/41277612
Some secondary outcomes positive, but that is common by chance alone.
Secondary outcomes help personalize treatment, but only when primary outcome is positive. Otherwise, ignore them.
Keto helped depression, but not anxiety, in 10 small trials:
pubmed.ncbi.nlm.nih.gov/41191382
But they tested it in medical disorders that respond to keto, and mood lifts when health improves.
One trial compared it to Mediterranean, which was more effective:
pubmed.ncbi.nlm.nih.gov/41197688
pubmed.ncbi.nlm.nih.gov/41191382
But they tested it in medical disorders that respond to keto, and mood lifts when health improves.
One trial compared it to Mediterranean, which was more effective:
pubmed.ncbi.nlm.nih.gov/41197688
February 4, 2026 at 1:02 PM
Keto helped depression, but not anxiety, in 10 small trials:
pubmed.ncbi.nlm.nih.gov/41191382
But they tested it in medical disorders that respond to keto, and mood lifts when health improves.
One trial compared it to Mediterranean, which was more effective:
pubmed.ncbi.nlm.nih.gov/41197688
pubmed.ncbi.nlm.nih.gov/41191382
But they tested it in medical disorders that respond to keto, and mood lifts when health improves.
One trial compared it to Mediterranean, which was more effective:
pubmed.ncbi.nlm.nih.gov/41197688
FDA fast-tracked centanafadine for #ADHD, a norepinephrine, dopamine, serotonin reuptake inhibitor:
▪ Similar benefit to non-stimulants, but faster onse
▪ 2 phase-III trials adults, 1 in adolescents, none in children
Structured interview for diagnosis:
www.advancedassessments.co.uk/resources/AD...
▪ Similar benefit to non-stimulants, but faster onse
▪ 2 phase-III trials adults, 1 in adolescents, none in children
Structured interview for diagnosis:
www.advancedassessments.co.uk/resources/AD...
February 3, 2026 at 1:01 PM
FDA fast-tracked centanafadine for #ADHD, a norepinephrine, dopamine, serotonin reuptake inhibitor:
▪ Similar benefit to non-stimulants, but faster onse
▪ 2 phase-III trials adults, 1 in adolescents, none in children
Structured interview for diagnosis:
www.advancedassessments.co.uk/resources/AD...
▪ Similar benefit to non-stimulants, but faster onse
▪ 2 phase-III trials adults, 1 in adolescents, none in children
Structured interview for diagnosis:
www.advancedassessments.co.uk/resources/AD...
Autism-leucovorin trial just retracted:
pubmed.ncbi.nlm.nih.gov/41606385
Remaining 4 trials have flaws: Small, poor blinding, not corrected for multiple measures. But plausible mechanism, large effect are promising.
FDA approved it for #autism in 2025, but should have funded a phase III trial
pubmed.ncbi.nlm.nih.gov/41606385
Remaining 4 trials have flaws: Small, poor blinding, not corrected for multiple measures. But plausible mechanism, large effect are promising.
FDA approved it for #autism in 2025, but should have funded a phase III trial
February 2, 2026 at 1:01 PM
Autism-leucovorin trial just retracted:
pubmed.ncbi.nlm.nih.gov/41606385
Remaining 4 trials have flaws: Small, poor blinding, not corrected for multiple measures. But plausible mechanism, large effect are promising.
FDA approved it for #autism in 2025, but should have funded a phase III trial
pubmed.ncbi.nlm.nih.gov/41606385
Remaining 4 trials have flaws: Small, poor blinding, not corrected for multiple measures. But plausible mechanism, large effect are promising.
FDA approved it for #autism in 2025, but should have funded a phase III trial
Which antipsychotics work fastest for agitation in the hospital?
> Orally disintegrating options (asenapine, olanzapine), 30 min
> Faster than inj (36-48 min), and less often refused
> Quetiapine = least effective
Large, naturalistic study:
pubmed.ncbi.nlm.nih.gov/41609240
Evidence grade: Low
> Orally disintegrating options (asenapine, olanzapine), 30 min
> Faster than inj (36-48 min), and less often refused
> Quetiapine = least effective
Large, naturalistic study:
pubmed.ncbi.nlm.nih.gov/41609240
Evidence grade: Low
February 1, 2026 at 1:00 PM
Which antipsychotics work fastest for agitation in the hospital?
> Orally disintegrating options (asenapine, olanzapine), 30 min
> Faster than inj (36-48 min), and less often refused
> Quetiapine = least effective
Large, naturalistic study:
pubmed.ncbi.nlm.nih.gov/41609240
Evidence grade: Low
> Orally disintegrating options (asenapine, olanzapine), 30 min
> Faster than inj (36-48 min), and less often refused
> Quetiapine = least effective
Large, naturalistic study:
pubmed.ncbi.nlm.nih.gov/41609240
Evidence grade: Low
Magnesium L-Threonate is a patented form of Mg that readily enters the brain. It improved cognition in a new RCT in young adults with insomnia (n=100), consistent with earlier RCTs in older adults:
pubmed.ncbi.nlm.nih.gov/41601871
Evidence grade: 9/10
#psychiatry #neurology #pmhnp
pubmed.ncbi.nlm.nih.gov/41601871
Evidence grade: 9/10
#psychiatry #neurology #pmhnp
January 31, 2026 at 1:00 PM
Magnesium L-Threonate is a patented form of Mg that readily enters the brain. It improved cognition in a new RCT in young adults with insomnia (n=100), consistent with earlier RCTs in older adults:
pubmed.ncbi.nlm.nih.gov/41601871
Evidence grade: 9/10
#psychiatry #neurology #pmhnp
pubmed.ncbi.nlm.nih.gov/41601871
Evidence grade: 9/10
#psychiatry #neurology #pmhnp
Gluten-free diet improved negative symptoms of schizophrenia in small, blinded randomized trial in patients with gluten antibodies (AGA IgG+), which are more common in #schizophrenia (35% vs 10%):
pubmed.ncbi.nlm.nih.gov/41544406
Replicates earlier trial.
pubmed.ncbi.nlm.nih.gov/41544406
Replicates earlier trial.
January 30, 2026 at 1:01 PM
Gluten-free diet improved negative symptoms of schizophrenia in small, blinded randomized trial in patients with gluten antibodies (AGA IgG+), which are more common in #schizophrenia (35% vs 10%):
pubmed.ncbi.nlm.nih.gov/41544406
Replicates earlier trial.
pubmed.ncbi.nlm.nih.gov/41544406
Replicates earlier trial.
Creativity may be linked to #bipolar, but it is a strength, not a cause of mental illness.
It predicts response to #therapy, and in this new study, better outcomes in social #anxiety disorder:
pubmed.ncbi.nlm.nih.gov/41497067
It predicts response to #therapy, and in this new study, better outcomes in social #anxiety disorder:
pubmed.ncbi.nlm.nih.gov/41497067
January 29, 2026 at 1:02 PM
Creativity may be linked to #bipolar, but it is a strength, not a cause of mental illness.
It predicts response to #therapy, and in this new study, better outcomes in social #anxiety disorder:
pubmed.ncbi.nlm.nih.gov/41497067
It predicts response to #therapy, and in this new study, better outcomes in social #anxiety disorder:
pubmed.ncbi.nlm.nih.gov/41497067
Stimulants for cognition in schizophrenia?
1. It's contraindicated
2. It failed in 22 trials, worsening psychosis in 50-70%
This new trial tests it again, but has too many flaws to move the needle:
pubmed.ncbi.nlm.nih.gov/41582768
1. It's contraindicated
2. It failed in 22 trials, worsening psychosis in 50-70%
This new trial tests it again, but has too many flaws to move the needle:
pubmed.ncbi.nlm.nih.gov/41582768
January 28, 2026 at 1:00 PM
Stimulants for cognition in schizophrenia?
1. It's contraindicated
2. It failed in 22 trials, worsening psychosis in 50-70%
This new trial tests it again, but has too many flaws to move the needle:
pubmed.ncbi.nlm.nih.gov/41582768
1. It's contraindicated
2. It failed in 22 trials, worsening psychosis in 50-70%
This new trial tests it again, but has too many flaws to move the needle:
pubmed.ncbi.nlm.nih.gov/41582768
Raspberries improved cognition, neuroinflammation, and insulin in older, overweight adults in single meal:
pubmed.ncbi.nlm.nih.gov/41536265
Evidence grade Moderate 6/10.
Similar findings with blueberries, both short- and long-term:
www.psychiatrictimes.com/view/blueber...
#therapy Art: T Jones
pubmed.ncbi.nlm.nih.gov/41536265
Evidence grade Moderate 6/10.
Similar findings with blueberries, both short- and long-term:
www.psychiatrictimes.com/view/blueber...
#therapy Art: T Jones
January 27, 2026 at 1:02 PM
Raspberries improved cognition, neuroinflammation, and insulin in older, overweight adults in single meal:
pubmed.ncbi.nlm.nih.gov/41536265
Evidence grade Moderate 6/10.
Similar findings with blueberries, both short- and long-term:
www.psychiatrictimes.com/view/blueber...
#therapy Art: T Jones
pubmed.ncbi.nlm.nih.gov/41536265
Evidence grade Moderate 6/10.
Similar findings with blueberries, both short- and long-term:
www.psychiatrictimes.com/view/blueber...
#therapy Art: T Jones
Recreational drugs that interact w/MAOIs:
pubmed.ncbi.nlm.nih.gov/41546846
▪ Alcohol if unpasteurized
▪ Dextromethorphan
▪ Meperidine, tramadol, methadone
▪ Kratom
▪ Cocaine, Meth
▪ Some psychedelics: ibogaine, psilocybin, DOI, mescaline, 2CB, PCP, toad serum, MDMA
More in:
amzn.to/45gbBTg
pubmed.ncbi.nlm.nih.gov/41546846
▪ Alcohol if unpasteurized
▪ Dextromethorphan
▪ Meperidine, tramadol, methadone
▪ Kratom
▪ Cocaine, Meth
▪ Some psychedelics: ibogaine, psilocybin, DOI, mescaline, 2CB, PCP, toad serum, MDMA
More in:
amzn.to/45gbBTg
January 26, 2026 at 1:03 PM
Recreational drugs that interact w/MAOIs:
pubmed.ncbi.nlm.nih.gov/41546846
▪ Alcohol if unpasteurized
▪ Dextromethorphan
▪ Meperidine, tramadol, methadone
▪ Kratom
▪ Cocaine, Meth
▪ Some psychedelics: ibogaine, psilocybin, DOI, mescaline, 2CB, PCP, toad serum, MDMA
More in:
amzn.to/45gbBTg
pubmed.ncbi.nlm.nih.gov/41546846
▪ Alcohol if unpasteurized
▪ Dextromethorphan
▪ Meperidine, tramadol, methadone
▪ Kratom
▪ Cocaine, Meth
▪ Some psychedelics: ibogaine, psilocybin, DOI, mescaline, 2CB, PCP, toad serum, MDMA
More in:
amzn.to/45gbBTg
Light at night raised the risk of insomnia 27% in a new meta-analysis of 691,851:
pubmed.ncbi.nlm.nih.gov/41500302
It also worsens obesity, #depression, #bipolar, and impedes learning. How to get the room dark:
chrisaikenmd.com/darktherapy
#psychiatry #pmhnp #therapy #psychology
pubmed.ncbi.nlm.nih.gov/41500302
It also worsens obesity, #depression, #bipolar, and impedes learning. How to get the room dark:
chrisaikenmd.com/darktherapy
#psychiatry #pmhnp #therapy #psychology
January 25, 2026 at 4:44 PM
Light at night raised the risk of insomnia 27% in a new meta-analysis of 691,851:
pubmed.ncbi.nlm.nih.gov/41500302
It also worsens obesity, #depression, #bipolar, and impedes learning. How to get the room dark:
chrisaikenmd.com/darktherapy
#psychiatry #pmhnp #therapy #psychology
pubmed.ncbi.nlm.nih.gov/41500302
It also worsens obesity, #depression, #bipolar, and impedes learning. How to get the room dark:
chrisaikenmd.com/darktherapy
#psychiatry #pmhnp #therapy #psychology
D-Cycloserine
▪ Enhances learning (low-dose)
▪ Ketamine-like effects (high-dose)
It augmented TMS (10-fold!) in a small trial of #depression, but failed in new small trial, possibly b/c given at night instead of right before TMS:
pubmed.ncbi.nlm.nih.gov/41510278
Chart from:
amzn.to/3YIZr1v
▪ Enhances learning (low-dose)
▪ Ketamine-like effects (high-dose)
It augmented TMS (10-fold!) in a small trial of #depression, but failed in new small trial, possibly b/c given at night instead of right before TMS:
pubmed.ncbi.nlm.nih.gov/41510278
Chart from:
amzn.to/3YIZr1v
January 24, 2026 at 1:01 PM
D-Cycloserine
▪ Enhances learning (low-dose)
▪ Ketamine-like effects (high-dose)
It augmented TMS (10-fold!) in a small trial of #depression, but failed in new small trial, possibly b/c given at night instead of right before TMS:
pubmed.ncbi.nlm.nih.gov/41510278
Chart from:
amzn.to/3YIZr1v
▪ Enhances learning (low-dose)
▪ Ketamine-like effects (high-dose)
It augmented TMS (10-fold!) in a small trial of #depression, but failed in new small trial, possibly b/c given at night instead of right before TMS:
pubmed.ncbi.nlm.nih.gov/41510278
Chart from:
amzn.to/3YIZr1v
The SNRI antidepressant duloxetine (Cymbalta) reduced chronic cough 60% in new RCT of people without psych disorders:
pubmed.ncbi.nlm.nih.gov/41530764
How? Perhaps modulation of sensory nerve hyperresponsiveness.
Evidence grade: High (9/10)
#psychiatry #pmhnp #medicine
pubmed.ncbi.nlm.nih.gov/41530764
How? Perhaps modulation of sensory nerve hyperresponsiveness.
Evidence grade: High (9/10)
#psychiatry #pmhnp #medicine
January 23, 2026 at 1:02 PM
The SNRI antidepressant duloxetine (Cymbalta) reduced chronic cough 60% in new RCT of people without psych disorders:
pubmed.ncbi.nlm.nih.gov/41530764
How? Perhaps modulation of sensory nerve hyperresponsiveness.
Evidence grade: High (9/10)
#psychiatry #pmhnp #medicine
pubmed.ncbi.nlm.nih.gov/41530764
How? Perhaps modulation of sensory nerve hyperresponsiveness.
Evidence grade: High (9/10)
#psychiatry #pmhnp #medicine
Cobenfy over a year in #schizophrenia (no placebo):
▪ Improvement in positive/negative symptoms
▪ Weight loss
▪ ~20% Nausea, vomit, constipation
▪ ~10% Hypertension, diarrhea, dry mouth, dizziness, headache
▪ ~5%: Dyspepsia, fatigue, sweats
pubmed.ncbi.nlm.nih.gov/41506001
#psychiatry #pmhnp
▪ Improvement in positive/negative symptoms
▪ Weight loss
▪ ~20% Nausea, vomit, constipation
▪ ~10% Hypertension, diarrhea, dry mouth, dizziness, headache
▪ ~5%: Dyspepsia, fatigue, sweats
pubmed.ncbi.nlm.nih.gov/41506001
#psychiatry #pmhnp
January 22, 2026 at 5:04 PM
Cobenfy over a year in #schizophrenia (no placebo):
▪ Improvement in positive/negative symptoms
▪ Weight loss
▪ ~20% Nausea, vomit, constipation
▪ ~10% Hypertension, diarrhea, dry mouth, dizziness, headache
▪ ~5%: Dyspepsia, fatigue, sweats
pubmed.ncbi.nlm.nih.gov/41506001
#psychiatry #pmhnp
▪ Improvement in positive/negative symptoms
▪ Weight loss
▪ ~20% Nausea, vomit, constipation
▪ ~10% Hypertension, diarrhea, dry mouth, dizziness, headache
▪ ~5%: Dyspepsia, fatigue, sweats
pubmed.ncbi.nlm.nih.gov/41506001
#psychiatry #pmhnp
Varenicline (Chantix) treats alcohol use disorder (even in non-smokers), but does it reduce #cannabis use?
Not likely. Large, RCT is negative, despite positive finding (in men) with data-fishing:
pubmed.ncbi.nlm.nih.gov/41536001
Treat cannabis use with therapy, possibly CBD oil, NAC, gabapentin
Not likely. Large, RCT is negative, despite positive finding (in men) with data-fishing:
pubmed.ncbi.nlm.nih.gov/41536001
Treat cannabis use with therapy, possibly CBD oil, NAC, gabapentin
January 21, 2026 at 1:02 PM
Varenicline (Chantix) treats alcohol use disorder (even in non-smokers), but does it reduce #cannabis use?
Not likely. Large, RCT is negative, despite positive finding (in men) with data-fishing:
pubmed.ncbi.nlm.nih.gov/41536001
Treat cannabis use with therapy, possibly CBD oil, NAC, gabapentin
Not likely. Large, RCT is negative, despite positive finding (in men) with data-fishing:
pubmed.ncbi.nlm.nih.gov/41536001
Treat cannabis use with therapy, possibly CBD oil, NAC, gabapentin
How does modern life cause mental illness?
▪ Noise, pollution, artificial lights, processed foods, sedentary, isolation
▪ Activates alarms that once helped us survive, but now alarms are 24/7
▪ Causing inflammation, auto-immune dz, infertility, mental illness:
pubmed.ncbi.nlm.nih.gov/41204658
▪ Noise, pollution, artificial lights, processed foods, sedentary, isolation
▪ Activates alarms that once helped us survive, but now alarms are 24/7
▪ Causing inflammation, auto-immune dz, infertility, mental illness:
pubmed.ncbi.nlm.nih.gov/41204658
January 20, 2026 at 1:01 PM
How does modern life cause mental illness?
▪ Noise, pollution, artificial lights, processed foods, sedentary, isolation
▪ Activates alarms that once helped us survive, but now alarms are 24/7
▪ Causing inflammation, auto-immune dz, infertility, mental illness:
pubmed.ncbi.nlm.nih.gov/41204658
▪ Noise, pollution, artificial lights, processed foods, sedentary, isolation
▪ Activates alarms that once helped us survive, but now alarms are 24/7
▪ Causing inflammation, auto-immune dz, infertility, mental illness:
pubmed.ncbi.nlm.nih.gov/41204658
How #depression resolves on an SSRI:
▪ Wk 1-2: Better mood, but depressing side effects (fatigue, libido, indecision, sleep disruption)
▪ Wk 2-6: Side effects fall, mood rises
▪ Sleep and libido resolve slower, improving after 6 wk
From new analysis:
pubmed.ncbi.nlm.nih.gov/41211530
#psychiatry
▪ Wk 1-2: Better mood, but depressing side effects (fatigue, libido, indecision, sleep disruption)
▪ Wk 2-6: Side effects fall, mood rises
▪ Sleep and libido resolve slower, improving after 6 wk
From new analysis:
pubmed.ncbi.nlm.nih.gov/41211530
#psychiatry
January 19, 2026 at 1:01 PM
How #depression resolves on an SSRI:
▪ Wk 1-2: Better mood, but depressing side effects (fatigue, libido, indecision, sleep disruption)
▪ Wk 2-6: Side effects fall, mood rises
▪ Sleep and libido resolve slower, improving after 6 wk
From new analysis:
pubmed.ncbi.nlm.nih.gov/41211530
#psychiatry
▪ Wk 1-2: Better mood, but depressing side effects (fatigue, libido, indecision, sleep disruption)
▪ Wk 2-6: Side effects fall, mood rises
▪ Sleep and libido resolve slower, improving after 6 wk
From new analysis:
pubmed.ncbi.nlm.nih.gov/41211530
#psychiatry
New interaction between tobacco and cannabis:
Together, they suppress anandamide, the "bliss molecule," which may be why those who smoke both have more #depression, #anxiety, #cannabis withdrawal/dependence (compared to people who use cannabis alone):
pubmed.ncbi.nlm.nih.gov/40799255
Art J Mecier
Together, they suppress anandamide, the "bliss molecule," which may be why those who smoke both have more #depression, #anxiety, #cannabis withdrawal/dependence (compared to people who use cannabis alone):
pubmed.ncbi.nlm.nih.gov/40799255
Art J Mecier
January 18, 2026 at 2:00 PM
New interaction between tobacco and cannabis:
Together, they suppress anandamide, the "bliss molecule," which may be why those who smoke both have more #depression, #anxiety, #cannabis withdrawal/dependence (compared to people who use cannabis alone):
pubmed.ncbi.nlm.nih.gov/40799255
Art J Mecier
Together, they suppress anandamide, the "bliss molecule," which may be why those who smoke both have more #depression, #anxiety, #cannabis withdrawal/dependence (compared to people who use cannabis alone):
pubmed.ncbi.nlm.nih.gov/40799255
Art J Mecier
#Antidepressant withdrawal becomes a bigger problem (rising 10-fold) after 2 years of use, from new NHS study:
pubmed.ncbi.nlm.nih.gov/40404538
Evidence grade Low 3/10
More on stopping meds in our interview with lead author, Mark Horowitz:
www.thecarlatreport.com/articles/487...
#psychiatry
pubmed.ncbi.nlm.nih.gov/40404538
Evidence grade Low 3/10
More on stopping meds in our interview with lead author, Mark Horowitz:
www.thecarlatreport.com/articles/487...
#psychiatry
January 17, 2026 at 3:15 PM
#Antidepressant withdrawal becomes a bigger problem (rising 10-fold) after 2 years of use, from new NHS study:
pubmed.ncbi.nlm.nih.gov/40404538
Evidence grade Low 3/10
More on stopping meds in our interview with lead author, Mark Horowitz:
www.thecarlatreport.com/articles/487...
#psychiatry
pubmed.ncbi.nlm.nih.gov/40404538
Evidence grade Low 3/10
More on stopping meds in our interview with lead author, Mark Horowitz:
www.thecarlatreport.com/articles/487...
#psychiatry
Should you test iron in psychiatry (serum ferritin)?
▪ Deficiency common in children and in menstruating women
▪ Correcting improves cognition, #ADHD, energy, #depression, #anxiety in new analysis, even when there is no anemia (when < 50 μg/L):
pubmed.ncbi.nlm.nih.gov/40945632
#psychiatry #pmhnp
▪ Deficiency common in children and in menstruating women
▪ Correcting improves cognition, #ADHD, energy, #depression, #anxiety in new analysis, even when there is no anemia (when < 50 μg/L):
pubmed.ncbi.nlm.nih.gov/40945632
#psychiatry #pmhnp
January 16, 2026 at 1:00 PM
Should you test iron in psychiatry (serum ferritin)?
▪ Deficiency common in children and in menstruating women
▪ Correcting improves cognition, #ADHD, energy, #depression, #anxiety in new analysis, even when there is no anemia (when < 50 μg/L):
pubmed.ncbi.nlm.nih.gov/40945632
#psychiatry #pmhnp
▪ Deficiency common in children and in menstruating women
▪ Correcting improves cognition, #ADHD, energy, #depression, #anxiety in new analysis, even when there is no anemia (when < 50 μg/L):
pubmed.ncbi.nlm.nih.gov/40945632
#psychiatry #pmhnp
How social media causes #depression:
▪ Rumination, triggered in part by comparing self to others
pubmed.ncbi.nlm.nih.gov/41529738
▪ Relationship conflict from politics (particularly with ≥ 2 hr/day use)
pubmed.ncbi.nlm.nih.gov/41495403
What are you seeing with clients?
#psychology #therapy
▪ Rumination, triggered in part by comparing self to others
pubmed.ncbi.nlm.nih.gov/41529738
▪ Relationship conflict from politics (particularly with ≥ 2 hr/day use)
pubmed.ncbi.nlm.nih.gov/41495403
What are you seeing with clients?
#psychology #therapy
January 15, 2026 at 2:00 PM
How social media causes #depression:
▪ Rumination, triggered in part by comparing self to others
pubmed.ncbi.nlm.nih.gov/41529738
▪ Relationship conflict from politics (particularly with ≥ 2 hr/day use)
pubmed.ncbi.nlm.nih.gov/41495403
What are you seeing with clients?
#psychology #therapy
▪ Rumination, triggered in part by comparing self to others
pubmed.ncbi.nlm.nih.gov/41529738
▪ Relationship conflict from politics (particularly with ≥ 2 hr/day use)
pubmed.ncbi.nlm.nih.gov/41495403
What are you seeing with clients?
#psychology #therapy