Chris Aiken, MD
@chrisaikenmd.bsky.social
Editor, Carlat Psychiatry Report.
Assist Prof, NYU & WFU medical schools.
www.chrisaikenmd.com
Posting daily updates on all things psychiatric
Assist Prof, NYU & WFU medical schools.
www.chrisaikenmd.com
Posting daily updates on all things psychiatric
New data on Acetaminophen (Tylenol) --> #Autism/#ADHD:
▪ No evidence of causal link in analysis of 9 systemic reviews
▪ When compared to outcomes in unexposed siblings, the small associations disappeared, suggesting other (eg, genetic) factors explain it:
www.bmj.com/content/391/...
▪ No evidence of causal link in analysis of 9 systemic reviews
▪ When compared to outcomes in unexposed siblings, the small associations disappeared, suggesting other (eg, genetic) factors explain it:
www.bmj.com/content/391/...
November 11, 2025 at 1:01 PM
New data on Acetaminophen (Tylenol) --> #Autism/#ADHD:
▪ No evidence of causal link in analysis of 9 systemic reviews
▪ When compared to outcomes in unexposed siblings, the small associations disappeared, suggesting other (eg, genetic) factors explain it:
www.bmj.com/content/391/...
▪ No evidence of causal link in analysis of 9 systemic reviews
▪ When compared to outcomes in unexposed siblings, the small associations disappeared, suggesting other (eg, genetic) factors explain it:
www.bmj.com/content/391/...
Keto and Mediterranean diets compared for mood in health subjects:
▪ Medit better for #depression
▪ #Keto better for impulsivity, weight
www.ncbi.nlm.nih.gov/pubmed/41197...
How to use Medit for mood:
chrisaikenmd.com/antidepressa...
Evidence: Low (small, high drop-out, not blinded, 3-mth RCT)
▪ Medit better for #depression
▪ #Keto better for impulsivity, weight
www.ncbi.nlm.nih.gov/pubmed/41197...
How to use Medit for mood:
chrisaikenmd.com/antidepressa...
Evidence: Low (small, high drop-out, not blinded, 3-mth RCT)
November 10, 2025 at 1:17 PM
Keto and Mediterranean diets compared for mood in health subjects:
▪ Medit better for #depression
▪ #Keto better for impulsivity, weight
www.ncbi.nlm.nih.gov/pubmed/41197...
How to use Medit for mood:
chrisaikenmd.com/antidepressa...
Evidence: Low (small, high drop-out, not blinded, 3-mth RCT)
▪ Medit better for #depression
▪ #Keto better for impulsivity, weight
www.ncbi.nlm.nih.gov/pubmed/41197...
How to use Medit for mood:
chrisaikenmd.com/antidepressa...
Evidence: Low (small, high drop-out, not blinded, 3-mth RCT)
"How to get the best night's #sleep: What the science says" a nice podcast from Nature journal:
cms-resources.apps.public.k8s.springernature.io/springer-cms...
They focus on light at night. These blue-light blockers improved sleep quality in two RCTs:
chrisaikenmd.com/darktherapy
#therapy
cms-resources.apps.public.k8s.springernature.io/springer-cms...
They focus on light at night. These blue-light blockers improved sleep quality in two RCTs:
chrisaikenmd.com/darktherapy
#therapy
November 9, 2025 at 1:00 PM
"How to get the best night's #sleep: What the science says" a nice podcast from Nature journal:
cms-resources.apps.public.k8s.springernature.io/springer-cms...
They focus on light at night. These blue-light blockers improved sleep quality in two RCTs:
chrisaikenmd.com/darktherapy
#therapy
cms-resources.apps.public.k8s.springernature.io/springer-cms...
They focus on light at night. These blue-light blockers improved sleep quality in two RCTs:
chrisaikenmd.com/darktherapy
#therapy
Saffron improved premenstrual syndrome with a moderate effect size (0.4-0.8) in meta-analysis of 7 randomized trials:
pubmed.ncbi.nlm.nih.gov/41151539
Saffron also improved #depression and #sleep quality in recent large trials.
How to use it:
chrisaikenmd.com/supplements
#naturalhealth
pubmed.ncbi.nlm.nih.gov/41151539
Saffron also improved #depression and #sleep quality in recent large trials.
How to use it:
chrisaikenmd.com/supplements
#naturalhealth
November 8, 2025 at 1:00 PM
Saffron improved premenstrual syndrome with a moderate effect size (0.4-0.8) in meta-analysis of 7 randomized trials:
pubmed.ncbi.nlm.nih.gov/41151539
Saffron also improved #depression and #sleep quality in recent large trials.
How to use it:
chrisaikenmd.com/supplements
#naturalhealth
pubmed.ncbi.nlm.nih.gov/41151539
Saffron also improved #depression and #sleep quality in recent large trials.
How to use it:
chrisaikenmd.com/supplements
#naturalhealth
FDA approved lumateperone (Caplyta) aug in #major depression:
▪ 42 mg qhs
▪ Effect size 0.6 (good for class)
▪ Lower risk of EPS, akathisia, and metabolic risks within class, but sedating
I'll need to update this table from my book, Difficult to Treat Depression, about to go to press.
#psychiatry
▪ 42 mg qhs
▪ Effect size 0.6 (good for class)
▪ Lower risk of EPS, akathisia, and metabolic risks within class, but sedating
I'll need to update this table from my book, Difficult to Treat Depression, about to go to press.
#psychiatry
November 7, 2025 at 1:01 PM
FDA approved lumateperone (Caplyta) aug in #major depression:
▪ 42 mg qhs
▪ Effect size 0.6 (good for class)
▪ Lower risk of EPS, akathisia, and metabolic risks within class, but sedating
I'll need to update this table from my book, Difficult to Treat Depression, about to go to press.
#psychiatry
▪ 42 mg qhs
▪ Effect size 0.6 (good for class)
▪ Lower risk of EPS, akathisia, and metabolic risks within class, but sedating
I'll need to update this table from my book, Difficult to Treat Depression, about to go to press.
#psychiatry
From ChatGPT's internal audit. Each week
▪ 1.2 million (0.15%) express suicidal intent
▪ 560,000 (0.07%) have signs of emergency mania/psychosis
New algorithm performs better those who use it for therapy, but still veers off in suicide conversations 1 in 10 times:
pubmed.ncbi.nlm.nih.gov/41167716
▪ 1.2 million (0.15%) express suicidal intent
▪ 560,000 (0.07%) have signs of emergency mania/psychosis
New algorithm performs better those who use it for therapy, but still veers off in suicide conversations 1 in 10 times:
pubmed.ncbi.nlm.nih.gov/41167716
November 6, 2025 at 1:02 PM
From ChatGPT's internal audit. Each week
▪ 1.2 million (0.15%) express suicidal intent
▪ 560,000 (0.07%) have signs of emergency mania/psychosis
New algorithm performs better those who use it for therapy, but still veers off in suicide conversations 1 in 10 times:
pubmed.ncbi.nlm.nih.gov/41167716
▪ 1.2 million (0.15%) express suicidal intent
▪ 560,000 (0.07%) have signs of emergency mania/psychosis
New algorithm performs better those who use it for therapy, but still veers off in suicide conversations 1 in 10 times:
pubmed.ncbi.nlm.nih.gov/41167716
Probiotics may help #autism, from meta-analysis of 8 small RCTs:
pubmed.ncbi.nlm.nih.gov/41139591
Bigger impact over > 3 mth and in younger children.
(Gut health is implicated in autism, but confidence limits in analysis barely positive)
How to use them:
chrisaikenmd.com/supplements
#therapy
pubmed.ncbi.nlm.nih.gov/41139591
Bigger impact over > 3 mth and in younger children.
(Gut health is implicated in autism, but confidence limits in analysis barely positive)
How to use them:
chrisaikenmd.com/supplements
#therapy
November 5, 2025 at 1:01 PM
Probiotics may help #autism, from meta-analysis of 8 small RCTs:
pubmed.ncbi.nlm.nih.gov/41139591
Bigger impact over > 3 mth and in younger children.
(Gut health is implicated in autism, but confidence limits in analysis barely positive)
How to use them:
chrisaikenmd.com/supplements
#therapy
pubmed.ncbi.nlm.nih.gov/41139591
Bigger impact over > 3 mth and in younger children.
(Gut health is implicated in autism, but confidence limits in analysis barely positive)
How to use them:
chrisaikenmd.com/supplements
#therapy
#Sleep deprivation linked to worse outcomes in this first-of-its kind study of surgeons:
pubmed.ncbi.nlm.nih.gov/41117395
Evidence grade low (4/10):
chrisaikenmd.com/ebm
Photo: Weird Al. #psychiatry #surgery #medicine
pubmed.ncbi.nlm.nih.gov/41117395
Evidence grade low (4/10):
chrisaikenmd.com/ebm
Photo: Weird Al. #psychiatry #surgery #medicine
November 4, 2025 at 1:02 PM
#Sleep deprivation linked to worse outcomes in this first-of-its kind study of surgeons:
pubmed.ncbi.nlm.nih.gov/41117395
Evidence grade low (4/10):
chrisaikenmd.com/ebm
Photo: Weird Al. #psychiatry #surgery #medicine
pubmed.ncbi.nlm.nih.gov/41117395
Evidence grade low (4/10):
chrisaikenmd.com/ebm
Photo: Weird Al. #psychiatry #surgery #medicine
Night owls procrastinate more in college, and have more #depression/anxiety, concludes new cross-sectional study:
www.ncbi.nlm.nih.gov/pubmed/41140...
Evidence grade low (3/10)
They benefit from blue-light blockers glasses and dawn simulators; how to use them: chrisaikenmd.com/darktherapy
www.ncbi.nlm.nih.gov/pubmed/41140...
Evidence grade low (3/10)
They benefit from blue-light blockers glasses and dawn simulators; how to use them: chrisaikenmd.com/darktherapy
November 3, 2025 at 1:01 PM
Night owls procrastinate more in college, and have more #depression/anxiety, concludes new cross-sectional study:
www.ncbi.nlm.nih.gov/pubmed/41140...
Evidence grade low (3/10)
They benefit from blue-light blockers glasses and dawn simulators; how to use them: chrisaikenmd.com/darktherapy
www.ncbi.nlm.nih.gov/pubmed/41140...
Evidence grade low (3/10)
They benefit from blue-light blockers glasses and dawn simulators; how to use them: chrisaikenmd.com/darktherapy
New #therapy for #depression, Dynamic Interpersonal Therapy, had better long-term effects than CBT or med:
pubmed.ncbi.nlm.nih.gov/41135204
Focuses on attachment, mentalization, and recurring patterns in relationships.
Evidence grade moderate 7/10
chrisaikenmd.com/ebm
#psychology #psychiatry
pubmed.ncbi.nlm.nih.gov/41135204
Focuses on attachment, mentalization, and recurring patterns in relationships.
Evidence grade moderate 7/10
chrisaikenmd.com/ebm
#psychology #psychiatry
November 2, 2025 at 1:01 PM
New #therapy for #depression, Dynamic Interpersonal Therapy, had better long-term effects than CBT or med:
pubmed.ncbi.nlm.nih.gov/41135204
Focuses on attachment, mentalization, and recurring patterns in relationships.
Evidence grade moderate 7/10
chrisaikenmd.com/ebm
#psychology #psychiatry
pubmed.ncbi.nlm.nih.gov/41135204
Focuses on attachment, mentalization, and recurring patterns in relationships.
Evidence grade moderate 7/10
chrisaikenmd.com/ebm
#psychology #psychiatry
Daylight savings changes worsen sleep, especially in the Spring and for night owls, concludes new analysis:
pubmed.ncbi.nlm.nih.gov/41110263
Dawn simulators help adjust to these changes and improve winter #depression:
chrisaikenmd.com/dawnsimulator
pubmed.ncbi.nlm.nih.gov/41110263
Dawn simulators help adjust to these changes and improve winter #depression:
chrisaikenmd.com/dawnsimulator
November 1, 2025 at 12:01 PM
Daylight savings changes worsen sleep, especially in the Spring and for night owls, concludes new analysis:
pubmed.ncbi.nlm.nih.gov/41110263
Dawn simulators help adjust to these changes and improve winter #depression:
chrisaikenmd.com/dawnsimulator
pubmed.ncbi.nlm.nih.gov/41110263
Dawn simulators help adjust to these changes and improve winter #depression:
chrisaikenmd.com/dawnsimulator
Camouflaging is when people on the #autism spectrum mask their symptoms or imitate normal interactions to avoid standing out.
It can work, but it's also a cause of distress, as new study finds:
pubmed.ncbi.nlm.nih.gov/41120451
How do you manage this potential side effect of social skills training?
It can work, but it's also a cause of distress, as new study finds:
pubmed.ncbi.nlm.nih.gov/41120451
How do you manage this potential side effect of social skills training?
October 31, 2025 at 12:27 PM
Camouflaging is when people on the #autism spectrum mask their symptoms or imitate normal interactions to avoid standing out.
It can work, but it's also a cause of distress, as new study finds:
pubmed.ncbi.nlm.nih.gov/41120451
How do you manage this potential side effect of social skills training?
It can work, but it's also a cause of distress, as new study finds:
pubmed.ncbi.nlm.nih.gov/41120451
How do you manage this potential side effect of social skills training?
Is "warm milk before bed" more than just a folk remedy?
Milk/dairy improved sleep quality in new analysis of 8 RCTs and 6 other studies, whether in day or night:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Likely through tryptophan/probiotics.
#psychiatry #psychology #nutrition #taylorswift
Milk/dairy improved sleep quality in new analysis of 8 RCTs and 6 other studies, whether in day or night:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Likely through tryptophan/probiotics.
#psychiatry #psychology #nutrition #taylorswift
October 30, 2025 at 3:48 PM
Is "warm milk before bed" more than just a folk remedy?
Milk/dairy improved sleep quality in new analysis of 8 RCTs and 6 other studies, whether in day or night:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Likely through tryptophan/probiotics.
#psychiatry #psychology #nutrition #taylorswift
Milk/dairy improved sleep quality in new analysis of 8 RCTs and 6 other studies, whether in day or night:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Likely through tryptophan/probiotics.
#psychiatry #psychology #nutrition #taylorswift
FDA approved folinic acid (Leucovorin) for #autism, a controversial move based on 2 small RCTs and the endorsement of a Florida man.
Folate is impaired in autism, 84% have genetic problems in its metabolism:
pubmed.ncbi.nlm.nih.gov/41112632
Can also use methylfolate:
chrisaikenmd.com/supplements
Folate is impaired in autism, 84% have genetic problems in its metabolism:
pubmed.ncbi.nlm.nih.gov/41112632
Can also use methylfolate:
chrisaikenmd.com/supplements
October 29, 2025 at 4:07 PM
FDA approved folinic acid (Leucovorin) for #autism, a controversial move based on 2 small RCTs and the endorsement of a Florida man.
Folate is impaired in autism, 84% have genetic problems in its metabolism:
pubmed.ncbi.nlm.nih.gov/41112632
Can also use methylfolate:
chrisaikenmd.com/supplements
Folate is impaired in autism, 84% have genetic problems in its metabolism:
pubmed.ncbi.nlm.nih.gov/41112632
Can also use methylfolate:
chrisaikenmd.com/supplements
Here's why you need to know about white matter hyperintensities. They are linked to...
▪ #Depression in elderly (vascular type)
▪ Antidepressant non-response
▪ 3x risk of stroke
▪ 2x risk of dementia
▪ 2x risk of suicide in new analysis of mood disorders:
www.ncbi.nlm.nih.gov/pubmed/41107...
▪ #Depression in elderly (vascular type)
▪ Antidepressant non-response
▪ 3x risk of stroke
▪ 2x risk of dementia
▪ 2x risk of suicide in new analysis of mood disorders:
www.ncbi.nlm.nih.gov/pubmed/41107...
October 28, 2025 at 12:03 PM
Here's why you need to know about white matter hyperintensities. They are linked to...
▪ #Depression in elderly (vascular type)
▪ Antidepressant non-response
▪ 3x risk of stroke
▪ 2x risk of dementia
▪ 2x risk of suicide in new analysis of mood disorders:
www.ncbi.nlm.nih.gov/pubmed/41107...
▪ #Depression in elderly (vascular type)
▪ Antidepressant non-response
▪ 3x risk of stroke
▪ 2x risk of dementia
▪ 2x risk of suicide in new analysis of mood disorders:
www.ncbi.nlm.nih.gov/pubmed/41107...
Shift work causes insomnia, particularly after 24 hours of shift work per week, concludes prospective observational study of nurses:
www.ncbi.nlm.nih.gov/pubmed/41063...
Shift work also contributes to #depression, obesity, heart disease, cancer.
How to manage:
chrisaikenmd.com/darkbedroom
www.ncbi.nlm.nih.gov/pubmed/41063...
Shift work also contributes to #depression, obesity, heart disease, cancer.
How to manage:
chrisaikenmd.com/darkbedroom
October 27, 2025 at 12:04 PM
Shift work causes insomnia, particularly after 24 hours of shift work per week, concludes prospective observational study of nurses:
www.ncbi.nlm.nih.gov/pubmed/41063...
Shift work also contributes to #depression, obesity, heart disease, cancer.
How to manage:
chrisaikenmd.com/darkbedroom
www.ncbi.nlm.nih.gov/pubmed/41063...
Shift work also contributes to #depression, obesity, heart disease, cancer.
How to manage:
chrisaikenmd.com/darkbedroom
Is #autism linked to dark triad traits of:
1. Machiavellianism (cunning, manipulative)
2. Narcissism
3. Sociopathy
No, concludes new study, which finds low levels of the first two and no increase of #3.
www.ncbi.nlm.nih.gov/pubmed/41090...
Good to hear positive news about mental differences.
1. Machiavellianism (cunning, manipulative)
2. Narcissism
3. Sociopathy
No, concludes new study, which finds low levels of the first two and no increase of #3.
www.ncbi.nlm.nih.gov/pubmed/41090...
Good to hear positive news about mental differences.
October 26, 2025 at 12:01 PM
Is #autism linked to dark triad traits of:
1. Machiavellianism (cunning, manipulative)
2. Narcissism
3. Sociopathy
No, concludes new study, which finds low levels of the first two and no increase of #3.
www.ncbi.nlm.nih.gov/pubmed/41090...
Good to hear positive news about mental differences.
1. Machiavellianism (cunning, manipulative)
2. Narcissism
3. Sociopathy
No, concludes new study, which finds low levels of the first two and no increase of #3.
www.ncbi.nlm.nih.gov/pubmed/41090...
Good to hear positive news about mental differences.
Trazodone is very effective at improving sleep quality in #depression, concludes new review:
www.ncbi.nlm.nih.gov/pubmed/41081...
That’s something we can’t say for most antidepressants (serotonergics can make sleep worse), nor for most sleep meds (orexins are an exception).
#psychiatry #pmhnp
www.ncbi.nlm.nih.gov/pubmed/41081...
That’s something we can’t say for most antidepressants (serotonergics can make sleep worse), nor for most sleep meds (orexins are an exception).
#psychiatry #pmhnp
October 25, 2025 at 12:02 PM
Trazodone is very effective at improving sleep quality in #depression, concludes new review:
www.ncbi.nlm.nih.gov/pubmed/41081...
That’s something we can’t say for most antidepressants (serotonergics can make sleep worse), nor for most sleep meds (orexins are an exception).
#psychiatry #pmhnp
www.ncbi.nlm.nih.gov/pubmed/41081...
That’s something we can’t say for most antidepressants (serotonergics can make sleep worse), nor for most sleep meds (orexins are an exception).
#psychiatry #pmhnp
Ketamine failed against midazolam (IV) in new trial of inpatient #depression:
pubmed.ncbi.nlm.nih.gov/41123905
Was earlier success (against IV saline) due to unblinding? Or is it that benzos are well-established rapid-acting antidepressants (they just don't last).
Evidence grade: Moderate (8/10)
pubmed.ncbi.nlm.nih.gov/41123905
Was earlier success (against IV saline) due to unblinding? Or is it that benzos are well-established rapid-acting antidepressants (they just don't last).
Evidence grade: Moderate (8/10)
October 24, 2025 at 12:32 PM
Ketamine failed against midazolam (IV) in new trial of inpatient #depression:
pubmed.ncbi.nlm.nih.gov/41123905
Was earlier success (against IV saline) due to unblinding? Or is it that benzos are well-established rapid-acting antidepressants (they just don't last).
Evidence grade: Moderate (8/10)
pubmed.ncbi.nlm.nih.gov/41123905
Was earlier success (against IV saline) due to unblinding? Or is it that benzos are well-established rapid-acting antidepressants (they just don't last).
Evidence grade: Moderate (8/10)
Antioxidants for #autism? Trials are small, but systematic review highlights NAC, l-carnosine, omega-3, sulforaphane (from brocolli), CoQ10 as the best of the lot
www.ncbi.nlm.nih.gov/pubmed/41071...
Evidence moderate (~6/10)
chrisaikenmd.com/ebm
How to use them:
chrisaikenmd.com/supplements/
www.ncbi.nlm.nih.gov/pubmed/41071...
Evidence moderate (~6/10)
chrisaikenmd.com/ebm
How to use them:
chrisaikenmd.com/supplements/
October 23, 2025 at 12:04 PM
Antioxidants for #autism? Trials are small, but systematic review highlights NAC, l-carnosine, omega-3, sulforaphane (from brocolli), CoQ10 as the best of the lot
www.ncbi.nlm.nih.gov/pubmed/41071...
Evidence moderate (~6/10)
chrisaikenmd.com/ebm
How to use them:
chrisaikenmd.com/supplements/
www.ncbi.nlm.nih.gov/pubmed/41071...
Evidence moderate (~6/10)
chrisaikenmd.com/ebm
How to use them:
chrisaikenmd.com/supplements/
The diet for #depression recommends 6 eggs/wk:
chrisaikenmd.com/antidepressa...
Same number may prevent cognitive decline (but more harms vascular health):
ncbi.nlm.nih.gov/pubmed/41061...
How? Choline, omega-3, D/B-vitamins, antioxidants
Evidence = Moderate 4/10
chrisaikenmd.com/antidepressa...
Same number may prevent cognitive decline (but more harms vascular health):
ncbi.nlm.nih.gov/pubmed/41061...
How? Choline, omega-3, D/B-vitamins, antioxidants
Evidence = Moderate 4/10
October 22, 2025 at 12:50 PM
The diet for #depression recommends 6 eggs/wk:
chrisaikenmd.com/antidepressa...
Same number may prevent cognitive decline (but more harms vascular health):
ncbi.nlm.nih.gov/pubmed/41061...
How? Choline, omega-3, D/B-vitamins, antioxidants
Evidence = Moderate 4/10
chrisaikenmd.com/antidepressa...
Same number may prevent cognitive decline (but more harms vascular health):
ncbi.nlm.nih.gov/pubmed/41061...
How? Choline, omega-3, D/B-vitamins, antioxidants
Evidence = Moderate 4/10
Light #therapy treats perinatal #depression, and new trial shows sustained benefits 7 months later (even though the light was only used for 5 weeks):
www.ncbi.nlm.nih.gov/pubmed/41070...
Evidence: Moderate (6/10)
How to use light therapy (new recs for LED boxes):
chrisaikenmd.com/lighttherapy
www.ncbi.nlm.nih.gov/pubmed/41070...
Evidence: Moderate (6/10)
How to use light therapy (new recs for LED boxes):
chrisaikenmd.com/lighttherapy
October 21, 2025 at 12:02 PM
Light #therapy treats perinatal #depression, and new trial shows sustained benefits 7 months later (even though the light was only used for 5 weeks):
www.ncbi.nlm.nih.gov/pubmed/41070...
Evidence: Moderate (6/10)
How to use light therapy (new recs for LED boxes):
chrisaikenmd.com/lighttherapy
www.ncbi.nlm.nih.gov/pubmed/41070...
Evidence: Moderate (6/10)
How to use light therapy (new recs for LED boxes):
chrisaikenmd.com/lighttherapy
A common med hair-loss med (finasteride) causes #depression and #suicide, concludes 8 studies in this report that examines why this signal was suppressed for 20 years
Likely mechanism = lowers allopregnanolone, neurosteroid that modulates GABA (benzo) receptors
pubmed.ncbi.nlm.nih.gov/41004169
Likely mechanism = lowers allopregnanolone, neurosteroid that modulates GABA (benzo) receptors
pubmed.ncbi.nlm.nih.gov/41004169
October 20, 2025 at 12:02 PM
A common med hair-loss med (finasteride) causes #depression and #suicide, concludes 8 studies in this report that examines why this signal was suppressed for 20 years
Likely mechanism = lowers allopregnanolone, neurosteroid that modulates GABA (benzo) receptors
pubmed.ncbi.nlm.nih.gov/41004169
Likely mechanism = lowers allopregnanolone, neurosteroid that modulates GABA (benzo) receptors
pubmed.ncbi.nlm.nih.gov/41004169
Does response to the first stimulant dose predict later response in #ADHD?
It did in new study of methylphenidate, using Qb test to compare immediate and 2-month response:
www.ncbi.nlm.nih.gov/pubmed/41053...
Art: Grace Venditti
#psychiatry #pmhnp
It did in new study of methylphenidate, using Qb test to compare immediate and 2-month response:
www.ncbi.nlm.nih.gov/pubmed/41053...
Art: Grace Venditti
#psychiatry #pmhnp
October 19, 2025 at 12:01 PM
Does response to the first stimulant dose predict later response in #ADHD?
It did in new study of methylphenidate, using Qb test to compare immediate and 2-month response:
www.ncbi.nlm.nih.gov/pubmed/41053...
Art: Grace Venditti
#psychiatry #pmhnp
It did in new study of methylphenidate, using Qb test to compare immediate and 2-month response:
www.ncbi.nlm.nih.gov/pubmed/41053...
Art: Grace Venditti
#psychiatry #pmhnp
Do GLP-1s treat #alcohol use d/o?
Belief is high, evidence is thin, so take it with a grain of salt when this case-control study of diabetes looks for the GLP most effective against alcohol.
Winners = Tirzepatide, semaglutide:
www.ncbi.nlm.nih.gov/pubmed/41058...
Evidence: Low 3/10
Belief is high, evidence is thin, so take it with a grain of salt when this case-control study of diabetes looks for the GLP most effective against alcohol.
Winners = Tirzepatide, semaglutide:
www.ncbi.nlm.nih.gov/pubmed/41058...
Evidence: Low 3/10
October 18, 2025 at 12:03 PM
Do GLP-1s treat #alcohol use d/o?
Belief is high, evidence is thin, so take it with a grain of salt when this case-control study of diabetes looks for the GLP most effective against alcohol.
Winners = Tirzepatide, semaglutide:
www.ncbi.nlm.nih.gov/pubmed/41058...
Evidence: Low 3/10
Belief is high, evidence is thin, so take it with a grain of salt when this case-control study of diabetes looks for the GLP most effective against alcohol.
Winners = Tirzepatide, semaglutide:
www.ncbi.nlm.nih.gov/pubmed/41058...
Evidence: Low 3/10