Tong Lan
@tonglan.bsky.social
Postdoc @Lingyin Li lab @Arc Institute & Stanford University. PhD @Dickinson lab @UChicagoChemistry.
Reposted by Tong Lan
Interesting work profiling surface proteins from the Kossiakoff lab U Chicago. Corroborates the concept of @oawlab.bsky.social on cancer specific csU5-snRNP200 and our work on csNPM1 but here with more than 500 (!) novel Fabs and 40 antibodies developed. Very cool www.biorxiv.org/content/10.1...
Dynamic translocation of Inside-Out proteins to the cell surface underlies cellular adaptation to cancer-induced stress
Inside-out (I-O) protein display, the non-canonical surface localization of intracellular proteins, represents an underexplored feature of tumor cell biology. Here, we map the molecular landscape and ...
www.biorxiv.org
November 2, 2025 at 7:44 PM
Interesting work profiling surface proteins from the Kossiakoff lab U Chicago. Corroborates the concept of @oawlab.bsky.social on cancer specific csU5-snRNP200 and our work on csNPM1 but here with more than 500 (!) novel Fabs and 40 antibodies developed. Very cool www.biorxiv.org/content/10.1...
Reposted by Tong Lan
ENPP1 drug developed by Institute Scholar @lingyinli.bsky.social gains FDA approval for Phase I cancer clinical trials: arcinstitute.org/news/stf-162...
Proof-of-concept innate immune checkpoint inhibitor shows promise against solid tumors in rodents | Arc Institute
Biochemist Lingyin Li has been pioneering a new direction for immunotherapy, searching for drugs that would turn these “cold” environments “hot”. Instead of stimulating T cells in the adaptive immune…
arcinstitute.org
September 29, 2025 at 9:30 PM
ENPP1 drug developed by Institute Scholar @lingyinli.bsky.social gains FDA approval for Phase I cancer clinical trials: arcinstitute.org/news/stf-162...
Reposted by Tong Lan
This paper is now online at @cp-cellrepmed.bsky.social! Congratulations to all the authors. Read the paper here: www.cell.com/cell-reports...
September 11, 2025 at 6:56 PM
This paper is now online at @cp-cellrepmed.bsky.social! Congratulations to all the authors. Read the paper here: www.cell.com/cell-reports...
Reposted by Tong Lan
PANCS-Binders (phage-assisted noncontinuous selection of protein binders) screens multiple high-diversity protein libraries against a panel of dozens of targets for high-throughput binder discovery. @chembiobryan.bsky.social @mstyles-chembiol.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 6, 2025 at 7:49 PM
PANCS-Binders (phage-assisted noncontinuous selection of protein binders) screens multiple high-diversity protein libraries against a panel of dozens of targets for high-throughput binder discovery. @chembiobryan.bsky.social @mstyles-chembiol.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Tong Lan
In the latest Research Matters feature, @lingyinli.bsky.social discusses her quest for more broadly efficacious cancer therapies and the importance of learning from failures.
news.stanford.edu/stories/2025...
news.stanford.edu/stories/2025...
‘Every failed experiment is a chance to learn faster’
Stanford biochemist Lingyin Li’s lab is studying a tumor-fighting “miracle molecule” that could one day inform therapies for cancer, as well as autoimmune, neurodegenerative, and age-related diseases.
news.stanford.edu
June 6, 2025 at 10:48 PM
In the latest Research Matters feature, @lingyinli.bsky.social discusses her quest for more broadly efficacious cancer therapies and the importance of learning from failures.
news.stanford.edu/stories/2025...
news.stanford.edu/stories/2025...
Reposted by Tong Lan
It's been a busy week for the Li lab! The 10th PhD in 10 years, @xujunc.bsky.social successfully defended his thesis! Congratulations, and keep an eye out for his work on new STING inhibitors and regulators!
May 24, 2025 at 6:25 AM
It's been a busy week for the Li lab! The 10th PhD in 10 years, @xujunc.bsky.social successfully defended his thesis! Congratulations, and keep an eye out for his work on new STING inhibitors and regulators!
Reposted by Tong Lan
The ninth PhD defense from the lab by @songnanwang.bsky.social, now forging ahead with her MD-PhD! Excited for great things from Songnan yet to come!
May 1, 2025 at 12:31 AM
The ninth PhD defense from the lab by @songnanwang.bsky.social, now forging ahead with her MD-PhD! Excited for great things from Songnan yet to come!
Reposted by Tong Lan
Call to arms by @lisamjarvis.bsky.social for biopharma to mobilize in support of the engines that power them - federally supported biomedical research and drug evaluation
Noticeably silent amid the upheaval at HHS? Big pharma. Every new drug has NIH somewhere in its DNA--and NIH funding supports the training of their workforce. Now they're finding out FDA isn't safe, either. Wrote about how keeping quiet isn't working My latest @opinion.bloomberg.com (gift link):
Big Pharma Needs to Get Off the Sidelines
The industry can’t continue to sit idly by while Robert F. Kennedy Jr. guts the nation’s public health agencies.
www.bloomberg.com
April 1, 2025 at 5:38 PM
Call to arms by @lisamjarvis.bsky.social for biopharma to mobilize in support of the engines that power them - federally supported biomedical research and drug evaluation
🎉🎉🎉
Rebecca Chan kicked off March for the lab by successfully defending her thesis! Watch this space for the newly minted Dr. Chan's phenomenal work on molecular mechanisms of STING signaling!
March 20, 2025 at 11:13 PM
🎉🎉🎉
Reposted by Tong Lan
Wanted to share this story about my colleague Bryant Lin. We’re working together on bringing art and science together but his story runs much deeper. www.nytimes.com/2025/02/26/u...
When This Stanford Professor Got Cancer, He Decided to Teach a Class About It
Dr. Bryant Lin, who teaches medicine at Stanford University, was given a terminal diagnosis. He wanted his students to understand the humanity at the core of medicine.
www.nytimes.com
February 27, 2025 at 4:41 AM
Wanted to share this story about my colleague Bryant Lin. We’re working together on bringing art and science together but his story runs much deeper. www.nytimes.com/2025/02/26/u...
Reposted by Tong Lan
We're excited to share that our fearless leader @lingyinli.bsky.social has been promoted to full Professor of Biochemistry! Here's to decades more of research in therapeutics harnessing the innate immunity!
February 13, 2025 at 6:08 PM
We're excited to share that our fearless leader @lingyinli.bsky.social has been promoted to full Professor of Biochemistry! Here's to decades more of research in therapeutics harnessing the innate immunity!
Reposted by Tong Lan
Happy International Day of Women and Girls in Science! 🧪 Celebrating the brilliant minds, past and present, who have pushed boundaries and shaped our understanding of the world. Here’s to the next generation of scientists who will take us even further!
February 11, 2025 at 3:00 PM
Happy International Day of Women and Girls in Science! 🧪 Celebrating the brilliant minds, past and present, who have pushed boundaries and shaped our understanding of the world. Here’s to the next generation of scientists who will take us even further!
Reposted by Tong Lan
Super excited to finally share PANCS-Binders: our group's decade-long quest to accelerate protein binder discovery.
TLDR: PANCS-binders is fast (2 days), cheap (pennies), has extremely high fidelity (low false positive and negatives), and high-throughput.
1/n
TLDR: PANCS-binders is fast (2 days), cheap (pennies), has extremely high fidelity (low false positive and negatives), and high-throughput.
1/n
While everyone esle has been concentrating on generative binder design, this group has demonstrated screening libraries in vivo! www.biorxiv.org/content/10.1...
#biosky
#biosky
High-throughput protein binder discovery by rapid in vivo selection
Proteins that selectively bind to a target of interest are foundational components of research pipelines, diagnostics, and therapeutics. Current immunization-based, display-based, and computational ap...
www.biorxiv.org
January 7, 2025 at 8:50 PM
Super excited to finally share PANCS-Binders: our group's decade-long quest to accelerate protein binder discovery.
TLDR: PANCS-binders is fast (2 days), cheap (pennies), has extremely high fidelity (low false positive and negatives), and high-throughput.
1/n
TLDR: PANCS-binders is fast (2 days), cheap (pennies), has extremely high fidelity (low false positive and negatives), and high-throughput.
1/n
Reposted by Tong Lan
The Li lab is at the Cell Symposium @cellpress.bsky.social! Lab leader @lingyinli.bsky.social presents the lab's work on new therapeutic modalities harnessing the STING pathway
December 3, 2024 at 6:51 PM
The Li lab is at the Cell Symposium @cellpress.bsky.social! Lab leader @lingyinli.bsky.social presents the lab's work on new therapeutic modalities harnessing the STING pathway
Reposted by Tong Lan
Too often we spend only two weeks choosing a problem and then many years trying solving it, but this limits our potential impact.
A must read for PhD students: Problem choice and decision trees in science and engineering.
pubmed.ncbi.nlm.nih.gov/38608651/
A must read for PhD students: Problem choice and decision trees in science and engineering.
pubmed.ncbi.nlm.nih.gov/38608651/
November 17, 2024 at 5:35 PM
Too often we spend only two weeks choosing a problem and then many years trying solving it, but this limits our potential impact.
A must read for PhD students: Problem choice and decision trees in science and engineering.
pubmed.ncbi.nlm.nih.gov/38608651/
A must read for PhD students: Problem choice and decision trees in science and engineering.
pubmed.ncbi.nlm.nih.gov/38608651/
Reposted by Tong Lan
📯📯 Chemical Biology starter pack 📯📯
140 PIs & groups posting primary research in chemical biology.
Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj
Let's make ChemBioSky even greater again!
#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange
140 PIs & groups posting primary research in chemical biology.
Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj
Let's make ChemBioSky even greater again!
#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange
November 17, 2024 at 10:58 PM
📯📯 Chemical Biology starter pack 📯📯
140 PIs & groups posting primary research in chemical biology.
Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj
Let's make ChemBioSky even greater again!
#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange
140 PIs & groups posting primary research in chemical biology.
Please reskeet (?) & reply to this post if you want to be added!
go.bsky.app/KLrTWoj
Let's make ChemBioSky even greater again!
#realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange