Lingyin Li Lab
@lingyinlilab.bsky.social
The lab of chemical immunology 🧬 🧫 💊 🐀 at Stanford University & Arc Institute.
Student-run account by the lab of Lingyin Li (@lingyinli.bsky.social)
lingyinlilab.stanford.edu
Student-run account by the lab of Lingyin Li (@lingyinli.bsky.social)
lingyinlilab.stanford.edu
This paper is now online at @cp-cellrepmed.bsky.social! Congratulations to all the authors. Read the paper here: www.cell.com/cell-reports...
September 11, 2025 at 6:56 PM
This paper is now online at @cp-cellrepmed.bsky.social! Congratulations to all the authors. Read the paper here: www.cell.com/cell-reports...
Reposted by Lingyin Li Lab
Activation of the stimulator of interferon genes (STING) pathway can be great for fighting pathogens and treating cancer. But when the pathway is too active, it can do more harm than good, aggravating autoimmune and neurodegenerative diseases. cen.acs.org/analytical-c... #chemsky 🧪
Structural insights into STING give new ways to inhibit it
Researchers have discovered a highly conserved post translational modification in the STING pathway that when inhibited stops its activity
cen.acs.org
July 9, 2025 at 4:27 PM
Activation of the stimulator of interferon genes (STING) pathway can be great for fighting pathogens and treating cancer. But when the pathway is too active, it can do more harm than good, aggravating autoimmune and neurodegenerative diseases. cen.acs.org/analytical-c... #chemsky 🧪
Reposted by Lingyin Li Lab
Core Investigator @lingyinli.bsky.social's new paper in Nature Chemical Biology investigates why human STING inhibitors have shown limited efficacy, despite strong activity in mouse models.
July 3, 2025 at 4:31 PM
Core Investigator @lingyinli.bsky.social's new paper in Nature Chemical Biology investigates why human STING inhibitors have shown limited efficacy, despite strong activity in mouse models.
The newest paper from the lab is now out @natchembio.nature.com! A hard-won effort by Rebecca and @xujunc.bsky.social uncovers a previously undescribed post-translationally modified site that regulates STING signaling and proposes a new strategy for inhibition.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cysteine allostery and autoinhibition govern human STING oligomer functionality - Nature Chemical Biology
Palmitoylation at C64 in stimulator of interferon genes (STING) is reported and, along with engagement of C91, is involved in dynamic cross talk with C148 to alter STING oligomer states and ultimately...
www.nature.com
July 3, 2025 at 3:18 PM
The newest paper from the lab is now out @natchembio.nature.com! A hard-won effort by Rebecca and @xujunc.bsky.social uncovers a previously undescribed post-translationally modified site that regulates STING signaling and proposes a new strategy for inhibition.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In the latest Research Matters feature, @lingyinli.bsky.social discusses her quest for more broadly efficacious cancer therapies and the importance of learning from failures.
news.stanford.edu/stories/2025...
news.stanford.edu/stories/2025...
‘Every failed experiment is a chance to learn faster’
Stanford biochemist Lingyin Li’s lab is studying a tumor-fighting “miracle molecule” that could one day inform therapies for cancer, as well as autoimmune, neurodegenerative, and age-related diseases.
news.stanford.edu
June 6, 2025 at 10:48 PM
In the latest Research Matters feature, @lingyinli.bsky.social discusses her quest for more broadly efficacious cancer therapies and the importance of learning from failures.
news.stanford.edu/stories/2025...
news.stanford.edu/stories/2025...
It's been a busy week for the Li lab! The 10th PhD in 10 years, @xujunc.bsky.social successfully defended his thesis! Congratulations, and keep an eye out for his work on new STING inhibitors and regulators!
May 24, 2025 at 6:25 AM
It's been a busy week for the Li lab! The 10th PhD in 10 years, @xujunc.bsky.social successfully defended his thesis! Congratulations, and keep an eye out for his work on new STING inhibitors and regulators!
How can we do better with cancer immunotherapy? By leveraging both adaptive and innate immunity: in our latest preprint, we and industrial partners provide the most comprehensive characterization to date of STF-1623, an inhibitor of the innate immune checkpoint ENPP1
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy
Only one in five patients is estimated to respond to immune checkpoint inhibitors, which primarily target adaptive immunity. To date, no FDA-approved immunotherapies directly activate the innate anti-...
www.biorxiv.org
May 23, 2025 at 4:53 PM
How can we do better with cancer immunotherapy? By leveraging both adaptive and innate immunity: in our latest preprint, we and industrial partners provide the most comprehensive characterization to date of STF-1623, an inhibitor of the innate immune checkpoint ENPP1
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The ninth PhD defense from the lab by @songnanwang.bsky.social, now forging ahead with her MD-PhD! Excited for great things from Songnan yet to come!
May 1, 2025 at 12:31 AM
The ninth PhD defense from the lab by @songnanwang.bsky.social, now forging ahead with her MD-PhD! Excited for great things from Songnan yet to come!
Reposted by Lingyin Li Lab
New preprint: The first whole-body map of both DNA methylation and 3D genome organization at single-cell resolution across 16 human tissues, with in-depth analyses of cell type diversity of these epigenome modalities at unprecedented resolutions. (1/5)
March 25, 2025 at 3:16 PM
New preprint: The first whole-body map of both DNA methylation and 3D genome organization at single-cell resolution across 16 human tissues, with in-depth analyses of cell type diversity of these epigenome modalities at unprecedented resolutions. (1/5)
Rebecca Chan kicked off March for the lab by successfully defending her thesis! Watch this space for the newly minted Dr. Chan's phenomenal work on molecular mechanisms of STING signaling!
March 20, 2025 at 7:16 PM
Rebecca Chan kicked off March for the lab by successfully defending her thesis! Watch this space for the newly minted Dr. Chan's phenomenal work on molecular mechanisms of STING signaling!
Reposted by Lingyin Li Lab
Same spot, two years apart. 🧬 Exciting to see how far we've come!
March 4, 2025 at 4:45 PM
Same spot, two years apart. 🧬 Exciting to see how far we've come!
Reposted by Lingyin Li Lab
🚨 New paper alert! 🚨
Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with Maze Therapeutics
🔗 Paper: doi.org/10.1016/j.ce... @cp-cell.bsky.social
Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with Maze Therapeutics
🔗 Paper: doi.org/10.1016/j.ce... @cp-cell.bsky.social
Redirecting
doi.org
February 17, 2025 at 11:53 PM
🚨 New paper alert! 🚨
Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with Maze Therapeutics
🔗 Paper: doi.org/10.1016/j.ce... @cp-cell.bsky.social
Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with Maze Therapeutics
🔗 Paper: doi.org/10.1016/j.ce... @cp-cell.bsky.social
We're excited to share that our fearless leader @lingyinli.bsky.social has been promoted to full Professor of Biochemistry! Here's to decades more of research in therapeutics harnessing the innate immunity!
February 13, 2025 at 6:08 PM
We're excited to share that our fearless leader @lingyinli.bsky.social has been promoted to full Professor of Biochemistry! Here's to decades more of research in therapeutics harnessing the innate immunity!
Reposted by Lingyin Li Lab
DNA repair pathways might be important beyond maintaining genome stability. Using a CRISPRi screen, Becky Fu in the Gilbert Lab & colleagues found that the Fanconi anemia pathway is also necessary for lysosome function.
Read about the work, now on @biorxivpreprint: www.biorxiv.org/content/10.1....
Read about the work, now on @biorxivpreprint: www.biorxiv.org/content/10.1....
February 4, 2025 at 5:41 PM
DNA repair pathways might be important beyond maintaining genome stability. Using a CRISPRi screen, Becky Fu in the Gilbert Lab & colleagues found that the Fanconi anemia pathway is also necessary for lysosome function.
Read about the work, now on @biorxivpreprint: www.biorxiv.org/content/10.1....
Read about the work, now on @biorxivpreprint: www.biorxiv.org/content/10.1....
Reposted by Lingyin Li Lab
Seeking pioneering scientists in immunology, neuroscience, and machine learning! Join Arc Institute as a Core Investigator + Stanford Bioengineering as Associate/Full Professor. Full lab funding and cutting-edge facilities in Palo Alto. Apply by Jan 15 for full consideration: shorturl.at/CuH1K
Associate or Full Professor Rank Search to join the Arc Institute as a Core Investigator and the Stanford Department of Bioengineering | Arc Institute
Arc Institute is a independent nonprofit research organization headquartered in Palo Alto, California.
arcinstitute.org
January 8, 2025 at 11:44 PM
Seeking pioneering scientists in immunology, neuroscience, and machine learning! Join Arc Institute as a Core Investigator + Stanford Bioengineering as Associate/Full Professor. Full lab funding and cutting-edge facilities in Palo Alto. Apply by Jan 15 for full consideration: shorturl.at/CuH1K
Happy holidays from the Li lab!
December 20, 2024 at 5:10 AM
Happy holidays from the Li lab!
Reposted by Lingyin Li Lab
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by Lingyin Li Lab
Incredible meeting #CSChemBio2024 in San Francisco including talks from @fleurmferguson.bsky.social, @danetteldaniels.bsky.social, Michelle Arkin, Ingrid Wertz, and @mishtudey.bsky.social!
December 4, 2024 at 8:41 PM
Incredible meeting #CSChemBio2024 in San Francisco including talks from @fleurmferguson.bsky.social, @danetteldaniels.bsky.social, Michelle Arkin, Ingrid Wertz, and @mishtudey.bsky.social!
The Li lab is at the Cell Symposium @cellpress.bsky.social! Lab leader @lingyinli.bsky.social presents the lab's work on new therapeutic modalities harnessing the STING pathway
December 3, 2024 at 6:51 PM
The Li lab is at the Cell Symposium @cellpress.bsky.social! Lab leader @lingyinli.bsky.social presents the lab's work on new therapeutic modalities harnessing the STING pathway
Reposted by Lingyin Li Lab
Excited that our Core investigators and Cofounders Silvana Konermann and Patrick Hsu are on this year's @vox.com #FuturePerfect50 List, highlighting also the work of @lingyinli.bsky.social, Songnan Wang, @mgdurrant.bsky.social, and Nick Perry.
www.vox.com/future-perfe...
www.vox.com/future-perfe...
November 21, 2024 at 8:00 PM
Excited that our Core investigators and Cofounders Silvana Konermann and Patrick Hsu are on this year's @vox.com #FuturePerfect50 List, highlighting also the work of @lingyinli.bsky.social, Songnan Wang, @mgdurrant.bsky.social, and Nick Perry.
www.vox.com/future-perfe...
www.vox.com/future-perfe...
Reposted by Lingyin Li Lab
The 2025 Bioorganic Gordon Research Conference organized by Denise Field and @doc-jlmeier.bsky.social has an amazing lineup of speakers. Sadly, I will not be able to travel, but if you are interested in #ChemicalBiology, #BioorganicChemistry or #ChemicalProteomics, make sure to check it out. (1/4)
Applications for the 2025 Bioorganic GRC are now live! Here is the link where you can check out the current line-up:
grc.org/bioorganic-c...
grc.org/bioorganic-c...
November 17, 2024 at 3:57 PM
The 2025 Bioorganic Gordon Research Conference organized by Denise Field and @doc-jlmeier.bsky.social has an amazing lineup of speakers. Sadly, I will not be able to travel, but if you are interested in #ChemicalBiology, #BioorganicChemistry or #ChemicalProteomics, make sure to check it out. (1/4)