Tommaso Marchetti
@tmarchetti.bsky.social
Postdoc @ University of Zurich 🇨🇭
Adaptive immunity, cytokines and cytotoxicity
Adaptive immunity, cytokines and cytotoxicity
Pinned
Selective IL-2 delivery modulates CD8+ T cells in human HLH and ameliorates disease features in a murine model
Primary hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory syndrome.
In familial HLH, loss-of-function mutations in genes such as Prf1 disrupt perforin-dependent
cytolysis, leading to s...
www.jacionline.org
The main part of my PhD work is published!
We found that targeted IL-2 therapy, instead of worsening HLH, improves disease by driving CD8 T cells into an exhaustion-like state, an immune brake we can harness to control inflammation, challenging the view that IL-2 only boosts CD8 T cell activity.
We found that targeted IL-2 therapy, instead of worsening HLH, improves disease by driving CD8 T cells into an exhaustion-like state, an immune brake we can harness to control inflammation, challenging the view that IL-2 only boosts CD8 T cell activity.
Reposted by Tommaso Marchetti
We are hiring! 🧫 🧬 🚀
Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland.
See here for details (Deadline: 7th November 2025):
join.com/companies/im...
Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland.
See here for details (Deadline: 7th November 2025):
join.com/companies/im...
Botnar Institute of Immune Engineering - BIIE (Zürich): Doctoral studentships, Molecular Mucosal Immunology Group
Botnar Institute of Immune Engineering - BIIE has a job opening for Doctoral studentships, Molecular Mucosal Immunology Group in Zürich (published: 29.10.2025). Apply now or check the other available...
join.com
October 29, 2025 at 12:51 PM
We are hiring! 🧫 🧬 🚀
Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland.
See here for details (Deadline: 7th November 2025):
join.com/companies/im...
Three PhD studentships with start dates in 2026 available in the Molecular Mucosal Immunology lab at the Botnar Institute of Immune Engineering, Basel, Switzerland.
See here for details (Deadline: 7th November 2025):
join.com/companies/im...
The main part of my PhD work is published!
We found that targeted IL-2 therapy, instead of worsening HLH, improves disease by driving CD8 T cells into an exhaustion-like state, an immune brake we can harness to control inflammation, challenging the view that IL-2 only boosts CD8 T cell activity.
We found that targeted IL-2 therapy, instead of worsening HLH, improves disease by driving CD8 T cells into an exhaustion-like state, an immune brake we can harness to control inflammation, challenging the view that IL-2 only boosts CD8 T cell activity.
Selective IL-2 delivery modulates CD8+ T cells in human HLH and ameliorates disease features in a murine model
Primary hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory syndrome.
In familial HLH, loss-of-function mutations in genes such as Prf1 disrupt perforin-dependent
cytolysis, leading to s...
www.jacionline.org
October 8, 2025 at 3:14 PM
The main part of my PhD work is published!
We found that targeted IL-2 therapy, instead of worsening HLH, improves disease by driving CD8 T cells into an exhaustion-like state, an immune brake we can harness to control inflammation, challenging the view that IL-2 only boosts CD8 T cell activity.
We found that targeted IL-2 therapy, instead of worsening HLH, improves disease by driving CD8 T cells into an exhaustion-like state, an immune brake we can harness to control inflammation, challenging the view that IL-2 only boosts CD8 T cell activity.
Reposted by Tommaso Marchetti
Nobel committee unable to reach prize winner who is ‘living his best life’ hiking off grid
Nobel committee unable to reach prize winner who is ‘living his best life’ hiking off grid
Fred Ramsdell was among those honoured with a 2025 Nobel Prize in Medicine but might not know because he is somewhere in Idaho and uncontactable
The Nobel committee has been unable to reach a winner of this year’s prize for medicine who is “living his best life” on an “off the grid” hiking foray.
Fred Ramsdell shared Monday’s prestigious prize with Mary Brunkow of Seattle, Washington and Shimon Sakaguchi of Osaka University in Japan for their discoveries related to the functioning of the immune system. Continue reading...
www.theguardian.com
October 7, 2025 at 12:03 AM
Nobel committee unable to reach prize winner who is ‘living his best life’ hiking off grid
Reposted by Tommaso Marchetti
Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles
Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase,
which is activated through nucleic-acid-induced oligomerization and is critical for
cell survival during immune ...
www.cell.com
August 27, 2025 at 7:04 PM
Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Tommaso Marchetti
These are the most challenging times for early-career scientists and engineers.
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
August 11, 2025 at 11:54 AM
These are the most challenging times for early-career scientists and engineers.
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
Reposted by Tommaso Marchetti
I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!
May 22, 2025 at 11:42 AM
I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!
Reposted by Tommaso Marchetti
🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱.
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense
Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...
www.science.org
May 23, 2025 at 1:26 AM
🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱.
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
Reposted by Tommaso Marchetti
Our @natrevimmunol.bsky.social review with @abhishekgarglab.bsky.social, @deadoc80.bsky.social and Kellie Smith is out!
We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections!
www.nature.com/articles/s41...
We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections!
www.nature.com/articles/s41...
The diversity of CD8+ T cell dysfunction in cancer and viral infection - Nature Reviews Immunology
Beyond exhaustion, CD8+ T cells can adopt various dysfunctional states, including tolerant, anergic, senescent, ignorant and dying states, that compromise their ability to eradicate viruses or tumours...
www.nature.com
April 14, 2025 at 8:53 AM
Our @natrevimmunol.bsky.social review with @abhishekgarglab.bsky.social, @deadoc80.bsky.social and Kellie Smith is out!
We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections!
www.nature.com/articles/s41...
We attempt to integrate the data on CD8 T cell dysfunction into a new framework of hypofunctionality in cancer and chronic infections!
www.nature.com/articles/s41...
Reposted by Tommaso Marchetti
A tour de force review of the connections between between the nervous and immune systems
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 12, 2025 at 4:29 PM
A tour de force review of the connections between between the nervous and immune systems
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Tommaso Marchetti
How did Cell, Nature & Science become the 3 hottest journals in biomedical research? You could call it 'The Curious Case of Benjamin Lewin’ & it's told in today's episode of the Night Science podcast with Keith Yamamoto (@kryamamoto.bsky.social ; starts at 15:00) @nightsciencepod.bsky.social ⬇️
January 28, 2025 at 1:13 AM
How did Cell, Nature & Science become the 3 hottest journals in biomedical research? You could call it 'The Curious Case of Benjamin Lewin’ & it's told in today's episode of the Night Science podcast with Keith Yamamoto (@kryamamoto.bsky.social ; starts at 15:00) @nightsciencepod.bsky.social ⬇️
Reposted by Tommaso Marchetti
Cytokine-Induced Cell Exhaustion to Mitigate Hyperinflammation https://www.biorxiv.org/content/10.1101/2024.08.12.607544v1
Cytokine-Induced Cell Exhaustion to Mitigate Hyperinflammation https://www.biorxiv.org/content/10.1101/2024.08.12.607544v1
Haemophagocytic lymphohistiocytosis (HLH), a life-threatening hyperinflammatory disorder often drive
www.biorxiv.org
August 12, 2024 at 4:16 PM
Cytokine-Induced Cell Exhaustion to Mitigate Hyperinflammation https://www.biorxiv.org/content/10.1101/2024.08.12.607544v1
Reposted by Tommaso Marchetti
Too often we spend only two weeks choosing a problem and then many years trying to solve it, but this limits our potential impact. For more listen to this really interesting @nightsciencepod.bsky.social episode!
Spotify: open.spotify.com/episode/6KMh...
Apple: podcasts.apple.com/us/podcast/n...
Spotify: open.spotify.com/episode/6KMh...
Apple: podcasts.apple.com/us/podcast/n...
66 | Michael Fischbach and the scientific decision tree
Podcast Episode · Night Science · 11/25/2024 · 51m
podcasts.apple.com
November 25, 2024 at 9:51 PM
Too often we spend only two weeks choosing a problem and then many years trying to solve it, but this limits our potential impact. For more listen to this really interesting @nightsciencepod.bsky.social episode!
Spotify: open.spotify.com/episode/6KMh...
Apple: podcasts.apple.com/us/podcast/n...
Spotify: open.spotify.com/episode/6KMh...
Apple: podcasts.apple.com/us/podcast/n...
Reposted by Tommaso Marchetti
"We love interdisciplinary work! But..."
November 19, 2024 at 12:36 PM
"We love interdisciplinary work! But..."
Reposted by Tommaso Marchetti
Vive La France! 🇫🇷
July 7, 2024 at 8:28 PM
Vive La France! 🇫🇷
Reposted by Tommaso Marchetti
So much new on #longcovid. I've tried to pull it all together in a new Ground Truths
erictopol.substack.com/p/lighting-u...
erictopol.substack.com/p/lighting-u...
January 19, 2024 at 10:05 PM
So much new on #longcovid. I've tried to pull it all together in a new Ground Truths
erictopol.substack.com/p/lighting-u...
erictopol.substack.com/p/lighting-u...