Sristi
@sristi.bsky.social
One thought at a time, ten stops deep..
#DevelopmentalBiology #CellBiology #mechanobiology
Student@KanazawaUniversity @preLights.bsky.social
#DevelopmentalBiology #CellBiology #mechanobiology
Student@KanazawaUniversity @preLights.bsky.social
Reposted by Sristi
You must have been looking forward to... October in preprints!
Check out the latest #preprints on #DevBio, #StemCell biology and related topics with, starting this month, @prelights.bsky.social picks 👇👀
thenode.biologists.com/october-in-p...
Check out the latest #preprints on #DevBio, #StemCell biology and related topics with, starting this month, @prelights.bsky.social picks 👇👀
thenode.biologists.com/october-in-p...
October in preprints - the Node
Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv.
thenode.biologists.com
November 13, 2025 at 12:30 PM
You must have been looking forward to... October in preprints!
Check out the latest #preprints on #DevBio, #StemCell biology and related topics with, starting this month, @prelights.bsky.social picks 👇👀
thenode.biologists.com/october-in-p...
Check out the latest #preprints on #DevBio, #StemCell biology and related topics with, starting this month, @prelights.bsky.social picks 👇👀
thenode.biologists.com/october-in-p...
Reposted by Sristi
Do you love the monthly #preprint lists on @the-node.bsky.social?
Good news, our #preLighters have teamed up with the Node to nominate standout articles and share one-paragraph insights on why they’re excited.
Check out their October highlights ⬇️ 👀
thenode.biologists.com/prelighters-...
Good news, our #preLighters have teamed up with the Node to nominate standout articles and share one-paragraph insights on why they’re excited.
Check out their October highlights ⬇️ 👀
thenode.biologists.com/prelighters-...
November 13, 2025 at 12:35 PM
Do you love the monthly #preprint lists on @the-node.bsky.social?
Good news, our #preLighters have teamed up with the Node to nominate standout articles and share one-paragraph insights on why they’re excited.
Check out their October highlights ⬇️ 👀
thenode.biologists.com/prelighters-...
Good news, our #preLighters have teamed up with the Node to nominate standout articles and share one-paragraph insights on why they’re excited.
Check out their October highlights ⬇️ 👀
thenode.biologists.com/prelighters-...
Reposted by Sristi
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
October 28, 2025 at 8:25 AM
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️ www.biorxiv.org/content/10.1...
Reposted by Sristi
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
October 1, 2025 at 6:21 PM
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
Reposted by Sristi
Happy October 1st!
A good time to share another #CellBio #preprint reading list put together by a team of preLighters: @sristi.bsky.social, Matthew Davies, @vibhasingh.bsky.social, @fadelvalle.bsky.social & Barbora Knotkova.
Check out their picks ⬇️👀
prelights.biologists.com/prelists/sep...
A good time to share another #CellBio #preprint reading list put together by a team of preLighters: @sristi.bsky.social, Matthew Davies, @vibhasingh.bsky.social, @fadelvalle.bsky.social & Barbora Knotkova.
Check out their picks ⬇️👀
prelights.biologists.com/prelists/sep...
September in preprints – Cell biology edition - preLights
prelights.biologists.com
October 1, 2025 at 11:49 AM
Happy October 1st!
A good time to share another #CellBio #preprint reading list put together by a team of preLighters: @sristi.bsky.social, Matthew Davies, @vibhasingh.bsky.social, @fadelvalle.bsky.social & Barbora Knotkova.
Check out their picks ⬇️👀
prelights.biologists.com/prelists/sep...
A good time to share another #CellBio #preprint reading list put together by a team of preLighters: @sristi.bsky.social, Matthew Davies, @vibhasingh.bsky.social, @fadelvalle.bsky.social & Barbora Knotkova.
Check out their picks ⬇️👀
prelights.biologists.com/prelists/sep...
Reposted by Sristi
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Reposted by Sristi
Tissue 'tectonic' collision is detrimental, but flies found two distinct solutions! Gratifying and grateful to be included in this collective effort, w/ Steffen Lemke, to crack the (or 'a') code of #cephalicfurrow, now out in @nature.com, all with @paveltomancak.bsky.social at the helm. (1/9)
September 4, 2025 at 5:18 PM
Tissue 'tectonic' collision is detrimental, but flies found two distinct solutions! Gratifying and grateful to be included in this collective effort, w/ Steffen Lemke, to crack the (or 'a') code of #cephalicfurrow, now out in @nature.com, all with @paveltomancak.bsky.social at the helm. (1/9)
Reposted by Sristi
Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd
September 26, 2025 at 12:55 PM
Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd
Reposted by Sristi
Excited to share our new review in Development, Growth and Differentiation(DGD) Journall!
With the amazing @yuchiunwang.bsky.social & @bipashadey29.bsky.social,we explore how rigidity transitions bridge cytoplasmic & tissue scales.
Read the full review: onlinelibrary.wiley.com/doi/full/10....
With the amazing @yuchiunwang.bsky.social & @bipashadey29.bsky.social,we explore how rigidity transitions bridge cytoplasmic & tissue scales.
Read the full review: onlinelibrary.wiley.com/doi/full/10....
Integrating Tissue and Cytoplasmic Rigidity Transitions During Morphogenesis
Multicellular organisms generate organizational complexity through morphogenesis, in which mechanical forces orchestrate the movements and deformations of cells and tissues, while chemical signals re...
onlinelibrary.wiley.com
September 12, 2025 at 6:20 AM
Excited to share our new review in Development, Growth and Differentiation(DGD) Journall!
With the amazing @yuchiunwang.bsky.social & @bipashadey29.bsky.social,we explore how rigidity transitions bridge cytoplasmic & tissue scales.
Read the full review: onlinelibrary.wiley.com/doi/full/10....
With the amazing @yuchiunwang.bsky.social & @bipashadey29.bsky.social,we explore how rigidity transitions bridge cytoplasmic & tissue scales.
Read the full review: onlinelibrary.wiley.com/doi/full/10....
Reposted by Sristi
Cancer cells that survive, thrive: capillary constrictions as a trigger of mechanotransduction in cancer progression.
Check out this #preLight by Sristilekha Nath, which talks about the work by @gsilvani.bsky.social, @kriskilian.bsky.social and the team.
Check out this #preLight by Sristilekha Nath, which talks about the work by @gsilvani.bsky.social, @kriskilian.bsky.social and the team.
Capillary constrictions prime cancer cell tumorigenicity through PIEZO1 - preLights
Cancer cells that survive, thrive: capillary constrictions as a trigger of mechanotransduction in cancer progression
prelights.biologists.com
August 5, 2025 at 8:50 AM
Cancer cells that survive, thrive: capillary constrictions as a trigger of mechanotransduction in cancer progression.
Check out this #preLight by Sristilekha Nath, which talks about the work by @gsilvani.bsky.social, @kriskilian.bsky.social and the team.
Check out this #preLight by Sristilekha Nath, which talks about the work by @gsilvani.bsky.social, @kriskilian.bsky.social and the team.
Reposted by Sristi
A Summer reading recommendation: new primer in @dev-journal.bsky.social explains how dynamical systems theory unlocks the logic of developmental patterning
Everything from bistable switches & oscillators to phase portraits & more with Python code to explore
journals.biologists.com/dev/article/...
Everything from bistable switches & oscillators to phase portraits & more with Python code to explore
journals.biologists.com/dev/article/...
From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms
Summary: Dynamical systems theory provides a powerful quantitative and intuitive framework to understand developmental processes. This Primer brings key concepts of this framework to the ever-growing ...
journals.biologists.com
August 4, 2025 at 8:44 AM
A Summer reading recommendation: new primer in @dev-journal.bsky.social explains how dynamical systems theory unlocks the logic of developmental patterning
Everything from bistable switches & oscillators to phase portraits & more with Python code to explore
journals.biologists.com/dev/article/...
Everything from bistable switches & oscillators to phase portraits & more with Python code to explore
journals.biologists.com/dev/article/...
Reposted by Sristi
CellPhePy is now available 🎉🎉🎉 in the journal of #microscopy. A python version for #CellPhe.
See doi.org/10.1111/jmi....
Thanks @ukri.org and @wellcometrust.bsky.social for funding
@globias.bsky.social @globalbioimaging.bsky.social @eurobioimaging.bsky.social @bioimaginguk.bsky.social
See doi.org/10.1111/jmi....
Thanks @ukri.org and @wellcometrust.bsky.social for funding
@globias.bsky.social @globalbioimaging.bsky.social @eurobioimaging.bsky.social @bioimaginguk.bsky.social
CellPhePy: A python implementation of the CellPhe toolkit for automated cell phenotyping from microscopy time‐lapse videos
We previously developed the CellPhe toolkit, an open-source R package for automated cell phenotyping from ptychography time-lapse videos. To align with the growing adoption of python-based image anal...
doi.org
April 28, 2025 at 12:50 PM
CellPhePy is now available 🎉🎉🎉 in the journal of #microscopy. A python version for #CellPhe.
See doi.org/10.1111/jmi....
Thanks @ukri.org and @wellcometrust.bsky.social for funding
@globias.bsky.social @globalbioimaging.bsky.social @eurobioimaging.bsky.social @bioimaginguk.bsky.social
See doi.org/10.1111/jmi....
Thanks @ukri.org and @wellcometrust.bsky.social for funding
@globias.bsky.social @globalbioimaging.bsky.social @eurobioimaging.bsky.social @bioimaginguk.bsky.social
Reposted by Sristi
Happy to share our new preprint on lens morphogenesis in ocular organoids. All thanks to Elin Stahl, Miguel Angel Delgado-Toscano, Ishwariya Saravanan, Anastasija Paneva and Jochen Wittbrodt @wittbrodtlab.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 23, 2025 at 9:19 PM
Happy to share our new preprint on lens morphogenesis in ocular organoids. All thanks to Elin Stahl, Miguel Angel Delgado-Toscano, Ishwariya Saravanan, Anastasija Paneva and Jochen Wittbrodt @wittbrodtlab.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sristi
Very happy and excited to share our latest work linking actin nematodynamics and endothelial cell mechanics under anisotropic tension, now published in @natphys.nature.com ! rdcu.be/eigWi
@ipparis.bsky.social @polytechniqueparis.bsky.social
@ipparis.bsky.social @polytechniqueparis.bsky.social
Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics
Nature Physics - Blood flow through a vessel deforms vessel walls. Cells lining these walls sense the changes in pressure as blood flows and reorient their actin fibres in the direction of largest...
rdcu.be
April 18, 2025 at 12:06 PM
Very happy and excited to share our latest work linking actin nematodynamics and endothelial cell mechanics under anisotropic tension, now published in @natphys.nature.com ! rdcu.be/eigWi
@ipparis.bsky.social @polytechniqueparis.bsky.social
@ipparis.bsky.social @polytechniqueparis.bsky.social
Reposted by Sristi
It’s about time to share the March #CellBio preprint picks!
8 preLighters (@girishkalephd.bsky.social, @fadelvalle.bsky.social, @ethanewe.bsky.social, @sristi.bsky.social, @vibhasingh.bsky.social, @deevithab.bsky.social) teamed up to curate this #preList ⬇️
prelights.biologists.com/prelists/mar...
8 preLighters (@girishkalephd.bsky.social, @fadelvalle.bsky.social, @ethanewe.bsky.social, @sristi.bsky.social, @vibhasingh.bsky.social, @deevithab.bsky.social) teamed up to curate this #preList ⬇️
prelights.biologists.com/prelists/mar...
March in preprints – the CellBio edition - preLights
prelights.biologists.com
April 8, 2025 at 1:48 PM
It’s about time to share the March #CellBio preprint picks!
8 preLighters (@girishkalephd.bsky.social, @fadelvalle.bsky.social, @ethanewe.bsky.social, @sristi.bsky.social, @vibhasingh.bsky.social, @deevithab.bsky.social) teamed up to curate this #preList ⬇️
prelights.biologists.com/prelists/mar...
8 preLighters (@girishkalephd.bsky.social, @fadelvalle.bsky.social, @ethanewe.bsky.social, @sristi.bsky.social, @vibhasingh.bsky.social, @deevithab.bsky.social) teamed up to curate this #preList ⬇️
prelights.biologists.com/prelists/mar...
Reposted by Sristi
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
www.science.org
April 3, 2025 at 6:24 PM
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Reposted by Sristi
The more jargon you have in your paper the less citations you'll get.
royalsocietypublishing.org/doi/10.1098/...
royalsocietypublishing.org/doi/10.1098/...
April 1, 2025 at 6:26 PM
The more jargon you have in your paper the less citations you'll get.
royalsocietypublishing.org/doi/10.1098/...
royalsocietypublishing.org/doi/10.1098/...
Reposted by Sristi
3D reconstruction of a 3-day-old #zebrafish heart beating. Credit to Michael Weber (prev. @mpi-cbg.de). #ZebrafishZunday 🧪
March 16, 2025 at 9:50 AM
3D reconstruction of a 3-day-old #zebrafish heart beating. Credit to Michael Weber (prev. @mpi-cbg.de). #ZebrafishZunday 🧪
Reposted by Sristi
A duo of preprints on the dynamics of the first cell fate decision in mouse by Madeleine Chalifoux (first grad student in the lab!) and Maria Avdeeva (Flatiron).
We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.
We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.
March 5, 2025 at 2:54 AM
A duo of preprints on the dynamics of the first cell fate decision in mouse by Madeleine Chalifoux (first grad student in the lab!) and Maria Avdeeva (Flatiron).
We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.
We use quantitative live imaging of key cell fate determinants to follow the segregation of inner cell mass and trophectoderm lineages.
Reposted by Sristi
This CellBio #preList is yet another great team effort! #community #ECRs
Many thanks Barbora, Matthew, @sristi.bsky.social , @girishkalephd.bsky.social, Prasanna, Vibha & @fadelvalle.bsky.social for putting it together! 🙌 #preLighters
Many thanks Barbora, Matthew, @sristi.bsky.social , @girishkalephd.bsky.social, Prasanna, Vibha & @fadelvalle.bsky.social for putting it together! 🙌 #preLighters
February in Preprints ! prelights.biologists.com/prelists/feb... don't miss this great selection of papers by preLighters at @prelights.bsky.social
February in preprints – the CellBio edition - preLights
prelights.biologists.com
March 5, 2025 at 4:35 PM
This CellBio #preList is yet another great team effort! #community #ECRs
Many thanks Barbora, Matthew, @sristi.bsky.social , @girishkalephd.bsky.social, Prasanna, Vibha & @fadelvalle.bsky.social for putting it together! 🙌 #preLighters
Many thanks Barbora, Matthew, @sristi.bsky.social , @girishkalephd.bsky.social, Prasanna, Vibha & @fadelvalle.bsky.social for putting it together! 🙌 #preLighters
Reposted by Sristi
Check out our latest podcast episode ( #spotLights ) in which we talk to the creator of #tidyplots: Jan Broder Engler🎙
Ep. 7 🎧: www.youtube.com/watch?v=o0kl...
Also, please take a look at the related #preLights post prepared by Felipe Del Valle Batalla: prelights.biologists.com/highlights/t...
Ep. 7 🎧: www.youtube.com/watch?v=o0kl...
Also, please take a look at the related #preLights post prepared by Felipe Del Valle Batalla: prelights.biologists.com/highlights/t...
February 25, 2025 at 11:38 AM
Check out our latest podcast episode ( #spotLights ) in which we talk to the creator of #tidyplots: Jan Broder Engler🎙
Ep. 7 🎧: www.youtube.com/watch?v=o0kl...
Also, please take a look at the related #preLights post prepared by Felipe Del Valle Batalla: prelights.biologists.com/highlights/t...
Ep. 7 🎧: www.youtube.com/watch?v=o0kl...
Also, please take a look at the related #preLights post prepared by Felipe Del Valle Batalla: prelights.biologists.com/highlights/t...
Reposted by Sristi
New paper out 🎇
It has been 13 years since @owenlabuob.bsky.social and co. published a stellar protocol on how to measure membrane order with smart probes! Since then, there has been new dyes, imaging modes and biology! We wrote a protocol for Nature Protocols:
www.nature.com/articles/s41...
It has been 13 years since @owenlabuob.bsky.social and co. published a stellar protocol on how to measure membrane order with smart probes! Since then, there has been new dyes, imaging modes and biology! We wrote a protocol for Nature Protocols:
www.nature.com/articles/s41...
Measuring plasma membrane fluidity using confocal microscopy - Nature Protocols
Membrane fluidity is a crucial feature in understanding cellular physiology. This protocol describes a robust pipeline for measuring plasma membrane fluidity using confocal imaging and new environment...
www.nature.com
February 19, 2025 at 3:58 PM
New paper out 🎇
It has been 13 years since @owenlabuob.bsky.social and co. published a stellar protocol on how to measure membrane order with smart probes! Since then, there has been new dyes, imaging modes and biology! We wrote a protocol for Nature Protocols:
www.nature.com/articles/s41...
It has been 13 years since @owenlabuob.bsky.social and co. published a stellar protocol on how to measure membrane order with smart probes! Since then, there has been new dyes, imaging modes and biology! We wrote a protocol for Nature Protocols:
www.nature.com/articles/s41...
Reposted by Sristi
Here it is, in collaboration with @lankylaste.bsky.social, Lina Gerontogianni & Gavin Kelly: www.biorxiv.org/content/10.1...
* Stats tests often used inappropriately
* Masses of data points are often unnecessary
* Inferring biological significance almost impossible without appropriate controls
* Stats tests often used inappropriately
* Masses of data points are often unnecessary
* Inferring biological significance almost impossible without appropriate controls
February 11, 2025 at 3:00 PM
Here it is, in collaboration with @lankylaste.bsky.social, Lina Gerontogianni & Gavin Kelly: www.biorxiv.org/content/10.1...
* Stats tests often used inappropriately
* Masses of data points are often unnecessary
* Inferring biological significance almost impossible without appropriate controls
* Stats tests often used inappropriately
* Masses of data points are often unnecessary
* Inferring biological significance almost impossible without appropriate controls
Reposted by Sristi
Deforming Nuclei: a way to move through the crowd!
Read this #BehindthePaper story from Mariana Maia-Gil about the work @nordenlab.bsky.social, looking into how nuclear properties influence nuclear positioning in the densely packed🐟retinal neuroepithelium:
thenode.biologists.com/deforming-nu...
Read this #BehindthePaper story from Mariana Maia-Gil about the work @nordenlab.bsky.social, looking into how nuclear properties influence nuclear positioning in the densely packed🐟retinal neuroepithelium:
thenode.biologists.com/deforming-nu...
Deforming Nuclei: a way to move through the crowd! - the Node
In their recent paper, Maia-Gil and colleagues explored whether and how nuclear properties can influence nuclear positioning in vivo. Their work revealed
thenode.biologists.com
February 4, 2025 at 8:50 AM
Deforming Nuclei: a way to move through the crowd!
Read this #BehindthePaper story from Mariana Maia-Gil about the work @nordenlab.bsky.social, looking into how nuclear properties influence nuclear positioning in the densely packed🐟retinal neuroepithelium:
thenode.biologists.com/deforming-nu...
Read this #BehindthePaper story from Mariana Maia-Gil about the work @nordenlab.bsky.social, looking into how nuclear properties influence nuclear positioning in the densely packed🐟retinal neuroepithelium:
thenode.biologists.com/deforming-nu...
Reposted by Sristi
📃January in preprints – the CellBio edition
This latest cell biology #preList was curated by Barbora Knotkova, Vibha Singh, Matthew Davies, @fadelvalle.bsky.social and @girishkalephd.bsky.social
Explore their favourite #CellBio #preprints!
⬇️
This latest cell biology #preList was curated by Barbora Knotkova, Vibha Singh, Matthew Davies, @fadelvalle.bsky.social and @girishkalephd.bsky.social
Explore their favourite #CellBio #preprints!
⬇️
January in preprints – the CellBio edition - preLights
prelights.biologists.com
February 3, 2025 at 4:10 PM
📃January in preprints – the CellBio edition
This latest cell biology #preList was curated by Barbora Knotkova, Vibha Singh, Matthew Davies, @fadelvalle.bsky.social and @girishkalephd.bsky.social
Explore their favourite #CellBio #preprints!
⬇️
This latest cell biology #preList was curated by Barbora Knotkova, Vibha Singh, Matthew Davies, @fadelvalle.bsky.social and @girishkalephd.bsky.social
Explore their favourite #CellBio #preprints!
⬇️