Siavash Moghadami
@simoghad.bsky.social
Ph.D. Student, Nobel laureate Carolyn Bertozzi and Longzhi Tan Labs, Stanford University🌲, Departments of Chemical and Systems Biology|Neurobiology|Sarafan ChEM-H, Passionate about Chemical Biology🧪, Neuroscience 🧠and Artificial Intelligence🤖
Such a tremendous loss for biology. I remember seeing her photos with primates in my biology textbooks and wondering how joyful science could be—and what true passion really means
www.cnn.com/2025/10/01/e...
www.cnn.com/2025/10/01/e...
Conservationist Jane Goodall, whose work revolutionized the study of primates, has died | CNN
Jane Goodall, whose lifelong work as a primatologist helped broaden the world’s understanding of animal behavior and emotions, has died, her institute said Wednesday. She was 91.
www.cnn.com
October 1, 2025 at 8:00 PM
Such a tremendous loss for biology. I remember seeing her photos with primates in my biology textbooks and wondering how joyful science could be—and what true passion really means
www.cnn.com/2025/10/01/e...
www.cnn.com/2025/10/01/e...
#AlzheimersDay reminds us why we go to the lab every day. Thanks to the incredible opportunities and support this country provides, we have the chance to turn research into real treatments. In the U.S., science can truly serve people — and that mission must always come before fame or money. 🇺🇸🧠✨
"… we are in a propitious position to accurately and precisely determine who is at high risk of developing #AlzheimersDisease years before signs of even mild cognitive deficit," writes Eric Topol in a #ScienceExpertVoices article.
Learn more on #WorldAlzheimersDay: https://scim.ag/3K4XxEl
Learn more on #WorldAlzheimersDay: https://scim.ag/3K4XxEl
September 21, 2025 at 7:30 PM
#AlzheimersDay reminds us why we go to the lab every day. Thanks to the incredible opportunities and support this country provides, we have the chance to turn research into real treatments. In the U.S., science can truly serve people — and that mission must always come before fame or money. 🇺🇸🧠✨
And that’s why “Virtual Cell” needs more real data and less hype!
an we understand biology from "infinite" amounts of perturbation data ?
- Only if we measure the relevant molecules.
Perturbations and data scale 𝐜𝐚𝐧𝐧𝐨𝐭 compensate for missing the relevant molecules.
🧵
- Only if we measure the relevant molecules.
Perturbations and data scale 𝐜𝐚𝐧𝐧𝐨𝐭 compensate for missing the relevant molecules.
🧵
September 15, 2025 at 4:05 PM
And that’s why “Virtual Cell” needs more real data and less hype!
Reposted by Siavash Moghadami
Discovery of a brain center (BNST) that controls consumption (including sweets, fats, salt and other foods) in mice
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
A brain center that controls consummatory responses
The BNST brain region integrates a broad range of external and internal signals to
flexibly regulate consumption, revealing a unified control over consummatory responses.
www.cell.com
September 10, 2025 at 2:56 PM
Discovery of a brain center (BNST) that controls consumption (including sweets, fats, salt and other foods) in mice
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Maybe @science.org should be more careful?! Richard Feynman doesn't have two Nobel prizes😟
www.science.org/content/arti...
www.science.org/content/arti...
September 10, 2025 at 4:43 AM
Maybe @science.org should be more careful?! Richard Feynman doesn't have two Nobel prizes😟
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Siavash Moghadami
Great perspective by @dereklowe.bsky.social on recent advances in cell surface #glycoRNA biology, including new work from @raflynn5.bsky.social and collaborators identifying an immune silencing effect of N-glycans on activation of TLRs by Acp3U-RNA (www.nature.com/articles/s41...)
September 9, 2025 at 6:19 PM
Great perspective by @dereklowe.bsky.social on recent advances in cell surface #glycoRNA biology, including new work from @raflynn5.bsky.social and collaborators identifying an immune silencing effect of N-glycans on activation of TLRs by Acp3U-RNA (www.nature.com/articles/s41...)
Such a loss! Thanks for all your contribution to help us better understand the world of biology!
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87 www.nytimes.com/2025/09/07/s...
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87 www.nytimes.com/2025/09/07/s...
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87
www.nytimes.com
September 8, 2025 at 1:16 AM
Such a loss! Thanks for all your contribution to help us better understand the world of biology!
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87 www.nytimes.com/2025/09/07/s...
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87 www.nytimes.com/2025/09/07/s...
Reposted by Siavash Moghadami
2022 Nobel Prize winner in Chemistry, #Stanford Prof. Carolyn Bertozzi, delivered an inspiring lecture on #BioorthogonalChemistry at #PekingUniversity on Aug. 28.
@stanford.edu @carolynbertozzi.bskyverified.social
@stanford.edu @carolynbertozzi.bskyverified.social
August 30, 2025 at 11:22 AM
2022 Nobel Prize winner in Chemistry, #Stanford Prof. Carolyn Bertozzi, delivered an inspiring lecture on #BioorthogonalChemistry at #PekingUniversity on Aug. 28.
@stanford.edu @carolynbertozzi.bskyverified.social
@stanford.edu @carolynbertozzi.bskyverified.social
Reposted by Siavash Moghadami
Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!
Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
August 27, 2025 at 3:27 AM
Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!
Reposted by Siavash Moghadami
Faculty opening in Cornell Chemistry at the Assistant Professor level in the area of chemical biology, broadly defined! academicjobsonline.org/ajo/jobs/30338 #chemjobs
Cornell University, Chemistry and Chemical Biology
Job #AJO30338, WDR-00054776 Assistant Professor - Chemistry and Chemical Biology, Cornell University (Ithaca, NY), Chemistry and Chemical Biology, Cornell University, Ithaca, New York, US
academicjobsonline.org
August 25, 2025 at 8:30 PM
Faculty opening in Cornell Chemistry at the Assistant Professor level in the area of chemical biology, broadly defined! academicjobsonline.org/ajo/jobs/30338 #chemjobs
Reposted by Siavash Moghadami
Another piece of the #glycoRNA puzzle revealed by @raflynn5.bsky.social and @vijayrathinam.bsky.social!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
www.nature.com
August 19, 2025 at 7:43 PM
Another piece of the #glycoRNA puzzle revealed by @raflynn5.bsky.social and @vijayrathinam.bsky.social!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Siavash Moghadami
Drawing the mind, one neuron at a time: A 2022 book walks readers through the life and work of Santiago Ramón y Cajal, the Spaniard whom many consider the founder of modern #neuroscience.
Check out the #ScienceBooks Review on #BookLoversDay: scim.ag/3RvHDmQ
Check out the #ScienceBooks Review on #BookLoversDay: scim.ag/3RvHDmQ
August 9, 2025 at 2:07 PM
Drawing the mind, one neuron at a time: A 2022 book walks readers through the life and work of Santiago Ramón y Cajal, the Spaniard whom many consider the founder of modern #neuroscience.
Check out the #ScienceBooks Review on #BookLoversDay: scim.ag/3RvHDmQ
Check out the #ScienceBooks Review on #BookLoversDay: scim.ag/3RvHDmQ
Reposted by Siavash Moghadami
Reposted by Siavash Moghadami
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
August 6, 2025 at 3:36 PM
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
Reposted by Siavash Moghadami
today.uconn.edu/2025/08/swee... Thanks to @uconnresearch.bsky.social and @kimkrieger.bsky.social for covering our glycoRNA paper @vinnieviruses.bsky.social @raflynn5.bsky.social
Sweet Disguise: Body Hides RNA With Sugar - UConn Today
Now that scientists understand the role of RNA glycosylation in deflecting immune system attention, they can check on whether that strategy is somehow going ...
today.uconn.edu
August 6, 2025 at 3:59 PM
today.uconn.edu/2025/08/swee... Thanks to @uconnresearch.bsky.social and @kimkrieger.bsky.social for covering our glycoRNA paper @vinnieviruses.bsky.social @raflynn5.bsky.social
Reposted by Siavash Moghadami
Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes
go.nature.com/40I9Ewv
go.nature.com/40I9Ewv
Cell's sugar coating mapped at below-nanometre resolution
Nature - Super-resolution technique works with off-the-shelf optical microscopes.
go.nature.com
August 3, 2025 at 8:59 AM
Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes
go.nature.com/40I9Ewv
go.nature.com/40I9Ewv
Reposted by Siavash Moghadami
@acs.org is recognizing Jennifer A. Doudna with the Priestley Medal for her discoveries on ribozyme function, the Dicer RNase enzyme, double-stranded RNA processing, and CRISPR gene editing, along with her impactful international science leadership. cen.acs.org/people/award... #chemsky 🧪
Jennifer Doudna is named 2026 Priestley Medalist
The award recognizes the biochemist for discoveries on ribozyme function and CRISPR gene editing, and international science leadership
cen.acs.org
August 2, 2025 at 4:08 PM
@acs.org is recognizing Jennifer A. Doudna with the Priestley Medal for her discoveries on ribozyme function, the Dicer RNase enzyme, double-stranded RNA processing, and CRISPR gene editing, along with her impactful international science leadership. cen.acs.org/people/award... #chemsky 🧪
I’ll be in Irvine, CA, from August 18–20, 2025, attending the 2025 Conference “The Changing Brain.” Excited to connect with fellow professionals passionate about neuroscience! If you’re attending or in the area, let’s meet up to discuss the latest advancements in brain science.
July 29, 2025 at 1:23 PM
I’ll be in Irvine, CA, from August 18–20, 2025, attending the 2025 Conference “The Changing Brain.” Excited to connect with fellow professionals passionate about neuroscience! If you’re attending or in the area, let’s meet up to discuss the latest advancements in brain science.
Reposted by Siavash Moghadami
Reposted by Siavash Moghadami
Reposted by Siavash Moghadami
Great to see #proudofalumni @nmriley.bsky.social on the @cenmag.bsky.social Talented 12 list! 🎉 🏆 Check out his #glycotime research program:
www.riley-research.com
www.riley-research.com
May 24, 2025 at 5:26 AM
Great to see #proudofalumni @nmriley.bsky.social on the @cenmag.bsky.social Talented 12 list! 🎉 🏆 Check out his #glycotime research program:
www.riley-research.com
www.riley-research.com
Reposted by Siavash Moghadami
Great piece on @stanford-chemh.bsky.social Institute Scholar @stanleyqilab.bsky.social’s work toward curing diseases with genome editing innovations #ResearchMatters
“Research is like a chemical reaction – it takes time to reach completion. If we ever slow down in training the next generation of scientists, we risk falling behind other competitors in the world – even if we have the better solution.” #ResearchMatters
‘For many people, waiting is not an option’
Stanford bioengineer Stanley Qi is developing advanced gene-editing tools to treat life-threatening diseases and slow the onset of neurological aging.
news.stanford.edu
May 20, 2025 at 11:36 PM
Great piece on @stanford-chemh.bsky.social Institute Scholar @stanleyqilab.bsky.social’s work toward curing diseases with genome editing innovations #ResearchMatters
Reposted by Siavash Moghadami
Cool application of in vivo bioorthogonal chemistry from Biogen, imaging biodistribution of ASOs in the brain 🤯
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
PET imaging of antisense oligonucleotide distribution in rat and nonhuman primate brains using click chemistry
Intrathecally dosed antisense oligonucleotide distribution can be imaged in rat and nonhuman primate brains using a PET tracer and click chemistry.
www.science.org
May 8, 2025 at 10:12 PM
Cool application of in vivo bioorthogonal chemistry from Biogen, imaging biodistribution of ASOs in the brain 🤯
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Siavash Moghadami
“Cell surface RNA biology: new roles for RNA binding proteins” Jennifer Porat and I discuss this new cellular topology on which to study RNA–RBP interactions and consider how changes in the csRBPs may drive autoimmune responses. @cp-trendsbiochem.bsky.social www.sciencedirect.com/science/arti...
Cell surface RNA biology: new roles for RNA binding proteins
Much of our understanding of RNA–protein interactions, and how these interactions shape gene expression and cell state, have come from studies looking…
www.sciencedirect.com
April 25, 2025 at 12:52 PM
“Cell surface RNA biology: new roles for RNA binding proteins” Jennifer Porat and I discuss this new cellular topology on which to study RNA–RBP interactions and consider how changes in the csRBPs may drive autoimmune responses. @cp-trendsbiochem.bsky.social www.sciencedirect.com/science/arti...
Reposted by Siavash Moghadami
Brief overview in @data.ft.com of recent work to build four-part assembloids as a model of the human somatosensory neural pathway
www.ft.com/content/f8d5...
www.ft.com/content/f8d5...
Scientists recreate brain circuit in lab for first time
Research breakthrough promises new treatments for severe pain
www.ft.com
April 10, 2025 at 10:23 PM
Brief overview in @data.ft.com of recent work to build four-part assembloids as a model of the human somatosensory neural pathway
www.ft.com/content/f8d5...
www.ft.com/content/f8d5...