Kalki
siddhikalki.bsky.social
Kalki
@siddhikalki.bsky.social
Programmer. Interested in Artificial Intelligence, Singularity, neuroscience.

Strong opinions on lot of things but held weakly
Pinned
This is perhaps the most important paper in Neuroscience currently published. If you are interested in unified brain theory, #consciousness, Artificial general intelligence #AGI you should read this.

also see:
1. www.goodreads.com/book/show/25...
2. www.goodreads.com/book/show/58...
The free-energy principle: a unified brain theory? - Nature Reviews Neuroscience
Karl Friston shows that different global brain theories all describe principles by which the brain optimizes value and surprise. He discusses how these brain theories fit into the free-energy framewor...
www.nature.com
Become a poll worker or election observer: The 2025 state elections and the 2026 federal elections are right around the corner, and will be massively consequential in shaping the future of our democracy.

#USA #felonpresident

contrarian.substack.com/p/15-ways-yo...
15 Ways You Can Fight for Democracy
Every day, hundreds of family members, friends, and Contrarian readers reach out to ask what they can do to stop Trump and turn the tide against autocracy. We can help
contrarian.substack.com
April 16, 2025 at 8:40 AM
eyes.mit.edu

Computationally Recreating the Cambrian Explosion of Vision:Starting with a single light-detecting cell, our digital creatures face challenges that shaped real eyes over millions of years: navigating the world, discerning food from poison,and evading predators

#neuroscience #compneuro
What if Eye...?
eyes.mit.edu
February 14, 2025 at 1:02 AM
Reposted by Kalki
Thanks to the more than *1100* members of the scientific community who have signed the letter to insist that the Royal Society remains true to values that we all hold dear but that Musk FRS has ridden roughshod over.

Please keep signing & sharing.

docs.google.com/forms/d/e/1F...
Open letter to the President of the Royal Society – time to stand up for your values
If you wish to show your support for the letter below regarding apparent inaction by the Royal Society in the face of breaches of its code of conduct by Elon Musk FRS, please sign below. I invite anyo...
docs.google.com
February 13, 2025 at 8:33 AM
Reposted by Kalki
AGI = Ant General Intelligence. 🐜🧠🤖
December 25, 2024 at 2:22 PM
Reposted by Kalki
We've just joined Bluesky 🎉 Follow us for research, news, comment and opinion from Nature journal 🧪
December 19, 2024 at 4:26 PM
Reposted by Kalki
Using too much cannabis increases your psychosis risk even if you do not have a genetic predisposition.

This is kind of a big finding.

neurosciencenews.com/psychosis-th...
Psychosis Risk Tied to Heavy Cannabis Use and Genetic Factors - Neuroscience News
Heavy cannabis use and genetic risk for schizophrenia independently contribute to the likelihood of developing psychosis.
neurosciencenews.com
December 7, 2024 at 12:17 PM
Reposted by Kalki
OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019).

The renamed:

Bluesky-sized history of neuroscience (biased by my interests)
December 1, 2024 at 8:29 PM
> If the ‘energy’ in energy-based schemes is variational free energy, prospective configuration can be seen as an implementation of variational Bayes that subsumes inference and learning

More evidence for free-energy/predictive processing?

www.nature.com/articles/s41...

#neuroscience #compneuro
Inferring neural activity before plasticity as a foundation for learning beyond backpropagation - Nature Neuroscience
This paper introduces ‘prospective configuration’, a new principle for learning in neural networks, which differs from backpropagation and is more efficient in learning and more consistent with data o...
www.nature.com
November 30, 2024 at 12:20 PM
Which theory of mind or consciousness do you find most convincing or compelling, and why?

#neuroscience #compneuro #cogpsyc #consciousness

Please respond using the following format:

Reply 1: Link to a high-quality journal article (e.g., Nature, Neuron, etc.) with at least 100 citations
November 27, 2024 at 3:26 PM
This is perhaps the most important paper in Neuroscience currently published. If you are interested in unified brain theory, #consciousness, Artificial general intelligence #AGI you should read this.

also see:
1. www.goodreads.com/book/show/25...
2. www.goodreads.com/book/show/58...
The free-energy principle: a unified brain theory? - Nature Reviews Neuroscience
Karl Friston shows that different global brain theories all describe principles by which the brain optimizes value and surprise. He discusses how these brain theories fit into the free-energy framewor...
www.nature.com
November 25, 2024 at 10:08 PM
Reposted by Kalki
A vertical takeoff of life science with #AI LLLMs.
Publication of 10 new foundation models of Proteins, DNA, RNA, methylation, cells, and interactions, evolution, and design in the past couple of weeks!
Unprecedented progress, reviewed in the new Ground Truths
erictopol.substack.com/p/learning-t...
November 24, 2024 at 6:12 PM
arxiv.org/abs/2406.19108

We show that when random, non self-replicating programs are placed in an environment lacking any explicit fitness landscape, self-replicators tend to arise.

#AI #AGI #Singularity
Computational Life: How Well-formed, Self-replicating Programs Emerge from Simple Interaction
The fields of Origin of Life and Artificial Life both question what life is and how it emerges from a distinct set of "pre-life" dynamics. One common feature of most substrates where life emerges is a...
arxiv.org
November 25, 2024 at 2:51 PM
arxiv.org/abs/2401.09514

> We propose a novel definition of life in terms of which its emergence in the universe is expected, and its ever-creative open-ended evolution is entailed by no law.

#AI #AGI #Singularity
Is the Emergence of Life an Expected Phase Transition in the Evolving Universe?
We propose a novel definition of life in terms of which its emergence in the universe is expected, and its ever-creative open-ended evolution is entailed by no law. Living organisms are Kantian Wholes...
arxiv.org
November 25, 2024 at 2:47 PM