Siva Kumar Natarajan
@shiva251993.bsky.social
University of Michigan| Michigan Pioneer Postdoctoral Fellow| ChadTough Defeat DIPG Foundation Fellow| Alex's Lemonade Stand Foundation Young Investigator|AACR-SONTAG Foundation Fellow
Human first, Scientist after😊
Human first, Scientist after😊
Reposted by Siva Kumar Natarajan
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Biomolecular condensates: organizers of cellular biochemistry - Nature Reviews Molecular Cell Biology
In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form thro...
www.nature.com
November 17, 2025 at 7:24 AM
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Reposted by Siva Kumar Natarajan
Glucose restriction: double edged sword in cancer treatment: Trends in Cancer www.cell.com/trends/cance...
As much as we like linear and simple scenarios, it is never that simple...
As much as we like linear and simple scenarios, it is never that simple...
Glucose restriction: double edged sword in cancer treatment
Glucose restriction generally limits tumor growth. Recently, Wu et al. reported that
glucose restriction inhibits primary tumors but promotes lung metastasis by forming
a macrophage-dominated, natural...
www.cell.com
September 14, 2025 at 5:43 AM
Glucose restriction: double edged sword in cancer treatment: Trends in Cancer www.cell.com/trends/cance...
As much as we like linear and simple scenarios, it is never that simple...
As much as we like linear and simple scenarios, it is never that simple...
Reposted by Siva Kumar Natarajan
Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity
The brain is a metabolically demanding organ as it orchestrates and stabilizes neuronal network activity through plasticity. This mechanism imposes enormous and prolonged energetic demands at synapses...
www.biorxiv.org
August 28, 2025 at 1:30 PM
Mitochondria structurally remodel near synapses to fuel the sustained energy demands of plasticity
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Siva Kumar Natarajan
Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trial
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trial - Nature Medicine
This pilot trial showed that perioperative treatment with the isocitrate dehydrogenase (IDH) inhibitor safusidenib of patients with low-grade IDH-mutant glioma, with craniotomy and lumbar puncture bef...
www.nature.com
August 25, 2025 at 6:38 AM
Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trial
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Siva Kumar Natarajan
Sign up for midwest metabolism & Trimad joint meeting! Abstracts are due 9/2/25. The vast majority of talks will come from the abstracts - great opportunity for trainees! www.vai.org/event/2025-m...
2025 Midwest Metabolism Meeting
Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.
www.vai.org
June 4, 2025 at 6:21 PM
Sign up for midwest metabolism & Trimad joint meeting! Abstracts are due 9/2/25. The vast majority of talks will come from the abstracts - great opportunity for trainees! www.vai.org/event/2025-m...
Reposted by Siva Kumar Natarajan
G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails https://www.biorxiv.org/content/10.1101/2025.05.02.651932v1
May 5, 2025 at 2:48 AM
G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails https://www.biorxiv.org/content/10.1101/2025.05.02.651932v1
Reposted by Siva Kumar Natarajan
For clear thinking, cultivate passionate indifference. Buddhists call it non-attachment. We all have hopes, desires and ambitions. Non-attachment means acknowledging them, accepting them, and then not inserting them into a process that has nothing to do with you. podcasts.apple.com/us/podcast/n...
April 22, 2025 at 3:03 PM
For clear thinking, cultivate passionate indifference. Buddhists call it non-attachment. We all have hopes, desires and ambitions. Non-attachment means acknowledging them, accepting them, and then not inserting them into a process that has nothing to do with you. podcasts.apple.com/us/podcast/n...
Reposted by Siva Kumar Natarajan
Reposted by Siva Kumar Natarajan
Reposted by Siva Kumar Natarajan
Reposted by Siva Kumar Natarajan
H3K27M Mutation Reshapes the Antigenic Landscape in Diffuse Midline Glioma https://www.biorxiv.org/content/10.1101/2025.04.07.647502v1
April 10, 2025 at 10:48 AM
H3K27M Mutation Reshapes the Antigenic Landscape in Diffuse Midline Glioma https://www.biorxiv.org/content/10.1101/2025.04.07.647502v1
Reposted by Siva Kumar Natarajan
Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion
Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion
Cancer cells subvert the immune system by reprogramming their metabolism. In a recent study in Nature, Ikeda et al. show how cancer cells can directly transfer mitophagy-resistant mitochondria to tumor-infiltrating lymphocytes, promoting their homoplasmic replacement and undermining cancer immunity.
dlvr.it
April 9, 2025 at 11:32 AM
Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion
Reposted by Siva Kumar Natarajan
Here are 19 tools that can make your research and writing go a lot more smoothly and save you time. ⏳
One of my most popular blog posts EVER -> https://annaclemens.com/blog/16-free-tools-scientists-write-better-more-productively/
#AcademicWriting #Academia #Postdoc
One of my most popular blog posts EVER -> https://annaclemens.com/blog/16-free-tools-scientists-write-better-more-productively/
#AcademicWriting #Academia #Postdoc
19 Academic Writing Tools (that are completely free!)
Whether you're looking for an academic phrase finder, a collaborative academic writing software, a tool to stay focused on your writing or a writing project management app - I've got you covered!
annaclemens.com
April 9, 2025 at 11:33 AM
Here are 19 tools that can make your research and writing go a lot more smoothly and save you time. ⏳
One of my most popular blog posts EVER -> https://annaclemens.com/blog/16-free-tools-scientists-write-better-more-productively/
#AcademicWriting #Academia #Postdoc
One of my most popular blog posts EVER -> https://annaclemens.com/blog/16-free-tools-scientists-write-better-more-productively/
#AcademicWriting #Academia #Postdoc
Reposted by Siva Kumar Natarajan
Reposted by Siva Kumar Natarajan
CHD7 binds to insulators during neuronal differentiation https://www.biorxiv.org/content/10.1101/2025.03.28.646031v1
March 30, 2025 at 3:17 AM
CHD7 binds to insulators during neuronal differentiation https://www.biorxiv.org/content/10.1101/2025.03.28.646031v1
Reposted by Siva Kumar Natarajan
PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors - Nature Neuroscience
The authors show PTEN mutations, which can cause both congenital hydrocephalus and autism spectrum disorder, disrupt CSF homeostasis and brain connectivity in mice. Reducing mTORC1 activation ameliora...
www.nature.com
February 26, 2025 at 3:46 PM
PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Siva Kumar Natarajan
Strong background in genomics and bioinformatics education and community engagement.
Currently located in Bethesda, MD.
Updated CV: app.box.com/s/hg5g6z05cz...
Currently located in Bethesda, MD.
Updated CV: app.box.com/s/hg5g6z05cz...
Katie Sandlin_ CV_v4.pdf | Powered by Box
app.box.com
February 16, 2025 at 2:02 AM
Strong background in genomics and bioinformatics education and community engagement.
Currently located in Bethesda, MD.
Updated CV: app.box.com/s/hg5g6z05cz...
Currently located in Bethesda, MD.
Updated CV: app.box.com/s/hg5g6z05cz...
Reposted by Siva Kumar Natarajan
Many universities can not cover the cost of doing research on indirect costs alone, even with negotiated rates >50%.
This will result in massive job losses across the country and many smaller programs will cease research activities entirely.
This will result in massive job losses across the country and many smaller programs will cease research activities entirely.
Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/
Estimated Single Year Loss of NIH Funding if 15% Indirect Cost Rate is Imposed
Based on analysis of 2024 NIH funding data. Sums are totals of losses in funding to programs if indirect costs had been capped at 15%
datawrapper.dwcdn.net
February 9, 2025 at 4:29 PM
Many universities can not cover the cost of doing research on indirect costs alone, even with negotiated rates >50%.
This will result in massive job losses across the country and many smaller programs will cease research activities entirely.
This will result in massive job losses across the country and many smaller programs will cease research activities entirely.
Reposted by Siva Kumar Natarajan
Apologies for this long post I put together to explain to non-scientists the impact of NIH cuts: Last night, an “atomic bomb” was dropped on the biomedical science community. We were informed that effective immediately, indirect costs on NIH grants (both current and future) would be fixed at 15%.
February 8, 2025 at 10:32 PM
Apologies for this long post I put together to explain to non-scientists the impact of NIH cuts: Last night, an “atomic bomb” was dropped on the biomedical science community. We were informed that effective immediately, indirect costs on NIH grants (both current and future) would be fixed at 15%.
Reposted by Siva Kumar Natarajan
"dazzling" "it enlightens and amazes".
Fabulous prepublication review of ENDS OF THE EARTH in Publisher's Weekly. 💙📚 #arctic #antarctica #science
www.publishersweekly.com/9780593186527
Fabulous prepublication review of ENDS OF THE EARTH in Publisher's Weekly. 💙📚 #arctic #antarctica #science
www.publishersweekly.com/9780593186527
Ends of the Earth: Journeys to the Polar Regions in Search of Life, the Cosmos, and Our Future by Neil Shubin
In this dazzling report, Shubin (Some Assembly Required), a biology professor at the University of Chicago, examines what the Ea...
www.publishersweekly.com
November 21, 2024 at 6:07 PM
"dazzling" "it enlightens and amazes".
Fabulous prepublication review of ENDS OF THE EARTH in Publisher's Weekly. 💙📚 #arctic #antarctica #science
www.publishersweekly.com/9780593186527
Fabulous prepublication review of ENDS OF THE EARTH in Publisher's Weekly. 💙📚 #arctic #antarctica #science
www.publishersweekly.com/9780593186527
Reposted by Siva Kumar Natarajan
Copper-controlled gene expression via transmembrane-induced ribosomal stalling https://www.biorxiv.org/content/10.1101/2025.02.05.636593v1
February 6, 2025 at 2:20 AM
Copper-controlled gene expression via transmembrane-induced ribosomal stalling https://www.biorxiv.org/content/10.1101/2025.02.05.636593v1
Reposted by Siva Kumar Natarajan
"... I ended up being reluctant to work with undergraduate researchers at all—until a new student helped me realize what is required to mentor undergraduates, and the rewards it can bring." #NationalMentoringMonth https://scim.ag/3E1bAYj
January 26, 2025 at 3:07 PM
"... I ended up being reluctant to work with undergraduate researchers at all—until a new student helped me realize what is required to mentor undergraduates, and the rewards it can bring." #NationalMentoringMonth https://scim.ag/3E1bAYj
Reposted by Siva Kumar Natarajan
Reposted by Siva Kumar Natarajan
The end of an era. @brandontwchen.bsky.social brought us kicking & screaming into cell biology, and what an exciting journey it’s been. We are so very proud of everything he’s accomplished! Join us 1/17 for his defense. Thereafter… watch out NYC, here he comes!!
January 3, 2025 at 6:34 PM
The end of an era. @brandontwchen.bsky.social brought us kicking & screaming into cell biology, and what an exciting journey it’s been. We are so very proud of everything he’s accomplished! Join us 1/17 for his defense. Thereafter… watch out NYC, here he comes!!