Sarah H. Shahmoradian
@shahmora.bsky.social
Assistant Professor, Center for Alzheimer's and Neurodegenerative Diseases at UT Southwestern. Our lab uses electrons to dissect molecular architecture in the brain. Engineering new tools for cryoEM in situ.
⚙️🧠❄️⚛️🔬
https://tinyurl.com/shahmoralab
⚙️🧠❄️⚛️🔬
https://tinyurl.com/shahmoralab
Reposted by Sarah H. Shahmoradian
Reposted by Sarah H. Shahmoradian
Janelia is hosting a course on DL for bioimage analysis www.janelia.org/you-janelia/...
Deep Learning for Microscopy Image Analysis
Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,
www.janelia.org
November 6, 2025 at 5:02 PM
Janelia is hosting a course on DL for bioimage analysis www.janelia.org/you-janelia/...
Reposted by Sarah H. Shahmoradian
New paper in Science identifying adipogenin as a critical seipin regulator in LD biogenesis. So glad our lab could help a little in this monumental study. Congrats to all authors!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex
The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...
www.science.org
November 6, 2025 at 7:47 PM
New paper in Science identifying adipogenin as a critical seipin regulator in LD biogenesis. So glad our lab could help a little in this monumental study. Congrats to all authors!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Sarah H. Shahmoradian
Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...
UT Southwestern researcher receives NIH Director’s New Innovator Award
David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...
www.utsouthwestern.edu
October 8, 2025 at 8:26 PM
Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...
Reposted by Sarah H. Shahmoradian
We have a preprint for you
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
June 8, 2025 at 11:22 AM
We have a preprint for you
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
Reposted by Sarah H. Shahmoradian
Building atomic models to cryo-EM maps of huge molecules is intimidating: crowded, uncertain copy numbers, variable resolution ...
Fan Liu and team incl us, show how cross-linking MS can be used to build novel models of unknown complexes, like a giant Melbourne virus
biorxiv.org/content/10.1...
Fan Liu and team incl us, show how cross-linking MS can be used to build novel models of unknown complexes, like a giant Melbourne virus
biorxiv.org/content/10.1...
June 19, 2025 at 1:54 PM
Building atomic models to cryo-EM maps of huge molecules is intimidating: crowded, uncertain copy numbers, variable resolution ...
Fan Liu and team incl us, show how cross-linking MS can be used to build novel models of unknown complexes, like a giant Melbourne virus
biorxiv.org/content/10.1...
Fan Liu and team incl us, show how cross-linking MS can be used to build novel models of unknown complexes, like a giant Melbourne virus
biorxiv.org/content/10.1...
Reposted by Sarah H. Shahmoradian
Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...
To tilt or not to tilt? Strategies for in situ cryo-EM data collection
Recent breakthroughs in single-particle cryogenic electron microscopy (cryo-EM) and protein structure prediction have transformed our ability to resol…
www.sciencedirect.com
June 28, 2025 at 2:04 PM
Check out our recent review discussing the merits of tilt series vs single micrographs for in situ cryo-EM! www.sciencedirect.com/science/arti...
Reposted by Sarah H. Shahmoradian
🧑🔬📰🚀 #RxivMaker is here! A framework automating the creation of publication-ready scientific #preprints from simple Markdown. Goodbye manual formatting, and hello gorgeous manuscripts! A great adventure with @guijacquemet.bsky.social's lab
📜: zenodo.org/records/1575...
👨💻: github.com/HenriquesLab...
📜: zenodo.org/records/1575...
👨💻: github.com/HenriquesLab...
June 27, 2025 at 12:34 PM
🧑🔬📰🚀 #RxivMaker is here! A framework automating the creation of publication-ready scientific #preprints from simple Markdown. Goodbye manual formatting, and hello gorgeous manuscripts! A great adventure with @guijacquemet.bsky.social's lab
📜: zenodo.org/records/1575...
👨💻: github.com/HenriquesLab...
📜: zenodo.org/records/1575...
👨💻: github.com/HenriquesLab...
Reposted by Sarah H. Shahmoradian
Full video here, originally shared by DW. What Jeremy says is exactly right—clear, urgent, and deeply important. Cuts to science affect everyone, sooner or later, everywhere. Illness knows no ideology, no borders. This concerns us all. Watch, reflect, share, discuss.
bsky.app/profile/deni...
bsky.app/profile/deni...
Powerful story about NIH and cancer to start Sunday Morning on CBS
Here is one of the two cases they examined: pancreatic cancer.
Part 1 of 4
Here is one of the two cases they examined: pancreatic cancer.
Part 1 of 4
June 29, 2025 at 5:33 PM
Full video here, originally shared by DW. What Jeremy says is exactly right—clear, urgent, and deeply important. Cuts to science affect everyone, sooner or later, everywhere. Illness knows no ideology, no borders. This concerns us all. Watch, reflect, share, discuss.
bsky.app/profile/deni...
bsky.app/profile/deni...
Reposted by Sarah H. Shahmoradian
Reposted by Sarah H. Shahmoradian
The National Institutes of Health, the largest funder of biomedical research in the world, has fired 1,300 employees and cancelled more than $2 billion in federal research grants. https://cbsn.ws/4daiCrv
How cuts at the National Institutes of Health could impact Americans' health
Cuts and layoffs to the National Institutes of Health threaten medical research around the U.S., agency insiders warn.
cbsn.ws
April 28, 2025 at 12:30 AM
The National Institutes of Health, the largest funder of biomedical research in the world, has fired 1,300 employees and cancelled more than $2 billion in federal research grants. https://cbsn.ws/4daiCrv
Reposted by Sarah H. Shahmoradian
Bluetorial: Non-Competitive Renewal (Continuation) Awards
Normally, multiyear NIH grants are paid with awards each year, pending administratively reviewed progress reports. “NIH” has been slow in making these awards. This has led to $1.83 B being withheld from institutions through February 2025.
Normally, multiyear NIH grants are paid with awards each year, pending administratively reviewed progress reports. “NIH” has been slow in making these awards. This has led to $1.83 B being withheld from institutions through February 2025.
a cartoon of homer simpson holding a card
ALT: a cartoon of homer simpson holding a card
media.tenor.com
March 17, 2025 at 7:23 PM
Bluetorial: Non-Competitive Renewal (Continuation) Awards
Normally, multiyear NIH grants are paid with awards each year, pending administratively reviewed progress reports. “NIH” has been slow in making these awards. This has led to $1.83 B being withheld from institutions through February 2025.
Normally, multiyear NIH grants are paid with awards each year, pending administratively reviewed progress reports. “NIH” has been slow in making these awards. This has led to $1.83 B being withheld from institutions through February 2025.
Reposted by Sarah H. Shahmoradian
They are going to make it harder for the scientists to stop, or even record, what comes next.
Breaking News: The EPA plans to eliminate its scientific research arm, firing as many as 1,155 chemists, biologists, toxicologists and other scientists.
Trump Administration Aims to Eliminate E.P.A.’s Scientific Research Arm
More than 1,000 chemists, biologists and other scientists could be laid off under a plan to dismantle the Office of Research and Development.
www.nytimes.com
March 18, 2025 at 3:04 AM
They are going to make it harder for the scientists to stop, or even record, what comes next.
Reposted by Sarah H. Shahmoradian
Walz: "The idea that the secretary of education would not know what IDEA is -- individuals with disability in education act -- that's like your mechanic not knowing how to put air in your tire. And she's in charge of this nation's education progress. It is catastrophic."
March 13, 2025 at 12:35 AM
Walz: "The idea that the secretary of education would not know what IDEA is -- individuals with disability in education act -- that's like your mechanic not knowing how to put air in your tire. And she's in charge of this nation's education progress. It is catastrophic."
Reposted by Sarah H. Shahmoradian
Dear all, Because of your help shining light on this all 15 were reinstated today. This is a huge win for science - When We Fight We Win!!!
On Valentine’s day, 15 Assistant Professors at NIH who had started their research labs in the last 2 years were fired. Their scientific expertise was built over 10-12 years of training, most if not all of which was supported by NIH. The start up funds for their laboratories were paid by NIH
March 13, 2025 at 1:26 AM
Dear all, Because of your help shining light on this all 15 were reinstated today. This is a huge win for science - When We Fight We Win!!!
Reposted by Sarah H. Shahmoradian
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 12, 2025 at 8:47 PM
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
Reposted by Sarah H. Shahmoradian
Bluetorial: Women, courage, and leadership
What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
March 9, 2025 at 4:33 AM
Bluetorial: Women, courage, and leadership
What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.
Reposted by Sarah H. Shahmoradian
Some good news: The Federal Register has just posted NIH study sections, which are to meet in late March.
NIH announces some key grant-review meetings will restart in late March | Science | AAAS www.science.org/content/arti...
NIH announces some key grant-review meetings will restart in late March | Science | AAAS www.science.org/content/arti...
NIH announces some key grant-review meetings will restart in late March
Trump policy blocking required notices has frozen reviews of thousands of grants
www.science.org
March 3, 2025 at 7:33 PM
Some good news: The Federal Register has just posted NIH study sections, which are to meet in late March.
NIH announces some key grant-review meetings will restart in late March | Science | AAAS www.science.org/content/arti...
NIH announces some key grant-review meetings will restart in late March | Science | AAAS www.science.org/content/arti...
Reposted by Sarah H. Shahmoradian
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
March 3, 2025 at 3:55 PM
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
Reposted by Sarah H. Shahmoradian
DOGE's crackdown on agency spending means that federal researchers can't do vital experiments, order liquid nitrogen tanks to preserve samples, or refill basic but necessary lab equipment. My story with @zoeschiffer.bsky.social: www.wired.com/story/doge-e...
Elon Musk’s $1 Spending Limit Is Paralyzing Federal Agencies
The DOGE-mandated credit card freeze is delaying shipments of critical supplies, stalling travel, and stopping employees from doing their jobs.
www.wired.com
March 4, 2025 at 1:09 AM
DOGE's crackdown on agency spending means that federal researchers can't do vital experiments, order liquid nitrogen tanks to preserve samples, or refill basic but necessary lab equipment. My story with @zoeschiffer.bsky.social: www.wired.com/story/doge-e...
Reposted by Sarah H. Shahmoradian
Reposted by Sarah H. Shahmoradian
Today's update: ICs will be barred from publishing Federal Register notices for at least TWO MORE WEEKS, according to an email to NIH staff.
In other (likely related) news, Jay Bhattacharya's confirmation hearing to become NIH director has been scheduled for March 5.
In other (likely related) news, Jay Bhattacharya's confirmation hearing to become NIH director has been scheduled for March 5.
UPDATE: NIH CSR will soon be able to publish a small set of Federal Register Notices (FRNs) - 50 or so. The lead time between notice and meeting will be reduced back to 30 days (from 35).
ICs might be allowed to resume publishing FRNs next week. An "indefinite hold" on Councils remains.
ICs might be allowed to resume publishing FRNs next week. An "indefinite hold" on Councils remains.
NEW: The Trump administration is exploiting a loophole to keep funding frozen at the NIH - a move that some legal scholars say is illegal.
Federal Register notices are blocked, so no grant-review sessions can be scheduled.
All the gritty details here, and a short 🧵:
www.nature.com/articles/d41...
Federal Register notices are blocked, so no grant-review sessions can be scheduled.
All the gritty details here, and a short 🧵:
www.nature.com/articles/d41...
February 27, 2025 at 4:59 PM
Today's update: ICs will be barred from publishing Federal Register notices for at least TWO MORE WEEKS, according to an email to NIH staff.
In other (likely related) news, Jay Bhattacharya's confirmation hearing to become NIH director has been scheduled for March 5.
In other (likely related) news, Jay Bhattacharya's confirmation hearing to become NIH director has been scheduled for March 5.