David W. Sanders!
@davidwsanders.bsky.social
Assistant Professor of Molecular Biology, Center for Alzheimer's and Neurodegenerative Diseases, UT Southwestern. My lab studies damaged things. Sometimes we fix them. Hiring! Write if interested in postdoc or tech position. https://www.davidwsanders.com
Pinned
UT Southwestern researcher receives NIH Director’s New Innovator Award
David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...
www.utsouthwestern.edu
Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...
DPRIT passes! $3-billion Texas investment in dementia research: www.alz.org/news/2025/te...
Texans Make History with Passage of Proposition 14, Launching Nation’s Largest State-Funded Dementia Research Initiative
Texas voters approved funding the Dementia Prevention and Research Institute of Texas (DPRIT), the nation's largest state-funded dementia research initiative. OG image: press release
www.alz.org
November 5, 2025 at 5:14 PM
DPRIT passes! $3-billion Texas investment in dementia research: www.alz.org/news/2025/te...
Reposted by David W. Sanders!
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
November 4, 2025 at 5:58 PM
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
Reposted by David W. Sanders!
mStayRose is published in JBC 🥳🎉
Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable:
www.jbc.org/article/S002...
Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable:
www.jbc.org/article/S002...
StayRose: a photostable StayGold derivative red-shifted by genetic code expansion
Photobleaching of fluorescent proteins often limits the acquisition of high-quality
images in microscopy. StayGold, a novel dimeric green fluorescent protein recently
monomerised through sequence engi...
www.jbc.org
October 22, 2025 at 4:58 PM
mStayRose is published in JBC 🥳🎉
Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable:
www.jbc.org/article/S002...
Congratulations @wsctt.bsky.social @sporemohan.bsky.social and team for the monumental effort to make a non-natural amino acid incorporating fluorescent protein accessible. It's based on mStayGold, bright, and photostable:
www.jbc.org/article/S002...
Ut southwestern is recruiting! 3-milly start-up for tenure-track or tenured PI positions in O’Donnell Brain institute. Basic and translational neuroscientists both. If I can call myself a neuroscientist, so can you! Please consider reposting :) #DPRITisComing apply.interfolio.com/174927
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 17, 2025 at 9:54 PM
Ut southwestern is recruiting! 3-milly start-up for tenure-track or tenured PI positions in O’Donnell Brain institute. Basic and translational neuroscientists both. If I can call myself a neuroscientist, so can you! Please consider reposting :) #DPRITisComing apply.interfolio.com/174927
Reposted by David W. Sanders!
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins
Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...
www.biorxiv.org
October 14, 2025 at 10:28 PM
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Reposted by David W. Sanders!
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
October 9, 2025 at 6:06 PM
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
Reposted by David W. Sanders!
Proud to announce that we received the NIH Director's New Innovator Award to develop a new class of genome editing tools!
Dr. Graham Erwin @grahamerwin.bsky.social receives NIH New Innovator Award! www.bcm.edu/news/dr-grah... @bcmhouston.bsky.social @bcmgenetics.bsky.social #BCMCancerCenter
October 8, 2025 at 8:05 PM
Proud to announce that we received the NIH Director's New Innovator Award to develop a new class of genome editing tools!
Reposted by David W. Sanders!
I’m extremely honored to be a recipient of the NIH Director’s Pioneer Award!
Congratulations to @ishmailsaboor.bsky.social on receiving the NIH Director’s Pioneer Award, celebrating “scientists with outstanding records of creativity.” His lab will explore how the sense of touch can help build relationships. 🫶🧠💡
See zuckermaninstitute.columbia.edu/zuckerman-in...
See zuckermaninstitute.columbia.edu/zuckerman-in...
October 8, 2025 at 8:45 PM
I’m extremely honored to be a recipient of the NIH Director’s Pioneer Award!
Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...
UT Southwestern researcher receives NIH Director’s New Innovator Award
David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...
www.utsouthwestern.edu
October 8, 2025 at 8:26 PM
Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...
Reposted by David W. Sanders!
Dr. Graham Erwin @grahamerwin.bsky.social receives NIH New Innovator Award! www.bcm.edu/news/dr-grah... @bcmhouston.bsky.social @bcmgenetics.bsky.social #BCMCancerCenter
October 8, 2025 at 7:22 PM
Dr. Graham Erwin @grahamerwin.bsky.social receives NIH New Innovator Award! www.bcm.edu/news/dr-grah... @bcmhouston.bsky.social @bcmgenetics.bsky.social #BCMCancerCenter
Reposted by David W. Sanders!
We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 6, 2025 at 5:52 PM
We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by David W. Sanders!
Last week, Washington University made the perhaps questionable decision to award me tenure.
September 29, 2025 at 12:53 PM
Last week, Washington University made the perhaps questionable decision to award me tenure.
Reposted by David W. Sanders!
A single brain infusion of miRNA targeting CAG repeats slows the progression of Huntington's disease by 75% in patients. This is something that I never thought I would see in my lifetime. www.uniqure.com/investors-me...
September 24, 2025 at 1:21 PM
A single brain infusion of miRNA targeting CAG repeats slows the progression of Huntington's disease by 75% in patients. This is something that I never thought I would see in my lifetime. www.uniqure.com/investors-me...
Reposted by David W. Sanders!
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
September 22, 2025 at 6:27 PM
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Reposted by David W. Sanders!
A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09...
#KeioMedicalSciencePrize
#KeioMedicalSciencePrize
Bioengineer Clifford Brangwynne wins Keio Medical Science Prize
Japan’s Keio University awards the prize annually to honor contributions in medicine and life sciences. Brangwynne is being recognized for groundbreaking work that has opened up a new field of cell bi...
www.princeton.edu
September 20, 2025 at 6:16 PM
A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09...
#KeioMedicalSciencePrize
#KeioMedicalSciencePrize
Reposted by David W. Sanders!
these people in my lab are amazing
September 20, 2025 at 12:16 AM
these people in my lab are amazing
Reposted by David W. Sanders!
🎉 Congratulations to HHMI Investigators Clifford Brangwynne and Akiko Iwasaki, the two winners of the 30th annual Keio Medical Science Prize. This international prize, awarded by Keio University in Tokyo, honors scientists who have made major contributions to the fields of medical or life sciences.
September 19, 2025 at 12:56 PM
🎉 Congratulations to HHMI Investigators Clifford Brangwynne and Akiko Iwasaki, the two winners of the 30th annual Keio Medical Science Prize. This international prize, awarded by Keio University in Tokyo, honors scientists who have made major contributions to the fields of medical or life sciences.
Reposted by David W. Sanders!
🎉 JUST ANNOUNCED: @haozhulab.bsky.social named project co-leader for UTSW liver cancer SPORE. His project will study how to prevent hepatocellular carcinoma — which accounts for >85% of liver cancer cases across the nation.
Read more ⬇️ cri.utsw.edu/zhu-named-co...
#relentlessdiscovery 🧪
Read more ⬇️ cri.utsw.edu/zhu-named-co...
#relentlessdiscovery 🧪
UTSW named Specialized Program of Research Excellence for liver cancer
The Liver Tumor Program at UT Southwestern Medical Center’s Harold C. Simmons Comprehensive Cancer Center has been selected by the National Cancer Institute as a Specialized Program of Research Excell...
cri.utsw.edu
September 17, 2025 at 4:41 PM
🎉 JUST ANNOUNCED: @haozhulab.bsky.social named project co-leader for UTSW liver cancer SPORE. His project will study how to prevent hepatocellular carcinoma — which accounts for >85% of liver cancer cases across the nation.
Read more ⬇️ cri.utsw.edu/zhu-named-co...
#relentlessdiscovery 🧪
Read more ⬇️ cri.utsw.edu/zhu-named-co...
#relentlessdiscovery 🧪
Reposted by David W. Sanders!
🔬 APPLY NOW: Seeking faculty scientists in #stemcells #TissueRegeneration #metabolism & #cancerbiology.
You ready for #relentlessdiscovery at our collaborative Institute? Learn more at cri.utsw.edu/careers & apply before Oct. 15. 🤜💥🤛
#jobs #faculty #facultyjobs #ScienceJobs 🧪
You ready for #relentlessdiscovery at our collaborative Institute? Learn more at cri.utsw.edu/careers & apply before Oct. 15. 🤜💥🤛
#jobs #faculty #facultyjobs #ScienceJobs 🧪
September 15, 2025 at 3:57 PM
🔬 APPLY NOW: Seeking faculty scientists in #stemcells #TissueRegeneration #metabolism & #cancerbiology.
You ready for #relentlessdiscovery at our collaborative Institute? Learn more at cri.utsw.edu/careers & apply before Oct. 15. 🤜💥🤛
#jobs #faculty #facultyjobs #ScienceJobs 🧪
You ready for #relentlessdiscovery at our collaborative Institute? Learn more at cri.utsw.edu/careers & apply before Oct. 15. 🤜💥🤛
#jobs #faculty #facultyjobs #ScienceJobs 🧪
I lost some faith in academic science over the years. But selection of McKnight for a Lasker restores my idealism. Days later, I'm still smiling. To see my scientific hero recognized is quite special. Sure, confused as to why "this" and not the many "thats". But clubs and committees, man.
September 13, 2025 at 6:21 AM
I lost some faith in academic science over the years. But selection of McKnight for a Lasker restores my idealism. Days later, I'm still smiling. To see my scientific hero recognized is quite special. Sure, confused as to why "this" and not the many "thats". But clubs and committees, man.
Reposted by David W. Sanders!
Steven McKnight was driving to Montana when he received the call about winning a #LaskerAward. "I was flabbergasted. I probably should have pulled over," he told me. That and more of the best in @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪
September 11, 2025 at 3:26 PM
Steven McKnight was driving to Montana when he received the call about winning a #LaskerAward. "I was flabbergasted. I probably should have pulled over," he told me. That and more of the best in @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪
Reposted by David W. Sanders!
The discoveries of D. Görlich & S. McKnight exposed the structures and functions of low-complexity domains within protein sequences, revealing new principles of intracellular transport and organization. 🧪
#LaskerAward #Lasker2025 #phaseseparation
@mpi-nat.bsky.social
www.youtube.com/watch?v=962P...
#LaskerAward #Lasker2025 #phaseseparation
@mpi-nat.bsky.social
www.youtube.com/watch?v=962P...
Low-complexity domains: structures & functions
YouTube video by Albert and Mary Lasker Foundation
www.youtube.com
September 11, 2025 at 4:53 PM
The discoveries of D. Görlich & S. McKnight exposed the structures and functions of low-complexity domains within protein sequences, revealing new principles of intracellular transport and organization. 🧪
#LaskerAward #Lasker2025 #phaseseparation
@mpi-nat.bsky.social
www.youtube.com/watch?v=962P...
#LaskerAward #Lasker2025 #phaseseparation
@mpi-nat.bsky.social
www.youtube.com/watch?v=962P...
Reposted by David W. Sanders!
House FY 2026 Proposal keeps NIH funding at $48 billion, which maintains NIH’s budget roughly at the FY 2025. NIH is protected compared to other areas that face sharper reductions. appropriations.house.gov/sites/evo-su...
appropriations.house.gov
September 1, 2025 at 11:24 PM
House FY 2026 Proposal keeps NIH funding at $48 billion, which maintains NIH’s budget roughly at the FY 2025. NIH is protected compared to other areas that face sharper reductions. appropriations.house.gov/sites/evo-su...
Reposted by David W. Sanders!
Proximity-specific ribosome profiling using LOV-BirA reveals two distinct strategies for mitochondrially-localized translation: one for long coding sequences and one for short. It was a pleasure to contribute to this beautiful work from Jonathan Weissman @weissmanlab.bsky.social and Jingchuan Luo
August 27, 2025 at 3:29 PM
Proximity-specific ribosome profiling using LOV-BirA reveals two distinct strategies for mitochondrially-localized translation: one for long coding sequences and one for short. It was a pleasure to contribute to this beautiful work from Jonathan Weissman @weissmanlab.bsky.social and Jingchuan Luo
Reposted by David W. Sanders!
Katz Early Stage Investigator Research Project Grant is back. Share with your ESI colleagues!
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
PAR-25-322: Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed) PAR-25-322. OD
grants.nih.gov
August 26, 2025 at 2:14 PM
Katz Early Stage Investigator Research Project Grant is back. Share with your ESI colleagues!
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...