Susanne Fleig
@sfleig.bsky.social
Nephrologist / Clinical Scientist at RWTH Aachen University Hospital. Vascular biology, tertiary lymphoid structures; outpatient clinic for CKD and hypertension; ultrasound instructor DEGUM2, renal nutrition
Reposted by Susanne Fleig
New in @science.org 🧬
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis
Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...
www.science.org
November 6, 2025 at 7:30 PM
New in @science.org 🧬
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
Reposted by Susanne Fleig
❣️New in @JExpMed
Proud to have contributed to the work of Cornelia Halin’s lab @ETH_en !
Single-cell & 3D imaging reveal unexpected diversity of human afferent lymphatic vessels including unique CD24⁺ valve LECs and key differences from mouse skin.
rupress.org/jem/article/...
Proud to have contributed to the work of Cornelia Halin’s lab @ETH_en !
Single-cell & 3D imaging reveal unexpected diversity of human afferent lymphatic vessels including unique CD24⁺ valve LECs and key differences from mouse skin.
rupress.org/jem/article/...
Transcriptomics- and 3D imaging–based characterization of the lymphatic vasculature in human skin | Journal of Experimental Medicine | Rockefeller University Press
This study reveals how the structure and cellular morphology of human dermal afferent lymphatic vessels differ from the current, primarily mouse tissue–bas
rupress.org
November 6, 2025 at 12:21 PM
❣️New in @JExpMed
Proud to have contributed to the work of Cornelia Halin’s lab @ETH_en !
Single-cell & 3D imaging reveal unexpected diversity of human afferent lymphatic vessels including unique CD24⁺ valve LECs and key differences from mouse skin.
rupress.org/jem/article/...
Proud to have contributed to the work of Cornelia Halin’s lab @ETH_en !
Single-cell & 3D imaging reveal unexpected diversity of human afferent lymphatic vessels including unique CD24⁺ valve LECs and key differences from mouse skin.
rupress.org/jem/article/...
Reposted by Susanne Fleig
#WeekendReads
Long term mortality after Renal Artery Stenting
🔗 academic.oup.com/ajh/article/... 🔓
#EditorsChoice #Free
Long term mortality after Renal Artery Stenting
🔗 academic.oup.com/ajh/article/... 🔓
#EditorsChoice #Free
Long-Term Mortality After Renal Artery Stenting in Patients With Severe Atherosclerotic Renal Artery Stenosis and High-Risk Clinical Manifestations
AbstractBACKGROUND. Atherosclerotic renal artery stenosis is a risk factor for cardiovascular death. Observational studies support the benefit of renal rev
academic.oup.com
September 7, 2025 at 12:30 PM
#WeekendReads
Long term mortality after Renal Artery Stenting
🔗 academic.oup.com/ajh/article/... 🔓
#EditorsChoice #Free
Long term mortality after Renal Artery Stenting
🔗 academic.oup.com/ajh/article/... 🔓
#EditorsChoice #Free
Reposted by Susanne Fleig
Kidney dysfunction was diagnosed at 5-months postpartum in 12% of patients who had gestational diabetes mellitus. Read more in #ASNCJASN kidney.pub/CJASN0802
September 7, 2025 at 2:00 PM
Kidney dysfunction was diagnosed at 5-months postpartum in 12% of patients who had gestational diabetes mellitus. Read more in #ASNCJASN kidney.pub/CJASN0802
Reposted by Susanne Fleig
New in #ASNJASN and at #Hypertension25: In a randomized, double-blind, placebo-controlled trial, Baxdrostat reduced systolic blood pressure in patients with CKD and uncontrolled hypertension. Read more about its safety and efficacy in patients with CKD here: kidney.pub/JASN0849
September 6, 2025 at 2:00 PM
New in #ASNJASN and at #Hypertension25: In a randomized, double-blind, placebo-controlled trial, Baxdrostat reduced systolic blood pressure in patients with CKD and uncontrolled hypertension. Read more about its safety and efficacy in patients with CKD here: kidney.pub/JASN0849
Reposted by Susanne Fleig
If you are a nephrology or kidney disease or renal professional or interested in the field - make sure you have liked/followed/pinned the nephrology feed
bsky.app/profile/did:...
Thanks again to @richardferro.xyz for creating & updating this! It’s a one-stop shop for nephrology needs
#NephSky
bsky.app/profile/did:...
Thanks again to @richardferro.xyz for creating & updating this! It’s a one-stop shop for nephrology needs
#NephSky
September 5, 2025 at 4:18 PM
If you are a nephrology or kidney disease or renal professional or interested in the field - make sure you have liked/followed/pinned the nephrology feed
bsky.app/profile/did:...
Thanks again to @richardferro.xyz for creating & updating this! It’s a one-stop shop for nephrology needs
#NephSky
bsky.app/profile/did:...
Thanks again to @richardferro.xyz for creating & updating this! It’s a one-stop shop for nephrology needs
#NephSky
Should you, too, feel like your brain is shrinking during the winter: here is why! 👇
(now, how closely related are we really to shrews!)
(now, how closely related are we really to shrews!)
❄️ Common shrews shrink their brains in winter.
🧠 The process is reversible and occurs because brain cells shrink, rather than die off. As a result, neuronal numbers stay constant and preserve brain function.
I can defo relate to seasonal brain shrinkage.
🧪🦊🌍
Paper: www.cell.com/current-biol...
🧠 The process is reversible and occurs because brain cells shrink, rather than die off. As a result, neuronal numbers stay constant and preserve brain function.
I can defo relate to seasonal brain shrinkage.
🧪🦊🌍
Paper: www.cell.com/current-biol...
September 5, 2025 at 11:21 AM
Should you, too, feel like your brain is shrinking during the winter: here is why! 👇
(now, how closely related are we really to shrews!)
(now, how closely related are we really to shrews!)
Reposted by Susanne Fleig
Now open access in @ndt-era.bsky.social
Anti-nephrin, anti-podocin and anti-Kirrel1 antibodies: Biological challenges and clinical implications
🧐 Clinical implementation of anti-slit diaphragm antibody testing = precision dx and tx in podocytopathies
▶️ academic.oup.com/ndt/article/...
Anti-nephrin, anti-podocin and anti-Kirrel1 antibodies: Biological challenges and clinical implications
🧐 Clinical implementation of anti-slit diaphragm antibody testing = precision dx and tx in podocytopathies
▶️ academic.oup.com/ndt/article/...
August 16, 2025 at 6:59 AM
Now open access in @ndt-era.bsky.social
Anti-nephrin, anti-podocin and anti-Kirrel1 antibodies: Biological challenges and clinical implications
🧐 Clinical implementation of anti-slit diaphragm antibody testing = precision dx and tx in podocytopathies
▶️ academic.oup.com/ndt/article/...
Anti-nephrin, anti-podocin and anti-Kirrel1 antibodies: Biological challenges and clinical implications
🧐 Clinical implementation of anti-slit diaphragm antibody testing = precision dx and tx in podocytopathies
▶️ academic.oup.com/ndt/article/...
Reposted by Susanne Fleig
Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...
July 14, 2025 at 10:09 AM
Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...
Reposted by Susanne Fleig
Exciting days ahead at the Wihuri Research Institute @wrihelsinki.bsky.social as we host #WRISymposium and #EVBOSummerSchool next week in Helsinki.
Looking forward to inspiring talks and scientific exchange with the #VascularBiology community!
wri.fi/research-act...
evbo.org/index.php/ev...
Looking forward to inspiring talks and scientific exchange with the #VascularBiology community!
wri.fi/research-act...
evbo.org/index.php/ev...
Wihuri Research Institute Symposium 2025 - Wihuri Research Institute
Since 2013, the Wihuri Research Institute (WRI) has been organizing the annual WRI Symposium, providing a platform for researchers and students to share knowledge and insights in cardiovascular resear...
wri.fi
June 8, 2025 at 12:28 PM
Exciting days ahead at the Wihuri Research Institute @wrihelsinki.bsky.social as we host #WRISymposium and #EVBOSummerSchool next week in Helsinki.
Looking forward to inspiring talks and scientific exchange with the #VascularBiology community!
wri.fi/research-act...
evbo.org/index.php/ev...
Looking forward to inspiring talks and scientific exchange with the #VascularBiology community!
wri.fi/research-act...
evbo.org/index.php/ev...
Reposted by Susanne Fleig
We also congratulate Dr. Laetitia Préau from Karlsruhe Institute of Technology (KIT) and Dr.Tore Bleckwehl from Uniklinik RWTH Aachen for their outstanding presentations
@cpi-exstra.bsky.social @sfb1531.bsky.social @sfleig.bsky.social
#PCVB2025
@cpi-exstra.bsky.social @sfb1531.bsky.social @sfleig.bsky.social
#PCVB2025
May 28, 2025 at 8:01 AM
We also congratulate Dr. Laetitia Préau from Karlsruhe Institute of Technology (KIT) and Dr.Tore Bleckwehl from Uniklinik RWTH Aachen for their outstanding presentations
@cpi-exstra.bsky.social @sfb1531.bsky.social @sfleig.bsky.social
#PCVB2025
@cpi-exstra.bsky.social @sfb1531.bsky.social @sfleig.bsky.social
#PCVB2025
Reposted by Susanne Fleig
🔬 Congrats to the 2025 #GfMVB Award Winners! 🏆
Proudly #sponsored by ibidi at “Perspectives in Cardiovascular Biology” Conference🫀
🏅Emerging Scientist: Dr. Haaglim Cho from
@mpi-hlr.bsky.social
🏅Young Investigator: Dr. Julian Wagner from Universitätsmedizin Frankfurt
🔗https://zurl.co/IAJmC
Proudly #sponsored by ibidi at “Perspectives in Cardiovascular Biology” Conference🫀
🏅Emerging Scientist: Dr. Haaglim Cho from
@mpi-hlr.bsky.social
🏅Young Investigator: Dr. Julian Wagner from Universitätsmedizin Frankfurt
🔗https://zurl.co/IAJmC
May 28, 2025 at 8:01 AM
🔬 Congrats to the 2025 #GfMVB Award Winners! 🏆
Proudly #sponsored by ibidi at “Perspectives in Cardiovascular Biology” Conference🫀
🏅Emerging Scientist: Dr. Haaglim Cho from
@mpi-hlr.bsky.social
🏅Young Investigator: Dr. Julian Wagner from Universitätsmedizin Frankfurt
🔗https://zurl.co/IAJmC
Proudly #sponsored by ibidi at “Perspectives in Cardiovascular Biology” Conference🫀
🏅Emerging Scientist: Dr. Haaglim Cho from
@mpi-hlr.bsky.social
🏅Young Investigator: Dr. Julian Wagner from Universitätsmedizin Frankfurt
🔗https://zurl.co/IAJmC
Reposted by Susanne Fleig
Resolution of steatohepatitis without worsening of fibrosis occurred in 62.9% in the semaglutide group & in 34.3% in the placebo group.
Reduction in liver fibrosis without worsening of steatohepatitis was reported in 36.8% in the semaglutide group & in 22.4% in the placebo group
tinyurl.com/338u24b2
Reduction in liver fibrosis without worsening of steatohepatitis was reported in 36.8% in the semaglutide group & in 22.4% in the placebo group
tinyurl.com/338u24b2
May 3, 2025 at 5:38 AM
Resolution of steatohepatitis without worsening of fibrosis occurred in 62.9% in the semaglutide group & in 34.3% in the placebo group.
Reduction in liver fibrosis without worsening of steatohepatitis was reported in 36.8% in the semaglutide group & in 22.4% in the placebo group
tinyurl.com/338u24b2
Reduction in liver fibrosis without worsening of steatohepatitis was reported in 36.8% in the semaglutide group & in 22.4% in the placebo group
tinyurl.com/338u24b2
Reposted by Susanne Fleig
Our Friday-Webinar with @christ-crain.bsky.social !
We talk about diagnosis and treatment of arginine vasopressin deficiency with our expert in german language!
youtu.be/jSl5K0aRTvs?...
We talk about diagnosis and treatment of arginine vasopressin deficiency with our expert in german language!
youtu.be/jSl5K0aRTvs?...
Vasopressin-Mangel (ehemalig Diabetes Insipidus) - Prof. Dr. Mirjam Christ-Crain (Basel, Schweiz)
YouTube video by MARKUS at HOMe
youtu.be
May 2, 2025 at 4:16 PM
Our Friday-Webinar with @christ-crain.bsky.social !
We talk about diagnosis and treatment of arginine vasopressin deficiency with our expert in german language!
youtu.be/jSl5K0aRTvs?...
We talk about diagnosis and treatment of arginine vasopressin deficiency with our expert in german language!
youtu.be/jSl5K0aRTvs?...
Reposted by Susanne Fleig
B cell-derived exosomal miR-483-5p and its potential role in promoting kidney function loss in IgA nephropathy
doi.org/10.1016/j.kint.2025.03.019
#OpenAccess #MedSky #NephSky #SkyNeph #IgAN #IgAnephropathy
doi.org/10.1016/j.kint.2025.03.019
#OpenAccess #MedSky #NephSky #SkyNeph #IgAN #IgAnephropathy
April 28, 2025 at 4:29 PM
B cell-derived exosomal miR-483-5p and its potential role in promoting kidney function loss in IgA nephropathy
doi.org/10.1016/j.kint.2025.03.019
#OpenAccess #MedSky #NephSky #SkyNeph #IgAN #IgAnephropathy
doi.org/10.1016/j.kint.2025.03.019
#OpenAccess #MedSky #NephSky #SkyNeph #IgAN #IgAnephropathy
Reposted by Susanne Fleig
Job - Alert 🚑
🩺 Full Professorship for Nephrology
Deadline: 2025-05-03
Location: Switzerland, Bern
www.academiceurope.com/job/?id=7332
#hiring #Nephrology #medicine #biomedicine #Leadership #professor #director
🩺 Full Professorship for Nephrology
Deadline: 2025-05-03
Location: Switzerland, Bern
www.academiceurope.com/job/?id=7332
#hiring #Nephrology #medicine #biomedicine #Leadership #professor #director
Academic Europe - Full Professorship for Nephrology
www.academiceurope.com
April 4, 2025 at 8:19 AM
Job - Alert 🚑
🩺 Full Professorship for Nephrology
Deadline: 2025-05-03
Location: Switzerland, Bern
www.academiceurope.com/job/?id=7332
#hiring #Nephrology #medicine #biomedicine #Leadership #professor #director
🩺 Full Professorship for Nephrology
Deadline: 2025-05-03
Location: Switzerland, Bern
www.academiceurope.com/job/?id=7332
#hiring #Nephrology #medicine #biomedicine #Leadership #professor #director
Reposted by Susanne Fleig
Congrats to Maria Dekrolia, Nivethitha Manickam, Leah Vanicek, and Sofia de la Puente Secades for receiving the Aletta Jacobs Award at the PCVB Meeting 2025 in Frankfurt! A well-deserved recognition of their outstanding contributions to science. #PCVB2025 #AlettaJacobsAward
April 5, 2025 at 10:08 AM
Congrats to Maria Dekrolia, Nivethitha Manickam, Leah Vanicek, and Sofia de la Puente Secades for receiving the Aletta Jacobs Award at the PCVB Meeting 2025 in Frankfurt! A well-deserved recognition of their outstanding contributions to science. #PCVB2025 #AlettaJacobsAward
Reposted by Susanne Fleig
Excited to share the most recent work from our lab and results from two exciting cooperations:
In this week's issue of @bloodjournal.bsky.social (ashpublications.org/blood/issue), Afra Anjum presents her cover story on how aging platelets gain inflammatory functions in the circulation. 1/4
In this week's issue of @bloodjournal.bsky.social (ashpublications.org/blood/issue), Afra Anjum presents her cover story on how aging platelets gain inflammatory functions in the circulation. 1/4
April 5, 2025 at 5:51 AM
Excited to share the most recent work from our lab and results from two exciting cooperations:
In this week's issue of @bloodjournal.bsky.social (ashpublications.org/blood/issue), Afra Anjum presents her cover story on how aging platelets gain inflammatory functions in the circulation. 1/4
In this week's issue of @bloodjournal.bsky.social (ashpublications.org/blood/issue), Afra Anjum presents her cover story on how aging platelets gain inflammatory functions in the circulation. 1/4
Reposted by Susanne Fleig
Presented at #ACC25:
Lepodisiran, an extended-duration, small interfering RNA, reduced lipoprotein(a) concentrations in participants with elevated levels. Full ALPACA trial results: nej.md/4kWjJyn
#MedSky @accintouch.bsky.social
Lepodisiran, an extended-duration, small interfering RNA, reduced lipoprotein(a) concentrations in participants with elevated levels. Full ALPACA trial results: nej.md/4kWjJyn
#MedSky @accintouch.bsky.social
March 30, 2025 at 6:35 PM
Presented at #ACC25:
Lepodisiran, an extended-duration, small interfering RNA, reduced lipoprotein(a) concentrations in participants with elevated levels. Full ALPACA trial results: nej.md/4kWjJyn
#MedSky @accintouch.bsky.social
Lepodisiran, an extended-duration, small interfering RNA, reduced lipoprotein(a) concentrations in participants with elevated levels. Full ALPACA trial results: nej.md/4kWjJyn
#MedSky @accintouch.bsky.social
Reposted by Susanne Fleig
During inflammation, CCL21 is down-regulated in the lymph node. Enzymes for production of oxysterols are induced and recruitment of naive/central memory cells relies more in oxysterols interacting with GPR183 (+ CCL19). in 🐭
Chen et al @cellpress.bsky.social 2025
pubmed.ncbi.nlm.nih.gov/39708807/
Chen et al @cellpress.bsky.social 2025
pubmed.ncbi.nlm.nih.gov/39708807/
March 30, 2025 at 6:34 PM
During inflammation, CCL21 is down-regulated in the lymph node. Enzymes for production of oxysterols are induced and recruitment of naive/central memory cells relies more in oxysterols interacting with GPR183 (+ CCL19). in 🐭
Chen et al @cellpress.bsky.social 2025
pubmed.ncbi.nlm.nih.gov/39708807/
Chen et al @cellpress.bsky.social 2025
pubmed.ncbi.nlm.nih.gov/39708807/
Reposted by Susanne Fleig
Finally!
(Psst it was never the fluid, it was always the sodium)
(Psst it was never the fluid, it was always the sodium)
FRESH-UP Trial #ACC25 #medsky
RCT comparing liberal vs restricted fluid intake (≤1500 ml/d) in 504 pts with stable chronic HF
🌊No difference in status health quantified by Kansas City Cardiomyopathy Questionnaire at 3 mths
🌊 More thirst distress with restriction
www.nature.com/articles/s41...
RCT comparing liberal vs restricted fluid intake (≤1500 ml/d) in 504 pts with stable chronic HF
🌊No difference in status health quantified by Kansas City Cardiomyopathy Questionnaire at 3 mths
🌊 More thirst distress with restriction
www.nature.com/articles/s41...
March 30, 2025 at 8:56 PM
Finally!
(Psst it was never the fluid, it was always the sodium)
(Psst it was never the fluid, it was always the sodium)
Reposted by Susanne Fleig
Cardiovascular, Kidney & Mortality Outcomes With Long-Acting Injectable & Oral GLP1-RA in T2 Diabetes
An updated meta-analysis of >70,000 patients after the SOUL trial
⬇️ 14% MACE
⬇️ 14% heart failure
⬇️ 17% CKD progression
⬇️ 12% all-cause mortality
diabetesjournals.org/care/article...
An updated meta-analysis of >70,000 patients after the SOUL trial
⬇️ 14% MACE
⬇️ 14% heart failure
⬇️ 17% CKD progression
⬇️ 12% all-cause mortality
diabetesjournals.org/care/article...
March 29, 2025 at 10:00 PM
Cardiovascular, Kidney & Mortality Outcomes With Long-Acting Injectable & Oral GLP1-RA in T2 Diabetes
An updated meta-analysis of >70,000 patients after the SOUL trial
⬇️ 14% MACE
⬇️ 14% heart failure
⬇️ 17% CKD progression
⬇️ 12% all-cause mortality
diabetesjournals.org/care/article...
An updated meta-analysis of >70,000 patients after the SOUL trial
⬇️ 14% MACE
⬇️ 14% heart failure
⬇️ 17% CKD progression
⬇️ 12% all-cause mortality
diabetesjournals.org/care/article...
Reposted by Susanne Fleig
Our latest publication investigating the role of #palmitoylation in #lymphatic endothelial integrity.
Big shoutout to Silvia Gonzalez-Nieves, Simon GUIGNARD and Thi Nguyen for their incredible work and dedication. 👏👏
www.sciencedirect.com/science/arti...
Big shoutout to Silvia Gonzalez-Nieves, Simon GUIGNARD and Thi Nguyen for their incredible work and dedication. 👏👏
www.sciencedirect.com/science/arti...
Insulin regulates lymphatic endothelial integrity via palmitoylation
Lipid metabolism plays a critical role in lymphatic endothelial cell (LEC) development and vessel maintenance. Altered lipid metabolism is associated …
www.sciencedirect.com
March 12, 2025 at 7:13 PM
Our latest publication investigating the role of #palmitoylation in #lymphatic endothelial integrity.
Big shoutout to Silvia Gonzalez-Nieves, Simon GUIGNARD and Thi Nguyen for their incredible work and dedication. 👏👏
www.sciencedirect.com/science/arti...
Big shoutout to Silvia Gonzalez-Nieves, Simon GUIGNARD and Thi Nguyen for their incredible work and dedication. 👏👏
www.sciencedirect.com/science/arti...