Cristina Popa
@nephroseeker.medsky.social
🩺 Nephrologist = kidney philosopher
📜History lover
🕊️ Aspiring to be better. Freethinker
📍 #NephJC editor-in-chief
📍@KIreportsbsky.social
📍ERAkidney #ERA25 social media co-leader
#NephSky #MedSky
📜History lover
🕊️ Aspiring to be better. Freethinker
📍 #NephJC editor-in-chief
📍@KIreportsbsky.social
📍ERAkidney #ERA25 social media co-leader
#NephSky #MedSky
Reposted by Cristina Popa
1/10 Last #NephJC we discussed Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN #TenPostNephJC
Given the central role of complement dysregulation in C3 glomerulonephritis, we assessed whether complement-targeted therapies confer therapeutic benefit.
www.nejm.org/doi/full/10....
Given the central role of complement dysregulation in C3 glomerulonephritis, we assessed whether complement-targeted therapies confer therapeutic benefit.
www.nejm.org/doi/full/10....
January 16, 2026 at 9:16 PM
1/10 Last #NephJC we discussed Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN #TenPostNephJC
Given the central role of complement dysregulation in C3 glomerulonephritis, we assessed whether complement-targeted therapies confer therapeutic benefit.
www.nejm.org/doi/full/10....
Given the central role of complement dysregulation in C3 glomerulonephritis, we assessed whether complement-targeted therapies confer therapeutic benefit.
www.nejm.org/doi/full/10....
Reposted by Cristina Popa
9’/10
We wouldn’t have a complete view on C3GN treatment if we didn’t discuss iptacopan and the APPEAR C3G trial
Read the #NephJCshort by @nephroseeker.medsky.social and @drpallaviprasad.bsky.social
www.nephjc.com/news/2026/1/...
We wouldn’t have a complete view on C3GN treatment if we didn’t discuss iptacopan and the APPEAR C3G trial
Read the #NephJCshort by @nephroseeker.medsky.social and @drpallaviprasad.bsky.social
www.nephjc.com/news/2026/1/...
A ray of hope APPEARS for C3G — NephJC
The NephJC shorts on APPEAR-G3C randomized controlled trial: iptacopan in C3GN
www.nephjc.com
January 16, 2026 at 9:16 PM
9’/10
We wouldn’t have a complete view on C3GN treatment if we didn’t discuss iptacopan and the APPEAR C3G trial
Read the #NephJCshort by @nephroseeker.medsky.social and @drpallaviprasad.bsky.social
www.nephjc.com/news/2026/1/...
We wouldn’t have a complete view on C3GN treatment if we didn’t discuss iptacopan and the APPEAR C3G trial
Read the #NephJCshort by @nephroseeker.medsky.social and @drpallaviprasad.bsky.social
www.nephjc.com/news/2026/1/...
Reposted by Cristina Popa
10/10 ➡️Next up: 1/27/26, 9pm EST #NephJC POTCAST trial!
www.nejm.org/doi/abs/10.1...
👋thread by @thekidneywhisperer.bsky.social
www.nejm.org/doi/abs/10.1...
👋thread by @thekidneywhisperer.bsky.social
Increasing the Potassium Level in Patients at High Risk for Ventricular Arrhythmias | NEJM
Hypokalemia and even low-normal plasma potassium levels increase the risk of ventricular
arrhythmias among patients with cardiovascular disease. An assessment of a strategy
of actively increasing p...
www.nejm.org
January 16, 2026 at 9:16 PM
10/10 ➡️Next up: 1/27/26, 9pm EST #NephJC POTCAST trial!
www.nejm.org/doi/abs/10.1...
👋thread by @thekidneywhisperer.bsky.social
www.nejm.org/doi/abs/10.1...
👋thread by @thekidneywhisperer.bsky.social
#ISNWCN social media team kickoff meeting was all about anticipation and good vibes ✨
📣 WCN’26 Social Media Team Kickoff Meeting
We’re delighted to welcome our new team members 🙌🏼
Meet the people behind the content:
🔗 theisn.org/wcn/media/so...
#ISNWCN
We’re delighted to welcome our new team members 🙌🏼
Meet the people behind the content:
🔗 theisn.org/wcn/media/so...
#ISNWCN
January 16, 2026 at 3:02 PM
#ISNWCN social media team kickoff meeting was all about anticipation and good vibes ✨
Reposted by Cristina Popa
4/ Our #Skeetorial is based on a recent publication by Dr. Dana Kim and VA by @husamjz.bsky.social:
Sex Differences Across Corticosteroid Response and Outcomes in IgA Nephropathy
🔗https://www.sciencedirect.com/science/article/pii/S2468024925004851
Sex Differences Across Corticosteroid Response and Outcomes in IgA Nephropathy
🔗https://www.sciencedirect.com/science/article/pii/S2468024925004851
January 15, 2026 at 8:13 PM
4/ Our #Skeetorial is based on a recent publication by Dr. Dana Kim and VA by @husamjz.bsky.social:
Sex Differences Across Corticosteroid Response and Outcomes in IgA Nephropathy
🔗https://www.sciencedirect.com/science/article/pii/S2468024925004851
Sex Differences Across Corticosteroid Response and Outcomes in IgA Nephropathy
🔗https://www.sciencedirect.com/science/article/pii/S2468024925004851
Reposted by Cristina Popa
T0b
The pathophysiology of C3GN & IC-MPGN is thought to be caused by:
Genetic mutations or
Acquired defect of complement proteins or
Auto-antibodies against complement factors and/or regulating proteins. #NephJC
The pathophysiology of C3GN & IC-MPGN is thought to be caused by:
Genetic mutations or
Acquired defect of complement proteins or
Auto-antibodies against complement factors and/or regulating proteins. #NephJC
January 14, 2026 at 2:08 AM
T0b
The pathophysiology of C3GN & IC-MPGN is thought to be caused by:
Genetic mutations or
Acquired defect of complement proteins or
Auto-antibodies against complement factors and/or regulating proteins. #NephJC
The pathophysiology of C3GN & IC-MPGN is thought to be caused by:
Genetic mutations or
Acquired defect of complement proteins or
Auto-antibodies against complement factors and/or regulating proteins. #NephJC
T0c
The new classification of MPGN relies on immunofluorescence (IF) patterns as well as pathobiology. #NephJC
The new classification of MPGN relies on immunofluorescence (IF) patterns as well as pathobiology. #NephJC
January 14, 2026 at 2:14 AM
Cristina Popa, Romanian nephrologist, no COI #NephJC
Super sleepy, 4 am 👉 lurking
Started gathering all the Christmas decorations, with these guys 😀
Super sleepy, 4 am 👉 lurking
Started gathering all the Christmas decorations, with these guys 😀
January 14, 2026 at 2:02 AM
Cristina Popa, Romanian nephrologist, no COI #NephJC
Super sleepy, 4 am 👉 lurking
Started gathering all the Christmas decorations, with these guys 😀
Super sleepy, 4 am 👉 lurking
Started gathering all the Christmas decorations, with these guys 😀
Reposted by Cristina Popa
✨It's that time of the year again, to nominate the most deserving people in our community for #NephJCKidneys award
👇Here's a reminder of previous winners #Nephsky
📌You can nominate worthy individuals/ initiatives by using the hashtag or by using the form
www.nephjc.com/news/2026/1/...
👇Here's a reminder of previous winners #Nephsky
📌You can nominate worthy individuals/ initiatives by using the hashtag or by using the form
www.nephjc.com/news/2026/1/...
January 8, 2026 at 4:04 PM
✨It's that time of the year again, to nominate the most deserving people in our community for #NephJCKidneys award
👇Here's a reminder of previous winners #Nephsky
📌You can nominate worthy individuals/ initiatives by using the hashtag or by using the form
www.nephjc.com/news/2026/1/...
👇Here's a reminder of previous winners #Nephsky
📌You can nominate worthy individuals/ initiatives by using the hashtag or by using the form
www.nephjc.com/news/2026/1/...
Reposted by Cristina Popa
Check out the VA for VALIANT from @nephromommy-akshu.bsky.social
#NephJC
www.nephjc.com/news/2026/1/11/valiant-the-visual-abstract
#NephJC
www.nephjc.com/news/2026/1/11/valiant-the-visual-abstract
VALIANT: The Visual Abstract — NephJC
The VALIANT phase 3 RCT shows that proximal C3 inhibition with pegcetacoplan leads to a significantly greater reduction in proteinuria compared with placebo in patients with C3G and primary immune-com...
www.nephjc.com
January 12, 2026 at 12:53 PM
Check out the VA for VALIANT from @nephromommy-akshu.bsky.social
#NephJC
www.nephjc.com/news/2026/1/11/valiant-the-visual-abstract
#NephJC
www.nephjc.com/news/2026/1/11/valiant-the-visual-abstract
Reposted by Cristina Popa
Wilst thou join us here, where the Sky is Blue? #NephJC
On 1/13/26 at 9pm EST 'tis true
We shall converse of the great knight's quest,
a VALIANT effort from Sir Pegcetacoplan vs complement! ⚔️
www.nephjc.com/news/valiant-c3g
On 1/13/26 at 9pm EST 'tis true
We shall converse of the great knight's quest,
a VALIANT effort from Sir Pegcetacoplan vs complement! ⚔️
www.nephjc.com/news/valiant-c3g
A VALIANT effort to combat complement disorders with pegcetacoplan — NephJC
This week, we will discuss the VALIANT study, pegcetacoplan in C3G and IC MPGN.
www.nephjc.com
January 12, 2026 at 12:50 PM
Wilst thou join us here, where the Sky is Blue? #NephJC
On 1/13/26 at 9pm EST 'tis true
We shall converse of the great knight's quest,
a VALIANT effort from Sir Pegcetacoplan vs complement! ⚔️
www.nephjc.com/news/valiant-c3g
On 1/13/26 at 9pm EST 'tis true
We shall converse of the great knight's quest,
a VALIANT effort from Sir Pegcetacoplan vs complement! ⚔️
www.nephjc.com/news/valiant-c3g
Reposted by Cristina Popa
🧬 C3G
APPEAR-C3G or VALIANT?
📉 Proteinuria vs placebo:
🔹 Iptacopan: 35%
🔹 Pegcetacoplan: 67%
🎯 Blocking factor B 🆚 🚫C3
Where would you place your bet today? #nephsky #Medsky @thelancet.com @nejm.org
🦋 join us today on #nephjc
APPEAR-C3G or VALIANT?
📉 Proteinuria vs placebo:
🔹 Iptacopan: 35%
🔹 Pegcetacoplan: 67%
🎯 Blocking factor B 🆚 🚫C3
Where would you place your bet today? #nephsky #Medsky @thelancet.com @nejm.org
🦋 join us today on #nephjc
January 13, 2026 at 3:34 PM
🧬 C3G
APPEAR-C3G or VALIANT?
📉 Proteinuria vs placebo:
🔹 Iptacopan: 35%
🔹 Pegcetacoplan: 67%
🎯 Blocking factor B 🆚 🚫C3
Where would you place your bet today? #nephsky #Medsky @thelancet.com @nejm.org
🦋 join us today on #nephjc
APPEAR-C3G or VALIANT?
📉 Proteinuria vs placebo:
🔹 Iptacopan: 35%
🔹 Pegcetacoplan: 67%
🎯 Blocking factor B 🆚 🚫C3
Where would you place your bet today? #nephsky #Medsky @thelancet.com @nejm.org
🦋 join us today on #nephjc
Reposted by Cristina Popa
Wow - excellent discussion of the totally underwhelming BICAR-ICU2 trial
podcasts.apple.com/ca/podcast/f...
@nephcrit.bsky.social fighting a line fight against the unimpressed nephrons with guest @weddellite.bsky.social
#NephSky #EMIMCC
podcasts.apple.com/ca/podcast/f...
@nephcrit.bsky.social fighting a line fight against the unimpressed nephrons with guest @weddellite.bsky.social
#NephSky #EMIMCC
FF 88 BICARICU-2, Bicarbonate in the ICU. Helpful or just a number fixer?
Podcast Episode · Freely Filtered, a NephJC Podcast · 2025-12-27 · 1h 25m
podcasts.apple.com
January 3, 2026 at 3:07 AM
Wow - excellent discussion of the totally underwhelming BICAR-ICU2 trial
podcasts.apple.com/ca/podcast/f...
@nephcrit.bsky.social fighting a line fight against the unimpressed nephrons with guest @weddellite.bsky.social
#NephSky #EMIMCC
podcasts.apple.com/ca/podcast/f...
@nephcrit.bsky.social fighting a line fight against the unimpressed nephrons with guest @weddellite.bsky.social
#NephSky #EMIMCC
Reposted by Cristina Popa
Safety and Effectiveness of Long-term #Isoniazid Treatment for the #Prevention of #Tuberculosis in High-risk #Dialysis Patients
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00733-8/fulltext
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00733-8/fulltext
January 2, 2026 at 2:00 PM
Safety and Effectiveness of Long-term #Isoniazid Treatment for the #Prevention of #Tuberculosis in High-risk #Dialysis Patients
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00733-8/fulltext
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00733-8/fulltext
Reposted by Cristina Popa
A #FIDELITY Analysis on #Finerenone With #SGLT2i and #GLP1RA in CKD
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00715-6/fulltext
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00715-6/fulltext
December 29, 2025 at 2:00 PM
A #FIDELITY Analysis on #Finerenone With #SGLT2i and #GLP1RA in CKD
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00715-6/fulltext
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00715-6/fulltext
Reposted by Cristina Popa
The Impact of #Homelessness on #Kidney #Outcomes Among Adults With #Diabetes
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00718-1/fulltext
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00718-1/fulltext
December 31, 2025 at 12:00 AM
The Impact of #Homelessness on #Kidney #Outcomes Among Adults With #Diabetes
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00718-1/fulltext
#VisualAbstract by Cristina Popa
https://www.kireports.org/article/S2468-0249(25)00718-1/fulltext
Reposted by Cristina Popa
1/10
Last #NephJC we discussed dialysis frequency in AKI-D #TenPostNephJC
We sought to answer an age-old question: Is less is really more? Or less is just simply what it is….less?
pubmed.ncbi.nlm.nih.gov/41201895/
Last #NephJC we discussed dialysis frequency in AKI-D #TenPostNephJC
We sought to answer an age-old question: Is less is really more? Or less is just simply what it is….less?
pubmed.ncbi.nlm.nih.gov/41201895/
December 19, 2025 at 12:23 PM
1/10
Last #NephJC we discussed dialysis frequency in AKI-D #TenPostNephJC
We sought to answer an age-old question: Is less is really more? Or less is just simply what it is….less?
pubmed.ncbi.nlm.nih.gov/41201895/
Last #NephJC we discussed dialysis frequency in AKI-D #TenPostNephJC
We sought to answer an age-old question: Is less is really more? Or less is just simply what it is….less?
pubmed.ncbi.nlm.nih.gov/41201895/
Reposted by Cristina Popa
We really don’t think BigPAK makes sense
From our journal club at @uottawa.ca into a #NephJC shorts
www.nephjc.com/news/2025/12...
From our journal club at @uottawa.ca into a #NephJC shorts
www.nephjc.com/news/2025/12...
BigPAK or a bundle of balderdash? — NephJC
We break down the latest salvo from Zarbock et al on a supposedly wonderful ‘bundle’
www.nephjc.com
December 17, 2025 at 11:13 PM
We really don’t think BigPAK makes sense
From our journal club at @uottawa.ca into a #NephJC shorts
www.nephjc.com/news/2025/12...
From our journal club at @uottawa.ca into a #NephJC shorts
www.nephjc.com/news/2025/12...
Reposted by Cristina Popa
We are then going back to our regularly scheduled programming 1/13/26 at 9pm EST
VALIANT: Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN. #NephJC
www.nejm.org/doi/ful...
VALIANT: Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN. #NephJC
www.nejm.org/doi/ful...
December 17, 2025 at 2:55 AM
We are then going back to our regularly scheduled programming 1/13/26 at 9pm EST
VALIANT: Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN. #NephJC
www.nejm.org/doi/ful...
VALIANT: Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN. #NephJC
www.nejm.org/doi/ful...
#NephJC it is important to point out that ‘1st day of recovery’ was defined retrospective. On that day, GFR may be very low (so not ‘recovered’ in the way many people use the word). See 2 figures below for illustration. Both these patients contributed to those Kaplan-Meier curves separating early.
December 17, 2025 at 2:41 AM
T2f
Dialysis-Free Days by Day 28:
Conservative: 21 days
Conventional: 5 days
Most pronounced divergence within the first 10-12 days
Clinically, this means these patients spent most of their hospital course not needing dialysis, something no earlier AKI-D trial has demonstrated so clearly. #NephJC
Dialysis-Free Days by Day 28:
Conservative: 21 days
Conventional: 5 days
Most pronounced divergence within the first 10-12 days
Clinically, this means these patients spent most of their hospital course not needing dialysis, something no earlier AKI-D trial has demonstrated so clearly. #NephJC
December 17, 2025 at 2:40 AM
Reposted by Cristina Popa
T1a
Population: stable AKI-D patients with realistic renal recovery potential
Exactly the “gray zone” group we debate daily whether dialysis continuation is necessary.
👀Check out the inclusion/exclusion criteria #NephJC
Population: stable AKI-D patients with realistic renal recovery potential
Exactly the “gray zone” group we debate daily whether dialysis continuation is necessary.
👀Check out the inclusion/exclusion criteria #NephJC
December 17, 2025 at 2:16 AM
T1a
Population: stable AKI-D patients with realistic renal recovery potential
Exactly the “gray zone” group we debate daily whether dialysis continuation is necessary.
👀Check out the inclusion/exclusion criteria #NephJC
Population: stable AKI-D patients with realistic renal recovery potential
Exactly the “gray zone” group we debate daily whether dialysis continuation is necessary.
👀Check out the inclusion/exclusion criteria #NephJC
Reposted by Cristina Popa
www.nephjc.com/news/...
Check out the excellent #NephJC summary by @msocomd.bsky.social and @sejalplakhani.bsky.social
Check out the excellent #NephJC summary by @msocomd.bsky.social and @sejalplakhani.bsky.social
Dialyze Less, Recover More? AKI’s Chance to Get LIBERATE-D — NephJC
This week, we will discuss whether less is more when it comes to
discontinuing dialysis in patients with AKI and a chance to recover.
www.nephjc.com
December 17, 2025 at 2:04 AM
www.nephjc.com/news/...
Check out the excellent #NephJC summary by @msocomd.bsky.social and @sejalplakhani.bsky.social
Check out the excellent #NephJC summary by @msocomd.bsky.social and @sejalplakhani.bsky.social
Hi! Cristina Popa here 👋 #NephJC
No COIs. Never practiced 3xHD per week in AKI
It’s harder to be awake at this hour when on vacation (although it’s only 3 am 🥱). Here are some pics👇
No COIs. Never practiced 3xHD per week in AKI
It’s harder to be awake at this hour when on vacation (although it’s only 3 am 🥱). Here are some pics👇
December 17, 2025 at 2:01 AM
Hi! Cristina Popa here 👋 #NephJC
No COIs. Never practiced 3xHD per week in AKI
It’s harder to be awake at this hour when on vacation (although it’s only 3 am 🥱). Here are some pics👇
No COIs. Never practiced 3xHD per week in AKI
It’s harder to be awake at this hour when on vacation (although it’s only 3 am 🥱). Here are some pics👇
Reposted by Cristina Popa
👉 New to #NephJC ?
Check out the infographic by @sstoneman.bsky.social on how this all works.
Let’s make this fun, fast, and global 🌏
Check out the infographic by @sstoneman.bsky.social on how this all works.
Let’s make this fun, fast, and global 🌏
December 17, 2025 at 1:45 AM
👉 New to #NephJC ?
Check out the infographic by @sstoneman.bsky.social on how this all works.
Let’s make this fun, fast, and global 🌏
Check out the infographic by @sstoneman.bsky.social on how this all works.
Let’s make this fun, fast, and global 🌏