Scott_Boyd_Lab_Stanford
@scottboydlab.bsky.social
Scott Boyd Lab for Human Immunology Research at Stanford University.
Reposted by Scott_Boyd_Lab_Stanford
Anyone that has been around a lab knows that the trainees really drive the research, while most professors just sort of guide the ship. Most innovation comes from our trainees.
Old professors like me will be able to survive these cuts, but our young scientists and our future will be destroyed.
Old professors like me will be able to survive these cuts, but our young scientists and our future will be destroyed.
June 3, 2025 at 2:32 PM
Anyone that has been around a lab knows that the trainees really drive the research, while most professors just sort of guide the ship. Most innovation comes from our trainees.
Old professors like me will be able to survive these cuts, but our young scientists and our future will be destroyed.
Old professors like me will be able to survive these cuts, but our young scientists and our future will be destroyed.
Reposted by Scott_Boyd_Lab_Stanford
Researcher Amita Gupta has spent more than a decade planning and running a $70-million trial to study a new tuberculosis drug, enrolling ~6,000 participants in 13 countries. It might all have been for nothing.
That's because a new NIH policy has abruptly cut off billions to trials abroad. 🧪
That's because a new NIH policy has abruptly cut off billions to trials abroad. 🧪
NIH grant cuts will axe clinical trials abroad — and could leave thousands without care
US agency’s new policy could abruptly end studies of infectious diseases and cancer, leaving researchers scrambling for funds.
www.nature.com
June 2, 2025 at 3:12 PM
Researcher Amita Gupta has spent more than a decade planning and running a $70-million trial to study a new tuberculosis drug, enrolling ~6,000 participants in 13 countries. It might all have been for nothing.
That's because a new NIH policy has abruptly cut off billions to trials abroad. 🧪
That's because a new NIH policy has abruptly cut off billions to trials abroad. 🧪
Reposted by Scott_Boyd_Lab_Stanford
Check out this news story that @nature.com wrote describing our recent preprint where we tested our H5 mRNA vaccine in calves.
The data look good and we are currently testing the vaccine in lactating cattle...more to come!
The data look good and we are currently testing the vaccine in lactating cattle...more to come!
As bird flu sweeps across US poultry and cattle farms, researchers are racing to find ways to contain the outbreaks before they ignite a human pandemic. Now, a team of scientists has developed a fresh approach: the first mRNA bird-flu vaccine for cattle.
https://go.nature.com/4kbOvTe
https://go.nature.com/4kbOvTe
Bird flu vaccine for cattle aces early test
Vaccines for livestock could reduce the risk of human outbreaks, but hurdles remain.
go.nature.com
May 21, 2025 at 12:15 AM
Check out this news story that @nature.com wrote describing our recent preprint where we tested our H5 mRNA vaccine in calves.
The data look good and we are currently testing the vaccine in lactating cattle...more to come!
The data look good and we are currently testing the vaccine in lactating cattle...more to come!
Wonderfully good video about the beauty of science and humanitarian motivation working together to defeat diseases and save people. youtube.com/watch?v=ybVZ... 🧪 #NIH #CDC #WHO #BMGF #NIAID
Defeating a Virus That Killed Half a Billion People – The Plea
YouTube video by Neil Halloran
youtube.com
May 17, 2025 at 6:23 AM
Reposted by Scott_Boyd_Lab_Stanford
So this is not a problem?...But we can't even buy an NIH researcher a cup of coffee because of conflicts of interest!? The hypocrisy is insane. Investigations into universities, but at the White House all gifts and straight up crypto-bribes are fine. WTF www.nytimes.com/2025/05/11/u...
Trump Is Poised to Accept a Luxury 747 From Qatar for Use as Air Force One
www.nytimes.com
May 12, 2025 at 4:41 PM
So this is not a problem?...But we can't even buy an NIH researcher a cup of coffee because of conflicts of interest!? The hypocrisy is insane. Investigations into universities, but at the White House all gifts and straight up crypto-bribes are fine. WTF www.nytimes.com/2025/05/11/u...
Reposted by Scott_Boyd_Lab_Stanford
Brain tissue artificially expanded to show how neurons wire together @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Light-microscopy-based connectomic reconstruction of mammalian brain tissue - Nature
A technique called LICONN (light-microscopy-based connectomics) allows mapping of brain tissue at synapse level and simultaneous measurement of molecular information, thus enabling quantification of c...
www.nature.com
May 8, 2025 at 7:21 PM
Brain tissue artificially expanded to show how neurons wire together @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Reposted by Scott_Boyd_Lab_Stanford
“This image from video posted on the Children's Health Defense [RFK Jr.’s anti-vax nonprofit] website on March 31 shows Dr. Ben Edwards with a measles rash on his face, while working in a makeshift clinic in Seminole, Texas.” www.cnn.com/2025/04/19/h...
Video shows doctor with measles treating kids. RFK Jr. later praised him as an ‘extraordinary’ healer | CNN
A Texas doctor who has been treating children in a measles outbreak was shown on video with a measles rash on his face in a clinic a week before Health Secretary Robert F. Kennedy Jr. met him and prai...
www.cnn.com
April 21, 2025 at 2:02 AM
“This image from video posted on the Children's Health Defense [RFK Jr.’s anti-vax nonprofit] website on March 31 shows Dr. Ben Edwards with a measles rash on his face, while working in a makeshift clinic in Seminole, Texas.” www.cnn.com/2025/04/19/h...
Reposted by Scott_Boyd_Lab_Stanford
The Senate Committee on Appropriations is holding a hearing on Biomedical Research: Keeping America’s Edge in Innovation on April 30 at 10:30am ET, chaired by Senator Susan Collins 🧪
www.appropriations.senate.gov/hearings/bio...
www.appropriations.senate.gov/hearings/bio...
Biomedical Research: Keeping America’s Edge in Innovation | United States Senate Committee on Appropriations
United States Senate Committee on Appropriations
www.appropriations.senate.gov
April 12, 2025 at 5:08 PM
The Senate Committee on Appropriations is holding a hearing on Biomedical Research: Keeping America’s Edge in Innovation on April 30 at 10:30am ET, chaired by Senator Susan Collins 🧪
www.appropriations.senate.gov/hearings/bio...
www.appropriations.senate.gov/hearings/bio...
Reposted by Scott_Boyd_Lab_Stanford
I can’t exaggerate how badly this will affect our field, also internationally since many missions are jointly funded with eg ESA and JAXA. We are basically pinning our hopes on congressfolk to fight for all the regions that will lose jobs, since the science isn’t winning any arguments. 😢🔭🧪
First the rumour was a 20% budget cut. Then, 50%. Now the president's NASA budget is out and it's a 68% cut to astrophysics ($1.5B to $487M).
Even if this gets reversed in four years, we will *never* recover the missions, partners, people who will be gone.
www.washingtonpost.com/science/2025...
Even if this gets reversed in four years, we will *never* recover the missions, partners, people who will be gone.
www.washingtonpost.com/science/2025...
Massive cuts to NASA science proposed in early White House budget plan
The preliminary version of President Donald Trump’s budget proposal to Congress, known as a “passback,” would cut the agency’s science budget funding nearly in half.
www.washingtonpost.com
April 13, 2025 at 6:40 AM
I can’t exaggerate how badly this will affect our field, also internationally since many missions are jointly funded with eg ESA and JAXA. We are basically pinning our hopes on congressfolk to fight for all the regions that will lose jobs, since the science isn’t winning any arguments. 😢🔭🧪
Reposted by Scott_Boyd_Lab_Stanford
THREAD
The numbers are in. @bsky.app research sharing volumes vs X Formerly Twitter
In March 2024, on most days, Bluesky hosts more posts linked to research published in 2025 than X.
By quite a lot.
Release the Kraken...
#AcademicSky #HigherEd #Altmetrics
1/11
The numbers are in. @bsky.app research sharing volumes vs X Formerly Twitter
In March 2024, on most days, Bluesky hosts more posts linked to research published in 2025 than X.
By quite a lot.
Release the Kraken...
#AcademicSky #HigherEd #Altmetrics
1/11
March 27, 2025 at 5:22 PM
THREAD
The numbers are in. @bsky.app research sharing volumes vs X Formerly Twitter
In March 2024, on most days, Bluesky hosts more posts linked to research published in 2025 than X.
By quite a lot.
Release the Kraken...
#AcademicSky #HigherEd #Altmetrics
1/11
The numbers are in. @bsky.app research sharing volumes vs X Formerly Twitter
In March 2024, on most days, Bluesky hosts more posts linked to research published in 2025 than X.
By quite a lot.
Release the Kraken...
#AcademicSky #HigherEd #Altmetrics
1/11
Reposted by Scott_Boyd_Lab_Stanford
Multiple sclerosis requires Epstein-Barr virus infection as an underpinning, exhibits self-directed antibodies to EBNA1, the virus's nuclear antigen, representing molecular mimicry. This combines with/ genetic risk factors (Figure, compared w/healthy controls)
@pnas.org
www.pnas.org/doi/epub/10....
@pnas.org
www.pnas.org/doi/epub/10....
March 10, 2025 at 7:21 PM
Multiple sclerosis requires Epstein-Barr virus infection as an underpinning, exhibits self-directed antibodies to EBNA1, the virus's nuclear antigen, representing molecular mimicry. This combines with/ genetic risk factors (Figure, compared w/healthy controls)
@pnas.org
www.pnas.org/doi/epub/10....
@pnas.org
www.pnas.org/doi/epub/10....
Many outstanding medical researchers at NIH threatened by non-renewal of contracts:
www.science.org/content/arti...
They give the US new discoveries & the economic benefits of doing the risky first steps toward innovative cures.
Harming medical research is a self-inflicted national injury.
www.science.org/content/arti...
They give the US new discoveries & the economic benefits of doing the risky first steps toward innovative cures.
Harming medical research is a self-inflicted national injury.
NIH ban on renewing senior scientists adds to assaults on its in-house research
Policy follows firings of tenure-track scientists and suspension of training programs
www.science.org
February 27, 2025 at 8:53 PM
Many outstanding medical researchers at NIH threatened by non-renewal of contracts:
www.science.org/content/arti...
They give the US new discoveries & the economic benefits of doing the risky first steps toward innovative cures.
Harming medical research is a self-inflicted national injury.
www.science.org/content/arti...
They give the US new discoveries & the economic benefits of doing the risky first steps toward innovative cures.
Harming medical research is a self-inflicted national injury.
Reposted by Scott_Boyd_Lab_Stanford
I am happy to announce our new paper "Univariate-guided sparse regression". It's a new lasso that leverages the signs and magnitude of univariate coefficients .
Sparser and more interpretable than the lasso. We're excited! arxiv.org/abs/2501.18360
R: github.com/trevorhastie...
Sparser and more interpretable than the lasso. We're excited! arxiv.org/abs/2501.18360
R: github.com/trevorhastie...
Univariate-Guided Sparse Regression
In this paper, we introduce ``UniLasso'' -- a novel statistical method for sparse regression. This two-stage approach preserves the signs of the univariate coefficients and leverages their magnitude. ...
arxiv.org
February 24, 2025 at 4:57 AM
I am happy to announce our new paper "Univariate-guided sparse regression". It's a new lasso that leverages the signs and magnitude of univariate coefficients .
Sparser and more interpretable than the lasso. We're excited! arxiv.org/abs/2501.18360
R: github.com/trevorhastie...
Sparser and more interpretable than the lasso. We're excited! arxiv.org/abs/2501.18360
R: github.com/trevorhastie...
Reposted by Scott_Boyd_Lab_Stanford
This is heartbreaking. But not an unfamiliar feeling for my science colleagues and my own lab who burnt the midnight oil 24/7 studying COVID immunity to understand how to protect American lives during the pandemic. Nonsensical, performative betrayal. No one will actually benefit and people will die.
Gregg is a former Marine and Forest Service ranger. He's saved the lives of hikers dangling off a cliff or going through cardiac arrest, and he's bravely fought forest fires to save small rural towns.
100% of his salary is paid by WA state.
Elon fired him. Share his story.
100% of his salary is paid by WA state.
Elon fired him. Share his story.
February 24, 2025 at 5:08 AM
This is heartbreaking. But not an unfamiliar feeling for my science colleagues and my own lab who burnt the midnight oil 24/7 studying COVID immunity to understand how to protect American lives during the pandemic. Nonsensical, performative betrayal. No one will actually benefit and people will die.
Reposted by Scott_Boyd_Lab_Stanford
Reposted by Scott_Boyd_Lab_Stanford
This week was the 1st publication using our immune cell sequencing to accurately make medical diagnoses. It has enormous implications, as I've reviewed here erictopol.substack.com/p/the-first-... @scottboydlab.bsky.social @science.org @anshulkundaje.bsky.social @maximzaslavsky.bsky.social
The First Diagnostic Immunome
A Big Step Forward By Sequencing B and T Cell Receptors Plus A.I.
erictopol.substack.com
February 22, 2025 at 5:19 PM
This week was the 1st publication using our immune cell sequencing to accurately make medical diagnoses. It has enormous implications, as I've reviewed here erictopol.substack.com/p/the-first-... @scottboydlab.bsky.social @science.org @anshulkundaje.bsky.social @maximzaslavsky.bsky.social
Attempting to read the language of B cell and T cell receptor sequences to diagnose immunological diseases:
Our new paper, led by the outstanding Maxim Zaslavsky @maximzaslavsky.bsky.social sky.bsky.social with help from me and Anshul Kundaje @anshulkundaje.bsky.social.
Link: buff.ly/3QvxSVf
Our new paper, led by the outstanding Maxim Zaslavsky @maximzaslavsky.bsky.social sky.bsky.social with help from me and Anshul Kundaje @anshulkundaje.bsky.social.
Link: buff.ly/3QvxSVf
February 21, 2025 at 1:26 PM
Attempting to read the language of B cell and T cell receptor sequences to diagnose immunological diseases:
Our new paper, led by the outstanding Maxim Zaslavsky @maximzaslavsky.bsky.social sky.bsky.social with help from me and Anshul Kundaje @anshulkundaje.bsky.social.
Link: buff.ly/3QvxSVf
Our new paper, led by the outstanding Maxim Zaslavsky @maximzaslavsky.bsky.social sky.bsky.social with help from me and Anshul Kundaje @anshulkundaje.bsky.social.
Link: buff.ly/3QvxSVf
Destructive, cruel and directly harmful to the health and security of America. The physical, real world of viruses and other pathogens doesn’t care about politics and won’t spare us.
CDC source:
“We just had word that all our fellows and post doc staff are laid off effective immediately. The famous Epidemic Intelligence Service, aka the Disease Detectives, is no more. That’s 1260 staff.
They are calling this ‘Phase 1’.”
“We just had word that all our fellows and post doc staff are laid off effective immediately. The famous Epidemic Intelligence Service, aka the Disease Detectives, is no more. That’s 1260 staff.
They are calling this ‘Phase 1’.”
February 15, 2025 at 4:15 AM
Destructive, cruel and directly harmful to the health and security of America. The physical, real world of viruses and other pathogens doesn’t care about politics and won’t spare us.
Reposted by Scott_Boyd_Lab_Stanford
This is so smart. @petebuttigieg.bsky.social , thoughts ?
And if you see this. A reminder. This is not Twitter. You can engage here and have thoughtful discussions !
We all look forward to reading your thoughts
And if you see this. A reminder. This is not Twitter. You can engage here and have thoughtful discussions !
We all look forward to reading your thoughts
I keep saying Dems need to do a daily briefing on Capitol Hill and fill the void, fact check the WH. Hire Pete Buttigeig and give him a staff to do this.
February 14, 2025 at 6:15 PM
This is so smart. @petebuttigieg.bsky.social , thoughts ?
And if you see this. A reminder. This is not Twitter. You can engage here and have thoughtful discussions !
We all look forward to reading your thoughts
And if you see this. A reminder. This is not Twitter. You can engage here and have thoughtful discussions !
We all look forward to reading your thoughts
Reposted by Scott_Boyd_Lab_Stanford
NIH-supported research saves lives: here are two "poster" human beings to prove it.
Emily Whitehead: cured of her leukemia by CAR-T developed at Penn.
Victoria Gray: major symptoms of her sickle cell disease resolved following CRISPR gene editing - path paved at Boston Childrens, UW, UC Berkeley.
Emily Whitehead: cured of her leukemia by CAR-T developed at Penn.
Victoria Gray: major symptoms of her sickle cell disease resolved following CRISPR gene editing - path paved at Boston Childrens, UW, UC Berkeley.
February 10, 2025 at 4:51 PM
NIH-supported research saves lives: here are two "poster" human beings to prove it.
Emily Whitehead: cured of her leukemia by CAR-T developed at Penn.
Victoria Gray: major symptoms of her sickle cell disease resolved following CRISPR gene editing - path paved at Boston Childrens, UW, UC Berkeley.
Emily Whitehead: cured of her leukemia by CAR-T developed at Penn.
Victoria Gray: major symptoms of her sickle cell disease resolved following CRISPR gene editing - path paved at Boston Childrens, UW, UC Berkeley.
Reposted by Scott_Boyd_Lab_Stanford
The 22 state AGs note that in 2017, Trump proposed a similar across-the-board rate cut, but Congress rejected it.
In 2018 & every year since, Congress has enacted an appropriations rider forbidding NIH from pursuing an across-the-board rate cut.
In 2018 & every year since, Congress has enacted an appropriations rider forbidding NIH from pursuing an across-the-board rate cut.
February 10, 2025 at 5:29 PM
The 22 state AGs note that in 2017, Trump proposed a similar across-the-board rate cut, but Congress rejected it.
In 2018 & every year since, Congress has enacted an appropriations rider forbidding NIH from pursuing an across-the-board rate cut.
In 2018 & every year since, Congress has enacted an appropriations rider forbidding NIH from pursuing an across-the-board rate cut.
Reposted by Scott_Boyd_Lab_Stanford
#BREAKING - 22 states sue to block Trump administration cuts to NIH research payments
22 states sue to block Trump administration cuts to NIH research payments
Attorneys general sued the Trump administration to block a NIH decision that would slash grant payments for research overhead
buff.ly
February 10, 2025 at 5:26 PM
#BREAKING - 22 states sue to block Trump administration cuts to NIH research payments
Reposted by Scott_Boyd_Lab_Stanford
Why should the public care about the freeze on the NIH? Aside from the need for scientific pursuits to make our society better…
-For every dollar we invest in NIH research, there is a $2.5 return.
-Research dollars help fund universities that employ non-academics. (1/)
-For every dollar we invest in NIH research, there is a $2.5 return.
-Research dollars help fund universities that employ non-academics. (1/)
January 23, 2025 at 12:46 AM
Why should the public care about the freeze on the NIH? Aside from the need for scientific pursuits to make our society better…
-For every dollar we invest in NIH research, there is a $2.5 return.
-Research dollars help fund universities that employ non-academics. (1/)
-For every dollar we invest in NIH research, there is a $2.5 return.
-Research dollars help fund universities that employ non-academics. (1/)
Reposted by Scott_Boyd_Lab_Stanford
Scientific advancements aside, this is economically irresponsible
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
January 22, 2025 at 11:04 PM
Scientific advancements aside, this is economically irresponsible
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)