Sahar
@saharsci.bsky.social
graduate student @torontometu 🇨🇦
cell biology, EGFR regulation, single particle tracking
cell biology, EGFR regulation, single particle tracking
Reposted by Sahar
I guess it never gets old...bc we love #CellMigration
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
November 14, 2025 at 8:38 PM
I guess it never gets old...bc we love #CellMigration
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
Reposted by Sahar
Multimodal learning enables chat-based exploration of single-cell data www.nature.com/articles/s41... 🧬🖥️🧪 github.com/epigen/cellw...
November 14, 2025 at 7:01 PM
Multimodal learning enables chat-based exploration of single-cell data www.nature.com/articles/s41... 🧬🖥️🧪 github.com/epigen/cellw...
Reposted by Sahar
Independent validation of the SnxA biosensor as a sensitive reporter of PI(3,5)P₂ dynamics by Gerald R Hammond and team: www.biorxiv.org/content/10.1...
November 12, 2025 at 6:57 PM
Independent validation of the SnxA biosensor as a sensitive reporter of PI(3,5)P₂ dynamics by Gerald R Hammond and team: www.biorxiv.org/content/10.1...
Reposted by Sahar
I wrote this insight for eLife. A friend said, "Why would you want to step on that rake?". Well, I guess that's just who I am. Enjoy. elifesciences.org/articles/109...
Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance
Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
elifesciences.org
November 11, 2025 at 7:37 PM
I wrote this insight for eLife. A friend said, "Why would you want to step on that rake?". Well, I guess that's just who I am. Enjoy. elifesciences.org/articles/109...
Reposted by Sahar
A new #ScienceImmunology study in mice provides insight into why malaria vaccines that contain the whole Plasmodium parasite may have limited efficacy in humans who live in endemic regions. https://scim.ag/4nONXn9
B cells targeting parasites capture spatially linked antigens to secure T cell help
Antigen location orchestrates T cell–B cell collaboration in response to large pathogens.
scim.ag
November 11, 2025 at 4:00 PM
A new #ScienceImmunology study in mice provides insight into why malaria vaccines that contain the whole Plasmodium parasite may have limited efficacy in humans who live in endemic regions. https://scim.ag/4nONXn9
Reposted by Sahar
See study by @kirstin-rollins.bsky.social, @sareenfiaz.bsky.social, Ishwaree Datta and @mmorrissey.bsky.social: rupress.org/jcb/article/...
Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis
Macrophages are presumed to attack antibody-opsonized cancer cells by phagocytosis. Rollins et al. found that macrophages attack adherent cells using trogo
rupress.org
November 10, 2025 at 3:04 PM
See study by @kirstin-rollins.bsky.social, @sareenfiaz.bsky.social, Ishwaree Datta and @mmorrissey.bsky.social: rupress.org/jcb/article/...
www.sciencedirect.com/science/arti...
sometimes a review is just so good you have to share it
sometimes a review is just so good you have to share it
EGFR Activation and Conformational “Convergence”: An Emerging Allosteric Model From Cancer Mutations
Since its isolation nearly 50 years ago, the Epidermal Growth Factor Receptor (EGFR) has become one of the most extensively studied oncogenes. However…
www.sciencedirect.com
November 7, 2025 at 3:31 AM
www.sciencedirect.com/science/arti...
sometimes a review is just so good you have to share it
sometimes a review is just so good you have to share it
performance anxiety is so silly cuz why is it the one time im observed i mess up in ways ive never had before doing the thing a million times 😬😂
November 6, 2025 at 7:57 PM
performance anxiety is so silly cuz why is it the one time im observed i mess up in ways ive never had before doing the thing a million times 😬😂
Reposted by Sahar
I love finding a paper published years ago (5, 10, 15, 20) that isn't famous or field changing or has a ton of citations but when you read it is just awesome. Like, beautifully designed & executed & written. Best part is that there are so many papers like that lurking in the literature.
November 6, 2025 at 6:13 PM
I love finding a paper published years ago (5, 10, 15, 20) that isn't famous or field changing or has a ton of citations but when you read it is just awesome. Like, beautifully designed & executed & written. Best part is that there are so many papers like that lurking in the literature.
mind blown
Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...
#ER_literature #Migration #Organelles
#ER_literature #Migration #Organelles
November 6, 2025 at 5:09 PM
mind blown
Reposted by Sahar
Janelia is hosting a course on DL for bioimage analysis www.janelia.org/you-janelia/...
Deep Learning for Microscopy Image Analysis
Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,
www.janelia.org
November 6, 2025 at 5:02 PM
Janelia is hosting a course on DL for bioimage analysis www.janelia.org/you-janelia/...
Reposted by Sahar
The FPbase spectra viewer just had it's biggest software refactor in 6 years. It *should* be largely invisible to the end user (hopefully just faster and less buggy). Please let me know if you find any issues as you use it!
www.fpbase.org/spectra/
www.fpbase.org/spectra/
FPbase Fluorescence Spectra Viewer
An interactive fluorescence spectra viewer to evaluate the spectral properties of fluorescent proteins, organic dyes, filters, and detectors.
www.fpbase.org
November 4, 2025 at 3:03 PM
The FPbase spectra viewer just had it's biggest software refactor in 6 years. It *should* be largely invisible to the end user (hopefully just faster and less buggy). Please let me know if you find any issues as you use it!
www.fpbase.org/spectra/
www.fpbase.org/spectra/
Reposted by Sahar
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
November 4, 2025 at 10:40 PM
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
Reposted by Sahar
Proud of our latest #glycotime review. Co-authored by my amazing cancer collaborator Dr. Eva Hernando and our students @faezehjame.bsky.social , Tigist Batu and Kylie Prutisto-Chang. 🧪
Glycosylation in Cancer: From Functional Roles to Therapeutic Implications - www.annualreviews.org/content/jour...
Glycosylation in Cancer: From Functional Roles to Therapeutic Implications - www.annualreviews.org/content/jour...
Glycosylation in Cancer: From Functional Roles to Therapeutic Implications
The field of cancer glycobiology aims to understand how aberrant glycosylation contributes to the development of cancer. While the significance of glycosylation to normal and pathological cellular fun...
www.annualreviews.org
November 5, 2025 at 1:03 AM
Proud of our latest #glycotime review. Co-authored by my amazing cancer collaborator Dr. Eva Hernando and our students @faezehjame.bsky.social , Tigist Batu and Kylie Prutisto-Chang. 🧪
Glycosylation in Cancer: From Functional Roles to Therapeutic Implications - www.annualreviews.org/content/jour...
Glycosylation in Cancer: From Functional Roles to Therapeutic Implications - www.annualreviews.org/content/jour...
Reposted by Sahar
Dr Donna Senger gave the next talk: Harnessing the power of macrophages for cancer therapy #CCRC2025
- 40% of a glioblastoma tumour can be recruited pro-tumour macrophages!
- inhibiting the expression of nuclear IL-33 reduces this recruitment/transformation
www.nature.com/articles/s41...
- 40% of a glioblastoma tumour can be recruited pro-tumour macrophages!
- inhibiting the expression of nuclear IL-33 reduces this recruitment/transformation
www.nature.com/articles/s41...
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression - Nature Communications
Elevated levels of interleukin-33 have been associated with poor prognosis in patients with glioma. Here the authors show that glioma-derived IL-33 modulates a pro-tumorigenic immune microenvironment ...
www.nature.com
November 2, 2025 at 6:50 PM
Dr Donna Senger gave the next talk: Harnessing the power of macrophages for cancer therapy #CCRC2025
- 40% of a glioblastoma tumour can be recruited pro-tumour macrophages!
- inhibiting the expression of nuclear IL-33 reduces this recruitment/transformation
www.nature.com/articles/s41...
- 40% of a glioblastoma tumour can be recruited pro-tumour macrophages!
- inhibiting the expression of nuclear IL-33 reduces this recruitment/transformation
www.nature.com/articles/s41...
cant imagine the sadness at union station tonight 🫠
November 2, 2025 at 4:29 AM
cant imagine the sadness at union station tonight 🫠
Reposted by Sahar
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sahar
ICYMI – Check out our latest #preprint list on FocalPlane, highlighting the latest tools and techniques in microscopy.
focalplane.biologists.com/2025/10/22/m...
focalplane.biologists.com/2025/10/22/m...
Microscopy preprints – new tools and techniques in imaging - FocalPlane
Microscopy preprints – new tools and techniques in imaging - News
focalplane.biologists.com
October 27, 2025 at 4:27 PM
ICYMI – Check out our latest #preprint list on FocalPlane, highlighting the latest tools and techniques in microscopy.
focalplane.biologists.com/2025/10/22/m...
focalplane.biologists.com/2025/10/22/m...
Reposted by Sahar
Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....
A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells
Photoswitchable fluorophores are critical for advanced bioimaging. Here, we develop a photoswitchable self-labeling HaloTag that can reversibly modulate the emission of a bound fluorogenic dye via a ....
onlinelibrary.wiley.com
October 25, 2025 at 8:56 AM
Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....
I love the GO train cuz you never know which aquaintance you'll randomly meet by pure chance
October 25, 2025 at 4:59 PM
I love the GO train cuz you never know which aquaintance you'll randomly meet by pure chance
Reposted by Sahar
How to develop good research questions
"This Comment describes the iterative creative process for designing good research questions, and includes practical suggestions and ways to avoid common traps."
www.nature.com/articles/s41...
"This Comment describes the iterative creative process for designing good research questions, and includes practical suggestions and ways to avoid common traps."
www.nature.com/articles/s41...
October 24, 2025 at 2:11 AM
How to develop good research questions
"This Comment describes the iterative creative process for designing good research questions, and includes practical suggestions and ways to avoid common traps."
www.nature.com/articles/s41...
"This Comment describes the iterative creative process for designing good research questions, and includes practical suggestions and ways to avoid common traps."
www.nature.com/articles/s41...
Reposted by Sahar
5-color STORM with a single laser using cos/sin filters and phasor plots: www.biorxiv.org/content/10.1...
We discussed along those lines with @malacridalab.bsky.social in Montevideo last year, great to see that it works!
We discussed along those lines with @malacridalab.bsky.social in Montevideo last year, great to see that it works!
October 24, 2025 at 6:51 AM
5-color STORM with a single laser using cos/sin filters and phasor plots: www.biorxiv.org/content/10.1...
We discussed along those lines with @malacridalab.bsky.social in Montevideo last year, great to see that it works!
We discussed along those lines with @malacridalab.bsky.social in Montevideo last year, great to see that it works!
Reposted by Sahar
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
October 21, 2025 at 11:14 AM
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Sahar
Golden Sky
6”x6” oil
Available
6”x6” oil
Available
October 18, 2025 at 5:38 PM
Golden Sky
6”x6” oil
Available
6”x6” oil
Available
Reposted by Sahar
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
October 13, 2025 at 8:47 PM
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...