Saber C. Saharkhiz🔬📊💻🧬
@sabersaharkhiz.bsky.social
PhD-ing Neuroscience🧠 @uOttawaMed @OHRI
Mol Cell Dev Biologist using AI for microscopy to study Neurodevelopmental disorders.
Views are my own.
Mol Cell Dev Biologist using AI for microscopy to study Neurodevelopmental disorders.
Views are my own.
Reposted by Saber C. Saharkhiz🔬📊💻🧬
Here’s a side-by-side comparison of the reference image input (from Sachs et al., 2009) and the AI generated figure (below)
November 24, 2025 at 7:49 PM
Here’s a side-by-side comparison of the reference image input (from Sachs et al., 2009) and the AI generated figure (below)
Reposted by Saber C. Saharkhiz🔬📊💻🧬
Gemini 3 created this figure in under 30 seconds from a couple reference images and a one sentence prompt
So I’m at a loss for words, honestly #MicroscopyMonday
So I’m at a loss for words, honestly #MicroscopyMonday
November 24, 2025 at 7:11 PM
Gemini 3 created this figure in under 30 seconds from a couple reference images and a one sentence prompt
So I’m at a loss for words, honestly #MicroscopyMonday
So I’m at a loss for words, honestly #MicroscopyMonday
WHat? ARe YoU SEriOus? Bullshit?????? @natureportfolio.nature.com
November 22, 2025 at 5:42 PM
WHat? ARe YoU SEriOus? Bullshit?????? @natureportfolio.nature.com
Reposted by Saber C. Saharkhiz🔬📊💻🧬
The Society for Neuroscience meeting starts tomorrow! I prepared some microscopy images for display at the convention center in San Diego. Let me know if you see one of my images around! 🤓 🔬 🧠
@sfn.org #SfN25 #FluorescenceFriday
@sfn.org #SfN25 #FluorescenceFriday
November 14, 2025 at 6:37 PM
The Society for Neuroscience meeting starts tomorrow! I prepared some microscopy images for display at the convention center in San Diego. Let me know if you see one of my images around! 🤓 🔬 🧠
@sfn.org #SfN25 #FluorescenceFriday
@sfn.org #SfN25 #FluorescenceFriday
And many research papers confirm that quote as well!
November 14, 2025 at 2:30 AM
And many research papers confirm that quote as well!
I always start my talks with this slide to encourage the audience, especially biologists 🧬🔬, to learn coding. This quote from the legendary Steve Jobs 🧑🏻💻 reshaped my research path almost 5 years ago, when I was a biologist with no computer science background.
November 14, 2025 at 1:58 AM
I always start my talks with this slide to encourage the audience, especially biologists 🧬🔬, to learn coding. This quote from the legendary Steve Jobs 🧑🏻💻 reshaped my research path almost 5 years ago, when I was a biologist with no computer science background.
Reposted by Saber C. Saharkhiz🔬📊💻🧬
A whole-brain single-cell atlas of circadian neural activity in mice | Science www.science.org/doi/10.1126/...
A whole-brain single-cell atlas of circadian neural activity in mice
The mammalian brain comprises numerous anatomical regions with distinct functions despite their extensive connectivity. However, how spontaneous neural activity is coordinated across regions over the ...
www.science.org
November 13, 2025 at 7:07 PM
A whole-brain single-cell atlas of circadian neural activity in mice | Science www.science.org/doi/10.1126/...
Do you know how many genetic tools used to visualize only the nuclei of these neurons? (From my PhD work)
1. Endogenous CRISPR knock-in tag
2. Promotor transgene fused to Histone
3. Endogenous CRISPR knock-in dual color tag with self-cleaving peptide T2A fused to Histone.
#FluorescenceFriday
1. Endogenous CRISPR knock-in tag
2. Promotor transgene fused to Histone
3. Endogenous CRISPR knock-in dual color tag with self-cleaving peptide T2A fused to Histone.
#FluorescenceFriday
November 9, 2025 at 5:39 AM
Do you know how many genetic tools used to visualize only the nuclei of these neurons? (From my PhD work)
1. Endogenous CRISPR knock-in tag
2. Promotor transgene fused to Histone
3. Endogenous CRISPR knock-in dual color tag with self-cleaving peptide T2A fused to Histone.
#FluorescenceFriday
1. Endogenous CRISPR knock-in tag
2. Promotor transgene fused to Histone
3. Endogenous CRISPR knock-in dual color tag with self-cleaving peptide T2A fused to Histone.
#FluorescenceFriday
Reposted by Saber C. Saharkhiz🔬📊💻🧬
Beating iPSC-derived heart muscle cells videoed through a microscope. Alpha-actinin-2 is shown. #CellBiology
November 9, 2025 at 3:12 AM
Beating iPSC-derived heart muscle cells videoed through a microscope. Alpha-actinin-2 is shown. #CellBiology
Reposted by Saber C. Saharkhiz🔬📊💻🧬
Required reading for cell biologists to get a sense of basic statistical principles!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ten essential tips for robust statistics in cell biology - Nature Cell Biology
Statistical thinking is a core part of solid, trustworthy biology. However, many studies still include insufficient sample sizes, have poor experimental design or select an incorrect statistical metho...
www.nature.com
November 4, 2025 at 7:23 PM
Required reading for cell biologists to get a sense of basic statistical principles!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Saber C. Saharkhiz🔬📊💻🧬
It's Halloween 🎃 #FlourescenceFriday! Here is a microscopic pumpkin generated by showing a cell nucleus in 🟠 with the primary cilium "stem" in 🟢! I hope everyone has a spooky 👻 day! 🔬 by @stjuderesearch.bsky.social grad student Christina Wang. 🧪
October 31, 2025 at 3:14 PM
It's Halloween 🎃 #FlourescenceFriday! Here is a microscopic pumpkin generated by showing a cell nucleus in 🟠 with the primary cilium "stem" in 🟢! I hope everyone has a spooky 👻 day! 🔬 by @stjuderesearch.bsky.social grad student Christina Wang. 🧪
Reposted by Saber C. Saharkhiz🔬📊💻🧬
#Atherosclerosis Epitranscriptomics
Mettl3-YTHDF3⏫m6A-MTRFA mRNA in SMCs➡️
⏫cholesterol-induced Mφ-like phenotype
SMC Mettl3 KO🐭+HFD AAV-PCSK9➡️
⏬Lesion burden, necrotic core, Mφ
👉Abolishes SMC contribution to lesion!
👉Reverted by AAV9-SM22-MRTFA
#CardiovascRes 2025
academic.oup.com/cardiovascre...
Mettl3-YTHDF3⏫m6A-MTRFA mRNA in SMCs➡️
⏫cholesterol-induced Mφ-like phenotype
SMC Mettl3 KO🐭+HFD AAV-PCSK9➡️
⏬Lesion burden, necrotic core, Mφ
👉Abolishes SMC contribution to lesion!
👉Reverted by AAV9-SM22-MRTFA
#CardiovascRes 2025
academic.oup.com/cardiovascre...
October 30, 2025 at 8:23 PM
#Atherosclerosis Epitranscriptomics
Mettl3-YTHDF3⏫m6A-MTRFA mRNA in SMCs➡️
⏫cholesterol-induced Mφ-like phenotype
SMC Mettl3 KO🐭+HFD AAV-PCSK9➡️
⏬Lesion burden, necrotic core, Mφ
👉Abolishes SMC contribution to lesion!
👉Reverted by AAV9-SM22-MRTFA
#CardiovascRes 2025
academic.oup.com/cardiovascre...
Mettl3-YTHDF3⏫m6A-MTRFA mRNA in SMCs➡️
⏫cholesterol-induced Mφ-like phenotype
SMC Mettl3 KO🐭+HFD AAV-PCSK9➡️
⏬Lesion burden, necrotic core, Mφ
👉Abolishes SMC contribution to lesion!
👉Reverted by AAV9-SM22-MRTFA
#CardiovascRes 2025
academic.oup.com/cardiovascre...
October 29, 2025 at 7:07 PM
Reposted by Saber C. Saharkhiz🔬📊💻🧬
Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation, say Ana Dias Maia Henriques, Julien Dumont, Gilliane Maton and colleagues @ijmonod.bsky.social: rupress.org/jcb/article/...
#Development #CellCycle #CellDivision #Celegans #Mitosis
#Development #CellCycle #CellDivision #Celegans #Mitosis
October 29, 2025 at 1:31 PM
Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation, say Ana Dias Maia Henriques, Julien Dumont, Gilliane Maton and colleagues @ijmonod.bsky.social: rupress.org/jcb/article/...
#Development #CellCycle #CellDivision #Celegans #Mitosis
#Development #CellCycle #CellDivision #Celegans #Mitosis
Reposted by Saber C. Saharkhiz🔬📊💻🧬
Episode 17 - perhaps my favorite yet. How do you write a forum.image.sc post that will get you the answers you need without revealing information you don't want to tell? @erinweisbart.bsky.social and I go through what the experts need to know to help you. Post your sci q's today on forum.image.sc !
October 27, 2025 at 6:20 PM
Episode 17 - perhaps my favorite yet. How do you write a forum.image.sc post that will get you the answers you need without revealing information you don't want to tell? @erinweisbart.bsky.social and I go through what the experts need to know to help you. Post your sci q's today on forum.image.sc !
Reposted by Saber C. Saharkhiz🔬📊💻🧬
As spooky season is upon us 🎃, we have cells that look like spider webs for #FluorescenceFriday 🧪🔬
October 24, 2025 at 7:03 PM
As spooky season is upon us 🎃, we have cells that look like spider webs for #FluorescenceFriday 🧪🔬
Reposted by Saber C. Saharkhiz🔬📊💻🧬
🧪 🤩 🔬
An iPSC-cardiac myocyte (heart muscle cell) in cell culture photographed through a microscope by former Burnette lab graduate student, Dr. James Hayes. We are preparing cover submissions for his last two first author papers from the lab! Actin filaments are shown. #CellBiology
October 22, 2025 at 4:20 PM
🧪 🤩 🔬
Reposted by Saber C. Saharkhiz🔬📊💻🧬
💡Just presented our new paper at the @iccv.bsky.social BioImage Computing workshop: cubic: CUDA-accelerated 3D Bioimage Computing. We introduce a simple way to add GPU acceleration to scikit-image–based bioimage processing pipelines by swapping import statements. 🧵
1/6 #iccv2025
1/6 #iccv2025
October 23, 2025 at 6:01 PM
💡Just presented our new paper at the @iccv.bsky.social BioImage Computing workshop: cubic: CUDA-accelerated 3D Bioimage Computing. We introduce a simple way to add GPU acceleration to scikit-image–based bioimage processing pipelines by swapping import statements. 🧵
1/6 #iccv2025
1/6 #iccv2025
Reposted by Saber C. Saharkhiz🔬📊💻🧬
We just hit 10 workshops submitted, with almost two weeks to go! Help us get to 20 before the last-day frantic mad dash? Teach your favorite tool today!
Halfway to I2K is BACK, friends of all kinds! Last year, 650 people attended 30+ TOTALLY FREE image analysis workshops of all kinds, across many timezones.
If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.
If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.
#HappyFluorescenceFriday!
#microscopycommunity- want to learn open source image analysis or share your knowledge to help others? We’ve got a FREE virtual workshop Nov 17-19! Now accepting workshop session applications!
Learn more & sign up: buff.ly/esGIotD
#microscopycommunity- want to learn open source image analysis or share your knowledge to help others? We’ve got a FREE virtual workshop Nov 17-19! Now accepting workshop session applications!
Learn more & sign up: buff.ly/esGIotD
October 20, 2025 at 2:52 PM
We just hit 10 workshops submitted, with almost two weeks to go! Help us get to 20 before the last-day frantic mad dash? Teach your favorite tool today!
Reposted by Saber C. Saharkhiz🔬📊💻🧬
Happy #FluorescenceFriday! This is a maximum intensity projection of depth shaded actin (🌈) in a section from an E9.5 🐭 neural tube (NT). 🔬 by postdoc @christinaadaly.bsky.social 👩🔬 🧪 Image shows the floor plate and lumen of the developing NT.
#SciArt #DevBio #DevNeuro
#SciArt #DevBio #DevNeuro
October 10, 2025 at 3:19 PM
Happy #FluorescenceFriday! This is a maximum intensity projection of depth shaded actin (🌈) in a section from an E9.5 🐭 neural tube (NT). 🔬 by postdoc @christinaadaly.bsky.social 👩🔬 🧪 Image shows the floor plate and lumen of the developing NT.
#SciArt #DevBio #DevNeuro
#SciArt #DevBio #DevNeuro
Reposted by Saber C. Saharkhiz🔬📊💻🧬
Today for #FluorescenceFriday I’m sharing a 👻Halloween-themed🎃 neural crest explant “web of cells” from Julia Godinez, a 4th year @ucdavis.bsky.social graduate student in the lab. She is studying mechanisms driving conserved and divergent cranial neural crest migration and differentiation. #DevBio
October 17, 2025 at 8:21 PM
Today for #FluorescenceFriday I’m sharing a 👻Halloween-themed🎃 neural crest explant “web of cells” from Julia Godinez, a 4th year @ucdavis.bsky.social graduate student in the lab. She is studying mechanisms driving conserved and divergent cranial neural crest migration and differentiation. #DevBio
Reposted by Saber C. Saharkhiz🔬📊💻🧬
Accurate somatic small variant discovery for multiple sequencing technologies with DeepSomatic www.nature.com/articles/s41... (read free: rdcu.be/eLny0) github.com/google/deeps...
October 16, 2025 at 7:29 PM
Accurate somatic small variant discovery for multiple sequencing technologies with DeepSomatic www.nature.com/articles/s41... (read free: rdcu.be/eLny0) github.com/google/deeps...
My son is so tired💤🤭😂🦜🪶
October 16, 2025 at 8:24 PM
My son is so tired💤🤭😂🦜🪶