Second part of Thinking like a Scientist, reflecting on how genome editing and multi-omics, while powerful, can introduce conceptual flaws that distort our understanding of gene function and biologica...

Recent clinical successes, and profits, have prompted a rush among pharma companies to try new isotopes and targeting strategies

imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

imageimagePathway-focused metabolite ratio-based analysis of 49 tumor and 8 normal epithelial cell lines grown in their respective standard conditions reveals common and distinctive metabolic signatur...

Dang et al. report that group-3 medulloblastomas (MBs) show c-MYC-driven high DLAT expression. In these tumors, wild-type IDH1 epigenetically regulates c-MYC, and inhibiting IDH1 lowers c-MYC and DLAT expression. Further, DLAT sensitizes group-3 MBs to cuproptosis. Notably, the copper ionophore elesclomol is toxic to multiple group-3 MB models, underscoring its therapeutic potential.

A population of TRAIL-positive astrocytes in glioblastoma contributes to an immunosuppressive tumour microenvironment and this mechanism can be targeted with an engineered oncolytic virus to improve o...

(Cell Metabolism 37, 1–16.e1–e4; July 1, 2025)

Neurons in a brain region linked with substance-use disorders can affect how much pain is felt when stopping chronic opioid use.

Radiotherapy induces expression of the EGFR ligand amphiregulin, which promotes metastasis growth at remote sites in mouse models and human patients by shifting myeloid cells towards an immunosup...

The taurine–taurine transporter axis is a critical dependency of aggressive myeloid leukaemias.