Hoy Lipid Metabolism Lab
@hoylipidlab.bsky.social
Located the Charles Perkins Centre at the University of Sydney with research interests in type 2 diabetes, cancer metabolism, and obesity led by A/Prof Andrew Hoy
Reposted by Hoy Lipid Metabolism Lab
Measuring mitochondrial membrane potential
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
November 17, 2025 at 2:28 PM
Measuring mitochondrial membrane potential
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
@marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells
www.embopress.org/doi/full/10....
Reposted by Hoy Lipid Metabolism Lab
As a reviewer, please don't overuse AI to write your grants. I understand the need for a quick editing/grammar check, but the structure of the paragraphs and the logic is absolutely awful. I can spot it in a nanosecond.
October 29, 2025 at 5:20 PM
As a reviewer, please don't overuse AI to write your grants. I understand the need for a quick editing/grammar check, but the structure of the paragraphs and the logic is absolutely awful. I can spot it in a nanosecond.
Reposted by Hoy Lipid Metabolism Lab
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Hoy Lipid Metabolism Lab
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 8:45 PM
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
Reposted by Hoy Lipid Metabolism Lab
reactant and product metabolite ratios revealed metabolic pathways differences between cancer subtypes and noncancer cell lines by @hoylipidlab.bsky.social @sydneyprecisionds.bsky.social @nancyts.bsky.social ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 10:11 AM
reactant and product metabolite ratios revealed metabolic pathways differences between cancer subtypes and noncancer cell lines by @hoylipidlab.bsky.social @sydneyprecisionds.bsky.social @nancyts.bsky.social ➡️ www.embopress.org/doi/full/10....
Reposted by Hoy Lipid Metabolism Lab
This is such an incredible paper. Must read if you care about metabolites and cores organ interactions. For me most interesting finding is that the liver is NOT the only organ that converts cholesterol to bile acids. But ther are so many cool onserbwtions www.cell.com/cell/abstrac...
Cross-organ metabolite production and consumption in healthy and atherogenic conditions
An atlas mapping organ-specific metabolite production and consumption across various
pathophysiological states in pigs shows impaired metabolic activity across organs
by a Western diet or hypercholest...
www.cell.com
June 12, 2025 at 3:41 AM
This is such an incredible paper. Must read if you care about metabolites and cores organ interactions. For me most interesting finding is that the liver is NOT the only organ that converts cholesterol to bile acids. But ther are so many cool onserbwtions www.cell.com/cell/abstrac...
Incredibly proud of our latest publication in @molsystbiol.org led by @nancyts.bsky.social in collab w/ Jean Yang and Lake-Ee Quek - www.embopress.org/doi/full/10....
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.
Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells | Molecular Systems Biology
imageimagePathway-focused metabolite ratio-based analysis of 49 tumor and 8 normal epithelial
cell lines grown in their respective standard conditions reveals common and distinctive
metabolic signatur...
www.embopress.org
June 6, 2025 at 1:23 AM
Incredibly proud of our latest publication in @molsystbiol.org led by @nancyts.bsky.social in collab w/ Jean Yang and Lake-Ee Quek - www.embopress.org/doi/full/10....
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.
We curated targeted metabolomic data into pathway-centric ratios and identified subclusters of cancer cells with distinct features.
Reposted by Hoy Lipid Metabolism Lab
Our group leader Prof Nigel Turner was interviewed for the Guardian earlier this week, discussing the hype and hope for NAD+ boosters as anti-ageing therapeutics. Read what he (and our collaborator A/Prof Lindsay Wu) had to say about it here: www.theguardian.com/australia-ne... 🧪
NAD boosters: Kendall Jenner and Hailey Bieber are into them, but do they actually stop ageing? | Antiviral
Despite social media hype, there is little evidence that the therapies, marketed as pills, shots and IV infusions, have any effects on ageing
www.theguardian.com
April 2, 2025 at 11:43 PM
Our group leader Prof Nigel Turner was interviewed for the Guardian earlier this week, discussing the hype and hope for NAD+ boosters as anti-ageing therapeutics. Read what he (and our collaborator A/Prof Lindsay Wu) had to say about it here: www.theguardian.com/australia-ne... 🧪
Reposted by Hoy Lipid Metabolism Lab
A Future Made in Australia … as long as no new knowledge is needed.
No budget increase for the Australian Research Council 😡
March 25, 2025 at 8:58 AM
A Future Made in Australia … as long as no new knowledge is needed.
Reposted by Hoy Lipid Metabolism Lab
ARC has “paused” future rounds of grant schemes pending outcomes of its NCGP Policy Review.
All schemes previously scheduled to open before 1 July this year will go ahead.
But next year’s Laureates, Industry Fellowships & Discovery Indigenous won’t.
See table👇 & www.arc.gov.au/funding-rese...
All schemes previously scheduled to open before 1 July this year will go ahead.
But next year’s Laureates, Industry Fellowships & Discovery Indigenous won’t.
See table👇 & www.arc.gov.au/funding-rese...
March 20, 2025 at 5:59 AM
ARC has “paused” future rounds of grant schemes pending outcomes of its NCGP Policy Review.
All schemes previously scheduled to open before 1 July this year will go ahead.
But next year’s Laureates, Industry Fellowships & Discovery Indigenous won’t.
See table👇 & www.arc.gov.au/funding-rese...
All schemes previously scheduled to open before 1 July this year will go ahead.
But next year’s Laureates, Industry Fellowships & Discovery Indigenous won’t.
See table👇 & www.arc.gov.au/funding-rese...
Reposted by Hoy Lipid Metabolism Lab
happy to share our forum now online @Cell_Metabolism! fun for us (Guy & myself) to collaborate with @dfazakerley.bsky.social, Joycelyn, & Sam in putting together what we hope will be a useful piece for the broad metabolism community re: in vitro modeling! www.cell.com/cell-metabol...
Seeing the world through the eyes of cultured cells
The metabolic environment experienced by cultured cells often differs from physiological
conditions. Here, we highlight the effects that the microenvironment can have on cultured
cell behavior and adv...
www.cell.com
March 12, 2025 at 3:54 PM
happy to share our forum now online @Cell_Metabolism! fun for us (Guy & myself) to collaborate with @dfazakerley.bsky.social, Joycelyn, & Sam in putting together what we hope will be a useful piece for the broad metabolism community re: in vitro modeling! www.cell.com/cell-metabol...
Reposted by Hoy Lipid Metabolism Lab
When I try to explain how things are actually getting worse, people look at me like I'm crazy.This piece is spot on. #SIStem (senior #womeninSTEM)
"Women full professors are 19% more likely than men at the same career stage to leave academia, as compared with 6% for women assistant professors and 10% for associates."
Women faculty feel ‘pushed’ from academia by poor workplace climate
The gender gap in faculty attrition worsens after tenure, according to a new study
www.science.org
December 9, 2024 at 12:07 PM
When I try to explain how things are actually getting worse, people look at me like I'm crazy.This piece is spot on. #SIStem (senior #womeninSTEM)
Reposted by Hoy Lipid Metabolism Lab
Join us in Austin, TXm Feb 9-10 2025, for an Abcam-sponsored symposium on Cancer and Metabolism. -RJD
events.abcam.com/event/cancer...
events.abcam.com/event/cancer...
Home - Cancer and Metabolism
events.abcam.com
December 5, 2024 at 11:18 PM
Join us in Austin, TXm Feb 9-10 2025, for an Abcam-sponsored symposium on Cancer and Metabolism. -RJD
events.abcam.com/event/cancer...
events.abcam.com/event/cancer...
Reposted by Hoy Lipid Metabolism Lab
a fitting first post to mark the beautiful PhD thesis defense this afternoon from our lab’s very first student! Kim’s courage to join a brand-new lab and her ensuing grit, enthusiasm, and creativity were exceptional! extremely proud of all she has achieved, stay tuned for some of her cool findings!
December 3, 2024 at 10:48 PM
a fitting first post to mark the beautiful PhD thesis defense this afternoon from our lab’s very first student! Kim’s courage to join a brand-new lab and her ensuing grit, enthusiasm, and creativity were exceptional! extremely proud of all she has achieved, stay tuned for some of her cool findings!
Reposted by Hoy Lipid Metabolism Lab
I'm thrilled to share our latest research, published in Nature Communications. This work highlights how pancreatic cancer cells hijack cell polarity proteins to regulate macropinocytosis and tumor metabolism, shedding light on potential therapeutic vulnerabilities.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cell polarity proteins promote macropinocytosis in response to metabolic stress - Nature Communications
Cancer cells rely on macropinocytosis to survive in a nutrient-deprived environment. Here, Lambies et al. identified various members of the cell polarity protein network as essential regulators of mac...
www.nature.com
December 4, 2024 at 12:52 AM
I'm thrilled to share our latest research, published in Nature Communications. This work highlights how pancreatic cancer cells hijack cell polarity proteins to regulate macropinocytosis and tumor metabolism, shedding light on potential therapeutic vulnerabilities.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Hoy Lipid Metabolism Lab
November 15, 2024 at 12:59 AM
Reposted by Hoy Lipid Metabolism Lab
We are hiring! There is still time to apply for an open postdoc position in stem cell metabolomics (mass spec experience required) in our lab, and we’ll soon open applications for a PhD student interested in studying metabolic crosstalk in the bone marrow (but feel free to already send me your CV)!
November 29, 2024 at 2:01 PM
We are hiring! There is still time to apply for an open postdoc position in stem cell metabolomics (mass spec experience required) in our lab, and we’ll soon open applications for a PhD student interested in studying metabolic crosstalk in the bone marrow (but feel free to already send me your CV)!
So good - @voodooglowskulls.bsky.social and Hey Smith in Sydney!
November 29, 2024 at 1:45 PM
So good - @voodooglowskulls.bsky.social and Hey Smith in Sydney!
Reposted by Hoy Lipid Metabolism Lab
We've seen this movie before, Minister @jasonclaremp.bsky.social, in Japan.
Please help us take a different path!
Please help us take a different path!
This article, in Nature, is called “Japanese research no longer world class — here's why”: www.nature.com/articles/d41...
But it could be called “Australian research in danger from underfunding & time fragmentation”.
This bit sounds eerily familiar👇
But it could be called “Australian research in danger from underfunding & time fragmentation”.
This bit sounds eerily familiar👇
November 29, 2024 at 5:13 AM
We've seen this movie before, Minister @jasonclaremp.bsky.social, in Japan.
Please help us take a different path!
Please help us take a different path!
Reposted by Hoy Lipid Metabolism Lab
We’ve had nearly 3 years of review, review, review.
We need reviews, but it’s blindingly obvious that Australian research needs much greater Government investment while those reviews are done.
This was true 3 years ago. Still true now.
By @drjr.bsky.social
We need reviews, but it’s blindingly obvious that Australian research needs much greater Government investment while those reviews are done.
This was true 3 years ago. Still true now.
By @drjr.bsky.social
Falling enrolments and funding cuts force Australian universities to take stock
The Australian Universities Accord offers a roadmap for reform, but there are major challenges ahead.
www.nature.com
November 29, 2024 at 5:13 AM
We’ve had nearly 3 years of review, review, review.
We need reviews, but it’s blindingly obvious that Australian research needs much greater Government investment while those reviews are done.
This was true 3 years ago. Still true now.
By @drjr.bsky.social
We need reviews, but it’s blindingly obvious that Australian research needs much greater Government investment while those reviews are done.
This was true 3 years ago. Still true now.
By @drjr.bsky.social
Reposted by Hoy Lipid Metabolism Lab
Only a subset of patients respond to immunotherapy
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
November 27, 2024 at 2:13 PM
Only a subset of patients respond to immunotherapy
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
Reposted by Hoy Lipid Metabolism Lab
You can't save your university by cutting. That's an illusion. You can only weaken it further. See: the logic of Mr George Osborne, 2010-c.2013. Every redundancy programme in fact takes you closer to the edge. How can there still be people out there who don't realise this?
November 26, 2024 at 5:37 PM
You can't save your university by cutting. That's an illusion. You can only weaken it further. See: the logic of Mr George Osborne, 2010-c.2013. Every redundancy programme in fact takes you closer to the edge. How can there still be people out there who don't realise this?
Reposted by Hoy Lipid Metabolism Lab
If your #NHMRC ideas grant was unsuccessful and you have a story to share about the impact of this on your #biomedicalresearch, career, team - get in touch. Federal DOH have asked #NARF to collect stories of impact of low funding. #SaveOzScience #DiscoveriesNeedDollars #EMCRs
November 26, 2024 at 1:46 AM
If your #NHMRC ideas grant was unsuccessful and you have a story to share about the impact of this on your #biomedicalresearch, career, team - get in touch. Federal DOH have asked #NARF to collect stories of impact of low funding. #SaveOzScience #DiscoveriesNeedDollars #EMCRs
Reposted by Hoy Lipid Metabolism Lab
Huge day in Australian Research with grant outcomes for both #ARC Discovery Projects and #NHMRC Ideas released.
Congratulations to all those successful, and sincere apologies to the >85-90% who missed out. It's a brutal, brutal system with so many great grants and research missing out.
Congratulations to all those successful, and sincere apologies to the >85-90% who missed out. It's a brutal, brutal system with so many great grants and research missing out.
November 26, 2024 at 2:07 AM