RajuBrainLab
@rajubrainlab.bsky.social
Physician-scientist; Director, Pediatric Neuro-Oncology @radychildrens, @UCSDNeuroDept, @UCSDCancer, #medulloblastoma,#DIPG,#infantbraintumors, #Neurofibromatosis/NF
Reposted by RajuBrainLab
Thanks @contagionlive.bsky.social for letting me put in some unscripted words
UC San Diego is the ideal place to receive your dream education or pursue a faculty career in collaborative medical or pharmaceutical sciences
@ucsandiego.bsky.social
@ucsdmedschool.bsky.social
@ucsdpharmacy.bsky.social
UC San Diego is the ideal place to receive your dream education or pursue a faculty career in collaborative medical or pharmaceutical sciences
@ucsandiego.bsky.social
@ucsdmedschool.bsky.social
@ucsdpharmacy.bsky.social
UC San Diego’s Collaborative Research Efforts, Community-Based Care Initiatives are in its DNA
Victor Nizet, MD, discusses how students can thrive at the university’s Skaggs School of Pharmacy and Pharmaceutical Sciences. He discusses the school's features including its rigorous coursework, foc...
www.contagionlive.com
September 20, 2025 at 5:47 AM
Thanks @contagionlive.bsky.social for letting me put in some unscripted words
UC San Diego is the ideal place to receive your dream education or pursue a faculty career in collaborative medical or pharmaceutical sciences
@ucsandiego.bsky.social
@ucsdmedschool.bsky.social
@ucsdpharmacy.bsky.social
UC San Diego is the ideal place to receive your dream education or pursue a faculty career in collaborative medical or pharmaceutical sciences
@ucsandiego.bsky.social
@ucsdmedschool.bsky.social
@ucsdpharmacy.bsky.social
Reposted by RajuBrainLab
Before coming to NIH, Collins identified the gene that is mutated in cystic fibrosis (CF). Years later, this discovery led to the development of an innovative therapy for CF that's saved countless children.
This is why we fight.
www.nejm.org/doi/full/10....
This is why we fight.
www.nejm.org/doi/full/10....
July 25, 2025 at 7:10 AM
Before coming to NIH, Collins identified the gene that is mutated in cystic fibrosis (CF). Years later, this discovery led to the development of an innovative therapy for CF that's saved countless children.
This is why we fight.
www.nejm.org/doi/full/10....
This is why we fight.
www.nejm.org/doi/full/10....
Reposted by RajuBrainLab
As a #childhoodcancer doctor, I'm proud to be able to advocate for children with cancer in any way that I can.
Here is a piece that I recently wrote for #TheDetroitNews, who kindly published it.
#PEDCan
#CANSky
www.detroitnews.com/story/opinio...
Here is a piece that I recently wrote for #TheDetroitNews, who kindly published it.
#PEDCan
#CANSky
www.detroitnews.com/story/opinio...
Prensner: ‘Big Beautiful Bill’ betrays children with cancer
In the United States, we’ve fought to achieve the world’s best care for children with cancer.
www.detroitnews.com
July 10, 2025 at 4:37 PM
As a #childhoodcancer doctor, I'm proud to be able to advocate for children with cancer in any way that I can.
Here is a piece that I recently wrote for #TheDetroitNews, who kindly published it.
#PEDCan
#CANSky
www.detroitnews.com/story/opinio...
Here is a piece that I recently wrote for #TheDetroitNews, who kindly published it.
#PEDCan
#CANSky
www.detroitnews.com/story/opinio...
Reposted by RajuBrainLab
This rapid action by the Prebys Foundation is the kind of thing I hope other regional philanthropies are doing. It isn't the entire solution by far but it is great to see them chipping in to help investigators in the San Diego academic science community.
www.prebysfdn.org/stories/blog...
www.prebysfdn.org/stories/blog...
Prebys Foundation Announces $7 Million in Emergency Support for Biomedical Research
www.prebysfdn.org
July 3, 2025 at 9:38 PM
This rapid action by the Prebys Foundation is the kind of thing I hope other regional philanthropies are doing. It isn't the entire solution by far but it is great to see them chipping in to help investigators in the San Diego academic science community.
www.prebysfdn.org/stories/blog...
www.prebysfdn.org/stories/blog...
Reposted by RajuBrainLab
Beyond taking #healthcare away from millions of kids, families, and the elderly, the Budget-Busting Bill would mean the loss of thousands of jobs in hospitals, research centers, nursing homes, clinics, doctors’ offices.
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
How Health Care Remade the U.S. Economy (Gift Article)
Medicine is now the nation’s largest employer, but its growth may be slowing.
www.nytimes.com
July 3, 2025 at 11:48 AM
Beyond taking #healthcare away from millions of kids, families, and the elderly, the Budget-Busting Bill would mean the loss of thousands of jobs in hospitals, research centers, nursing homes, clinics, doctors’ offices.
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Reposted by RajuBrainLab
“I represent 67,000 pediatricians, and let me be clear: this bill will devastate children’s health,” said Dr. Susan Kressly, President of @ameracadpeds.bsky.social “Kids are 22% of our population—but 100% of our future. We cannot afford to fail them.”
Call your senators and demand a NO vote.
Call your senators and demand a NO vote.
June 29, 2025 at 11:31 PM
“I represent 67,000 pediatricians, and let me be clear: this bill will devastate children’s health,” said Dr. Susan Kressly, President of @ameracadpeds.bsky.social “Kids are 22% of our population—but 100% of our future. We cannot afford to fail them.”
Call your senators and demand a NO vote.
Call your senators and demand a NO vote.
Reposted by RajuBrainLab
The promise and problems with multi-cancer early detection tests
by Sid Mukherjee @newyorker.com
www.newyorker.com/magazine/202...
by Sid Mukherjee @newyorker.com
www.newyorker.com/magazine/202...
The Catch in Catching Cancer Early
New blood tests promise to detect malignancies before they’ve spread. But proving that these tests actually improve outcomes remains a stubborn challenge.
www.newyorker.com
June 16, 2025 at 2:17 PM
The promise and problems with multi-cancer early detection tests
by Sid Mukherjee @newyorker.com
www.newyorker.com/magazine/202...
by Sid Mukherjee @newyorker.com
www.newyorker.com/magazine/202...
Nice to see this important translational hurdle- crossing the BBB- highlighted in Nature! Of note is the point that it would be ideal to not only cross the BBB, but deliver therapeutics specifically to the CNS site of disease which current brain shuttles don’t do. Stay tuned:) #SelectinTherapeutics
Brain shuttles - new technologies to traverse the blood-brain barrier - are showing promise in Alzheimer's, cancer, and more
https://go.nature.com/3T5WuF7
https://go.nature.com/3T5WuF7
Brain drugs can now cross the once impenetrable blood–brain barrier
Nature - New technologies to shuttle drugs into the brain are showing promise in Alzheimer’s disease, cancer and more.
go.nature.com
June 4, 2025 at 1:25 PM
Nice to see this important translational hurdle- crossing the BBB- highlighted in Nature! Of note is the point that it would be ideal to not only cross the BBB, but deliver therapeutics specifically to the CNS site of disease which current brain shuttles don’t do. Stay tuned:) #SelectinTherapeutics
Reposted by RajuBrainLab
Reposted by RajuBrainLab
Tumor antigens preferentially derive from unmutated genomic sequences in melanoma and non-small cell lung cancer
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Tumor antigens preferentially derive from unmutated genomic sequences in melanoma and non-small cell lung cancer - Nature Cancer
Based on a proteogenomic analysis, Perreault and colleagues report that the majority of predicted tumor antigens originate from unmutated genomic sequences in melanoma and non-small cell lung cancer.
www.nature.com
June 3, 2025 at 7:27 PM
Tumor antigens preferentially derive from unmutated genomic sequences in melanoma and non-small cell lung cancer
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by RajuBrainLab
My quote of the day
If an elderly but distinguished scientist says that something is possible, he is almost certainly right; but if he says that it is impossible, he is very probably wrong.
Arthur C. Clarke
If an elderly but distinguished scientist says that something is possible, he is almost certainly right; but if he says that it is impossible, he is very probably wrong.
Arthur C. Clarke
June 1, 2025 at 1:05 PM
My quote of the day
If an elderly but distinguished scientist says that something is possible, he is almost certainly right; but if he says that it is impossible, he is very probably wrong.
Arthur C. Clarke
If an elderly but distinguished scientist says that something is possible, he is almost certainly right; but if he says that it is impossible, he is very probably wrong.
Arthur C. Clarke
Reposted by RajuBrainLab
CBTN offers pediatric brain tumor data and samples to researchers worldwide for free. Request these resources to accelerate discoveries for kids: https://monkeylink.co/5c6c96
#WeAreCBTN #OpenScience
#WeAreCBTN #OpenScience
May 29, 2025 at 4:30 PM
CBTN offers pediatric brain tumor data and samples to researchers worldwide for free. Request these resources to accelerate discoveries for kids: https://monkeylink.co/5c6c96
#WeAreCBTN #OpenScience
#WeAreCBTN #OpenScience
Reposted by RajuBrainLab
Cuts to NIH funding have dire consequences!
Neuroscience Professor Robert Greene shares why efforts to treat brain disease will suffer due to recent changes in U.S. government policies.
#Neurosky #AcademicChatter
Neuroscience Professor Robert Greene shares why efforts to treat brain disease will suffer due to recent changes in U.S. government policies.
#Neurosky #AcademicChatter
May 23, 2025 at 3:01 PM
Cuts to NIH funding have dire consequences!
Neuroscience Professor Robert Greene shares why efforts to treat brain disease will suffer due to recent changes in U.S. government policies.
#Neurosky #AcademicChatter
Neuroscience Professor Robert Greene shares why efforts to treat brain disease will suffer due to recent changes in U.S. government policies.
#Neurosky #AcademicChatter
Reposted by RajuBrainLab
Medicaid Covers
• 42% of all children nationwide
• 77% of children living in poverty in the U.S.
• 44% of children and youth with special health care needs nationwide
• 41% of births in the U.S.
• 37% of U.S. children with cancer
• 99% of children and youth in foster care
• 42% of all children nationwide
• 77% of children living in poverty in the U.S.
• 44% of children and youth with special health care needs nationwide
• 41% of births in the U.S.
• 37% of U.S. children with cancer
• 99% of children and youth in foster care
May 7, 2025 at 4:48 PM
Medicaid Covers
• 42% of all children nationwide
• 77% of children living in poverty in the U.S.
• 44% of children and youth with special health care needs nationwide
• 41% of births in the U.S.
• 37% of U.S. children with cancer
• 99% of children and youth in foster care
• 42% of all children nationwide
• 77% of children living in poverty in the U.S.
• 44% of children and youth with special health care needs nationwide
• 41% of births in the U.S.
• 37% of U.S. children with cancer
• 99% of children and youth in foster care
Reposted by RajuBrainLab
A Characterization of the Immune Cells in Immunocompetent and Immunodeficient Mice with Orthotopic Brain Tumors. https://www.biorxiv.org/content/10.1101/2025.04.29.651335v1
May 5, 2025 at 3:49 AM
A Characterization of the Immune Cells in Immunocompetent and Immunodeficient Mice with Orthotopic Brain Tumors. https://www.biorxiv.org/content/10.1101/2025.04.29.651335v1
Reposted by RajuBrainLab
Cell classification should be based on more than just DNA
Cell classification should be based on more than just DNA
Letter to the Editor
www.nature.com
April 29, 2025 at 10:10 AM
Cell classification should be based on more than just DNA
Reposted by RajuBrainLab
Toxicity in phase III oncology clinical trials is often incompletely reported - Fumiko Ladd Chino
@fumikochino.bsky.social
oncodaily.com/opinion/fumi...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
@fumikochino.bsky.social
oncodaily.com/opinion/fumi...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
Fumiko Ladd Chino: Toxicity in phase III oncology clinical trials is often incompletely reported - OncoDaily
Fumiko Ladd Chino: Toxicity in phase III oncology clinical trials is often incompletely reported / Adina H Passy, Alexander D. Sherry, Avital M Miller,
oncodaily.com
April 6, 2025 at 10:04 PM
Toxicity in phase III oncology clinical trials is often incompletely reported - Fumiko Ladd Chino
@fumikochino.bsky.social
oncodaily.com/opinion/fumi...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
@fumikochino.bsky.social
oncodaily.com/opinion/fumi...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews
Reposted by RajuBrainLab
This bottleneck in research funding threatens research that took decades to build, as well as the cures of tomorrow. Publicly-funded research is the highest economic yield there is, with 2.5X of economic gains for every $.
Call your Senator and Rep to ask them to protect federal research!
Call your Senator and Rep to ask them to protect federal research!
So what's happening with medical research in the US? This is the cumulative award count from the NIH for the year.
Doesn't look so good.
But it gets worse.
1/
Doesn't look so good.
But it gets worse.
1/
March 2, 2025 at 9:55 PM
This bottleneck in research funding threatens research that took decades to build, as well as the cures of tomorrow. Publicly-funded research is the highest economic yield there is, with 2.5X of economic gains for every $.
Call your Senator and Rep to ask them to protect federal research!
Call your Senator and Rep to ask them to protect federal research!
Reposted by RajuBrainLab
The NIH grant that has supported 38 years of training the best pediatrician-scientists in the country (I’m a proud former recipient) was cancelled. It was just approved for a 5 year renewal. The PSDP has supported the careers of many NIH-funded pediatrician-scientists and thought leaders
March 25, 2025 at 2:53 PM
The NIH grant that has supported 38 years of training the best pediatrician-scientists in the country (I’m a proud former recipient) was cancelled. It was just approved for a 5 year renewal. The PSDP has supported the careers of many NIH-funded pediatrician-scientists and thought leaders
Reposted by RajuBrainLab
Pediatric research. When grants are pulled, the infrastructure suffers
www.wcvb.com/article/bost...
www.wcvb.com/article/bost...
March 20, 2025 at 12:08 AM
Pediatric research. When grants are pulled, the infrastructure suffers
www.wcvb.com/article/bost...
www.wcvb.com/article/bost...
Reposted by RajuBrainLab
On the front page of @cnn.com is a feature on how #NIH funding cuts might impact #childhoodcancer. Thanks to MJ Lee for spotlighting this issue, and I was glad to be able to contribute.
These kids deserve the best, not cuts!
#CANSky
#PEDSky
www.cnn.com/2025/02/25/h...
These kids deserve the best, not cuts!
#CANSky
#PEDSky
www.cnn.com/2025/02/25/h...
A kindergartner’s hopes for beating cancer are tied to federal grants now on the chopping block | CNN
A family whose 6-year-old is battling cancer says a move to slash funding by the National Institutes of Health (NIH) for research at universities and medical centers would be “devastating.”
www.cnn.com
February 25, 2025 at 4:24 PM
On the front page of @cnn.com is a feature on how #NIH funding cuts might impact #childhoodcancer. Thanks to MJ Lee for spotlighting this issue, and I was glad to be able to contribute.
These kids deserve the best, not cuts!
#CANSky
#PEDSky
www.cnn.com/2025/02/25/h...
These kids deserve the best, not cuts!
#CANSky
#PEDSky
www.cnn.com/2025/02/25/h...
Reposted by RajuBrainLab
Who benefits from US funding uncertainty? Hours after posting this, I got an email inviting me to China with a “package to support my research for 20 years.” Apparently, generous offers are available to all good scientists!🧪🧠
I expect that most academic biomedical researchers have considered leaving the US—if only in theory for now. What a colossal mess! Our representatives need to hear this. Please amplify so they know this matters. @levin.house.gov @repscottpeters.bsky.social @schiff.senate.gov @padilla.senate.gov
“For the last 75 yrs, the NIH has been the biggest funder of biomedical research in the world. Most advances in medicine were seeded by NIH funding. When we became scientists, we just bought into this system. This is how it works. — @tuthill.bsky.social 🧵
www.theguardian.com/us-news/2025...
www.theguardian.com/us-news/2025...
February 23, 2025 at 10:35 PM
Who benefits from US funding uncertainty? Hours after posting this, I got an email inviting me to China with a “package to support my research for 20 years.” Apparently, generous offers are available to all good scientists!🧪🧠
Reposted by RajuBrainLab
American science is under attack
Opinion piece by Dr Harold Varmus, Nobel Prize winner, former director of the #NIH and the #NCI 🧪
“Perhaps what’s most disheartening is what feels like the absence of widespread opposition to this unraveling”
www.nytimes.com/2025/02/14/o...
Opinion piece by Dr Harold Varmus, Nobel Prize winner, former director of the #NIH and the #NCI 🧪
“Perhaps what’s most disheartening is what feels like the absence of widespread opposition to this unraveling”
www.nytimes.com/2025/02/14/o...
Opinion | American Science is Under Attack (Gift Article)
The Trump administration hobbles research and endangers the public health.
www.nytimes.com
February 14, 2025 at 1:58 PM
American science is under attack
Opinion piece by Dr Harold Varmus, Nobel Prize winner, former director of the #NIH and the #NCI 🧪
“Perhaps what’s most disheartening is what feels like the absence of widespread opposition to this unraveling”
www.nytimes.com/2025/02/14/o...
Opinion piece by Dr Harold Varmus, Nobel Prize winner, former director of the #NIH and the #NCI 🧪
“Perhaps what’s most disheartening is what feels like the absence of widespread opposition to this unraveling”
www.nytimes.com/2025/02/14/o...
Reposted by RajuBrainLab
The NIH’s new imposed standard indirect cost rate threatens life-saving brain & behavior research that benefits millions of Americans. SfN, with other scientific organizations,urge reversal of this policy & implore Congress to protect critical research infrastructure.
Full statement: bit.ly/4jVJnCL
Full statement: bit.ly/4jVJnCL
Statement on the NIH Imposed Standard Indirect Cost Rate
bit.ly
February 11, 2025 at 10:28 PM
The NIH’s new imposed standard indirect cost rate threatens life-saving brain & behavior research that benefits millions of Americans. SfN, with other scientific organizations,urge reversal of this policy & implore Congress to protect critical research infrastructure.
Full statement: bit.ly/4jVJnCL
Full statement: bit.ly/4jVJnCL
Reposted by RajuBrainLab
how the NIH contributes to the economy in my home state —
find yours www.unitedformedicalresearch.org/nih-in-your-...
dollars cut is a 2.5x economic return nullified, many good jobs lost, and locally economies and their healthcare weakened
no savings to our country, but rather incredible losses
find yours www.unitedformedicalresearch.org/nih-in-your-...
dollars cut is a 2.5x economic return nullified, many good jobs lost, and locally economies and their healthcare weakened
no savings to our country, but rather incredible losses
February 8, 2025 at 4:39 AM
how the NIH contributes to the economy in my home state —
find yours www.unitedformedicalresearch.org/nih-in-your-...
dollars cut is a 2.5x economic return nullified, many good jobs lost, and locally economies and their healthcare weakened
no savings to our country, but rather incredible losses
find yours www.unitedformedicalresearch.org/nih-in-your-...
dollars cut is a 2.5x economic return nullified, many good jobs lost, and locally economies and their healthcare weakened
no savings to our country, but rather incredible losses