Pugh Lab
@pughlab.bsky.social
Translational Cancer Genomics Lab | Dr. Trevor Pugh, PhD, FACMG | Single-cell Genomics. Immunogenomics. Cell-free DNA. | Toronto, Ontario, Canada
Reposted by Pugh Lab
Today is a great day for cancer research in Canada and, more importantly, for the health of all Canadians! We sincerely thank the Government of Canada for its ongoing commitment to improve the lives of Canadians diagnosed with cancer through the work of the Network.
Full statement ▶️ bit.ly/4oSuFhp
Full statement ▶️ bit.ly/4oSuFhp
November 4, 2025 at 10:25 PM
Today is a great day for cancer research in Canada and, more importantly, for the health of all Canadians! We sincerely thank the Government of Canada for its ongoing commitment to improve the lives of Canadians diagnosed with cancer through the work of the Network.
Full statement ▶️ bit.ly/4oSuFhp
Full statement ▶️ bit.ly/4oSuFhp
Reposted by Pugh Lab
🎉 Congratulations to LTRI alumna Dr. Mary Brunkow on receiving the 2025 Nobel Prize in Physiology or Medicine for her groundbreaking immune system research.
Read the story: www.sinaihealth.ca/news/ltri-al...
Read the story: www.sinaihealth.ca/news/ltri-al...
October 6, 2025 at 7:16 PM
🎉 Congratulations to LTRI alumna Dr. Mary Brunkow on receiving the 2025 Nobel Prize in Physiology or Medicine for her groundbreaking immune system research.
Read the story: www.sinaihealth.ca/news/ltri-al...
Read the story: www.sinaihealth.ca/news/ltri-al...
Reposted by Pugh Lab
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
August 28, 2025 at 6:34 AM
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
Reposted by Pugh Lab
Mark your calendar with #CGCAnnual2026—we look forward to seeing you in Houston next year!
#CGCAnnual2026 #genomics #cancer #research #genetics #clinicaltesting #bioinformatics #cytogenetics #molecular
#CGCAnnual2026 #genomics #cancer #research #genetics #clinicaltesting #bioinformatics #cytogenetics #molecular
August 25, 2025 at 7:00 PM
Mark your calendar with #CGCAnnual2026—we look forward to seeing you in Houston next year!
#CGCAnnual2026 #genomics #cancer #research #genetics #clinicaltesting #bioinformatics #cytogenetics #molecular
#CGCAnnual2026 #genomics #cancer #research #genetics #clinicaltesting #bioinformatics #cytogenetics #molecular
Reposted by Pugh Lab
After a quarter of a century, the UCSC Genome Browser remains an essential tool for navigating the genome and understanding its structure, function and clinical impact
https://go.nature.com/40wPxkB
https://go.nature.com/40wPxkB
’We couldn’t live without it’: the UCSC Genome Browser turns 25
After a quarter of a century, the website remains an essential tool for navigating the genome and understanding its structure, function and clinical impact.
go.nature.com
June 30, 2025 at 11:49 AM
After a quarter of a century, the UCSC Genome Browser remains an essential tool for navigating the genome and understanding its structure, function and clinical impact
https://go.nature.com/40wPxkB
https://go.nature.com/40wPxkB
Reposted by Pugh Lab
For those of you who may not have known him, Dr. Atul Butte, a pioneer in informatics, was the winner of the 2024 Morris F. Collen award, a pinnacle achievement in our field, as part of his storied career.
His passing is a major loss to us all.
RIP Dr. Butte
#MedSky
His passing is a major loss to us all.
RIP Dr. Butte
#MedSky
2024 Morris F. Collen Award Winner - Atul Butte, MD, PhD, FACMI
This is "2024 Morris F. Collen Award Winner - Atul Butte, MD, PhD, FACMI" by AMIA on Vimeo, the home for high quality videos and the people who love them.
vimeo.com
June 14, 2025 at 1:59 PM
For those of you who may not have known him, Dr. Atul Butte, a pioneer in informatics, was the winner of the 2024 Morris F. Collen award, a pinnacle achievement in our field, as part of his storied career.
His passing is a major loss to us all.
RIP Dr. Butte
#MedSky
His passing is a major loss to us all.
RIP Dr. Butte
#MedSky
Reposted by Pugh Lab
Excited to share our first lab paper, now published in Developmental Cell @cellpress.bsky.social !
🧠 How do glioblastoma (GBM) cells invade the brain, and what enables them to spread so effectively?
🧠 How do glioblastoma (GBM) cells invade the brain, and what enables them to spread so effectively?
May 16, 2025 at 3:47 PM
Excited to share our first lab paper, now published in Developmental Cell @cellpress.bsky.social !
🧠 How do glioblastoma (GBM) cells invade the brain, and what enables them to spread so effectively?
🧠 How do glioblastoma (GBM) cells invade the brain, and what enables them to spread so effectively?
Reposted by Pugh Lab
Cell therapy has revolutionized cancer treatment. Now, its potential is expanding far beyond.
Join us for the launch of the Centre for Immunology to Immunotherapy at UHN to explore the future of cell therapy:
events.myconferencesuite.com/Ci2iSymposiu...
Join us for the launch of the Centre for Immunology to Immunotherapy at UHN to explore the future of cell therapy:
events.myconferencesuite.com/Ci2iSymposiu...
May 12, 2025 at 1:01 PM
Cell therapy has revolutionized cancer treatment. Now, its potential is expanding far beyond.
Join us for the launch of the Centre for Immunology to Immunotherapy at UHN to explore the future of cell therapy:
events.myconferencesuite.com/Ci2iSymposiu...
Join us for the launch of the Centre for Immunology to Immunotherapy at UHN to explore the future of cell therapy:
events.myconferencesuite.com/Ci2iSymposiu...
Reposted by Pugh Lab
New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Clonal Hematopoiesis as a Driver of Solid Tumors | NEJM
Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production.1 Clonal hematopoies...
www.nejm.org
April 23, 2025 at 10:22 PM
New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Pugh Lab
A recent study shows how extrachromosomal DNA contributes to tumor heterogeneity and may drive cancer progression. Learn more: nej.md/42jfYdH
#MedSky #Oncology #Genetics
#MedSky #Oncology #Genetics
April 13, 2025 at 1:01 PM
A recent study shows how extrachromosomal DNA contributes to tumor heterogeneity and may drive cancer progression. Learn more: nej.md/42jfYdH
#MedSky #Oncology #Genetics
#MedSky #Oncology #Genetics
Reposted by Pugh Lab
The Allan Slaight Breakthrough Forum brought together 60+ scientists from Princess Margaret Cancer Centre, Krembil Research Institute, and CAMH to explore the links between cancer, neuroscience, & mental health. Looking forward to the exciting discoveries ahead!
www.uhnresearch.ca/news/advanci...
www.uhnresearch.ca/news/advanci...
April 4, 2025 at 2:13 PM
The Allan Slaight Breakthrough Forum brought together 60+ scientists from Princess Margaret Cancer Centre, Krembil Research Institute, and CAMH to explore the links between cancer, neuroscience, & mental health. Looking forward to the exciting discoveries ahead!
www.uhnresearch.ca/news/advanci...
www.uhnresearch.ca/news/advanci...
Reposted by Pugh Lab
Excellent Op-Ed by Peter Zandstra on improving 🇨🇦 science at a time when 🇺🇸 is throttling their golden goose. Instead of bespoke, targeted & ultimately short term solutions limited to a few people, build a deep, more attractive ecosysyem. The best will thrive. www.theglobeandmail.com/gift/46242ee...
Canada’s U.S. brain gain is risky without more foundational support for science
Scientists want to come to Canada not only to escape the chaos and uncertainty emerging in U.S. science but also because they are drawn to the energy here
www.theglobeandmail.com
April 3, 2025 at 7:36 PM
Excellent Op-Ed by Peter Zandstra on improving 🇨🇦 science at a time when 🇺🇸 is throttling their golden goose. Instead of bespoke, targeted & ultimately short term solutions limited to a few people, build a deep, more attractive ecosysyem. The best will thrive. www.theglobeandmail.com/gift/46242ee...
Reposted by Pugh Lab
We're excited to join Bluesky! Follow us for the latest news about cBioPortal.
March 10, 2025 at 7:38 PM
We're excited to join Bluesky! Follow us for the latest news about cBioPortal.
Reposted by Pugh Lab
First newsletter of 2025! Read to get the latest news and all the details on GSoC 2025 projects and application process #cBioPortal #newsletter #gsoc2025 www.linkedin.com/pulse/welcom...
Welcome to the March 2025 edition of the cBioPortal Newsletter!
As we step into 2025, we're excited to share the latest updates and enhancements in cBioPortal. cBioPortal is hosting Google Summer of Code (GSoC) 2025 We are excited to announce that cBioPortal has o...
www.linkedin.com
March 10, 2025 at 7:41 PM
First newsletter of 2025! Read to get the latest news and all the details on GSoC 2025 projects and application process #cBioPortal #newsletter #gsoc2025 www.linkedin.com/pulse/welcom...
Reposted by Pugh Lab
Reposted by Pugh Lab
🇨🇦 Fast-track your computational biology/bioinformatics career in cancer research! 🇨🇦
The Lupien Lab is looking to recruit a Postdoctoral Fellow in computational biology/bioinformatics ready for a challenge.
Apply now: www.nature.com/naturecareer...
The Lupien Lab is looking to recruit a Postdoctoral Fellow in computational biology/bioinformatics ready for a challenge.
Apply now: www.nature.com/naturecareer...
Postdoctoral Fellow - Computational - Toronto (Region), Ontario (CA) job with Princess Margaret Cancer Centre | 12836915
We a seeking applications for a computational postdoctoral fellow with expertise in cancer epigenomics, chromatin biology, and data-driven research.
www.nature.com
February 12, 2025 at 7:23 PM
🇨🇦 Fast-track your computational biology/bioinformatics career in cancer research! 🇨🇦
The Lupien Lab is looking to recruit a Postdoctoral Fellow in computational biology/bioinformatics ready for a challenge.
Apply now: www.nature.com/naturecareer...
The Lupien Lab is looking to recruit a Postdoctoral Fellow in computational biology/bioinformatics ready for a challenge.
Apply now: www.nature.com/naturecareer...
Reposted by Pugh Lab
#REVIEW
Vallot, Lupien and Lasine describe how epigenomic heterogeneity generates dynamic reservoirs of tumour cell states, which can be leveraged in the design of novel therapies.
📖 👉 https://bit.ly/40PCQ...
Vallot, Lupien and Lasine describe how epigenomic heterogeneity generates dynamic reservoirs of tumour cell states, which can be leveraged in the design of novel therapies.
📖 👉 https://bit.ly/40PCQ...
Epigenomic heterogeneity as a source of tumour evolution - Nature Reviews Cancer
Single-cell epigenomic technologies are refining our understanding of cancer evolution.
bit.ly
January 27, 2025 at 3:13 PM
#REVIEW
Vallot, Lupien and Lasine describe how epigenomic heterogeneity generates dynamic reservoirs of tumour cell states, which can be leveraged in the design of novel therapies.
📖 👉 https://bit.ly/40PCQ...
Vallot, Lupien and Lasine describe how epigenomic heterogeneity generates dynamic reservoirs of tumour cell states, which can be leveraged in the design of novel therapies.
📖 👉 https://bit.ly/40PCQ...
Reposted by Pugh Lab
Rates of #cancer in #young #adults have risen dramatically in recent years - as discussed in this article..
We urgently need to invest in #research 🧪 on early-onset cancers to understand - why?
www.theguardian.com/science/2025...
We urgently need to invest in #research 🧪 on early-onset cancers to understand - why?
www.theguardian.com/science/2025...
Ultra-processed food? Forever chemicals? Declining birth rates? What’s behind rising cancer in the under-50s?
Research into the disease has never been more far-reaching, but there is little consensus as to what is causing the rocketing rates of diagnosis in young adults
www.theguardian.com
January 26, 2025 at 1:53 PM
Rates of #cancer in #young #adults have risen dramatically in recent years - as discussed in this article..
We urgently need to invest in #research 🧪 on early-onset cancers to understand - why?
www.theguardian.com/science/2025...
We urgently need to invest in #research 🧪 on early-onset cancers to understand - why?
www.theguardian.com/science/2025...
Reposted by Pugh Lab
Come be my boss!
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...
Program Head - Molecular Medicine, The Hospital for Sick Children Research Institute - Toronto (City), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 667223
Provide leadership and mentorship to members of the Molecular Medicine Program and influence the scientific direction of the Research Institute
jobs.sciencecareers.org
January 24, 2025 at 11:02 PM
Come be my boss!
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...
Reposted by Pugh Lab
Indeed, there are a number of open positions for early career investigators in Toronto. It's a great city in a great country to pursue impactful science.
Seems like a perfect day to consider continuing your research career in beautiful Canada! Recruiting an ECR in cancer research, a week left to apply.
We are recruiting! Princess Margaret Cancer Centre in Toronto is recruiting an early career cancer research scientist at Assistant Professor level. Apply! Spread the word!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
January 23, 2025 at 3:55 PM
Indeed, there are a number of open positions for early career investigators in Toronto. It's a great city in a great country to pursue impactful science.
Reposted by Pugh Lab
Seems like a perfect day to consider continuing your research career in beautiful Canada! Recruiting an ECR in cancer research, a week left to apply.
We are recruiting! Princess Margaret Cancer Centre in Toronto is recruiting an early career cancer research scientist at Assistant Professor level. Apply! Spread the word!
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Scientist I - Cancer Biology - Toronto (City), Ontario (CA) job with Princess Margaret Cancer Centre | 12831982
Princess Margaret seeks early-career faculty scientists to establish research programs in Cancer Biology - broadly defined.
www.nature.com
January 23, 2025 at 2:18 PM
Seems like a perfect day to consider continuing your research career in beautiful Canada! Recruiting an ECR in cancer research, a week left to apply.
Absolutely thrilled to see the next next-generation sequencer arrive on our doorstep. Looking forward to affordable deep dives into cell-free genomes. Will we be able to reconstruct cancer genomes from blood without a biopsy, even for early cancers? We think so!
We’re delighted to introduce the #UltimaGenomics UG100 high-throughput sequencer, a groundbreaking addition to our state-of-the-art genomics arsenal at @oicr.on.ca #Genomics. Stay tuned for our official launch date!!
Learn more about the UG100 sequencer here: www.ultimagenomics.com/ug-100-tm-se...
Learn more about the UG100 sequencer here: www.ultimagenomics.com/ug-100-tm-se...
UG 100™ Sequencer
Ultima Genomics, Inc. is revolutionizing DNA sequencing technology with the UG 100 by providing scalability for the $100 genome
www.ultimagenomics.com
January 16, 2025 at 2:53 PM
Absolutely thrilled to see the next next-generation sequencer arrive on our doorstep. Looking forward to affordable deep dives into cell-free genomes. Will we be able to reconstruct cancer genomes from blood without a biopsy, even for early cancers? We think so!