Pradeep Natarajan
@pnatarajanmd.bsky.social
Cardiologist, genetics researcher.
Massachusetts General Hospital | Harvard Medical School | Broad Institute of Harvard & MIT
Massachusetts General Hospital | Harvard Medical School | Broad Institute of Harvard & MIT
Reposted by Pradeep Natarajan
What is spontaneous coronary artery dissection (SCAD)? ♥️💬 Watch as Drs. Mark Lindsay, Tiffany Bellomo, and Pradeep Natarajan share information about this condition.
gvascstudy.org
#SCAD #genetics #scadgenetics @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social
gvascstudy.org
#SCAD #genetics #scadgenetics @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social
September 19, 2025 at 5:55 PM
What is spontaneous coronary artery dissection (SCAD)? ♥️💬 Watch as Drs. Mark Lindsay, Tiffany Bellomo, and Pradeep Natarajan share information about this condition.
gvascstudy.org
#SCAD #genetics #scadgenetics @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social
gvascstudy.org
#SCAD #genetics #scadgenetics @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social
Reposted by Pradeep Natarajan
Excited to share that I’m launching a Computational Genetics Lab spanning MGB Personalized Medicine, Cardiovascular Research Center at MGH, @harvardmed.bsky.social, and @broadinstitute.org. Our research focuses on the genetics of common diseases, with a particular emphasis on cardiovascular disease.
October 2, 2025 at 12:57 AM
Excited to share that I’m launching a Computational Genetics Lab spanning MGB Personalized Medicine, Cardiovascular Research Center at MGH, @harvardmed.bsky.social, and @broadinstitute.org. Our research focuses on the genetics of common diseases, with a particular emphasis on cardiovascular disease.
Reposted by Pradeep Natarajan
How do you join the gVasc Research Study? Visit gvascstudy.org 💻 and follow these easy steps! Complete a few short surveys about your health and receive the saliva kit in the mail 📝 📦 ❤️ #scad #heartresearch #scadalliance @scadalliance.bsky.social @pnatarajanmd.bsky.social @markelindsay.bsky.social
August 26, 2025 at 5:37 PM
How do you join the gVasc Research Study? Visit gvascstudy.org 💻 and follow these easy steps! Complete a few short surveys about your health and receive the saliva kit in the mail 📝 📦 ❤️ #scad #heartresearch #scadalliance @scadalliance.bsky.social @pnatarajanmd.bsky.social @markelindsay.bsky.social
Reposted by Pradeep Natarajan
In the Summer we usually slow down… 🏖️ but here are some Fast Facts ⏱️🗒️ about spontaneous coronary artery dissection (SCAD). Visit gvascstudy.org to learn more about the gVasc study today🫀 #SCAD #heartresearch #cardiology @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social
August 26, 2025 at 5:57 PM
In the Summer we usually slow down… 🏖️ but here are some Fast Facts ⏱️🗒️ about spontaneous coronary artery dissection (SCAD). Visit gvascstudy.org to learn more about the gVasc study today🫀 #SCAD #heartresearch #cardiology @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social
Reposted by Pradeep Natarajan
Meet the Team! 🩺 gVasc investigators have extensive experience in cardiovascular disease and genetics🫀🧬 They bring together their expertise to uncover the genetic underpinnings of SCAD 🔍 gvascstudy.org #SCAD #cardiology @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social
August 26, 2025 at 6:49 PM
Meet the Team! 🩺 gVasc investigators have extensive experience in cardiovascular disease and genetics🫀🧬 They bring together their expertise to uncover the genetic underpinnings of SCAD 🔍 gvascstudy.org #SCAD #cardiology @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social
Reposted by Pradeep Natarajan
gVasc is a research study trying to find out if there are genetic factors behind why SCAD happens🫀Click the link in our bio or head to gvascstudy.org to learn more about our study and to participate! #gvasc #SCAD #research #heart #hearthealth #heartresearch #scadalliance @scadalliance.bsky.social
August 12, 2025 at 2:54 PM
gVasc is a research study trying to find out if there are genetic factors behind why SCAD happens🫀Click the link in our bio or head to gvascstudy.org to learn more about our study and to participate! #gvasc #SCAD #research #heart #hearthealth #heartresearch #scadalliance @scadalliance.bsky.social
Reposted by Pradeep Natarajan
🗓️ At #CSANZ2025? JAMA Associate Editors @rohankhera.bsky.social, MD, MS and @pnatarajanmd.bsky.social, MD, MMSc, will be at Plaza 4 today, Saturday, August 16 from 3 PM to 3:30 PM.
➡️ Stop by to ask questions
➡️ Learn about publishing opportunities
@cardiacsociety.bsky.social
➡️ Stop by to ask questions
➡️ Learn about publishing opportunities
@cardiacsociety.bsky.social
August 15, 2025 at 11:01 PM
🗓️ At #CSANZ2025? JAMA Associate Editors @rohankhera.bsky.social, MD, MS and @pnatarajanmd.bsky.social, MD, MMSc, will be at Plaza 4 today, Saturday, August 16 from 3 PM to 3:30 PM.
➡️ Stop by to ask questions
➡️ Learn about publishing opportunities
@cardiacsociety.bsky.social
➡️ Stop by to ask questions
➡️ Learn about publishing opportunities
@cardiacsociety.bsky.social
Our study led by T. Bellomo and with @aniruddhpatelmd.bsky.social describes the relationship between lipoprotein(a) and incident & progressive extracoronary atherosclerotic vascular disease www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social
@broadinstitute.org @mgbresearch.bsky.social
@broadinstitute.org @mgbresearch.bsky.social
July 28, 2025 at 10:58 AM
Our study led by T. Bellomo and with @aniruddhpatelmd.bsky.social describes the relationship between lipoprotein(a) and incident & progressive extracoronary atherosclerotic vascular disease www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social
@broadinstitute.org @mgbresearch.bsky.social
@broadinstitute.org @mgbresearch.bsky.social
New polygenic risk score for obesity predicts response with weight loss across 2 lifestyle intervention RCTs nature.com/articles/s41... @natureportfolio.nature.com
My comments in @nytimes.com nytimes.com/2025/07/21/h...
My comments in @nytimes.com nytimes.com/2025/07/21/h...
Polygenic prediction of body mass index and obesity through the life course and across ancestries - Nature Medicine
Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to a...
nature.com
July 21, 2025 at 1:01 PM
New polygenic risk score for obesity predicts response with weight loss across 2 lifestyle intervention RCTs nature.com/articles/s41... @natureportfolio.nature.com
My comments in @nytimes.com nytimes.com/2025/07/21/h...
My comments in @nytimes.com nytimes.com/2025/07/21/h...
Reposted by Pradeep Natarajan
Should I tell anyone that I suspect misconduct in a paper I’m reviewing?
So important and with more ECRs reviewing this guidance is very welcome.
Things to keep in mind:
- Extend the benefit of the doubt
- Talk to the editor
- Check your tone
- Balance your responsibilities and your limits
So important and with more ECRs reviewing this guidance is very welcome.
Things to keep in mind:
- Extend the benefit of the doubt
- Talk to the editor
- Check your tone
- Balance your responsibilities and your limits
Agony aunt 🖋️ A cancer researcher is suspicious about a paper they’ve been asked to review. What steps should they take?
go.nature.com/3UhImt0
go.nature.com/3UhImt0
Should I tell anyone that I suspect misconduct in a paper I’m reviewing?
A cancer researcher is suspicious about a paper they’ve been asked to review. What steps should they take?
go.nature.com
July 18, 2025 at 11:47 AM
Should I tell anyone that I suspect misconduct in a paper I’m reviewing?
So important and with more ECRs reviewing this guidance is very welcome.
Things to keep in mind:
- Extend the benefit of the doubt
- Talk to the editor
- Check your tone
- Balance your responsibilities and your limits
So important and with more ECRs reviewing this guidance is very welcome.
Things to keep in mind:
- Extend the benefit of the doubt
- Talk to the editor
- Check your tone
- Balance your responsibilities and your limits
Delighted to collaborate on this work led by @kellybolton.bsky.social describing how germline genetic variation influences the trajectory of clonal hematopoiesis to hematologic malignancy www.nature.com/articles/s41... @natureportfolio.nature.com @broadinstitute.org @mgbresearch.bsky.social
July 16, 2025 at 5:07 PM
Delighted to collaborate on this work led by @kellybolton.bsky.social describing how germline genetic variation influences the trajectory of clonal hematopoiesis to hematologic malignancy www.nature.com/articles/s41... @natureportfolio.nature.com @broadinstitute.org @mgbresearch.bsky.social
An abs risk generalizable risk calculator is challenging. Led by @somijemmacho.bsky.social, evaluating AHA PREVENT across 4 academic health systems, we found similar discrimination but variable calibration. A universal abs risk threshold may not suitably guide www.sciencedirect.com/science/arti...
July 14, 2025 at 3:10 PM
An abs risk generalizable risk calculator is challenging. Led by @somijemmacho.bsky.social, evaluating AHA PREVENT across 4 academic health systems, we found similar discrimination but variable calibration. A universal abs risk threshold may not suitably guide www.sciencedirect.com/science/arti...
Reposted by Pradeep Natarajan
Thrilled that our work on integrating genetic, contemporary and traditional risk factors into acute MI models has been published in
@CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !!
Are genetic and contemporary risk factors as powerful as traditional RFs?
#CardioSky #cvPrev
@CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !!
Are genetic and contemporary risk factors as powerful as traditional RFs?
#CardioSky #cvPrev
Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are:
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
July 3, 2025 at 2:00 PM
Thrilled that our work on integrating genetic, contemporary and traditional risk factors into acute MI models has been published in
@CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !!
Are genetic and contemporary risk factors as powerful as traditional RFs?
#CardioSky #cvPrev
@CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !!
Are genetic and contemporary risk factors as powerful as traditional RFs?
#CardioSky #cvPrev
Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are:
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
July 3, 2025 at 12:29 PM
Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are:
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
Reposted by Pradeep Natarajan
Check out this PRS (www.pgscatalog.org/publication/...) and more in the latest PGS Catalog data release! Thanks to @pnatarajanmd.bsky.social & co for submitting their scores! See www.pgscatalog.org/submit for information about how to share your work!
June 17, 2025 at 3:24 PM
Check out this PRS (www.pgscatalog.org/publication/...) and more in the latest PGS Catalog data release! Thanks to @pnatarajanmd.bsky.social & co for submitting their scores! See www.pgscatalog.org/submit for information about how to share your work!
Delighted to write this viewpoint with C. Tcheandjieu & C. Robinson on gleaning and translating genomic insights across communities www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social
May 27, 2025 at 4:23 PM
Delighted to write this viewpoint with C. Tcheandjieu & C. Robinson on gleaning and translating genomic insights across communities www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social
Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio
May 21, 2025 at 4:02 PM
Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio
Reposted by Pradeep Natarajan
📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41...
Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms
tl;dr 👉 There's little/no evidence for this
Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms
tl;dr 👉 There's little/no evidence for this
May 12, 2025 at 3:49 PM
📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41...
Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms
tl;dr 👉 There's little/no evidence for this
Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms
tl;dr 👉 There's little/no evidence for this
Very excited to Chair this webinar on Cardiovascular Health May 21 7:30-8:30p ET hosted by @indiaspora.bsky.social with Opening Remarks from Vivek Murthy.
Register us02web.zoom.us/meeting/regi...
@drmarthagulati.bsky.social
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
.
Register us02web.zoom.us/meeting/regi...
@drmarthagulati.bsky.social
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
.
May 12, 2025 at 7:36 PM
Very excited to Chair this webinar on Cardiovascular Health May 21 7:30-8:30p ET hosted by @indiaspora.bsky.social with Opening Remarks from Vivek Murthy.
Register us02web.zoom.us/meeting/regi...
@drmarthagulati.bsky.social
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
.
Register us02web.zoom.us/meeting/regi...
@drmarthagulati.bsky.social
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
.
Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025
May 7, 2025 at 1:39 PM
Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025
A cross-ancestry integrated (clinical + genetic) coronary artery disease risk score outperforms the Pooled Cohort Equations alone for CAD risk prediction across 4 cohorts www.nature.com/articles/s44...
May 7, 2025 at 1:05 AM
A cross-ancestry integrated (clinical + genetic) coronary artery disease risk score outperforms the Pooled Cohort Equations alone for CAD risk prediction across 4 cohorts www.nature.com/articles/s44...
The most math equations written on a whiteboard by a clinician I've seen - yet amazingly well delivered to a broad audience!
S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS...
@mgbresearch.bsky.social @harvardmed.bsky.social
S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS...
@mgbresearch.bsky.social @harvardmed.bsky.social
MPG Primer: A Practical Primer on Bayesian Statistics (2025)
YouTube video by Broad Institute
youtube.com
May 6, 2025 at 2:58 PM
The most math equations written on a whiteboard by a clinician I've seen - yet amazingly well delivered to a broad audience!
S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS...
@mgbresearch.bsky.social @harvardmed.bsky.social
S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS...
@mgbresearch.bsky.social @harvardmed.bsky.social
End of an era icelandmonitor.mbl.is/news/news/20...
Kári Stefánsson steps down as CEO of DeCode Genetics
Kári Stefánsson, founder and long-time CEO of DeCode Genetics, has officially stepped down from his leadership role at the company he established nearly three decades ago. The announcement marks the e...
icelandmonitor.mbl.is
May 5, 2025 at 4:01 PM
End of an era icelandmonitor.mbl.is/news/news/20...
Reposted by Pradeep Natarajan
Great paper on the intrinsic link between LDL and diabetes risk from @pnatarajanmd.bsky.social @skoyama.bsky.social @somijemmacho.bsky.social and colleagues:
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Genetic Predisposition to LDL-C and Incident Type 2 Diabetes
This cohort study uses whole-exome sequencing, genome-wide genotyping, baseline lipid levels, and incident events to assess the association of genetic predisposition to low-density lipoprotein cholest...
jamanetwork.com
May 2, 2025 at 5:37 AM
Great paper on the intrinsic link between LDL and diabetes risk from @pnatarajanmd.bsky.social @skoyama.bsky.social @somijemmacho.bsky.social and colleagues:
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Pradeep Natarajan
Out today in AJHG, this work from my (recently graduated) student Teng Heng on recessive effects in 44k British South Asians from the Genes & Health project @genesandhealth.bsky.social . She found 185 independent hits of which >40% were novel. Worth looking for these in your own cohorts!
📣New from @hilarycmartin.bsky.social & co!
📄Widespread recessive effects on common diseases in a cohort of 44,000 British Pakistanis and Bangladeshis with high autozygosity
📄Widespread recessive effects on common diseases in a cohort of 44,000 British Pakistanis and Bangladeshis with high autozygosity
Widespread recessive effects on common diseases in a cohort of 44,000 British Pakistanis and Bangladeshis with high autozygosity
We leveraged the increased homozygosity in the Genes & Health cohort to perform recessive
association testing between 898 diseases and 10,045,406 whole-genome imputed variants,
as well as 607,981 whol...
www.cell.com
April 30, 2025 at 7:29 PM
Out today in AJHG, this work from my (recently graduated) student Teng Heng on recessive effects in 44k British South Asians from the Genes & Health project @genesandhealth.bsky.social . She found 185 independent hits of which >40% were novel. Worth looking for these in your own cohorts!