Romit Bhattacharya
@romitb.bsky.social
Preventive Cardiologist at Mass General Hospital | Lifestyle, Genomics, Digital Health, South Asian CVD
Was happy to join @boston25news.com 🎥for a discussion of alcohol and heart disease yesterday!
Recent trends show Americans are drinking 🥃🍺 less - what does this mean for the heart? 🫀
www.boston25news.com/news/local/d...
@massgeneralbrigham.bsky.social
Recent trends show Americans are drinking 🥃🍺 less - what does this mean for the heart? 🫀
www.boston25news.com/news/local/d...
@massgeneralbrigham.bsky.social
Dr. Romit Bhattacharya: Survey shows fewer adults drinking alcohol for health reasons
A new Gallup survey reveals that more Americans are choosing to abstain from alcohol.
www.boston25news.com
August 20, 2025 at 1:19 PM
Was happy to join @boston25news.com 🎥for a discussion of alcohol and heart disease yesterday!
Recent trends show Americans are drinking 🥃🍺 less - what does this mean for the heart? 🫀
www.boston25news.com/news/local/d...
@massgeneralbrigham.bsky.social
Recent trends show Americans are drinking 🥃🍺 less - what does this mean for the heart? 🫀
www.boston25news.com/news/local/d...
@massgeneralbrigham.bsky.social
Reposted by Romit Bhattacharya
🆕 New in AJPC: High-Density Lipoproteins, Part 1
Explore HDL's role in CVD prevention—epidemiology, antiatherogenic effects & therapies to raise serum levels.
🔗 www.sciencedirect.com/science/arti...
#HDL #Cardiology #LipidHealth #AJPC #PreventiveCardiology
Explore HDL's role in CVD prevention—epidemiology, antiatherogenic effects & therapies to raise serum levels.
🔗 www.sciencedirect.com/science/arti...
#HDL #Cardiology #LipidHealth #AJPC #PreventiveCardiology
July 23, 2025 at 4:44 PM
🆕 New in AJPC: High-Density Lipoproteins, Part 1
Explore HDL's role in CVD prevention—epidemiology, antiatherogenic effects & therapies to raise serum levels.
🔗 www.sciencedirect.com/science/arti...
#HDL #Cardiology #LipidHealth #AJPC #PreventiveCardiology
Explore HDL's role in CVD prevention—epidemiology, antiatherogenic effects & therapies to raise serum levels.
🔗 www.sciencedirect.com/science/arti...
#HDL #Cardiology #LipidHealth #AJPC #PreventiveCardiology
Reposted by Romit Bhattacharya
An abs risk generalizable risk calculator is challenging. Led by @somijemmacho.bsky.social, evaluating AHA PREVENT across 4 academic health systems, we found similar discrimination but variable calibration. A universal abs risk threshold may not suitably guide www.sciencedirect.com/science/arti...
July 14, 2025 at 3:10 PM
An abs risk generalizable risk calculator is challenging. Led by @somijemmacho.bsky.social, evaluating AHA PREVENT across 4 academic health systems, we found similar discrimination but variable calibration. A universal abs risk threshold may not suitably guide www.sciencedirect.com/science/arti...
Thrilled that our work on integrating genetic, contemporary and traditional risk factors into acute MI models has been published in
@CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !!
Are genetic and contemporary risk factors as powerful as traditional RFs?
#CardioSky #cvPrev
@CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !!
Are genetic and contemporary risk factors as powerful as traditional RFs?
#CardioSky #cvPrev
Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are:
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
July 3, 2025 at 2:00 PM
Thrilled that our work on integrating genetic, contemporary and traditional risk factors into acute MI models has been published in
@CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !!
Are genetic and contemporary risk factors as powerful as traditional RFs?
#CardioSky #cvPrev
@CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !!
Are genetic and contemporary risk factors as powerful as traditional RFs?
#CardioSky #cvPrev
Huge thank you to Dr. Steve Grinspoon for inviting me to moderate the Harvard Nutrition Obesity Research Symposium at MGH!
Watch this space for insights and work from our faculty!
#CardioSky #EndoSky @mghcvrc.bsky.social @jsawallagusehmd.bsky.social @drprao.bsky.social @pnatarajanmd.bsky.social
Watch this space for insights and work from our faculty!
#CardioSky #EndoSky @mghcvrc.bsky.social @jsawallagusehmd.bsky.social @drprao.bsky.social @pnatarajanmd.bsky.social
June 4, 2025 at 12:34 PM
Huge thank you to Dr. Steve Grinspoon for inviting me to moderate the Harvard Nutrition Obesity Research Symposium at MGH!
Watch this space for insights and work from our faculty!
#CardioSky #EndoSky @mghcvrc.bsky.social @jsawallagusehmd.bsky.social @drprao.bsky.social @pnatarajanmd.bsky.social
Watch this space for insights and work from our faculty!
#CardioSky #EndoSky @mghcvrc.bsky.social @jsawallagusehmd.bsky.social @drprao.bsky.social @pnatarajanmd.bsky.social
Reposted by Romit Bhattacharya
Flavonoid food and beverage intake—quantity and diversity— is linked to reduced all-cause mortality, cancer, cardiovascular disease, Type 2 diabetes, and neurodegenerative disease
www.nature.com/articles/s43...
www.nature.com/articles/s43...
June 2, 2025 at 1:05 PM
Flavonoid food and beverage intake—quantity and diversity— is linked to reduced all-cause mortality, cancer, cardiovascular disease, Type 2 diabetes, and neurodegenerative disease
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Romit Bhattacharya
Steffensen, Rasmussen, et al. show that deep whole-exome sequencing of human atherosclerotic plaques reveals that the expansion of large mutated clones within plaque tissue is an intrinsic feature of human atherosclerosis: buff.ly/zdEM0dm
May 29, 2025 at 3:13 PM
Steffensen, Rasmussen, et al. show that deep whole-exome sequencing of human atherosclerotic plaques reveals that the expansion of large mutated clones within plaque tissue is an intrinsic feature of human atherosclerosis: buff.ly/zdEM0dm
Peer Review In Peril
@aniloza.bsky.social
"But now, “the Trump administration feels very strongly that the president’s agenda is the most important consideration for any government spending"
www.statnews.com/2025/05/27/r...
#Cardiosky
@aniloza.bsky.social
"But now, “the Trump administration feels very strongly that the president’s agenda is the most important consideration for any government spending"
www.statnews.com/2025/05/27/r...
#Cardiosky
‘Corrupt’ medical journals have to change, RFK Jr. says, or the NIH will publish in-house
The criticism of The Lancet, NEJM and JAMA is not new, but the health secretary may use his position to influence research that journals publish.
www.statnews.com
May 28, 2025 at 1:25 PM
Peer Review In Peril
@aniloza.bsky.social
"But now, “the Trump administration feels very strongly that the president’s agenda is the most important consideration for any government spending"
www.statnews.com/2025/05/27/r...
#Cardiosky
@aniloza.bsky.social
"But now, “the Trump administration feels very strongly that the president’s agenda is the most important consideration for any government spending"
www.statnews.com/2025/05/27/r...
#Cardiosky
Reposted by Romit Bhattacharya
📢 Just published!
New insights on Lipoprotein(a): How it interacts with common cardiovascular risk factors to influence CVD risk — findings from the UK Biobank.
www.sciencedirect.com/science/arti...
#LipoproteinA #CVDprevention #CardioSky #PreventiveCardiology #ASPC #HeartHealth #UKBiobank
New insights on Lipoprotein(a): How it interacts with common cardiovascular risk factors to influence CVD risk — findings from the UK Biobank.
www.sciencedirect.com/science/arti...
#LipoproteinA #CVDprevention #CardioSky #PreventiveCardiology #ASPC #HeartHealth #UKBiobank
May 23, 2025 at 5:03 PM
📢 Just published!
New insights on Lipoprotein(a): How it interacts with common cardiovascular risk factors to influence CVD risk — findings from the UK Biobank.
www.sciencedirect.com/science/arti...
#LipoproteinA #CVDprevention #CardioSky #PreventiveCardiology #ASPC #HeartHealth #UKBiobank
New insights on Lipoprotein(a): How it interacts with common cardiovascular risk factors to influence CVD risk — findings from the UK Biobank.
www.sciencedirect.com/science/arti...
#LipoproteinA #CVDprevention #CardioSky #PreventiveCardiology #ASPC #HeartHealth #UKBiobank
New online! LDL-cholesterol lowering with obicetrapib #CardioSky
LDL-cholesterol lowering with obicetrapib
Nature Reviews Cardiology, Published online: 22 May 2025; doi:10.1038/s41569-025-01173-8In the TANDEM and BROADWAY clinical trials, treatment with the CETP inhibitor obicetrapib in addition to background lipid-lowering therapy significantly reduced plasma LDL-cholesterol levels.
bit.ly
May 22, 2025 at 2:29 PM
Reposted by Romit Bhattacharya
Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio
May 21, 2025 at 4:02 PM
Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio
Reposted by Romit Bhattacharya
Wow!!! These human genetic insights could enable the next generation of pain management therapies:
rupress.org/jem/article/...
Fascinating @jem.org article!
rupress.org/jem/article/...
Fascinating @jem.org article!
A pathological missense mutation in the deubiquitinase USP5 leads to insensitivity to pain | Journal of Experimental Medicine | Rockefeller University Press
The manuscript reports on patient with a USP5 mutation that gives rise to insensitivity to pain. The patient’s pathology is phenocopied in a knock-in mouse
rupress.org
May 17, 2025 at 7:57 PM
Wow!!! These human genetic insights could enable the next generation of pain management therapies:
rupress.org/jem/article/...
Fascinating @jem.org article!
rupress.org/jem/article/...
Fascinating @jem.org article!
Reposted by Romit Bhattacharya
In stable patients with extensive noncalcified plaque volume at baseline, 18 months of evolocumab treatment was associated with a shift toward a lower risk quantitative plaque phenotype and reduction in microcalcification activity
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
Effects of Evolocumab on Coronary Plaque Composition and Microcalcification Activity by Coronary PET and CT Angiography:
www.jacc.org
May 16, 2025 at 10:32 PM
In stable patients with extensive noncalcified plaque volume at baseline, 18 months of evolocumab treatment was associated with a shift toward a lower risk quantitative plaque phenotype and reduction in microcalcification activity
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
Here's the thing... pseudoscience can't do this. Only real science can.
www.nytimes.com/2025/05/15/h...
www.nytimes.com/2025/05/15/h...
Baby Is Healed With World’s First Personalized Gene-Editing Treatment
www.nytimes.com
May 15, 2025 at 5:17 PM
Here's the thing... pseudoscience can't do this. Only real science can.
www.nytimes.com/2025/05/15/h...
www.nytimes.com/2025/05/15/h...
Reposted by Romit Bhattacharya
Very excited to Chair this webinar on Cardiovascular Health May 21 7:30-8:30p ET hosted by @indiaspora.bsky.social with Opening Remarks from Vivek Murthy.
Register us02web.zoom.us/meeting/regi...
@drmarthagulati.bsky.social
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
.
Register us02web.zoom.us/meeting/regi...
@drmarthagulati.bsky.social
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
.
May 12, 2025 at 7:36 PM
Very excited to Chair this webinar on Cardiovascular Health May 21 7:30-8:30p ET hosted by @indiaspora.bsky.social with Opening Remarks from Vivek Murthy.
Register us02web.zoom.us/meeting/regi...
@drmarthagulati.bsky.social
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
.
Register us02web.zoom.us/meeting/regi...
@drmarthagulati.bsky.social
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
.
Reposted by Romit Bhattacharya
Lp(a) & recurrent atherosclerotic CV events: US Family Heart Database
#CardioSky
academic.oup.com/eurheartj/ad...
@hsbhatia.bsky.social @psatishmd.bsky.social @vietheartpa.bsky.social @anastasiasmihaili.bsky.social @michaeldshapiro.bsky.social @romitb.bsky.social @dlbhattmd.bsky.social
#CardioSky
academic.oup.com/eurheartj/ad...
@hsbhatia.bsky.social @psatishmd.bsky.social @vietheartpa.bsky.social @anastasiasmihaili.bsky.social @michaeldshapiro.bsky.social @romitb.bsky.social @dlbhattmd.bsky.social
May 8, 2025 at 1:25 AM
Lp(a) & recurrent atherosclerotic CV events: US Family Heart Database
#CardioSky
academic.oup.com/eurheartj/ad...
@hsbhatia.bsky.social @psatishmd.bsky.social @vietheartpa.bsky.social @anastasiasmihaili.bsky.social @michaeldshapiro.bsky.social @romitb.bsky.social @dlbhattmd.bsky.social
#CardioSky
academic.oup.com/eurheartj/ad...
@hsbhatia.bsky.social @psatishmd.bsky.social @vietheartpa.bsky.social @anastasiasmihaili.bsky.social @michaeldshapiro.bsky.social @romitb.bsky.social @dlbhattmd.bsky.social
Reposted by Romit Bhattacharya
Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025
May 7, 2025 at 1:39 PM
Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025
Reposted by Romit Bhattacharya
The most math equations written on a whiteboard by a clinician I've seen - yet amazingly well delivered to a broad audience!
S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS...
@mgbresearch.bsky.social @harvardmed.bsky.social
S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS...
@mgbresearch.bsky.social @harvardmed.bsky.social
MPG Primer: A Practical Primer on Bayesian Statistics (2025)
YouTube video by Broad Institute
youtube.com
May 6, 2025 at 2:58 PM
The most math equations written on a whiteboard by a clinician I've seen - yet amazingly well delivered to a broad audience!
S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS...
@mgbresearch.bsky.social @harvardmed.bsky.social
S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS...
@mgbresearch.bsky.social @harvardmed.bsky.social
Reposted by Romit Bhattacharya
Now the discovery of the 4th gene variant which promotes short sleep (4-6 hours) with full restfulness, potentially a path to a drug for sleep efficiency someday
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
The SIK3-N783Y mutation is associated with the human natural short sleep trait | PNAS
Sleep is an essential component of our daily life. A mutation in human salt induced
kinase 3 (hSIK3), which is critical for regulating sleep durati...
www.pnas.org
May 5, 2025 at 8:08 PM
Now the discovery of the 4th gene variant which promotes short sleep (4-6 hours) with full restfulness, potentially a path to a drug for sleep efficiency someday
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Nice of @indiaspora.bsky.social to feature the OurHealth Study in their newsletter!
#cvPrev
#SouthAsianCVD
#CardioSky
#cvPrev
#SouthAsianCVD
#CardioSky
The OurHealth Study – Discovering the Causes Behind High Rates of Cardiovascular Disease and Diabetes in South Asians www.indiaspora.org/the-ourhealt... @indiaspora.bsky.social
Please sign up and share! ourhealthstudy.org
@romitb.bsky.social
Please sign up and share! ourhealthstudy.org
@romitb.bsky.social
April 29, 2025 at 1:12 AM
Nice of @indiaspora.bsky.social to feature the OurHealth Study in their newsletter!
#cvPrev
#SouthAsianCVD
#CardioSky
#cvPrev
#SouthAsianCVD
#CardioSky
Great study!
Our study led by A. Shankar shows that genotype-phenotype discordance of LDL-C (stronger polygenic predisposition to hypercholesterolemia for a given LDL-C) stratifies CAD risk - esp in normocholesterolemia. www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCADv
April 28, 2025 at 5:49 PM
Great study!
Thrilled to join Ankur Kalra and Jaideep Patel on the Parallax Podcast to discuss South Asian Cardiometabolic Disease
We get into:
- Knowledge gaps
- Lifestyle and Genetics
- Common difficulties for the cardiologist in guiding South Asian patients
#SouthAsianCVD
bit.ly/4jVIuti
We get into:
- Knowledge gaps
- Lifestyle and Genetics
- Common difficulties for the cardiologist in guiding South Asian patients
#SouthAsianCVD
bit.ly/4jVIuti
Ep 133: South Asian Heart Health: Unveiling Risk Patterns and Prevention Strategies
Podcast Episode · Parallax by Ankur Kalra · 04/28/2025 · 55m
podcasts.apple.com
April 28, 2025 at 5:20 PM
Thrilled to join Ankur Kalra and Jaideep Patel on the Parallax Podcast to discuss South Asian Cardiometabolic Disease
We get into:
- Knowledge gaps
- Lifestyle and Genetics
- Common difficulties for the cardiologist in guiding South Asian patients
#SouthAsianCVD
bit.ly/4jVIuti
We get into:
- Knowledge gaps
- Lifestyle and Genetics
- Common difficulties for the cardiologist in guiding South Asian patients
#SouthAsianCVD
bit.ly/4jVIuti
Reposted by Romit Bhattacharya
Our @aspcardio.bsky.social statement on South Asians & Cardiometabolic Health in @ajpcardio.bsky.social
I had the honour of co-chairing this w/ the amazing Dr. Rohatji & @jaideeppatel.bsky.social
🙏🏽 to our entire talented team who brought this to life
📎 shorturl.at/4bJGz
#CVPrev #Cardiosky
I had the honour of co-chairing this w/ the amazing Dr. Rohatji & @jaideeppatel.bsky.social
🙏🏽 to our entire talented team who brought this to life
📎 shorturl.at/4bJGz
#CVPrev #Cardiosky
April 23, 2025 at 6:57 PM
Our @aspcardio.bsky.social statement on South Asians & Cardiometabolic Health in @ajpcardio.bsky.social
I had the honour of co-chairing this w/ the amazing Dr. Rohatji & @jaideeppatel.bsky.social
🙏🏽 to our entire talented team who brought this to life
📎 shorturl.at/4bJGz
#CVPrev #Cardiosky
I had the honour of co-chairing this w/ the amazing Dr. Rohatji & @jaideeppatel.bsky.social
🙏🏽 to our entire talented team who brought this to life
📎 shorturl.at/4bJGz
#CVPrev #Cardiosky
Reposted by Romit Bhattacharya
Honored to contribute to the @aspcardio.bsky.social Clinical Practice Statement on optimizing cardiometabolic health among South Asian individuals spearheaded by A. Rohatgi @drmarthagulati.bsky.social J. Patel www.sciencedirect.com/science/arti...
April 23, 2025 at 2:19 PM
Honored to contribute to the @aspcardio.bsky.social Clinical Practice Statement on optimizing cardiometabolic health among South Asian individuals spearheaded by A. Rohatgi @drmarthagulati.bsky.social J. Patel www.sciencedirect.com/science/arti...
Reposted by Romit Bhattacharya
Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations!
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
April 23, 2025 at 11:35 AM
Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations!
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social