@acscardiology.bsky.social
Results of the FINEARTS-HF randomized clinical trial demonstrate that the PREDICT-HFpEF models performed well in terms of calibration and discrimination. Baseline risk did not modify the benefit of finerenone.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Finerenone for Heart Failure and Risk Estimated by the PREDICT-HFpEF Model
This randomized clinical trial evaluated the effectiveness of finerenone in patients with heart failure and mildly reduced ejection fraction or preserved ejection fraction across the spectrum of risk ...
jamanetwork.com
June 23, 2025 at 1:31 PM
Results of the FINEARTS-HF randomized clinical trial demonstrate that the PREDICT-HFpEF models performed well in terms of calibration and discrimination. Baseline risk did not modify the benefit of finerenone.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
There was no association between liberal fasting policies and witnessed aspiration. Further study of more liberal fasting policies is unlikely to find an association
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
No association between preprocedural fasting and witnessed pulmonary aspiration: A systematic review and meta-analysis
Preprocedural fasting has been a standard component of preoperative care since 1946 when an association between gastric volume and aspiration was made…
www.sciencedirect.com
June 21, 2025 at 10:33 PM
There was no association between liberal fasting policies and witnessed aspiration. Further study of more liberal fasting policies is unlikely to find an association
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Results of this cohort study suggest that the prevalence of CMP-PLP variants was substantial in patients with early-onset AF. Patients with AF carrying a CMP-PLP variant had an associated increased risk of future CMP/HF, independent of clinical and polygenic risk.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Cardiomyopathy-Associated Gene Variants in Atrial Fibrillation
This cohort study investigates the prevalence and clinical implications of cardiomyopathy-associated pathogenic or likely pathogenic variants in patients with atrial fibrillation.
jamanetwork.com
June 18, 2025 at 3:10 PM
Results of this cohort study suggest that the prevalence of CMP-PLP variants was substantial in patients with early-onset AF. Patients with AF carrying a CMP-PLP variant had an associated increased risk of future CMP/HF, independent of clinical and polygenic risk.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Among persons with both chronic kidney disease and type 2 diabetes, initial therapy with finerenone plus empagliflozin led to a greater reduction in the urinary albumin-to-creatinine ratio than either treatment alone.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes | NEJM
Limited evidence exists to support the simultaneous initiation of sodium–glucose cotransporter-2
inhibitors and finerenone, a nonsteroidal mineralocorticoid receptor antagonist, in
persons with chr...
www.nejm.org
June 5, 2025 at 4:55 PM
Among persons with both chronic kidney disease and type 2 diabetes, initial therapy with finerenone plus empagliflozin led to a greater reduction in the urinary albumin-to-creatinine ratio than either treatment alone.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
High PCATRCA was independently associated with PoCE after PCI using current-generation DES. Combining PCATRCA with traditional cardiovascular risk factors and cCTA findings may enhance risk assessment for PoCE after PCI.
eurointervention.pcronline.com/article/impa...
eurointervention.pcronline.com/article/impa...
Impact of pericoronary adipose tissue attenuation on clinical outcomes after percutaneous coronary intervention
This study examined the association between coronary inflammation, measured by pericoronary adipose tissue attenuation, and clinical outcomes after percutaneous coronary intervention with drug-eluting...
eurointervention.pcronline.com
June 4, 2025 at 7:31 PM
High PCATRCA was independently associated with PoCE after PCI using current-generation DES. Combining PCATRCA with traditional cardiovascular risk factors and cCTA findings may enhance risk assessment for PoCE after PCI.
eurointervention.pcronline.com/article/impa...
eurointervention.pcronline.com/article/impa...
ATTR-specific treatment and AVR both result in significant survival benefit in dual pathology AS and ATTR-CA. Results should be interpreted in the context of the non-randomized study setting and differences in patient characteristics.
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
Cardiac transthyretin amyloidosis treatment improves outcomes after aortic valve replacement for severe stenosis
AbstractBackground and Aims. Concomitant aortic stenosis (AS) and transthyretin-associated cardiac amyloidosis (ATTR-CA) is an increasingly recognized caus
academic.oup.com
June 4, 2025 at 6:54 PM
ATTR-specific treatment and AVR both result in significant survival benefit in dual pathology AS and ATTR-CA. Results should be interpreted in the context of the non-randomized study setting and differences in patient characteristics.
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
Among older adults with high-risk or intermediate-risk PE, patients treated with CBT experienced lower mortality over the follow-up of up to 3 years, but higher risk of in-hospital bleeding complications
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
Long-Term Outcomes Following Catheter-Based Therapies in Older Adults With Acute Pulmonary Embolism:
www.jacc.org
May 31, 2025 at 1:45 PM
Among older adults with high-risk or intermediate-risk PE, patients treated with CBT experienced lower mortality over the follow-up of up to 3 years, but higher risk of in-hospital bleeding complications
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
In stable patients with extensive noncalcified plaque volume at baseline, 18 months of evolocumab treatment was associated with a shift toward a lower risk quantitative plaque phenotype and reduction in microcalcification activity
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
Effects of Evolocumab on Coronary Plaque Composition and Microcalcification Activity by Coronary PET and CT Angiography:
www.jacc.org
May 31, 2025 at 11:42 AM
In stable patients with extensive noncalcified plaque volume at baseline, 18 months of evolocumab treatment was associated with a shift toward a lower risk quantitative plaque phenotype and reduction in microcalcification activity
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
A significant burden of elevated Lp(a) was found in China, highlighting the necessity of prioritized Lp(a) screening in high-risk groups. Elevated Lp(a) was identified as a significant risk factor for site-specific subclinical atherosclerosis
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
Prevalence of Elevated Lipoprotein(a) and its Association With Subclinical Atherosclerosis in 2.9 Million Chinese Adults:
www.jacc.org
May 28, 2025 at 2:35 AM
A significant burden of elevated Lp(a) was found in China, highlighting the necessity of prioritized Lp(a) screening in high-risk groups. Elevated Lp(a) was identified as a significant risk factor for site-specific subclinical atherosclerosis
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
n this prespecified analysis of a randomized clinical trial, patients with HFimpEF remained at high risk of CV events, underscoring the need for continued management despite LVEF improvement.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Finerenone in Heart Failure With Improved Ejection Fraction
This prespecified analysis of a randomized trial examines profiles, risk, and response to finerenone among patients with hearth failure with improved ejection fraction compared with patients with left...
jamanetwork.com
May 24, 2025 at 6:42 AM
n this prespecified analysis of a randomized clinical trial, patients with HFimpEF remained at high risk of CV events, underscoring the need for continued management despite LVEF improvement.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Deferred stenting did not reduce all-cause mortality or the composite primary outcome after 10 years but reduced hospitalization for heart failure compared with conventional PCI.
www.ahajournals.org/doi/full/10....
www.ahajournals.org/doi/full/10....
10-Year Outcomes of Deferred or Conventional Stent Implantation in Patients With STEMI (DANAMI-3-DEFER) | Circulation: Cardiovascular Interventions
BACKGROUND: Primary percutaneous coronary intervention (PCI) with stenting is recommended in ST-segment–elevation
myocardial infarction. Immediate stenting may cause distal embolization, microvascular...
www.ahajournals.org
May 21, 2025 at 2:55 PM
Deferred stenting did not reduce all-cause mortality or the composite primary outcome after 10 years but reduced hospitalization for heart failure compared with conventional PCI.
www.ahajournals.org/doi/full/10....
www.ahajournals.org/doi/full/10....
In ACS patients treated with DCS, a 1-month prasugrel-based DAPT strategy followed by prasugrel 5 mg monotherapy reduced NACE by 49%, mainly driven by a 77% reduction of bleeding events without compromising ischaemic safety
eurointervention.pcronline.com/article/one-...
eurointervention.pcronline.com/article/one-...
One-month dual antiplatelet therapy followed by prasugrel monotherapy at a reduced dose: the 4D-ACS randomised trial
Find out more about this article on One-month dual antiplatelet therapy followed by prasugrel monotherapy at a reduced dose: the 4D-ACS randomised trial
eurointervention.pcronline.com
May 21, 2025 at 1:47 PM
In ACS patients treated with DCS, a 1-month prasugrel-based DAPT strategy followed by prasugrel 5 mg monotherapy reduced NACE by 49%, mainly driven by a 77% reduction of bleeding events without compromising ischaemic safety
eurointervention.pcronline.com/article/one-...
eurointervention.pcronline.com/article/one-...
The RV/LV diameter ratio offers real-time risk stratification and is a predictor of low cardiac index in patients with acute PE.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Real-time risk stratification in acute pulmonary embolism: the utility of RV/LV diameter ratio
This study evaluates the prognostic utility of the RV/LV diameter ratio in predicting low cardiac index (CI) in patients with acute intermediate-risk …
www.sciencedirect.com
May 18, 2025 at 2:23 PM
The RV/LV diameter ratio offers real-time risk stratification and is a predictor of low cardiac index in patients with acute PE.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Results reveal that long-term QOL and chest pain outcomes were the same with CT- vs ICA- guided first-test strategies at 3.5 years
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Health Status After CT or ICA for Stable Chest Pain
This secondary analysis of the Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) randomized clinical trial investigates if ...
jamanetwork.com
May 17, 2025 at 12:20 PM
Results reveal that long-term QOL and chest pain outcomes were the same with CT- vs ICA- guided first-test strategies at 3.5 years
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
In stable patients with extensive noncalcified plaque volume at baseline, 18 months of evolocumab treatment was associated with a shift toward a lower risk quantitative plaque phenotype and reduction in microcalcification activity
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
Effects of Evolocumab on Coronary Plaque Composition and Microcalcification Activity by Coronary PET and CT Angiography:
www.jacc.org
May 16, 2025 at 10:32 PM
In stable patients with extensive noncalcified plaque volume at baseline, 18 months of evolocumab treatment was associated with a shift toward a lower risk quantitative plaque phenotype and reduction in microcalcification activity
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
However, post-TAVR patients required greater fluoroscopic time (21.9 vs 17.7 mins, p<0.001) and had higher rates of post-procedural stroke (0.8% vs 0.4%, p=0.02) and bleeding (5.1% vs 2.9%, p<0.001).
www.ajconline.org/article/S000...
www.ajconline.org/article/S000...
Outcomes of Percutaneous Coronary Interventions Following Transcatheter Aortic Valve Replacement: Insights from the CathPCI Registry
Although transcatheter aortic valve replacement (TAVR) devices can impair coronary
access, there are limited real-world data comparing outcomes of percutaneous coronary
intervention (PCI) in post-TAVR...
www.ajconline.org
May 16, 2025 at 1:34 AM
However, post-TAVR patients required greater fluoroscopic time (21.9 vs 17.7 mins, p<0.001) and had higher rates of post-procedural stroke (0.8% vs 0.4%, p=0.02) and bleeding (5.1% vs 2.9%, p<0.001).
www.ajconline.org/article/S000...
www.ajconline.org/article/S000...
Contrast-derived indices have high specificity and negative predictive value, enabling rapid exclusion of microvascular dysfunction. This method is feasible, clinically useful and cost-saving compared with routine adenosine testing.
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
American Heart Association Journals
www.ahajournals.org
May 3, 2025 at 12:18 AM
Contrast-derived indices have high specificity and negative predictive value, enabling rapid exclusion of microvascular dysfunction. This method is feasible, clinically useful and cost-saving compared with routine adenosine testing.
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Among patients with recent NSTEMI, a high baseline hsCRP level was associated with the presence of pan-coronary atherosclerosis and focal high-risk plaques
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
Relationships of hsCRP to High-Risk Vulnerable Plaque After NSTEMI: Insights From the PROSPECT II Trial
www.jacc.org
April 26, 2025 at 12:08 AM
Among patients with recent NSTEMI, a high baseline hsCRP level was associated with the presence of pan-coronary atherosclerosis and focal high-risk plaques
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
Among statin-treated patients undergoing PCI, residual inflammation but not cholesterol risk was associated with an increased risk of MACE during follow-up.
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
Residual cholesterol and inflammatory risk in statin-treated patients undergoing percutaneous coronary intervention†
AbstractBackground and Aims. Elevated LDL-cholesterol levels and inflammation, as assessed by high-sensitivity C-reactive protein, correlate with cardiovas
academic.oup.com
April 23, 2025 at 3:22 PM
Among statin-treated patients undergoing PCI, residual inflammation but not cholesterol risk was associated with an increased risk of MACE during follow-up.
academic.oup.com/eurheartj/ad...
academic.oup.com/eurheartj/ad...
Exemplary effort by University Hospitals and Harrington Heart and Vascular Institute in Cleveland Ohio to reduce CV Mortality in a Rural Community in Ohio
www.beckershospitalreview.com/cardiology/i...
www.beckershospitalreview.com/cardiology/i...
Inside the multipronged effort to reduce CVD mortality at University Hospitals - Becker's Hospital Review | Healthcare News & Analysis
After making a $2.5 million investment in Cleveland-based University Hospitals Harrington Heart & Vascular Institute at the UH Portage Medical Center, which included establishing a catheterization lab...
www.beckershospitalreview.com
April 21, 2025 at 2:44 PM
Exemplary effort by University Hospitals and Harrington Heart and Vascular Institute in Cleveland Ohio to reduce CV Mortality in a Rural Community in Ohio
www.beckershospitalreview.com/cardiology/i...
www.beckershospitalreview.com/cardiology/i...
In patients with nonobstructive HCM, there was a reduction in myocardial T1 time with eplerenone, consistent with a reduction in diffuse myocardial fibrosis.
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
The Antifibrotic Effects of Eplerenone in Hypertrophic Cardiomyopathy: A Randomized Clinical Trial
www.jacc.org
April 21, 2025 at 12:30 AM
In patients with nonobstructive HCM, there was a reduction in myocardial T1 time with eplerenone, consistent with a reduction in diffuse myocardial fibrosis.
www.jacc.org/doi/10.1016/...
www.jacc.org/doi/10.1016/...
Interventional cardiologists experience significant stress, as measured by the LF/HF ratio, during complex, emergency, and complicated procedures; however, stress levels decrease later in the IC fellowship.
www.doximity.com/newsfeed/c82...
www.doximity.com/newsfeed/c82...
www.doximity.com
April 20, 2025 at 2:48 PM
Interventional cardiologists experience significant stress, as measured by the LF/HF ratio, during complex, emergency, and complicated procedures; however, stress levels decrease later in the IC fellowship.
www.doximity.com/newsfeed/c82...
www.doximity.com/newsfeed/c82...
Independent of the timing of statin initiation (i.e., whether for primary vs. secondary prevention of CVD), this study found an all-cause mortality benefit with statin therapy in patients on dialysis who had a very high risk for CVD or established CVD
www.acc.org/Latest-in-Ca...
www.acc.org/Latest-in-Ca...
Statins in Patients on Dialysis: A Mortality Benefit? - American College of Cardiology
www.acc.org
April 20, 2025 at 2:02 PM
Independent of the timing of statin initiation (i.e., whether for primary vs. secondary prevention of CVD), this study found an all-cause mortality benefit with statin therapy in patients on dialysis who had a very high risk for CVD or established CVD
www.acc.org/Latest-in-Ca...
www.acc.org/Latest-in-Ca...
Non-LAD CTO PCI significantly improved LVEF (8.2%) in HFrEF patients over two years, regardless of pre-procedure viability testing or post-procedural medical therapy.
www.doximity.com/newsfeed/186...
www.doximity.com/newsfeed/186...
Impact of Chronic Total Occlusion PCI in Non-LAD Coronary Arteries on Patients with Cardiomyopathy
: To evaluate the impact of left circumflex artery (LCX) or right coronary artery
(RCA) chronic total occlusion percutaneous coronary intervention (CTO PCI) on left
ventricular ejection fraction (LVEF...
www.doximity.com
April 20, 2025 at 1:57 PM
Non-LAD CTO PCI significantly improved LVEF (8.2%) in HFrEF patients over two years, regardless of pre-procedure viability testing or post-procedural medical therapy.
www.doximity.com/newsfeed/186...
www.doximity.com/newsfeed/186...
Individuals who are genetically predisposed to developing CAD also face an increased risk of developing dementia in old age. This risk is reduced in those demonstrating healthy lifestyle profiles earlier in the lifespan
www.ahajournals.org/doi/full/10....
www.ahajournals.org/doi/full/10....
Genetic and Lifestyle Risks for Coronary Artery Disease and Long-Term Risk of Incident Dementia Subtypes | Circulation
BACKGROUND: Shared genetic and lifestyle risk factors may underlie the development of both coronary
artery disease (CAD) and dementia. We examined whether an increased genetic risk for
CAD is associat...
www.ahajournals.org
April 18, 2025 at 10:11 PM
Individuals who are genetically predisposed to developing CAD also face an increased risk of developing dementia in old age. This risk is reduced in those demonstrating healthy lifestyle profiles earlier in the lifespan
www.ahajournals.org/doi/full/10....
www.ahajournals.org/doi/full/10....