Pradeep Natarajan
@pnatarajanmd.bsky.social
Cardiologist, genetics researcher.
Massachusetts General Hospital | Harvard Medical School | Broad Institute of Harvard & MIT
Massachusetts General Hospital | Harvard Medical School | Broad Institute of Harvard & MIT
Our study led by T. Bellomo and with @aniruddhpatelmd.bsky.social describes the relationship between lipoprotein(a) and incident & progressive extracoronary atherosclerotic vascular disease www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social
@broadinstitute.org @mgbresearch.bsky.social
@broadinstitute.org @mgbresearch.bsky.social
July 28, 2025 at 10:58 AM
Our study led by T. Bellomo and with @aniruddhpatelmd.bsky.social describes the relationship between lipoprotein(a) and incident & progressive extracoronary atherosclerotic vascular disease www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social
@broadinstitute.org @mgbresearch.bsky.social
@broadinstitute.org @mgbresearch.bsky.social
Delighted to collaborate on this work led by @kellybolton.bsky.social describing how germline genetic variation influences the trajectory of clonal hematopoiesis to hematologic malignancy www.nature.com/articles/s41... @natureportfolio.nature.com @broadinstitute.org @mgbresearch.bsky.social
July 16, 2025 at 5:07 PM
Delighted to collaborate on this work led by @kellybolton.bsky.social describing how germline genetic variation influences the trajectory of clonal hematopoiesis to hematologic malignancy www.nature.com/articles/s41... @natureportfolio.nature.com @broadinstitute.org @mgbresearch.bsky.social
An abs risk generalizable risk calculator is challenging. Led by @somijemmacho.bsky.social, evaluating AHA PREVENT across 4 academic health systems, we found similar discrimination but variable calibration. A universal abs risk threshold may not suitably guide www.sciencedirect.com/science/arti...
July 14, 2025 at 3:10 PM
An abs risk generalizable risk calculator is challenging. Led by @somijemmacho.bsky.social, evaluating AHA PREVENT across 4 academic health systems, we found similar discrimination but variable calibration. A universal abs risk threshold may not suitably guide www.sciencedirect.com/science/arti...
Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are:
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
July 3, 2025 at 12:29 PM
Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are:
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...
Delighted to write this viewpoint with C. Tcheandjieu & C. Robinson on gleaning and translating genomic insights across communities www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social
May 27, 2025 at 4:23 PM
Delighted to write this viewpoint with C. Tcheandjieu & C. Robinson on gleaning and translating genomic insights across communities www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social
Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio
May 21, 2025 at 4:02 PM
Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio
Very excited to Chair this webinar on Cardiovascular Health May 21 7:30-8:30p ET hosted by @indiaspora.bsky.social with Opening Remarks from Vivek Murthy.
Register us02web.zoom.us/meeting/regi...
@drmarthagulati.bsky.social
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
.
Register us02web.zoom.us/meeting/regi...
@drmarthagulati.bsky.social
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
.
May 12, 2025 at 7:36 PM
Very excited to Chair this webinar on Cardiovascular Health May 21 7:30-8:30p ET hosted by @indiaspora.bsky.social with Opening Remarks from Vivek Murthy.
Register us02web.zoom.us/meeting/regi...
@drmarthagulati.bsky.social
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
.
Register us02web.zoom.us/meeting/regi...
@drmarthagulati.bsky.social
@mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
.
Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025
May 7, 2025 at 1:39 PM
Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025
A cross-ancestry integrated (clinical + genetic) coronary artery disease risk score outperforms the Pooled Cohort Equations alone for CAD risk prediction across 4 cohorts www.nature.com/articles/s44...
May 7, 2025 at 1:05 AM
A cross-ancestry integrated (clinical + genetic) coronary artery disease risk score outperforms the Pooled Cohort Equations alone for CAD risk prediction across 4 cohorts www.nature.com/articles/s44...
The OurHealth Study – Discovering the Causes Behind High Rates of Cardiovascular Disease and Diabetes in South Asians www.indiaspora.org/the-ourhealt... @indiaspora.bsky.social
Please sign up and share! ourhealthstudy.org
@romitb.bsky.social
Please sign up and share! ourhealthstudy.org
@romitb.bsky.social
April 29, 2025 at 1:04 AM
The OurHealth Study – Discovering the Causes Behind High Rates of Cardiovascular Disease and Diabetes in South Asians www.indiaspora.org/the-ourhealt... @indiaspora.bsky.social
Please sign up and share! ourhealthstudy.org
@romitb.bsky.social
Please sign up and share! ourhealthstudy.org
@romitb.bsky.social
Our study led by A. Shankar shows that genotype-phenotype discordance of LDL-C (stronger polygenic predisposition to hypercholesterolemia for a given LDL-C) stratifies CAD risk - esp in normocholesterolemia. www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCADv
April 28, 2025 at 3:49 PM
Our study led by A. Shankar shows that genotype-phenotype discordance of LDL-C (stronger polygenic predisposition to hypercholesterolemia for a given LDL-C) stratifies CAD risk - esp in normocholesterolemia. www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCADv
Honored to contribute to the @aspcardio.bsky.social Clinical Practice Statement on optimizing cardiometabolic health among South Asian individuals spearheaded by A. Rohatgi @drmarthagulati.bsky.social J. Patel www.sciencedirect.com/science/arti...
April 23, 2025 at 2:19 PM
Honored to contribute to the @aspcardio.bsky.social Clinical Practice Statement on optimizing cardiometabolic health among South Asian individuals spearheaded by A. Rohatgi @drmarthagulati.bsky.social J. Patel www.sciencedirect.com/science/arti...
Interact with all of the results in the Pleiotropy Atlas (PLATLAS)!
platlas.cels.anl.gov
platlas.cels.anl.gov
April 23, 2025 at 11:35 AM
Interact with all of the results in the Pleiotropy Atlas (PLATLAS)!
platlas.cels.anl.gov
platlas.cels.anl.gov
Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations!
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
April 23, 2025 at 11:35 AM
Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations!
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social
Delighted to share our American Heart Association Scientific Statement on Direct-to-Consumer Genetic Testing for Cardiovascular Disease! www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social
March 13, 2025 at 11:36 AM
Delighted to share our American Heart Association Scientific Statement on Direct-to-Consumer Genetic Testing for Cardiovascular Disease! www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social
Individual polygenic risk scores for the same trait can yield different results due to various derivation differences. Our study led by A. Misra & w A. Patel demonstrates how successive integration of scores can improve accuracy & stability www.nature.com/articles/s41... @naturecomms.bsky.social
February 12, 2025 at 5:31 PM
Individual polygenic risk scores for the same trait can yield different results due to various derivation differences. Our study led by A. Misra & w A. Patel demonstrates how successive integration of scores can improve accuracy & stability www.nature.com/articles/s41... @naturecomms.bsky.social
Our paper led by J. Shin & A. Small evaluating the longitudinal penetrance of HCM alleles in the Mass General Brigham Biobank www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCAdv @broadinstitute.org @cgm-mgh.bsky.social @mgbresearch.bsky.social
February 5, 2025 at 3:57 PM
Our paper led by J. Shin & A. Small evaluating the longitudinal penetrance of HCM alleles in the Mass General Brigham Biobank www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCAdv @broadinstitute.org @cgm-mgh.bsky.social @mgbresearch.bsky.social
Genotype-first identification of Wilson’s Disease in the Estonian Biobank. 17 identified and only 8 previously diagnosed. Very high prevalence of neurodegenerative symptoms for those with WD genotypes www.nature.com/articles/s41...
December 16, 2024 at 1:53 PM
Genotype-first identification of Wilson’s Disease in the Estonian Biobank. 17 identified and only 8 previously diagnosed. Very high prevalence of neurodegenerative symptoms for those with WD genotypes www.nature.com/articles/s41...
Very nice viewpoint from @dranulala.bsky.social who walks the walk www.jacc.org/doi/10.1016/... @jaccjournals.bsky.social #JACCAdv
December 11, 2024 at 9:21 PM
Very nice viewpoint from @dranulala.bsky.social who walks the walk www.jacc.org/doi/10.1016/... @jaccjournals.bsky.social #JACCAdv
Polygenic predisposition to prolonged QTc among individuals with a normal baseline QTc predicted those having QTc prolongation after sotalol 80mg www.ahajournals.org/doi/abs/10.1... @ahajournals.bsky.social
December 10, 2024 at 10:30 PM
Polygenic predisposition to prolonged QTc among individuals with a normal baseline QTc predicted those having QTc prolongation after sotalol 80mg www.ahajournals.org/doi/abs/10.1... @ahajournals.bsky.social
HUGE congrats to @artschuermans.bsky.social for winning the 2024 @ukbiobank.bsky.social Early Career Researcher of the Year Award!!
Wonderful and bright visiting medical student with @mchonig.bsky.social & me @broadinstitute.org / MGH!!
Wonderful and bright visiting medical student with @mchonig.bsky.social & me @broadinstitute.org / MGH!!
December 10, 2024 at 4:18 PM
HUGE congrats to @artschuermans.bsky.social for winning the 2024 @ukbiobank.bsky.social Early Career Researcher of the Year Award!!
Wonderful and bright visiting medical student with @mchonig.bsky.social & me @broadinstitute.org / MGH!!
Wonderful and bright visiting medical student with @mchonig.bsky.social & me @broadinstitute.org / MGH!!
Among mice continuously administered AngII/Epi, a fibroblast activation protein (FAP) vaccine mitigated cardiac fibrosis www.ahajournals.org/doi/epdf/10....
December 9, 2024 at 3:26 PM
Among mice continuously administered AngII/Epi, a fibroblast activation protein (FAP) vaccine mitigated cardiac fibrosis www.ahajournals.org/doi/epdf/10....
The common IL6R p.Asp358Ala missense variant is associated with 5% ↓odds for CAD (inhibiting pathway validated & more inhibitors in RCTs), & 5% ↓odds for rheumatoid arthritis (w approved inhibitors for pathway).
New study shows even greater (10% ↓odds) for AAA.
www.ahajournals.org/doi/full/10....
New study shows even greater (10% ↓odds) for AAA.
www.ahajournals.org/doi/full/10....
December 9, 2024 at 3:21 PM
The common IL6R p.Asp358Ala missense variant is associated with 5% ↓odds for CAD (inhibiting pathway validated & more inhibitors in RCTs), & 5% ↓odds for rheumatoid arthritis (w approved inhibitors for pathway).
New study shows even greater (10% ↓odds) for AAA.
www.ahajournals.org/doi/full/10....
New study shows even greater (10% ↓odds) for AAA.
www.ahajournals.org/doi/full/10....
Topline of SURMOUNT-5: ph3b open-label among adults with overweight/obesity + related conditions & w/o T2D, Zepbound (tirzepatide) led to 47% relative greater weight loss than Wegovy (semaglutide) - 20.2% (50.3lb) v 13.7% (33.1lb) over 72w investor.lilly.com/news-release...
December 4, 2024 at 2:11 PM
Topline of SURMOUNT-5: ph3b open-label among adults with overweight/obesity + related conditions & w/o T2D, Zepbound (tirzepatide) led to 47% relative greater weight loss than Wegovy (semaglutide) - 20.2% (50.3lb) v 13.7% (33.1lb) over 72w investor.lilly.com/news-release...
Join us Dec 17 7p EST for a free webinar by me on 'Tips for Preventing Heart Disease' from @americanheart.bsky.social MA moderated by A. Bhatt
register: heart.zoom.us/webinar/regi...
series: www.heart.org/en/affiliate...
register: heart.zoom.us/webinar/regi...
series: www.heart.org/en/affiliate...
December 3, 2024 at 7:35 PM
Join us Dec 17 7p EST for a free webinar by me on 'Tips for Preventing Heart Disease' from @americanheart.bsky.social MA moderated by A. Bhatt
register: heart.zoom.us/webinar/regi...
series: www.heart.org/en/affiliate...
register: heart.zoom.us/webinar/regi...
series: www.heart.org/en/affiliate...