Carina de Oliveira Mann
@oliveiramann.bsky.social
Reposted by Carina de Oliveira Mann
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
October 8, 2025 at 9:45 PM
Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
Reposted by Carina de Oliveira Mann
The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...
The mechanistic basis of cargo selection during Golgi maturation
Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.
www.science.org
October 6, 2025 at 11:39 AM
The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...
Reposted by Carina de Oliveira Mann
Kicking off the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors organized by our department in Lausanne!
@brozlab.bsky.social @martinon.bsky.social @rebsamenlab.bsky.social @fbm-unil.bsky.social
@brozlab.bsky.social @martinon.bsky.social @rebsamenlab.bsky.social @fbm-unil.bsky.social
October 1, 2025 at 9:30 AM
Kicking off the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors organized by our department in Lausanne!
@brozlab.bsky.social @martinon.bsky.social @rebsamenlab.bsky.social @fbm-unil.bsky.social
@brozlab.bsky.social @martinon.bsky.social @rebsamenlab.bsky.social @fbm-unil.bsky.social
Reposted by Carina de Oliveira Mann
We're hosting the 8th Austrian CryoEM symposium at ISTA Nov 11-12 @istaresearch.bsky.social this year - you don't want to miss! We have a fantastic lineup of invited speakers + selected talks from abstracts #cryoEM
Deadline for abstracts Oct 15
Final deadline Oct 31
cryoem-symposium.pages.ist.ac.at
Deadline for abstracts Oct 15
Final deadline Oct 31
cryoem-symposium.pages.ist.ac.at
8th Austrian Cryo-EM Symposium
cryoem-symposium.pages.ist.ac.at
October 1, 2025 at 8:39 AM
We're hosting the 8th Austrian CryoEM symposium at ISTA Nov 11-12 @istaresearch.bsky.social this year - you don't want to miss! We have a fantastic lineup of invited speakers + selected talks from abstracts #cryoEM
Deadline for abstracts Oct 15
Final deadline Oct 31
cryoem-symposium.pages.ist.ac.at
Deadline for abstracts Oct 15
Final deadline Oct 31
cryoem-symposium.pages.ist.ac.at
Reposted by Carina de Oliveira Mann
🚀 Check out our new preprint on extending the scope of single-particle cryo-EM with 2D template matching!
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv!
www.biorxiv.org/content/10.1...
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv!
www.biorxiv.org/content/10.1...
September 17, 2025 at 5:07 PM
🚀 Check out our new preprint on extending the scope of single-particle cryo-EM with 2D template matching!
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv!
www.biorxiv.org/content/10.1...
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv!
www.biorxiv.org/content/10.1...
Reposted by Carina de Oliveira Mann
Myeloperoxidase transforms chromatin into neutrophil extracellular traps @nature.com @intein.bsky.social @mpiib-berlin.mpg.de
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 18, 2025 at 2:07 AM
Myeloperoxidase transforms chromatin into neutrophil extracellular traps @nature.com @intein.bsky.social @mpiib-berlin.mpg.de
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Carina de Oliveira Mann
What is cell death?
Honored to participate in this article where the question was posed to a dozen experts.
Thanks to the fantastic team at Nature Structural & Molecular Biology for organizing this discussion.
rdcu.be/eG1Nm
Honored to participate in this article where the question was posed to a dozen experts.
Thanks to the fantastic team at Nature Structural & Molecular Biology for organizing this discussion.
rdcu.be/eG1Nm
Towards a molecular and structural definition of cell death
Nature Structural & Molecular Biology - Cell death contributes to tissue homeostasis and plays critical roles in inflammation and host defense. Our increasing understanding of the physiological...
rdcu.be
September 18, 2025 at 10:47 AM
What is cell death?
Honored to participate in this article where the question was posed to a dozen experts.
Thanks to the fantastic team at Nature Structural & Molecular Biology for organizing this discussion.
rdcu.be/eG1Nm
Honored to participate in this article where the question was posed to a dozen experts.
Thanks to the fantastic team at Nature Structural & Molecular Biology for organizing this discussion.
rdcu.be/eG1Nm
Reposted by Carina de Oliveira Mann
📢 New preprint alert!
We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses.
This could transform phage therapy + genetic engineering.
Here’s what we found 🧵
Preprint🔗: www.biorxiv.org/content/10.1...
We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses.
This could transform phage therapy + genetic engineering.
Here’s what we found 🧵
Preprint🔗: www.biorxiv.org/content/10.1...
Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection
Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...
www.biorxiv.org
September 2, 2025 at 7:36 AM
📢 New preprint alert!
We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses.
This could transform phage therapy + genetic engineering.
Here’s what we found 🧵
Preprint🔗: www.biorxiv.org/content/10.1...
We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses.
This could transform phage therapy + genetic engineering.
Here’s what we found 🧵
Preprint🔗: www.biorxiv.org/content/10.1...
Reposted by Carina de Oliveira Mann
Laser flash melting cryo-EM samples to overcome preferred orientation pubmed.ncbi.nlm.nih.gov/40877464/ #cryoem
August 29, 2025 at 2:04 PM
Laser flash melting cryo-EM samples to overcome preferred orientation pubmed.ncbi.nlm.nih.gov/40877464/ #cryoem
Reposted by Carina de Oliveira Mann
Feeling recharged after our lab retreat in Obergurgl 🌞⛰️
Great hikes, perfect weather, motivating talks from @oliveiramann.bsky.social, Liudmila Andreeva and lots of inspiring discussions. Big thanks for the warm hospitality!
Great hikes, perfect weather, motivating talks from @oliveiramann.bsky.social, Liudmila Andreeva and lots of inspiring discussions. Big thanks for the warm hospitality!
August 27, 2025 at 12:54 PM
Feeling recharged after our lab retreat in Obergurgl 🌞⛰️
Great hikes, perfect weather, motivating talks from @oliveiramann.bsky.social, Liudmila Andreeva and lots of inspiring discussions. Big thanks for the warm hospitality!
Great hikes, perfect weather, motivating talks from @oliveiramann.bsky.social, Liudmila Andreeva and lots of inspiring discussions. Big thanks for the warm hospitality!
Reposted by Carina de Oliveira Mann
Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at @istaresearch.bsky.social, with speakers inc. @grigoriefflab.bsky.social, @oliveiramann.bsky.social, @bjgreber.bsky.social @svenklumpe.bsky.social @sebastianglatt.bsky.social https://tinyurl.com/cryo2025
Austrian Cryo-EM Symposium
cryoem-symposium.pages.ist.ac.at
July 25, 2025 at 3:45 PM
Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at @istaresearch.bsky.social, with speakers inc. @grigoriefflab.bsky.social, @oliveiramann.bsky.social, @bjgreber.bsky.social @svenklumpe.bsky.social @sebastianglatt.bsky.social https://tinyurl.com/cryo2025
Reposted by Carina de Oliveira Mann
I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social.
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!
www.cell.com/cell/fulltex...
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!
www.cell.com/cell/fulltex...
Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection.
However, modified nucleosides common in self-RNA—most notably pseudouridine—evade
recognition. This study finds t...
www.cell.com
June 30, 2025 at 5:01 PM
I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social.
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!
www.cell.com/cell/fulltex...
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!
www.cell.com/cell/fulltex...
Reposted by Carina de Oliveira Mann
Proud to present a cover inspired by the structural and functional analysis of OAS2 by @oliveiramann.bsky.social, @indrabekere.bsky.social, and Veronika Merold, live at @cp-molcell.bsky.social. Big news on RNA sensing and antiviral defenses!
#sciart ⌬ #research ⌬ #chemistry ⌬ #immunology
#sciart ⌬ #research ⌬ #chemistry ⌬ #immunology
June 13, 2025 at 10:04 AM
Proud to present a cover inspired by the structural and functional analysis of OAS2 by @oliveiramann.bsky.social, @indrabekere.bsky.social, and Veronika Merold, live at @cp-molcell.bsky.social. Big news on RNA sensing and antiviral defenses!
#sciart ⌬ #research ⌬ #chemistry ⌬ #immunology
#sciart ⌬ #research ⌬ #chemistry ⌬ #immunology
Reposted by Carina de Oliveira Mann
Excited to share our latest update on @cp-cell.bsky.social!
We introduce VICAR (VIral-induced Centromeric DNA Amplification and Recognition) : a newly identified nuclear cGAS defense system to detect viruses.
www.cell.com/cell/abstrac...
We introduce VICAR (VIral-induced Centromeric DNA Amplification and Recognition) : a newly identified nuclear cGAS defense system to detect viruses.
www.cell.com/cell/abstrac...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification
and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune
surveillance mechanism in the nu...
www.cell.com
June 2, 2025 at 3:47 PM
Excited to share our latest update on @cp-cell.bsky.social!
We introduce VICAR (VIral-induced Centromeric DNA Amplification and Recognition) : a newly identified nuclear cGAS defense system to detect viruses.
www.cell.com/cell/abstrac...
We introduce VICAR (VIral-induced Centromeric DNA Amplification and Recognition) : a newly identified nuclear cGAS defense system to detect viruses.
www.cell.com/cell/abstrac...
Reposted by Carina de Oliveira Mann
Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!
Online Now: Structural basis for OAS2 regulation and its antiviral function Online now:
Structural basis for OAS2 regulation and its antiviral function
Merold and Bekere et al. reveal that OAS2 exists as a zinc-mediated dimer in an autoinhibited state, preventing autoreactivity to short RNAs. Dimer-to-monomer transition, dsRNA binding to a non-canonical interface, and targeting to the Golgi by myristoylation are necessary for OAS2 activation and restriction of viruses that form double membrane vesicles.
dlvr.it
May 23, 2025 at 4:31 PM
Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!
Reposted by Carina de Oliveira Mann
Wow, so cool!🌟
Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition
Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy
🥂🥳🤩
www.lmu.de/en/newsroom/...
@v-hornung.bsky.social
Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition
Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy
🥂🥳🤩
www.lmu.de/en/newsroom/...
@v-hornung.bsky.social
NUCLEATE Cluster of Excellence: beacon of nucleic acid research
The new NUCLEATE Cluster of Excellence is all about nucleic acids. The research alliance seeks to better understand their various functions and open up new areas of application.
www.lmu.de
May 22, 2025 at 6:03 PM
Wow, so cool!🌟
Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition
Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy
🥂🥳🤩
www.lmu.de/en/newsroom/...
@v-hornung.bsky.social
Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition
Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy
🥂🥳🤩
www.lmu.de/en/newsroom/...
@v-hornung.bsky.social
Reposted by Carina de Oliveira Mann
Together with the Roers Lab from @uniheidelberg.bsky.social and @bms-us.bsky.social we propose that controlled low level systemic activation of #cGAS by endogenous nucleic acids is a safe and effective way to boost #cancer #immunotherapy.
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Systemic Inactivation of TREX1 Induces Selective Inflammation of the Tumor Microenvironment and Invigorated T Cell-Mediated Tumor Control
Abstract. Therapeutic innate immune stimulation within the tumor microenvironment can potentiate endogenous antitumor T cell immunity. Strategies for controlled activation of cGAS/STING signaling are ...
aacrjournals.org
May 21, 2025 at 12:41 PM
Together with the Roers Lab from @uniheidelberg.bsky.social and @bms-us.bsky.social we propose that controlled low level systemic activation of #cGAS by endogenous nucleic acids is a safe and effective way to boost #cancer #immunotherapy.
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Reposted by Carina de Oliveira Mann
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
March 21, 2025 at 3:16 PM
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
Reposted by Carina de Oliveira Mann
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
@wehi-research.bsky.social @komanderlab.bsky.social
March 13, 2025 at 7:20 PM
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
@wehi-research.bsky.social @komanderlab.bsky.social
Reposted by Carina de Oliveira Mann
Meet Carina Baer de Oliveira Mann, our newly appointed professor of #Biomolecular Cryo-Electron Microscopy, in the latest NewIn episode. She aims to identify #molecularswitches in the human #immunesystem that activate the immune defenses: go.tum.de/157504
@oliveiramann.bsky.social
🎥ProLehre
@oliveiramann.bsky.social
🎥ProLehre
In search of molecular switches in the immune system
A decades-long search culminated in 2013 with the discovery of cGAS – a molecular switch that plays a key role in the human immune system. Carina Baer de Oliveira Mann was a doctoral student with the ...
go.tum.de
February 20, 2025 at 1:28 PM
Meet Carina Baer de Oliveira Mann, our newly appointed professor of #Biomolecular Cryo-Electron Microscopy, in the latest NewIn episode. She aims to identify #molecularswitches in the human #immunesystem that activate the immune defenses: go.tum.de/157504
@oliveiramann.bsky.social
🎥ProLehre
@oliveiramann.bsky.social
🎥ProLehre
Reposted by Carina de Oliveira Mann
Structural Basis for OAS2 Regulation and its Antiviral Function https://www.biorxiv.org/content/10.1101/2025.01.28.635220v1
January 29, 2025 at 2:46 AM
Structural Basis for OAS2 Regulation and its Antiviral Function https://www.biorxiv.org/content/10.1101/2025.01.28.635220v1
Reposted by Carina de Oliveira Mann
🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...
C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.
www.nature.com
January 29, 2025 at 4:29 PM
🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...
Reposted by Carina de Oliveira Mann
Confirmed speakers:
A. Ablasser
L. Andreeva
@audeber.bsky.social
@jelenalab.bsky.social
V. Dixit
@v-hornung.bsky.social
B. Lemaitre
O. Majer
@manellab.bsky.social
E. Miao
@oliveiramann.bsky.social
M. Pasparakis
@inflammasomelab.bsky.social
@sparrerlab.bsky.social
R. Vance
@lozanzi.bsky.social
A. Ablasser
L. Andreeva
@audeber.bsky.social
@jelenalab.bsky.social
V. Dixit
@v-hornung.bsky.social
B. Lemaitre
O. Majer
@manellab.bsky.social
E. Miao
@oliveiramann.bsky.social
M. Pasparakis
@inflammasomelab.bsky.social
@sparrerlab.bsky.social
R. Vance
@lozanzi.bsky.social
January 28, 2025 at 2:33 PM
Confirmed speakers:
A. Ablasser
L. Andreeva
@audeber.bsky.social
@jelenalab.bsky.social
V. Dixit
@v-hornung.bsky.social
B. Lemaitre
O. Majer
@manellab.bsky.social
E. Miao
@oliveiramann.bsky.social
M. Pasparakis
@inflammasomelab.bsky.social
@sparrerlab.bsky.social
R. Vance
@lozanzi.bsky.social
A. Ablasser
L. Andreeva
@audeber.bsky.social
@jelenalab.bsky.social
V. Dixit
@v-hornung.bsky.social
B. Lemaitre
O. Majer
@manellab.bsky.social
E. Miao
@oliveiramann.bsky.social
M. Pasparakis
@inflammasomelab.bsky.social
@sparrerlab.bsky.social
R. Vance
@lozanzi.bsky.social
Happy to share the first preprint from my lab by
@indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity!
Check out Indra’s thread for a summary:
@indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity!
Check out Indra’s thread for a summary:
I’m very excited to share our first preprint “Structural Basis for OAS2 Regulation and its Antiviral Function” from my postdoc together with Veronika Merold (Vroni) from NTase lab with @oliveiramann.bsky.social www.biorxiv.org/content/10.1...
January 29, 2025 at 1:57 PM
Happy to share the first preprint from my lab by
@indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity!
Check out Indra’s thread for a summary:
@indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity!
Check out Indra’s thread for a summary:
Reposted by Carina de Oliveira Mann
We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳
Re-posts appreciated.
www.nature.com/naturecareer...
Re-posts appreciated.
www.nature.com/naturecareer...
Research Group Leader Tenure Track - Structural Studies - LMB 2549 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12835196
Research Group Leader Tenure Track Starting Salary £65,940 to £74,448 per annum MRC Laboratory of Molecular Biology, Cambridge, UK
www.nature.com
January 27, 2025 at 9:38 AM
We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳
Re-posts appreciated.
www.nature.com/naturecareer...
Re-posts appreciated.
www.nature.com/naturecareer...