Indra_Beķere
@indrabekere.bsky.social
Postdoc in the lab of Carina de Oliveira Mann
TUM, Munich, Germany, interested in pathogens and innate immunity
https://www.bio.nat.tum.de/en/cryoem/home/
TUM, Munich, Germany, interested in pathogens and innate immunity
https://www.bio.nat.tum.de/en/cryoem/home/
Excited to share my latest work in the @oliveiramann.bsky.social lab, where we examined STING dependent and independent nucleotide signalling pathways in human cells with a library of 78 nucleotides by RNA-seq and imaging analysis
Profiling Nucleotide Signalling Pathways and STING Agonist Activity with a Nucleotide Library https://www.biorxiv.org/content/10.1101/2025.11.11.687896v1
November 13, 2025 at 7:37 PM
Excited to share my latest work in the @oliveiramann.bsky.social lab, where we examined STING dependent and independent nucleotide signalling pathways in human cells with a library of 78 nucleotides by RNA-seq and imaging analysis
Reposted by Indra_Beķere
Finding a foothold to fight: New insights into the viral RNA sensing and activation mechanism of OAS2
Finding a foothold to fight: New insights into the viral RNA sensing and activation mechanism of OAS2
Oligoadenylate synthetases (OASs) are a family of double-stranded RNA (dsRNA)-activated nucleotidyltransferases involved in pathogen sensing and innate immune response. In this issue of Molecular Cell, Merold et al. define a mechanism of OAS2 activation by dsRNA-length discrimination and its deficiency associated with autoimmune disorder.
dlvr.it
June 10, 2025 at 7:14 PM
Finding a foothold to fight: New insights into the viral RNA sensing and activation mechanism of OAS2
Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!
Online Now: Structural basis for OAS2 regulation and its antiviral function Online now:
Structural basis for OAS2 regulation and its antiviral function
Merold and Bekere et al. reveal that OAS2 exists as a zinc-mediated dimer in an autoinhibited state, preventing autoreactivity to short RNAs. Dimer-to-monomer transition, dsRNA binding to a non-canonical interface, and targeting to the Golgi by myristoylation are necessary for OAS2 activation and restriction of viruses that form double membrane vesicles.
dlvr.it
May 23, 2025 at 4:31 PM
Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!
Reposted by Indra_Beķere
Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:
April 14, 2025 at 4:56 PM
Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:
Reposted by Indra_Beķere
Meet Carina Baer de Oliveira Mann, our newly appointed professor of #Biomolecular Cryo-Electron Microscopy, in the latest NewIn episode. She aims to identify #molecularswitches in the human #immunesystem that activate the immune defenses: go.tum.de/157504
@oliveiramann.bsky.social
🎥ProLehre
@oliveiramann.bsky.social
🎥ProLehre
In search of molecular switches in the immune system
A decades-long search culminated in 2013 with the discovery of cGAS – a molecular switch that plays a key role in the human immune system. Carina Baer de Oliveira Mann was a doctoral student with the ...
go.tum.de
February 20, 2025 at 1:28 PM
Meet Carina Baer de Oliveira Mann, our newly appointed professor of #Biomolecular Cryo-Electron Microscopy, in the latest NewIn episode. She aims to identify #molecularswitches in the human #immunesystem that activate the immune defenses: go.tum.de/157504
@oliveiramann.bsky.social
🎥ProLehre
@oliveiramann.bsky.social
🎥ProLehre
Reposted by Indra_Beķere
Happy to share the first preprint from my lab by
@indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity!
Check out Indra’s thread for a summary:
@indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity!
Check out Indra’s thread for a summary:
I’m very excited to share our first preprint “Structural Basis for OAS2 Regulation and its Antiviral Function” from my postdoc together with Veronika Merold (Vroni) from NTase lab with @oliveiramann.bsky.social www.biorxiv.org/content/10.1...
January 29, 2025 at 1:57 PM
Happy to share the first preprint from my lab by
@indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity!
Check out Indra’s thread for a summary:
@indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity!
Check out Indra’s thread for a summary:
Reposted by Indra_Beķere
Structural Basis for OAS2 Regulation and its Antiviral Function https://www.biorxiv.org/content/10.1101/2025.01.28.635220v1
January 29, 2025 at 2:46 AM
Structural Basis for OAS2 Regulation and its Antiviral Function https://www.biorxiv.org/content/10.1101/2025.01.28.635220v1
I’m very excited to share our first preprint “Structural Basis for OAS2 Regulation and its Antiviral Function” from my postdoc together with Veronika Merold (Vroni) from NTase lab with @oliveiramann.bsky.social www.biorxiv.org/content/10.1...
January 29, 2025 at 7:14 AM
I’m very excited to share our first preprint “Structural Basis for OAS2 Regulation and its Antiviral Function” from my postdoc together with Veronika Merold (Vroni) from NTase lab with @oliveiramann.bsky.social www.biorxiv.org/content/10.1...