Apoorva Baluapuri
@baluapuri.bsky.social
Working @adelmanlab.bsky.social @hms-bcmp.bsky.social + Vik Khurana lab @mgbresearch.bsky.social. Previously at Eilers/Wolf Lab @uni-wuerzburg.de. Interested in transcription and dsRNA biology - with a special focus on RNA Pol II.
Pinned
Apoorva Baluapuri
@baluapuri.bsky.social
· Apr 14
Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:
Reposted by Apoorva Baluapuri
Our collaborative paper with the Arndt lab is out today: doi.org/10.1093/nar/... (originally bioRxiv: www.biorxiv.org/content/10.1...). Here we asked the question of how CHD1 localizes to chromatin.
A direct interaction between the Chd1 CHCT domain and Rtf1 controls Chd1 distribution and nucleosome positioning on active genes
Abstract. The nucleosome remodeler Chd1 is required for the re-establishment of nucleosome positioning in the wake of transcription elongation by RNA Polym
doi.org
August 28, 2025 at 11:07 PM
Our collaborative paper with the Arndt lab is out today: doi.org/10.1093/nar/... (originally bioRxiv: www.biorxiv.org/content/10.1...). Here we asked the question of how CHD1 localizes to chromatin.
Reposted by Apoorva Baluapuri
Excited to see this work published online at @cp-cell.bsky.social today!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
August 20, 2025 at 3:20 PM
Excited to see this work published online at @cp-cell.bsky.social today!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Apoorva Baluapuri
The Vlaming lab is expanding! If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.
My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.
PhD position in Gene Regulation
Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!
www.uu.nl
August 15, 2025 at 10:22 AM
The Vlaming lab is expanding! If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.
My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.
Reposted by Apoorva Baluapuri
🎉 Thrilled to share our new paper in @narjournal.bsky.social!
We uncover how the Hox TF Ultrabithorax controls alternative splicing to shape muscle patterning and homeotic identity 🧬 @igmm-montpel.bsky.social
🔗 doi.org/10.1093/nar/...
We uncover how the Hox TF Ultrabithorax controls alternative splicing to shape muscle patterning and homeotic identity 🧬 @igmm-montpel.bsky.social
🔗 doi.org/10.1093/nar/...
Synergistic DNA and RNA binding of the Hox transcription factor Ultrabithorax coordinates splicing and shapes in vivo homeotic functions
Abstract. The dual interaction of many transcription factors (TFs) with both DNA and RNA is an underexplored issue that could fundamentally reshape our und
doi.org
July 4, 2025 at 5:40 PM
🎉 Thrilled to share our new paper in @narjournal.bsky.social!
We uncover how the Hox TF Ultrabithorax controls alternative splicing to shape muscle patterning and homeotic identity 🧬 @igmm-montpel.bsky.social
🔗 doi.org/10.1093/nar/...
We uncover how the Hox TF Ultrabithorax controls alternative splicing to shape muscle patterning and homeotic identity 🧬 @igmm-montpel.bsky.social
🔗 doi.org/10.1093/nar/...
Reposted by Apoorva Baluapuri
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology
Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...
www.nature.com
June 30, 2025 at 1:12 PM
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Much appreciate the spotlight on our (@adelmanlab.bsky.social) paper about INT depletion/dsRNA-induced stress responses by @hanzlikovalab.bsky.social Amazing to see the finding being placed in perspective of the big picture of neurodevelopmental diseases and therapeutic targets 🙏 #RNABiology
Integrator complex collapse: A mechanistic route to integrated stress response and disease
Integrator complex collapse: A mechanistic route to integrated stress response and disease
In a recent Cell article, Baluapuri et al. show that loss of the Integrator (INT) complex activates the integrated stress response via double-stranded RNA from incomplete pre-mRNAs, revealing a link to INT-related neurodevelopmental diseases and potential therapeutic targets.
dlvr.it
June 20, 2025 at 2:01 PM
Much appreciate the spotlight on our (@adelmanlab.bsky.social) paper about INT depletion/dsRNA-induced stress responses by @hanzlikovalab.bsky.social Amazing to see the finding being placed in perspective of the big picture of neurodevelopmental diseases and therapeutic targets 🙏 #RNABiology
Reposted by Apoorva Baluapuri
Do you or someone you know have an exciting new chromatin/transcription story that you'll be ready to talk about in the Fall?
Then fill out or share this form to speak in the @fnucleosome.bsky.social seminar series! All models, organisms, and complexes welcome 🧬🧪🔬
Then fill out or share this form to speak in the @fnucleosome.bsky.social seminar series! All models, organisms, and complexes welcome 🧬🧪🔬
FN is taking a summer vacation 🏖️, but we'll be back in September with more exciting talks on chromatin and transcription!
If you've got a new story you'd like to share with the FN audience this fall, fill out the form here: docs.google.com/forms/d/e/1F...
If you've got a new story you'd like to share with the FN audience this fall, fill out the form here: docs.google.com/forms/d/e/1F...
Application to speak in the Fragile Nucleosome series
Thank you for your interest in our seminar series!
We use a variety of different session formats but, in general, trainees can plan for a ~15 min talk + 5min Q/A and PIs can plan for a ~25min talk +...
docs.google.com
June 19, 2025 at 9:41 PM
Do you or someone you know have an exciting new chromatin/transcription story that you'll be ready to talk about in the Fall?
Then fill out or share this form to speak in the @fnucleosome.bsky.social seminar series! All models, organisms, and complexes welcome 🧬🧪🔬
Then fill out or share this form to speak in the @fnucleosome.bsky.social seminar series! All models, organisms, and complexes welcome 🧬🧪🔬
Reposted by Apoorva Baluapuri
Reposted by Apoorva Baluapuri
Exciting new work from Apoorva Baluapuri of the Adelman lab! @baluapuri.bsky.social
@adelmanlab.bsky.social
www.sciencedirect.com/science/arti...
@adelmanlab.bsky.social
www.sciencedirect.com/science/arti...
April 18, 2025 at 8:44 PM
Exciting new work from Apoorva Baluapuri of the Adelman lab! @baluapuri.bsky.social
@adelmanlab.bsky.social
www.sciencedirect.com/science/arti...
@adelmanlab.bsky.social
www.sciencedirect.com/science/arti...
Thrilled to see my work with @adelmanlab.bsky.social on INT/dsRNA highlighted by @willgarland.bsky.social and @heick.bsky.social ! Thanks for beautifully capturing how nuclear RNA guardians prevent cellular chaos. The ripple effects of transcriptional dysregulation are indeed profound! #RNABiology
We put together a spotlight for @cp-cellchembiol.bsky.social highlighting the recent work from @baluapuri.bsky.social and @adelmanlab.bsky.social published in @cp-cell.bsky.social.
Here they show how a breakdown in nuclear RNA regulation sends ripples of stress throughout the cell.
Here they show how a breakdown in nuclear RNA regulation sends ripples of stress throughout the cell.
June 19, 2025 at 7:47 PM
Thrilled to see my work with @adelmanlab.bsky.social on INT/dsRNA highlighted by @willgarland.bsky.social and @heick.bsky.social ! Thanks for beautifully capturing how nuclear RNA guardians prevent cellular chaos. The ripple effects of transcriptional dysregulation are indeed profound! #RNABiology
Reposted by Apoorva Baluapuri
Join us next Wed, for three amazing ECR researchers_ @fueyoraquel.bsky.social, @kaiamattioli.bsky.social and Laura talk about their work in #FragileNucleosome seminar series!
In case you haven't joined any of the previous 2025 sessions, here is registration link:
us06web.zoom.us/webinar/regi...
In case you haven't joined any of the previous 2025 sessions, here is registration link:
us06web.zoom.us/webinar/regi...
June 14, 2025 at 9:54 AM
Join us next Wed, for three amazing ECR researchers_ @fueyoraquel.bsky.social, @kaiamattioli.bsky.social and Laura talk about their work in #FragileNucleosome seminar series!
In case you haven't joined any of the previous 2025 sessions, here is registration link:
us06web.zoom.us/webinar/regi...
In case you haven't joined any of the previous 2025 sessions, here is registration link:
us06web.zoom.us/webinar/regi...
Reposted by Apoorva Baluapuri
Why are there intronic reads in your bulk RNA-seq data?
You're not alone—it's common, and the reasons are more layered than you think.
Let’s break it down. 🧵
You're not alone—it's common, and the reasons are more layered than you think.
Let’s break it down. 🧵
June 6, 2025 at 1:45 PM
Why are there intronic reads in your bulk RNA-seq data?
You're not alone—it's common, and the reasons are more layered than you think.
Let’s break it down. 🧵
You're not alone—it's common, and the reasons are more layered than you think.
Let’s break it down. 🧵
Reposted by Apoorva Baluapuri
Sometimes when I am having a bad day I remember that after my TED talk in 2016 this woman mobbed me afterwards and threw herself on me with the hugest hug saying "Oh my god you were incredible and inspirational I want to BE you"
It was Cher
It was Cher
May 25, 2025 at 11:37 PM
Sometimes when I am having a bad day I remember that after my TED talk in 2016 this woman mobbed me afterwards and threw herself on me with the hugest hug saying "Oh my god you were incredible and inspirational I want to BE you"
It was Cher
It was Cher
Was great presenting at @fnucleosome.bsky.social - amazing feedback and participation from the audience. Thanks once again to the organizers:) here’s the link press release for the story for those who missed it : hms.harvard.edu/news/what-ha...
May 7, 2025 at 8:33 PM
Was great presenting at @fnucleosome.bsky.social - amazing feedback and participation from the audience. Thanks once again to the organizers:) here’s the link press release for the story for those who missed it : hms.harvard.edu/news/what-ha...
Reposted by Apoorva Baluapuri
Read all about Apoorva Baluapuri’s new work on Integrator (INT) in HMS News! @baluapuri.bsky.social @adelmanlab.bsky.social
tinyurl.com/y2fx22c2
tinyurl.com/y2fx22c2
What Happens When a Gene Quality-Control Mechanism Fails?
Study solves riddle of how mutations in Integrator complex relate to neurodegeneration, cancer
tinyurl.com
May 6, 2025 at 3:56 PM
Read all about Apoorva Baluapuri’s new work on Integrator (INT) in HMS News! @baluapuri.bsky.social @adelmanlab.bsky.social
tinyurl.com/y2fx22c2
tinyurl.com/y2fx22c2
Reposted by Apoorva Baluapuri
You can read our full Review @science.org here 👉👉https://www.science.org/doi/10.1126/science.adp2959
May 2, 2025 at 9:05 AM
You can read our full Review @science.org here 👉👉https://www.science.org/doi/10.1126/science.adp2959
Looking forward to share my postdoc work done with @adelmanlab.bsky.social, and to revisit @fnucleosome.bsky.social as a presenter once more after 3 years !!! Super excited….
⚡Next Wednesday! In our next #FragileNucleosome seminar session, we are delighted to host, @baluapuri.bsky.social and @juliecocquet.bsky.social!
If you've registered to one of our previous 2025 sessions, you can use the same link to join our next session. If not:
us06web.zoom.us/webinar/regi...
If you've registered to one of our previous 2025 sessions, you can use the same link to join our next session. If not:
us06web.zoom.us/webinar/regi...
May 1, 2025 at 9:56 AM
Looking forward to share my postdoc work done with @adelmanlab.bsky.social, and to revisit @fnucleosome.bsky.social as a presenter once more after 3 years !!! Super excited….
Thanks @mpi-ie.bsky.social for the having me over last week and for the great conversations I had at your nice institute cradled in the beautiful Schwarzwald !!
This Friday, we have a guest from Harvard Med School: Apoorva @baluapuri.bsky.social is a @dfg.de Walter Benjamin Fellowship holder who studies mRNA synthesis in the @adelmanlab.bsky.social. We are looking forward to a talk to learn more about gene regulation mechanisms by the Integrator complex.
April 28, 2025 at 3:05 PM
Thanks @mpi-ie.bsky.social for the having me over last week and for the great conversations I had at your nice institute cradled in the beautiful Schwarzwald !!
Reposted by Apoorva Baluapuri
Another McGill Assistant Professor job at the Lady Davis Institute (where I am)! This is for an immunology (host-virus interactions) position! Come by my colleague! mcgill.wd3.myworkdayjobs.com/en-US/McGill...
Assistant Professor (Research), Department of Microbiology & Immunology, (C2-240724)
Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...
mcgill.wd3.myworkdayjobs.com
April 24, 2025 at 9:14 PM
Another McGill Assistant Professor job at the Lady Davis Institute (where I am)! This is for an immunology (host-virus interactions) position! Come by my colleague! mcgill.wd3.myworkdayjobs.com/en-US/McGill...
Reposted by Apoorva Baluapuri
🧵 Want to automate bioinformatics tasks?
Start by mastering one of the most powerful tools:
the for loop in bash.
I know I posted about GNU parallel :)
but even "for loops" have a lot to learn
Let’s go.
Start by mastering one of the most powerful tools:
the for loop in bash.
I know I posted about GNU parallel :)
but even "for loops" have a lot to learn
Let’s go.
April 18, 2025 at 1:45 PM
🧵 Want to automate bioinformatics tasks?
Start by mastering one of the most powerful tools:
the for loop in bash.
I know I posted about GNU parallel :)
but even "for loops" have a lot to learn
Let’s go.
Start by mastering one of the most powerful tools:
the for loop in bash.
I know I posted about GNU parallel :)
but even "for loops" have a lot to learn
Let’s go.
Reposted by Apoorva Baluapuri
Evidence of substrate control of Cdk phosphorylation during the budding yeast cell cycle
Evidence of substrate control of Cdk phosphorylation during the budding yeast cell cycle
Control over protein phosphorylation timing is crucial for faithful cell cycle progression. Takacs et al. revisit existing qualitative and quantitative models for cyclin-dependent kinase (Cdk) control of the cell cycle. They provide evidence of a third mechanism in which the substrates themselves contribute to controlling their phosphorylation timing.
dlvr.it
April 16, 2025 at 11:24 PM
Evidence of substrate control of Cdk phosphorylation during the budding yeast cell cycle
Reposted by Apoorva Baluapuri
Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:
April 14, 2025 at 4:56 PM
Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:
Reposted by Apoorva Baluapuri
Excellent opportunity available for a motivated #postdoc to join @kellythd-nguyen.bsky.social’s group investigating the roles of histones in regulating telomerase using a multi-disciplinary approach.
More details: www.nature.com/naturecareer...
Apply by 04 MAY
#PostdocJobs #ScienceJobs
More details: www.nature.com/naturecareer...
Apply by 04 MAY
#PostdocJobs #ScienceJobs
April 16, 2025 at 8:16 AM
Excellent opportunity available for a motivated #postdoc to join @kellythd-nguyen.bsky.social’s group investigating the roles of histones in regulating telomerase using a multi-disciplinary approach.
More details: www.nature.com/naturecareer...
Apply by 04 MAY
#PostdocJobs #ScienceJobs
More details: www.nature.com/naturecareer...
Apply by 04 MAY
#PostdocJobs #ScienceJobs
Reposted by Apoorva Baluapuri
Now online! Integrator loss leads to dsRNA formation that triggers the integrated stress response
Integrator loss leads to dsRNA formation that triggers the integrated stress response
Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination, accumulation of immunogenic dsRNA, and activation of the integrated stress response (ISR) observed in patient cells.
dlvr.it
April 14, 2025 at 10:38 PM
Now online! Integrator loss leads to dsRNA formation that triggers the integrated stress response
Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:
April 14, 2025 at 4:56 PM
Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes: