Nico Claassens
@nicoc-micsynmet.bsky.social
Associate Professor Microbial Synthetic Metabolism
Wageningen University | Synthetic Biology | Sustainability | working at @mib-wur.bsky.social
http://wur.eu/micsynme
Wageningen University | Synthetic Biology | Sustainability | working at @mib-wur.bsky.social
http://wur.eu/micsynme
Great to see our MOSAIC story about an easy, cloning-free efficient protocol for mutating plasmids using recombineering is out now officially and the cover story of ASC Synthetic Biology pubs.acs.org/toc/asbcd6/1... ! Great shoutout to Marijn van den Brink, Tim Althuis and Christophe Danelon!
ACS Synthetic Biology
We introduce MOSAIC, a highly efficient protocol for the editing of plasmids and generation of combinatorial plasmid libraries. This quick protocol employs the single-stranded DNA annealing protein Cs...
pubs.acs.org
October 17, 2025 at 8:39 AM
Great to see our MOSAIC story about an easy, cloning-free efficient protocol for mutating plasmids using recombineering is out now officially and the cover story of ASC Synthetic Biology pubs.acs.org/toc/asbcd6/1... ! Great shoutout to Marijn van den Brink, Tim Althuis and Christophe Danelon!
Reposted by Nico Claassens
'hey mela' is the first vegan pregnancy test in the world. Now available in Germany.
What could be vegan about it?
These tests are based on antibodies that are usually farmed from small rodents kept in cages, infected with hybridoma cells.
This test is based on AB expressed from algae!! 🧪
What could be vegan about it?
These tests are based on antibodies that are usually farmed from small rodents kept in cages, infected with hybridoma cells.
This test is based on AB expressed from algae!! 🧪
October 3, 2025 at 8:09 AM
'hey mela' is the first vegan pregnancy test in the world. Now available in Germany.
What could be vegan about it?
These tests are based on antibodies that are usually farmed from small rodents kept in cages, infected with hybridoma cells.
This test is based on AB expressed from algae!! 🧪
What could be vegan about it?
These tests are based on antibodies that are usually farmed from small rodents kept in cages, infected with hybridoma cells.
This test is based on AB expressed from algae!! 🧪
Reposted by Nico Claassens
Archaeal Virus Ph.D. project! (With Tessa Quax)
www.rug.nl/about-ug/wor...
www.rug.nl/about-ug/wor...
Vacatures bij de RUG
www.rug.nl
September 12, 2025 at 4:34 AM
Archaeal Virus Ph.D. project! (With Tessa Quax)
www.rug.nl/about-ug/wor...
www.rug.nl/about-ug/wor...
Reposted by Nico Claassens
Please repost!
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
efzu.fa.em2.oraclecloud.com
September 12, 2025 at 11:43 AM
Please repost!
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
Reposted by Nico Claassens
Fijn dat het deze verkiezingen een keer over belastingen gaat.
Nu nog zorgen dat de feiten het winnen van de framing.
De middenklasse in NL betaalt de belastingkortingen van de allerrijksten. Hoe rijker je bent, hoe lager je belastingdruk.
Dit komt door politieke keuzes. Ga stemmen 29 oktober.
Nu nog zorgen dat de feiten het winnen van de framing.
De middenklasse in NL betaalt de belastingkortingen van de allerrijksten. Hoe rijker je bent, hoe lager je belastingdruk.
Dit komt door politieke keuzes. Ga stemmen 29 oktober.
September 9, 2025 at 2:08 PM
Fijn dat het deze verkiezingen een keer over belastingen gaat.
Nu nog zorgen dat de feiten het winnen van de framing.
De middenklasse in NL betaalt de belastingkortingen van de allerrijksten. Hoe rijker je bent, hoe lager je belastingdruk.
Dit komt door politieke keuzes. Ga stemmen 29 oktober.
Nu nog zorgen dat de feiten het winnen van de framing.
De middenklasse in NL betaalt de belastingkortingen van de allerrijksten. Hoe rijker je bent, hoe lager je belastingdruk.
Dit komt door politieke keuzes. Ga stemmen 29 oktober.
Reposted by Nico Claassens
🧵 Our study on the elusive titration control mechanism of the replication initiator DnaA in Escherichia coli is now out on @natcomms.nature.com! @stephkoe.bsky.social
@hohlbeinlab.bsky.social @nicoc-micsynmet.bsky.social @ettema.bsky.social @mib-wur.bsky.social
doi.org/10.1038/s414...
@hohlbeinlab.bsky.social @nicoc-micsynmet.bsky.social @ettema.bsky.social @mib-wur.bsky.social
doi.org/10.1038/s414...
The Escherichia coli replication initiator DnaA is titrated on the chromosome - Nature Communications
A DNA-binding protein, DnaA, regulates the initiation of chromosomal replication in bacteria. Here, Olivi et al. show that the bacterial chromosome sequesters DnaA in a growth rate-dependent manner, s...
doi.org
August 22, 2025 at 8:58 AM
🧵 Our study on the elusive titration control mechanism of the replication initiator DnaA in Escherichia coli is now out on @natcomms.nature.com! @stephkoe.bsky.social
@hohlbeinlab.bsky.social @nicoc-micsynmet.bsky.social @ettema.bsky.social @mib-wur.bsky.social
doi.org/10.1038/s414...
@hohlbeinlab.bsky.social @nicoc-micsynmet.bsky.social @ettema.bsky.social @mib-wur.bsky.social
doi.org/10.1038/s414...
Reposted by Nico Claassens
I'm going to be advertising for a few positions in my group in the next couple of months for a big project on synthetic microbial communities.
I would love to hear from you if you are interested and I'd also appreciate if everyone could share this far and wide!
I would love to hear from you if you are interested and I'd also appreciate if everyone could share this far and wide!
August 13, 2025 at 9:35 AM
I'm going to be advertising for a few positions in my group in the next couple of months for a big project on synthetic microbial communities.
I would love to hear from you if you are interested and I'd also appreciate if everyone could share this far and wide!
I would love to hear from you if you are interested and I'd also appreciate if everyone could share this far and wide!
Reposted by Nico Claassens
New paper from our lab on synthetic genome work in yeast is out - Iterative SCRaMbLE for Engineering Synthetic Genome Modules and Chromosomes. Exciting project led by Jane (Xinyu) Lu in our group, now online. t.co/0LuGwgAWlA
https://www.nature.com/articles/s41467-025-62356-y
t.co
August 11, 2025 at 12:36 PM
New paper from our lab on synthetic genome work in yeast is out - Iterative SCRaMbLE for Engineering Synthetic Genome Modules and Chromosomes. Exciting project led by Jane (Xinyu) Lu in our group, now online. t.co/0LuGwgAWlA
Reposted by Nico Claassens
Outstanding Faculty opportunity in the broad area of 'life sciences engineering' @EPFL School of Life Sciences, open to both junior and senior researchers. We may prefer metabolism-centric applications but remain open to outstanding applications across domains:
www.epfl.ch/about/workin...
www.epfl.ch/about/workin...
Faculty Position in Life Science Engineering
The School of Life Sciences at EPFL invites applications for a faculty position in life science engineering. Appointments will be at Tenure Track Assistant Professor or at Associate Professor level. W...
www.epfl.ch
August 6, 2025 at 2:11 PM
Outstanding Faculty opportunity in the broad area of 'life sciences engineering' @EPFL School of Life Sciences, open to both junior and senior researchers. We may prefer metabolism-centric applications but remain open to outstanding applications across domains:
www.epfl.ch/about/workin...
www.epfl.ch/about/workin...
Reposted by Nico Claassens
#Growth-coupled #selection just got an update ! In the last years, E. coli selection strains for #central , #amino #acid and #energy metabolism intermediates were created by the community. So, we compiled them and revisit the core concepts of growth coupling.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Escherichia coli selection strains for growth-coupled metabolic engineering
Synthetic metabolism has the potential to transform carbon capture, bioremediation, or bioproduction strategies. To transfer metabolic designs from an…
www.sciencedirect.com
July 12, 2025 at 3:57 PM
#Growth-coupled #selection just got an update ! In the last years, E. coli selection strains for #central , #amino #acid and #energy metabolism intermediates were created by the community. So, we compiled them and revisit the core concepts of growth coupling.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Nico Claassens
Proteins of amino acid metabolism form large structures and determine diffusion in the cytoplasm!
Our 7-year-long tour-de-force is now out on Bioxriv www.biorxiv.org/content/10.1...
Thanks everyone involved! And especially to Jose Losa who pioneered this!
Our 7-year-long tour-de-force is now out on Bioxriv www.biorxiv.org/content/10.1...
Thanks everyone involved! And especially to Jose Losa who pioneered this!
June 27, 2025 at 11:58 AM
Proteins of amino acid metabolism form large structures and determine diffusion in the cytoplasm!
Our 7-year-long tour-de-force is now out on Bioxriv www.biorxiv.org/content/10.1...
Thanks everyone involved! And especially to Jose Losa who pioneered this!
Our 7-year-long tour-de-force is now out on Bioxriv www.biorxiv.org/content/10.1...
Thanks everyone involved! And especially to Jose Losa who pioneered this!
Reposted by Nico Claassens
I get annoyed at the narrative that all the awareness and work on climate change hasn't done anything. Yes, global CO₂ emissions indeed continue to climb, but we don't know the counterfactual. When I was in grad school, we were on track for 5°C of warming. Now it's below 3°C. That's progress.
June 22, 2025 at 5:09 PM
I get annoyed at the narrative that all the awareness and work on climate change hasn't done anything. Yes, global CO₂ emissions indeed continue to climb, but we don't know the counterfactual. When I was in grad school, we were on track for 5°C of warming. Now it's below 3°C. That's progress.
Reposted by Nico Claassens
Reposted by Nico Claassens
New vacancy in my team!
PhD student position on microbial genome evolution, focusing on the evolutionary principles underlying bacterial genome architecture.
Please repost and share with talented MSc students in #evobio, bioinformatics or related :)
www.uu.nl/en/organisat...
#MEvoSky #MicroSky
PhD student position on microbial genome evolution, focusing on the evolutionary principles underlying bacterial genome architecture.
Please repost and share with talented MSc students in #evobio, bioinformatics or related :)
www.uu.nl/en/organisat...
#MEvoSky #MicroSky
May 14, 2025 at 2:07 PM
New vacancy in my team!
PhD student position on microbial genome evolution, focusing on the evolutionary principles underlying bacterial genome architecture.
Please repost and share with talented MSc students in #evobio, bioinformatics or related :)
www.uu.nl/en/organisat...
#MEvoSky #MicroSky
PhD student position on microbial genome evolution, focusing on the evolutionary principles underlying bacterial genome architecture.
Please repost and share with talented MSc students in #evobio, bioinformatics or related :)
www.uu.nl/en/organisat...
#MEvoSky #MicroSky
Reposted by Nico Claassens
Very nice lab to do a PhD
New vacancy in my team!
PhD student position on microbial genome evolution, focusing on the evolutionary principles underlying bacterial genome architecture.
Please repost and share with talented MSc students in #evobio, bioinformatics or related :)
www.uu.nl/en/organisat...
#MEvoSky #MicroSky
PhD student position on microbial genome evolution, focusing on the evolutionary principles underlying bacterial genome architecture.
Please repost and share with talented MSc students in #evobio, bioinformatics or related :)
www.uu.nl/en/organisat...
#MEvoSky #MicroSky
May 14, 2025 at 4:21 PM
Very nice lab to do a PhD
Ik vind deze campagne erg belangrijk - doe je ook mee? actie.degoedezaak.org/petitions/mo...
Teken voor een motie van wantrouwen tegen minister Faber
De ondertekenaars van deze petitie laten zien dat het Nederlandse volk klaar is met een minister die de hand boven het hoofd gehouden wordt om de coalitie bij elkaar te houden. Dit terwijl de minister...
actie.degoedezaak.org
May 12, 2025 at 8:01 PM
Ik vind deze campagne erg belangrijk - doe je ook mee? actie.degoedezaak.org/petitions/mo...
Reposted by Nico Claassens
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
May 2, 2025 at 2:39 PM
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Reposted by Nico Claassens
>4 megabase synthetic genome assembled in E.coli with 7 of life's 64 codons removed throughout. A new landmark for synthetic genomes. I wonder how well this little cell grows...
Escherichia coli with a 57-codon genetic code https://www.biorxiv.org/content/10.1101/2025.05.02.651837v1
May 2, 2025 at 9:35 PM
>4 megabase synthetic genome assembled in E.coli with 7 of life's 64 codons removed throughout. A new landmark for synthetic genomes. I wonder how well this little cell grows...
Reposted by Nico Claassens
We have 3 openings for ambitious postdocs or PhD students in our #CDlab - for exciting single-molecule biophysics research on nuclear pores, peroxisomes, or archaeal divisomes.
Check it out and apply: ceesdekkerlab.nl/come-join-us/
RT=nice!
Check it out and apply: ceesdekkerlab.nl/come-join-us/
RT=nice!
March 13, 2025 at 4:37 PM
We have 3 openings for ambitious postdocs or PhD students in our #CDlab - for exciting single-molecule biophysics research on nuclear pores, peroxisomes, or archaeal divisomes.
Check it out and apply: ceesdekkerlab.nl/come-join-us/
RT=nice!
Check it out and apply: ceesdekkerlab.nl/come-join-us/
RT=nice!
Reposted by Nico Claassens
Wij zeggen: Er is wél een rode lijn. Onze advertentie, vandaag in het AD, Trouw en de Volkskrant.
Deel dit statement en help ons om meer partijen te overtuigen! 👇🏼👊🏼
Deel dit statement en help ons om meer partijen te overtuigen! 👇🏼👊🏼
April 19, 2025 at 9:56 AM
Wij zeggen: Er is wél een rode lijn. Onze advertentie, vandaag in het AD, Trouw en de Volkskrant.
Deel dit statement en help ons om meer partijen te overtuigen! 👇🏼👊🏼
Deel dit statement en help ons om meer partijen te overtuigen! 👇🏼👊🏼
Reposted by Nico Claassens
✨ Our #SynBio map is growing! 🌍🔬
Excited to welcome 3 new labs to the #EUSynBioMap, connecting #SyntheticBiology labs and associations across Europe!
Find out more here 👉 www.linkedin.com/posts/eusynb...
⭐️ Want to add your lab? Contact us!
Excited to welcome 3 new labs to the #EUSynBioMap, connecting #SyntheticBiology labs and associations across Europe!
Find out more here 👉 www.linkedin.com/posts/eusynb...
⭐️ Want to add your lab? Contact us!
#eusynbiomap #syntheticbiology #europe #bristol #barcelona #leeds #synbio… | European Synthetic Biology Society (EUSynBioS)
✨ 𝗢𝘂𝗿 𝗦𝘆𝗻𝘁𝗵𝗲𝘁𝗶𝗰 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 𝗠𝗮𝗽 𝗶𝘀 𝗴𝗿𝗼𝘄𝗶𝗻𝗴! 🌍
We’re excited to welcome 3 new labs to our #EUSynBioMap, our initiative dedicated…
www.linkedin.com
April 1, 2025 at 11:40 AM
✨ Our #SynBio map is growing! 🌍🔬
Excited to welcome 3 new labs to the #EUSynBioMap, connecting #SyntheticBiology labs and associations across Europe!
Find out more here 👉 www.linkedin.com/posts/eusynb...
⭐️ Want to add your lab? Contact us!
Excited to welcome 3 new labs to the #EUSynBioMap, connecting #SyntheticBiology labs and associations across Europe!
Find out more here 👉 www.linkedin.com/posts/eusynb...
⭐️ Want to add your lab? Contact us!
Ik vind deze campagne erg belangrijk - doe je ook mee? actie.degoedezaak.org/petitions/ee...
Eerlijkere loonverdeling in het hoger onderwijs
Zeker nu minister Bruins van OCW de grootste bezuinigingen op het hoger onderwijs in decennia heeft aangekondigd is het essentieel dat de sector zich niet tegen elkaar uit laat spelen en solidair met ...
actie.degoedezaak.org
April 9, 2025 at 5:48 AM
Ik vind deze campagne erg belangrijk - doe je ook mee? actie.degoedezaak.org/petitions/ee...
Reposted by Nico Claassens
NTR weg......? Het lijkt wel alsof we ook een DOGE hebben.
Teken de petitie als protest. Heb ik ook net gedaan.
Teken de petitie als protest. Heb ik ook net gedaan.
En weer iets om woedend van te worden: wegbezuinigen van de NTR die misschien wel het summum is van de taak van een publieke omroep. Petitie voor behoud NTR is inmiddels 14.460 keer getekend.
https://petities.nl/petitions/behoud-de-ntr-en-haar-programma-s?locale=nl
https://petities.nl/petitions/behoud-de-ntr-en-haar-programma-s?locale=nl
Behoud de NTR en haar programma’s
Minister Bruins van OCW ziet geen toekomst voor de NTR binnen de publieke omroep. Maar zonder de NTR geen onafhankelijke programmering op het gebied van educatie, jeugd, cultuur, wetenschap en informatie. Essentieel voor een goed geïnformeerde, inclusieve en democratische samenleving.
petities.nl
April 7, 2025 at 6:28 PM
NTR weg......? Het lijkt wel alsof we ook een DOGE hebben.
Teken de petitie als protest. Heb ik ook net gedaan.
Teken de petitie als protest. Heb ik ook net gedaan.
Reposted by Nico Claassens
Sam Lovat, Elad Noor, Ron Milo run the numbers on #VerticalFarming to get ⚡️ cost ≈$10/kg dry plant matter.
Which explains why it's viable only for high-value 🥬 ('fru-fru baby lettuce')
Vertical farming limitations & potential demonstrated by back-of-the-envelope calculations
doi.org/10.1093/plph...
Which explains why it's viable only for high-value 🥬 ('fru-fru baby lettuce')
Vertical farming limitations & potential demonstrated by back-of-the-envelope calculations
doi.org/10.1093/plph...
April 5, 2025 at 4:53 PM
Sam Lovat, Elad Noor, Ron Milo run the numbers on #VerticalFarming to get ⚡️ cost ≈$10/kg dry plant matter.
Which explains why it's viable only for high-value 🥬 ('fru-fru baby lettuce')
Vertical farming limitations & potential demonstrated by back-of-the-envelope calculations
doi.org/10.1093/plph...
Which explains why it's viable only for high-value 🥬 ('fru-fru baby lettuce')
Vertical farming limitations & potential demonstrated by back-of-the-envelope calculations
doi.org/10.1093/plph...
Reposted by Nico Claassens
During our recent consortium meeting in Marburg, we visited the cutting-edge research facilities at @mpimicrobiomarburg.bsky.social.
Thank you, Nicole Paczia & Timo Glatter, for showing us around your Metabolomics and Proteomics installations! 🧪
#Microbiology #SynBio #SolarFuels #HorizonEU
Thank you, Nicole Paczia & Timo Glatter, for showing us around your Metabolomics and Proteomics installations! 🧪
#Microbiology #SynBio #SolarFuels #HorizonEU
April 1, 2025 at 2:36 PM
During our recent consortium meeting in Marburg, we visited the cutting-edge research facilities at @mpimicrobiomarburg.bsky.social.
Thank you, Nicole Paczia & Timo Glatter, for showing us around your Metabolomics and Proteomics installations! 🧪
#Microbiology #SynBio #SolarFuels #HorizonEU
Thank you, Nicole Paczia & Timo Glatter, for showing us around your Metabolomics and Proteomics installations! 🧪
#Microbiology #SynBio #SolarFuels #HorizonEU