Nick Chavkin
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nickchavkin.bsky.social
Nick Chavkin
@nickchavkin.bsky.social
160 followers 170 following 1 posts
Assistant Professor of Pediatric Cardiology - Seattle Children’s Research Institute - University of Washington. Cardiovascular Biology, Endothelial Cells, Age-Related Somatic Mutations, Cell Cycle, Heart Failure.
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Reposted by Nick Chavkin
wormsense.bsky.social
Molecular & Cellular Physiology (MCP) Monday

We are recruiting a tenure-track assistant professor to join the Dept of Molecular & Cellular Physiology at Stanford. Apply to be our colleague 1/n
facultypositions.stanford.edu/en-us/job/49...
Stanford | Faculty Positions: Details - Assistant Professor of Molecular and Cellular Physiology
facultypositions.stanford.edu
October 27, 2025 at 11:33 PM
Reposted by Nick Chavkin
haoyin.bsky.social
#Senescence #Mechanobiology

Senescent #EndothelialCell HUVEC (+H2O2 or Doxorubicin) have ⬆️ #Viscoelasticity
(Microfluidic cytometric measurement of suspended whole-cell deformation)

⏫F-actin, Calnexin ER, Lamin A Nuclear envelope

#CellRepPhysSci 2025
www.sciencedirect.com/science/arti...
September 20, 2025 at 7:06 PM
Reposted by Nick Chavkin
nejm.org
In patients with nonobstructive HCM, mavacamten did not significantly improve peak oxygen uptake or decrease symptoms as compared with placebo, and more patients had a reduction in LVEF with mavacamten. Full ODYSSEY-HCM phase 3 trial results and Research Summary: nej.md/4oSZx2m

#MedSky
The New England Journal of Medicine Mavacamten in Nonobstructive Hypertrophic Cardiomyopathy A Research Summary based on Desai MY et al. | 10.1056/NEJMoa2505927 | Published on August 30, 2025 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.
September 16, 2025 at 1:04 PM
Reposted by Nick Chavkin
natrevcardiol.nature.com
New online! The prevention of adult cardiovascular disease must begin in childhood: evidence and imperative #CardioSky
The prevention of adult cardiovascular disease must begin in childhood: evidence and imperative
Nature Reviews Cardiology, Published online: 12 September 2025; doi:10.1038/s41569-025-01209-zIn this Review, Khoury and colleagues examine the growing body of evidence demonstrating the benefits of screening for cardiovascular risk factors, including dyslipidaemia and high blood pressure, starting in childhood to reduce the lifetime burden of cardiovascular disease.
bit.ly
September 12, 2025 at 3:28 PM
Reposted by Nick Chavkin
scinews.bsky.social
Natural medicines target tumor vascular microenvironment to inhibit cancer growth

www.sciencedirect.com/science/arti...
September 6, 2025 at 8:45 AM
Reposted by Nick Chavkin
nicolilab.bsky.social
Check out how mRNA can influence cell motility! See how here: www.cell.com/cell-reports.... Thanks for the shout-out Yale News and @cp-trendscellbio.bsky.social!

news.yale.edu/2025/02/13/f...

www.cell.com/trends/cell-...
G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration
Boraas et al. identify that mRNAs and the stress granule RNA-binding protein G3BP1 form ribonucleoprotein (RNP) complexes at FAs. These RNPs regulate FA protein mobility and cell migration under norma...
www.cell.com
July 29, 2025 at 1:27 PM
Reposted by Nick Chavkin
lfsantana68.bsky.social
Manning & Rivera et al. (www.jacc.org/doi/10.1016/...) show that pruning just a few capillaries in the SA node plunges the heart’s pacemaker into metabolic overdraft—slowing the rate and jacking up beat-to-beat variability. The physiological equivalent of running on fumes. @jaccjournals.bsky.social
Microvascular Rarefaction in the Sinoatrial Node: A Potential Mechanism for Pacemaker Dysfunction in Early HFpEF
www.jacc.org
July 23, 2025 at 6:06 PM
Reposted by Nick Chavkin
natcardiovascres.nature.com
❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more!

www.nature.com/natcardiovas...
July 15, 2025 at 4:11 PM
nickchavkin.bsky.social
Excited to share a recent review article that I published on Cardiovascular Aging and Hematopoietic Mosaic Loss of Y Chromosome. Main take-home: there are strong similarities between loss of Y and aging in clinical correlations and disease progression.
www.oaepublish.com/articles/jca...
Age-related cardiovascular disease and mosaic hematopoietic loss of the Y chromosome
Age is the strongest risk factor for cardiovascular morbidity and mortality, driven in part by aging leukocytes negatively impact cardiovascular health. This effect is particularly pronounced in men, ...
www.oaepublish.com
July 9, 2025 at 2:15 PM
Reposted by Nick Chavkin
seattlechildrens.org
Bluesky, we're here! 👋

We’re excited to connect with the growing biomedical research community here.
Follow us for groundbreaking discoveries, new insights, and research updates from Seattle Children's Research Institute. 🧬

#MedSky
Researchers in a lab. Text reads Seattle Children's Research Institute. Turning discoveries into lifesaving therapies. Follow Us!
July 8, 2025 at 3:55 PM
Reposted by Nick Chavkin
evborg.bsky.social
#EVBOSeminarSeries Moderated by Joanna Kalucka. Speakers: Ralf Adams and Mariona Graupera. ⏰When: Wednesday, 18th June 2025, 3PM EU time (2PM UK). Place: online. See you there! For registration evbo.org
June 13, 2025 at 12:00 PM
Reposted by Nick Chavkin
natrevcardiol.nature.com
New online! Dual mechanotherapy for the treatment of cardiac fibrosis #CardioSky
Dual mechanotherapy for the treatment of cardiac fibrosis
Nature Reviews Cardiology, Published online: 19 May 2025; doi:10.1038/s41569-025-01172-9Inhibition of mechanotransduction selectively in cardiac fibrolasts, especially when combined with inhibition of transforming growth factor-β signalling, triggers a reversal of fibroblast activation and suppresses fibrosis in diseased hearts.
bit.ly
May 19, 2025 at 5:59 PM
Reposted by Nick Chavkin
navbo.bsky.social
Please join us next Tuesday April 29th at 1 pm EST for our next Symposium on Precision Genomics: CRISPR and Single-Cell Technologies in Vascular Biology, featuring #AaronJames @bgcoonlab.bsky.social @chadweldy.bsky.social and moderated by @vsleekim.bsky.social !
Register here: tinyurl.com/yhcdr68a
April 23, 2025 at 2:21 AM
Reposted by Nick Chavkin
saravasconcelos.bsky.social
Big thanks to Karen Hirschi for the great presentation and for visiting us in Toronto! We really appreciated the insights and the chance to connect in person.
@medicinebydesign.bsky.social @uhnresearch.bsky.social
Seminar presentation 4 ppl having dinner
April 23, 2025 at 2:38 AM
Reposted by Nick Chavkin
uvacvrc.bsky.social
@lukedunaway.bsky.social, PhD, recently received an @americanheart.bsky.social Career Development Award to study iron's role in chronic kidney disease. Luke is a postdoc in @brantisakson.bsky.social's Lab and member of our Cardiovascular Training Program. Congratulations!

#CardioSky #MedSky
Luke Dunaway, PhD, Wins AHA Award for Chronic Kidney Disease Research – Robert M. Berne Cardiovascular Research Center
www.cvrc.virginia.edu
March 20, 2025 at 5:15 PM
Reposted by Nick Chavkin
taijamakinenlab.bsky.social
If you’re curious about why lymphatic endothelial cells have their jigsaw puzzle-like shape,
check out our paper
@Nature
rdcu.be/eejhZ
Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium
Nature - Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result...
rdcu.be
March 20, 2025 at 9:15 AM
Reposted by Nick Chavkin
hancardiomd.bsky.social
Update on preclinical models of cancer therapy-related cardiac dysfunction: Challenges and perspectives
A scientific statement of the #HFA of @escardio.bsky.social

onlinelibrary.wiley.com/doi/full/10.... @shelleyzieroth.bsky.social @cardioobdoc.bsky.social @drrajivsankar.bsky.social #CardioSky
March 20, 2025 at 3:35 PM
Reposted by Nick Chavkin
cp-immunity.bsky.social
Online now: Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors
Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors
Central nervous system malignancies include primary tumors and brain metastases (BrMs) originating from extracranial cancers. Bejarano et al. examine primary and metastatic brain tumors and find distinct vascular alterations in IDH mutant gliomas, IDH WT…
dlvr.it
March 18, 2025 at 7:55 PM
Reposted by Nick Chavkin
deniswirtz.bsky.social
"NIH admit freezing is illegal, will resume issuing grants"

popular.info/p/breaking-n...
BREAKING: NIH admits funding freeze is illegal, will resume issuing grants
An internal memo issued February 12 was obtained by Popular Information.
popular.info
February 12, 2025 at 8:34 PM
Reposted by Nick Chavkin
yalecvrc.bsky.social
Hello from the Yale Cardiovascular Research Center! We look forward to interacting with the science community on blue sky!
January 30, 2025 at 4:38 PM
Reposted by Nick Chavkin
blacoste.bsky.social
New study shows that genomic instability promotes brain endothelial cell aging and impairs brain homeostasis doi.org/10.1038/s414... #cerebrovascular
Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction - Cell Death & Disease
Cell Death & Disease - Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction
doi.org
January 9, 2025 at 3:22 AM
Reposted by Nick Chavkin
erictopol.bsky.social
Mosaic pattern loss of Y chromosome, which occurs in ~40% of men by age 70, is causally linked to heightened risk of many diseases, including cardiovascular, bladder cancer, and Alzheimer's. But it's almost never assessed clinically.
A new review
nature.com/articles/s41...
January 5, 2025 at 6:34 PM
Reposted by Nick Chavkin
appliedcvb.bsky.social
Member publication alert:

Monocyte adhesion to and transmigration through endothelium following cardiopulmonary bypass shearing is mediated by IL-8 signaling

www.frontiersin.org/journals/car...
Frontiers | Monocyte adhesion to and transmigration through endothelium following cardiopulmonary bypass shearing is mediated by IL-8 signaling
www.frontiersin.org
December 29, 2024 at 7:09 PM