ISACB
@appliedcvb.bsky.social
International Society For Applied Cardiovascular Biology
ISACB.org
ISACB.org
Member publication alert:
Atherosclerotic Fibrous Plaques in Women Present ECM Remodeling Linked to TGF-β
www.ahajournals.org/doi/10.1161/...
Atherosclerotic Fibrous Plaques in Women Present ECM Remodeling Linked to TGF-β
www.ahajournals.org/doi/10.1161/...
Atherosclerotic Fibrous Plaques in Women Present ECM Remodeling Linked to TGF-β | Circulation Research
BACKGROUND: Sex and atherosclerotic plaque histology are intertwined, with fibrous plaques being
more prevalent in women. Plaque erosion, a significant contributor to acute coronary
syndromes, is link...
www.ahajournals.org
February 8, 2026 at 6:47 PM
Member publication alert:
Atherosclerotic Fibrous Plaques in Women Present ECM Remodeling Linked to TGF-β
www.ahajournals.org/doi/10.1161/...
Atherosclerotic Fibrous Plaques in Women Present ECM Remodeling Linked to TGF-β
www.ahajournals.org/doi/10.1161/...
Member publication alert:
Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection
www.ahajournals.org/doi/10.1161/...
Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection
www.ahajournals.org/doi/10.1161/...
Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection | Circulation Research
BACKGROUND: Cardiovascular disease remains the leading cause of death worldwide, with coronary
artery disease being the primary contributor. Our recent studies suggest that activation
of LepRs (leptin...
www.ahajournals.org
February 8, 2026 at 6:46 PM
Member publication alert:
Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection
www.ahajournals.org/doi/10.1161/...
Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection
www.ahajournals.org/doi/10.1161/...
Member publication alert:
Quantification of Alpha-Gal Expression in Commercial BioProsthetic Heart Valves and Its Potential Mitigation
www.structuralheartjournal.org/article/S247...
Quantification of Alpha-Gal Expression in Commercial BioProsthetic Heart Valves and Its Potential Mitigation
www.structuralheartjournal.org/article/S247...
Quantification of Alpha-Gal Expression in Commercial BioProsthetic Heart Valves and Its Potential Mitigation
Bioprosthetic heart valves (BHVs) are inherently susceptible to structural degeneration,
driven by a combination of mechanical stress, lipid infiltration, glutaraldehyde-induced
crosslinking instabili...
www.structuralheartjournal.org
February 8, 2026 at 6:46 PM
Member publication alert:
Quantification of Alpha-Gal Expression in Commercial BioProsthetic Heart Valves and Its Potential Mitigation
www.structuralheartjournal.org/article/S247...
Quantification of Alpha-Gal Expression in Commercial BioProsthetic Heart Valves and Its Potential Mitigation
www.structuralheartjournal.org/article/S247...
Member publication alert:
Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe
www.sciencedirect.com/science/arti...
Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe
www.sciencedirect.com/science/arti...
Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe
Sprouting angiogenesis and blood vessel stabilization require precise coordination between endothelial cells (ECs) and pericytes. Bone Morphogenic Pro…
www.sciencedirect.com
February 8, 2026 at 6:45 PM
Member publication alert:
Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe
www.sciencedirect.com/science/arti...
Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe
www.sciencedirect.com/science/arti...
Member publication alert:
Cardiac Lymphatics Predict Survival After Heart Transplantation
www.ahajournals.org/doi/10.1161/...
Cardiac Lymphatics Predict Survival After Heart Transplantation
www.ahajournals.org/doi/10.1161/...
Cardiac Lymphatics Predict Survival After Heart Transplantation | Journal of the American Heart Association
www.ahajournals.org
February 2, 2026 at 5:16 AM
Member publication alert:
Cardiac Lymphatics Predict Survival After Heart Transplantation
www.ahajournals.org/doi/10.1161/...
Cardiac Lymphatics Predict Survival After Heart Transplantation
www.ahajournals.org/doi/10.1161/...
Member publication alert:
Model Choice and Interpretation in Coronary Tissue Engineering: Still More Questions Than Answers?
www.jacc.org/doi/10.1016/...
Model Choice and Interpretation in Coronary Tissue Engineering: Still More Questions Than Answers?
www.jacc.org/doi/10.1016/...
Model Choice and Interpretation in Coronary Tissue Engineering: Still More Questions Than Answers?
www.jacc.org
February 2, 2026 at 5:15 AM
Member publication alert:
Model Choice and Interpretation in Coronary Tissue Engineering: Still More Questions Than Answers?
www.jacc.org/doi/10.1016/...
Model Choice and Interpretation in Coronary Tissue Engineering: Still More Questions Than Answers?
www.jacc.org/doi/10.1016/...
Member publication alert:
Rat models for arterial calcification associated with chronic kidney disease: a systematic review and meta-analysis
link.springer.com/article/10.1...
Rat models for arterial calcification associated with chronic kidney disease: a systematic review and meta-analysis
link.springer.com/article/10.1...
Rat models for arterial calcification associated with chronic kidney disease: a systematic review and meta-analysis - BMC Cardiovascular Disorders
Arterial calcification represents a major burden in chronic kidney disease (CKD) and is an independent risk factor for cardiovascular diseases (CVD). Rodent models are essential for preclinical resear...
link.springer.com
February 2, 2026 at 5:14 AM
Member publication alert:
Rat models for arterial calcification associated with chronic kidney disease: a systematic review and meta-analysis
link.springer.com/article/10.1...
Rat models for arterial calcification associated with chronic kidney disease: a systematic review and meta-analysis
link.springer.com/article/10.1...
Member publication alert:
Shear Stress Initiates Endothelial-to-Mesenchymal Transition in Endocardial Endothelial Cells
link.springer.com/article/10.1...
Shear Stress Initiates Endothelial-to-Mesenchymal Transition in Endocardial Endothelial Cells
link.springer.com/article/10.1...
Shear Stress Initiates Endothelial-to-Mesenchymal Transition in Endocardial Endothelial Cells - Annals of Biomedical Engineering
Discrete subaortic stenosis (DSS) is a congenital heart disease in which a fibrotic membrane forms below the aortic valve; the underlying cellular mechanisms are currently unknown. Since an elevated p...
link.springer.com
February 2, 2026 at 5:14 AM
Member publication alert:
Shear Stress Initiates Endothelial-to-Mesenchymal Transition in Endocardial Endothelial Cells
link.springer.com/article/10.1...
Shear Stress Initiates Endothelial-to-Mesenchymal Transition in Endocardial Endothelial Cells
link.springer.com/article/10.1...
Member publication alert:
Elevated asporin expression in human atherosclerotic plaques promotes their stability and reduces the risk for cardiovascular events
academic.oup.com/cardiovascre...
Elevated asporin expression in human atherosclerotic plaques promotes their stability and reduces the risk for cardiovascular events
academic.oup.com/cardiovascre...
Elevated asporin expression in human atherosclerotic plaques promotes their stability and reduces the risk for cardiovascular events
AbstractAims. Vascular atherosclerotic calcification is a pathological process marked by the abnormal deposition of calcium minerals in the intima. Asporin
academic.oup.com
January 25, 2026 at 6:28 PM
Member publication alert:
Elevated asporin expression in human atherosclerotic plaques promotes their stability and reduces the risk for cardiovascular events
academic.oup.com/cardiovascre...
Elevated asporin expression in human atherosclerotic plaques promotes their stability and reduces the risk for cardiovascular events
academic.oup.com/cardiovascre...
Member publication alert:
Two Faces of Mitral Stenosis: Uncovering Structural and Hemodynamic Signatures of Rheumatic and Mitral Annular Calcification-Induced Disease
www.ahajournals.org/doi/10.1161/...
Two Faces of Mitral Stenosis: Uncovering Structural and Hemodynamic Signatures of Rheumatic and Mitral Annular Calcification-Induced Disease
www.ahajournals.org/doi/10.1161/...
Two Faces of Mitral Stenosis: Uncovering Structural and Hemodynamic Signatures of Rheumatic and Mitral Annular Calcification–Induced Disease | Journal of the American Heart Association
www.ahajournals.org
January 25, 2026 at 6:27 PM
Member publication alert:
Two Faces of Mitral Stenosis: Uncovering Structural and Hemodynamic Signatures of Rheumatic and Mitral Annular Calcification-Induced Disease
www.ahajournals.org/doi/10.1161/...
Two Faces of Mitral Stenosis: Uncovering Structural and Hemodynamic Signatures of Rheumatic and Mitral Annular Calcification-Induced Disease
www.ahajournals.org/doi/10.1161/...
Member publication alert:
Plasma and pericardial fluid metabolomic signatures of patients with ischemic heart disease
www.nature.com/articles/s43...
Plasma and pericardial fluid metabolomic signatures of patients with ischemic heart disease
www.nature.com/articles/s43...
Plasma and pericardial fluid metabolomic signatures of patients with ischemic heart disease - Communications Medicine
De Castro, Coppola et al. analyze metabolic profiles in blood and pericardial fluid from patients with ischemic heart disease. They identify distinct energy-related changes that reflect myocardial str...
www.nature.com
January 25, 2026 at 6:27 PM
Member publication alert:
Plasma and pericardial fluid metabolomic signatures of patients with ischemic heart disease
www.nature.com/articles/s43...
Plasma and pericardial fluid metabolomic signatures of patients with ischemic heart disease
www.nature.com/articles/s43...
Member publication alert:
Arrhythmias across the tree of life: comparative insights for human electrophysiology
www.frontiersin.org/journals/car...
Arrhythmias across the tree of life: comparative insights for human electrophysiology
www.frontiersin.org/journals/car...
Frontiers | Arrhythmias across the tree of life: comparative insights for human electrophysiology
IntroductionArrhythmias in non-human animals offer insights into human electrophysiology, yet physicians may be unaware of their occurrence and significance....
www.frontiersin.org
January 25, 2026 at 6:26 PM
Member publication alert:
Arrhythmias across the tree of life: comparative insights for human electrophysiology
www.frontiersin.org/journals/car...
Arrhythmias across the tree of life: comparative insights for human electrophysiology
www.frontiersin.org/journals/car...
Member publication alert:
Clinical proteomics in cardiovascular medicine: Current capabilities, limitations, and future directions
www.atherosclerosis-journal.com/article/S002...
Clinical proteomics in cardiovascular medicine: Current capabilities, limitations, and future directions
www.atherosclerosis-journal.com/article/S002...
Clinical proteomics in cardiovascular medicine: Current capabilities, limitations, and future directions
Commercial high-throughput proteomics platforms, such as Olink and SomaLogic, enable
large-scale epidemiological studies with integrated multi-omics measurements. While
these proteomics approaches hav...
www.atherosclerosis-journal.com
January 18, 2026 at 8:16 PM
Member publication alert:
Clinical proteomics in cardiovascular medicine: Current capabilities, limitations, and future directions
www.atherosclerosis-journal.com/article/S002...
Clinical proteomics in cardiovascular medicine: Current capabilities, limitations, and future directions
www.atherosclerosis-journal.com/article/S002...
Member publication alert:
Computational Optimization of a Stent for the Femoropopliteal Artery
link.springer.com/article/10.1...
Computational Optimization of a Stent for the Femoropopliteal Artery
link.springer.com/article/10.1...
Computational Optimization of a Stent for the Femoropopliteal Artery - Annals of Biomedical Engineering
Purpose Clinical outcomes of peripheral artery disease (PAD) stenting, particularly in the highly dynamic regions of the femoropopliteal artery at the adductor hiatus and behind the knee, leave signif...
link.springer.com
January 18, 2026 at 8:15 PM
Member publication alert:
Computational Optimization of a Stent for the Femoropopliteal Artery
link.springer.com/article/10.1...
Computational Optimization of a Stent for the Femoropopliteal Artery
link.springer.com/article/10.1...
Member publication alert:
1-Phosphatidylinositol 3-Phosphate 5-Kinase Inhibition by Apilimod Promotes an Adipocyte-Like Vascular Smooth Muscle Cell Phenotype and Prevents Arterial Calcification
www.ahajournals.org/doi/10.1161/...
1-Phosphatidylinositol 3-Phosphate 5-Kinase Inhibition by Apilimod Promotes an Adipocyte-Like Vascular Smooth Muscle Cell Phenotype and Prevents Arterial Calcification
www.ahajournals.org/doi/10.1161/...
American Heart Association Journals
www.ahajournals.org
January 18, 2026 at 8:14 PM
Member publication alert:
1-Phosphatidylinositol 3-Phosphate 5-Kinase Inhibition by Apilimod Promotes an Adipocyte-Like Vascular Smooth Muscle Cell Phenotype and Prevents Arterial Calcification
www.ahajournals.org/doi/10.1161/...
1-Phosphatidylinositol 3-Phosphate 5-Kinase Inhibition by Apilimod Promotes an Adipocyte-Like Vascular Smooth Muscle Cell Phenotype and Prevents Arterial Calcification
www.ahajournals.org/doi/10.1161/...
Member publication alert:
Omega-3 PUFAs reduce inflammation by targeting NRF2 and NF-κB activity in an ex vivo model of cardiac mature adipocytes and adipose derived stem cells from atherosclerotic patients
pubs.rsc.org/en/content/a...
Omega-3 PUFAs reduce inflammation by targeting NRF2 and NF-κB activity in an ex vivo model of cardiac mature adipocytes and adipose derived stem cells from atherosclerotic patients
pubs.rsc.org/en/content/a...
Omega-3 PUFAs reduce inflammation by targeting NRF2 and NF-κB activity in an ex vivo model of cardiac mature adipocytes and adipose derived stem cells from atherosclerotic patients
Under proatherogenic conditions, epicardial (EAT) and pericardial adipose tissue (PAT) acquire inflammatory/pro-atherogenic phenotypes that contribute to coronary atherosclerosis. Recent data have hig...
pubs.rsc.org
January 18, 2026 at 8:14 PM
Member publication alert:
Omega-3 PUFAs reduce inflammation by targeting NRF2 and NF-κB activity in an ex vivo model of cardiac mature adipocytes and adipose derived stem cells from atherosclerotic patients
pubs.rsc.org/en/content/a...
Omega-3 PUFAs reduce inflammation by targeting NRF2 and NF-κB activity in an ex vivo model of cardiac mature adipocytes and adipose derived stem cells from atherosclerotic patients
pubs.rsc.org/en/content/a...
Member publication alert:
Variant burden and severity of cardiomyopathy in patients with DMD-related Duchenne muscular dystrophy
www.nature.com/articles/s41...
Variant burden and severity of cardiomyopathy in patients with DMD-related Duchenne muscular dystrophy
www.nature.com/articles/s41...
Client Challenge
www.nature.com
January 12, 2026 at 4:50 AM
Member publication alert:
Variant burden and severity of cardiomyopathy in patients with DMD-related Duchenne muscular dystrophy
www.nature.com/articles/s41...
Variant burden and severity of cardiomyopathy in patients with DMD-related Duchenne muscular dystrophy
www.nature.com/articles/s41...
Member publication alert:
Investigating the role of structural wall stress in aortic growth prognosis in acute uncomplicated type B aortic dissection
link.springer.com/article/10.1...
Investigating the role of structural wall stress in aortic growth prognosis in acute uncomplicated type B aortic dissection
link.springer.com/article/10.1...
Client Challenge
link.springer.com
January 12, 2026 at 4:50 AM
Member publication alert:
Investigating the role of structural wall stress in aortic growth prognosis in acute uncomplicated type B aortic dissection
link.springer.com/article/10.1...
Investigating the role of structural wall stress in aortic growth prognosis in acute uncomplicated type B aortic dissection
link.springer.com/article/10.1...
Member publication alert:
Myocardial Infarction Elicits a Robust Inflammatory Response in the Pericardial Space
onlinecjc.ca/article/S082...
Myocardial Infarction Elicits a Robust Inflammatory Response in the Pericardial Space
onlinecjc.ca/article/S082...
Myocardial Infarction Elicits a Robust Inflammatory Response in the Pericardial Space
The pericardium and its contents, including pericardial fluid (PF), provide a homeostatic
environment for optimal cardiac function. Since the heart is bathed in PF, the components
of PF can potentiall...
onlinecjc.ca
January 12, 2026 at 4:49 AM
Member publication alert:
Myocardial Infarction Elicits a Robust Inflammatory Response in the Pericardial Space
onlinecjc.ca/article/S082...
Myocardial Infarction Elicits a Robust Inflammatory Response in the Pericardial Space
onlinecjc.ca/article/S082...
Member publication alert:
Comprehensive Evaluation of Plasma Biomarkers in Patients with Abdominal Aortic Aneurysm Using High-Throughput Label-Free Quantitative Proteomic Profiling
journals.physiology.org/doi/abs/10.1...
Comprehensive Evaluation of Plasma Biomarkers in Patients with Abdominal Aortic Aneurysm Using High-Throughput Label-Free Quantitative Proteomic Profiling
journals.physiology.org/doi/abs/10.1...
Comprehensive Evaluation of Plasma Biomarkers in Patients with Abdominal Aortic Aneurysm Using High-Throughput Label-Free Quantitative Proteomic Profiling | American Journal of Physiology-Heart and Ci...
The use of comprehensive unbiased proteomic evaluations coupled with physiological and clinical insight offers the possibility to enhance our understanding of disease mechanisms and identify potential...
journals.physiology.org
January 12, 2026 at 4:49 AM
Member publication alert:
Comprehensive Evaluation of Plasma Biomarkers in Patients with Abdominal Aortic Aneurysm Using High-Throughput Label-Free Quantitative Proteomic Profiling
journals.physiology.org/doi/abs/10.1...
Comprehensive Evaluation of Plasma Biomarkers in Patients with Abdominal Aortic Aneurysm Using High-Throughput Label-Free Quantitative Proteomic Profiling
journals.physiology.org/doi/abs/10.1...
Member publication alert:
Vitamin-B6 Pretreated Bovine Pericardial Bioprosthetic Heart Valve Leaflets Demonstrate Reduced Platelet Adhesion and Activation
onlinelibrary.wiley.com/doi/10.1002/...
Vitamin-B6 Pretreated Bovine Pericardial Bioprosthetic Heart Valve Leaflets Demonstrate Reduced Platelet Adhesion and Activation
onlinelibrary.wiley.com/doi/10.1002/...
Vitamin‐B6 Pretreated Bovine Pericardial Bioprosthetic Heart Valve Leaflets Demonstrate Reduced Platelet Adhesion and Activation
Bioprosthetic heart valves (BHV) fabricated from heterograft tissue such as glutaraldehyde fixed bovine pericardium (BP), while less thrombogenic than mechanical valve prostheses, nevertheless demons...
onlinelibrary.wiley.com
January 12, 2026 at 4:48 AM
Member publication alert:
Vitamin-B6 Pretreated Bovine Pericardial Bioprosthetic Heart Valve Leaflets Demonstrate Reduced Platelet Adhesion and Activation
onlinelibrary.wiley.com/doi/10.1002/...
Vitamin-B6 Pretreated Bovine Pericardial Bioprosthetic Heart Valve Leaflets Demonstrate Reduced Platelet Adhesion and Activation
onlinelibrary.wiley.com/doi/10.1002/...
Member publication alert:
Insights into arteriovenous fistula (non)maturation: single-cell transcriptomics reveals new drivers of arteriovenous fistula remodeling
www.kidney-international.org/article/S008...
Insights into arteriovenous fistula (non)maturation: single-cell transcriptomics reveals new drivers of arteriovenous fistula remodeling
www.kidney-international.org/article/S008...
Insights into arteriovenous fistula (non)maturation: single-cell transcriptomics reveals new drivers of arteriovenous fistula remodeling
Single-cell transcriptomics of arteriovenous fistulas reveal that failure is likely
driven less by smooth muscle proliferation than by continuous inflammation, endothelial
dysfunction, and fibroblast-...
www.kidney-international.org
January 12, 2026 at 4:47 AM
Member publication alert:
Insights into arteriovenous fistula (non)maturation: single-cell transcriptomics reveals new drivers of arteriovenous fistula remodeling
www.kidney-international.org/article/S008...
Insights into arteriovenous fistula (non)maturation: single-cell transcriptomics reveals new drivers of arteriovenous fistula remodeling
www.kidney-international.org/article/S008...
Member publication alert:
Translational Strategies for Developing and Evaluating Transcatheter Devices in Swine Heart Failure Models
link.springer.com/article/10.1...
Translational Strategies for Developing and Evaluating Transcatheter Devices in Swine Heart Failure Models
link.springer.com/article/10.1...
Client Challenge
link.springer.com
January 12, 2026 at 4:46 AM
Member publication alert:
Translational Strategies for Developing and Evaluating Transcatheter Devices in Swine Heart Failure Models
link.springer.com/article/10.1...
Translational Strategies for Developing and Evaluating Transcatheter Devices in Swine Heart Failure Models
link.springer.com/article/10.1...
Member publication alert:
Robotically assisted, minimally invasive ascending aortic replacement: A feasibility study in anatomical models
academic.oup.com/ejcts/advanc...
Robotically assisted, minimally invasive ascending aortic replacement: A feasibility study in anatomical models
academic.oup.com/ejcts/advanc...
Robotically assisted, minimally invasive ascending aortic replacement: A feasibility study in anatomical models
AbstractOBJECTIVES. Robotic cardiac surgery is well established in mitral valve repair and coronary artery bypass grafting. Outside of limited applications
academic.oup.com
December 29, 2025 at 2:32 AM
Member publication alert:
Robotically assisted, minimally invasive ascending aortic replacement: A feasibility study in anatomical models
academic.oup.com/ejcts/advanc...
Robotically assisted, minimally invasive ascending aortic replacement: A feasibility study in anatomical models
academic.oup.com/ejcts/advanc...
Member publication alert:
Miniaturized device for assessing calcification propensity of biohybrid implants under continuous flow
pubs.rsc.org/en/content/a...
Miniaturized device for assessing calcification propensity of biohybrid implants under continuous flow
pubs.rsc.org/en/content/a...
Miniaturized device for assessing calcification propensity of biohybrid implants under continuous flow
Biohybrid implants are a promising development for cardiovascular disease treatment but suffer from problems like thrombogenesis and calcification. However, testing and validating biohybrid implants c...
pubs.rsc.org
December 29, 2025 at 2:31 AM
Member publication alert:
Miniaturized device for assessing calcification propensity of biohybrid implants under continuous flow
pubs.rsc.org/en/content/a...
Miniaturized device for assessing calcification propensity of biohybrid implants under continuous flow
pubs.rsc.org/en/content/a...