Heissler Lab
myosin.bsky.social
Heissler Lab
@myosin.bsky.social
Assistant Professor. Myosin enthusiast. Fascinated by proteins and cells. Opinions are my own.
Reposted by Heissler Lab
Structural basis of human Nav1.5 gating mechanisms | PNAS www.pnas.org/doi/10.1073/...

Check our work on sodium channel. We are very proud of this study.
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
May 14, 2025 at 3:52 PM
Reposted by Heissler Lab
📢Excited to share our new paper in Nature Physics
@naturephysics.bsky.social: Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular Stentor!

How do single-celled organisms benefit from teamwork? Let’s dive in! #Multicellularity nature.com/articles/s41...?
April 2, 2025 at 12:14 PM
Reposted by Heissler Lab
Interested in how the heart generates contractile forces to pump blood? Then take a look at our new paper "α- and β-myosin II can be non-uniformly distributed within the cardiac sarcomere". #CellBiology
www.sciencedirect.com/science/arti...
March 31, 2025 at 4:40 PM
Reposted by Heissler Lab
Congrats 👏 Hsiang-Ling Huang, Giovanna Grandinetti, Sarah Heissler & Krishna Chinthalapudi on the wwPDB Foundation award at the 2025 @BiophysicalSociety Meeting for their work on mechanisms of dysferlin-mediated membrane repair!

🔗 www.wwpdb.org/news/news?ye...

#bps2025 #BPSAnnualMeeting
March 13, 2025 at 10:00 AM
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I am excited to finally be able to share with you our work reporting the first Extracellular Vesicle with a personality! This video does not show a cell, it is a Blebbisome! #CellBiology
www.nature.com/articles/s41...
February 21, 2025 at 12:59 PM
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Some happy news. Pleased to see our paper showing how afadin strengthens cytoskeletal engagement by the cadherin-catenin cell adhesion complex out in Science Advances: bit.ly/3EFpD6h
Afadin mediates cadherin-catenin complex clustering on F-actin linked to cooperative binding and filament curvature
Afadin strengthens adherens junctions by stabilizing cadherin-catenin complex clusters on curved F-actin.
bit.ly
February 18, 2025 at 3:37 AM
Reposted by Heissler Lab
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
Reposted by Heissler Lab
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.

Please amplify. If you are also able to host fly strains, add your name as well.
January 28, 2025 at 9:45 PM
Reposted by Heissler Lab
My first post on this forum! 😄

I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social

www.cell.com/trends/cell-...

Big thanks to my amazing colleagues in Dortmund
January 23, 2025 at 9:08 AM
Reposted by Heissler Lab
If you were to look for changes in gene expression in cells differentiating into neurons related to the microtubule cytoskeleton, what genes would you look to be up-regulated? HDACs? Glutamylases? Detyrosinases? Down-regulated?
patrick star from spongebob squarepants is sitting on a couch with a snail on his head .
ALT: patrick star from spongebob squarepants is sitting on a couch with a snail on his head .
media.tenor.com
January 15, 2025 at 12:19 AM
Reposted by Heissler Lab
I’m looking for a motivated postdoc to join my lab with a structural biology background. Reach out to me if you are interested in the structure-function studies of actin cytoskeleton and membrane repair processes.
December 3, 2024 at 1:21 PM
Reposted by Heissler Lab
Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8

elifesciences.org/reviewed-pre...
Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8
elifesciences.org
November 19, 2024 at 2:42 AM