We used live-cell imaging with plus-end binding protein EB3 to determine microtubule polarity in astrocytes for the first time. They are ~88% plus-ends out.

3/x

The two key studies of the International Brain Laboratory @intlbrainlab.bsky.social are out today!

A brain-wide map of neural activity during complex behaviour
www.nature.com/articles/s41...

Brain-wide representations of prior information in mouse decision-making
www.nature.com/articles/s41...

Just dropped in @natcomms.nature.com: we show that re-engaging a thalamic–ventral tegmental circuit with deep brain stimulation can reignite consciousness in patients with severe brain injury. Work led by Aaron Warren, with @andreashorn.org @foxmdphd.bsky.social @ others! tinyurl.com/4kz8j89b

Nature research paper: Remodelling of corticostriatal axonal boutons during motor learning

go.nature.com/3He5N3C

This video, created by Andy Moore, a Research Scientist at @hhmijanelia.bsky.social, shows a cell w a dynamic network of endoplasmic reticulum (ER) tubules—present in every eukaryotic cell—as well as mitochondria migrating through the cell’s interior. The ER is orange, and the mitochondria are blue.

Tetanus on demand! (not for bioweapons, but for neuroscience research)

Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release.

To harness this toxicity and use it as a beneficial tool for neuroscience,

Antipsychotics is often used to suppress hyper-aggression. Does it really suppress aggression or just cause sedation? Antipsychotics targets dopamine receptors. Our new study revealed that dopamine modulates aggression based on animals' fighting experience.

www.nature.com/articles/s41...

“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO

🛠️ December's most-read Tools and Resources paper presents a toolbox for ablating excitatory and inhibitory synapses: https://buff.ly/3PmIlBE

Learn more about publishing your tools or resources with us: https://buff.ly/4f2O0Ht

Understanding GABAergic synapse diversity and its implications for GABAergic pharmacotherapy: doi.org/10.1016/j.ti...

Review on the diversity of GABAergic synapse organizer proteins

Through monitoring a large group of marmosets, researchers have categorised their behaviours to find baselines for typical and atypical responses that can help us study psychiatric disorders.

🔗 https://buff.ly/3ZReXbt

Aging-related losses in dopamine D2/3 receptor availability are linked to working-memory decline across five years
doi.org/10.1093/cerc...
#neuroscience

🧪 New research provides a first test of using a Janelia-developed technique to detect molecular motion inside cells, showing its potential to track other types of molecular movement & study interactions like the binding of pharmaceutical targets in a cellular environment. https://hhmi.news/401LKMq