Michal Minczuk
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mitogene.bsky.social
Michal Minczuk
@mitogene.bsky.social
Prof. at University of Cambridge @mrc-mbu.bsky.social; co-founder of Pretzeltx.com
Reposted by Michal Minczuk
Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier.

CRISPR-based tools can’t easily access the DNA in these organelles, but researchers are finding other ways in

www.nature.com/articles/d41...
Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier
CRISPR-based tools can’t easily access the DNA in these organelles, but researchers are finding other ways in.
www.nature.com
October 15, 2025 at 1:30 PM
Reposted by Michal Minczuk
@mitogene.bsky.social we are looking forward to your presentation at #MitoCellFate in Malta!
Please share this with your followers to let them know the Earlybird & Talk submission deadline is fast approaching - Monday 10 November.
Register & Submit here: bit.ly/46TS4Ii
September 30, 2025 at 4:19 PM
Reposted by Michal Minczuk
It’s here – World Mitochondrial Disease Week! 💚

We’re proud to collaborate with other mito charities across the UK to put mito on the map – let's spread the word together!

👉 See how you can get involved:
🔗 thelilyfoundation.org.uk/charity/get-involved/world-mitochondrial-disease-week
September 15, 2025 at 2:21 PM
Reposted by Michal Minczuk
Don't forget to register and submit your abstract for our #MitoCellFate conference in Malta next year ☀️

📢Check out our wonderful speaker line-up so far!
📅Early-bird & talk deadline: 10 Nov 2025
bit.ly/46xBYVt

#FusionStemCells #FusionAgingResearch
September 11, 2025 at 9:40 AM
Massive congratulations to @lucialugut.bsky.social on receiving the prestigious 2025 CSAR Award! 🎉 Lucia's groundbreaking work in modeling and correcting mtDNA mutations paves the way for innovative future therapies for mitochondrial diseases. @mrc-mbu.bsky.social www.csar.org.uk/student-awar...
July 2, 2025 at 1:44 PM
Reposted by Michal Minczuk
The first-ever conference dedicated entirely to mitochondrial DNA just wrapped up in Nashville!

From mutation mechanisms to repair strategies and cutting-edge editing techniques, it was a landmark event.

See the full recap 👇

mitoworld.org/mechanisms-o...
Mechanisms of Mitochondrial DNA Mutation and Repair - MitoWorld
If our website is MitoWorld, the Mechanisms of Mitochondrial DNA Mutation and Repair conference was the introductory gathering of what could be called “mtDNA World.” The organizers, Patrick Chinnery (...
mitoworld.org
June 23, 2025 at 10:58 PM
Reposted by Michal Minczuk
🎙️ Focus Speakers – Michal Minczuk
@mitogene.bsky.social

👀 Curious to know who will be speaking at #euromit2026 ?
✨ Today, we’re introducing Michal Minczuk who will be taking the stage at the congress.
#euromit2026 #mitochondria #angers @univangers.bsky.social @ua-recherche.bsky.social
June 2, 2025 at 8:15 AM
Last chance to join us for the Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee @faseborg.bsky.social
Last call for genetics scientists to save $150 at #MDNASRC 2025 with a can't-miss keynote presentation from Thomas Langer from @mpiage.bsky.social ... Save your seat by May 12: buff.ly/A12895w
May 6, 2025 at 3:24 PM
Reposted by Michal Minczuk
🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
April 12, 2025 at 1:42 PM
Reposted by Michal Minczuk
Hello fellow mitochondriacs! Are you passionate about mtDNA? We now offer a 2-year postdoc opportunity for studies of mtDNA instability and its signaling. Apply by May 18th to join our international team in exotic Umeå. Please share!
www.umu.se/en/work-with...
Postdoctoral fellowship (2 years) to study mitochondrial DNA stability
www.umu.se
April 16, 2025 at 11:43 AM
Reposted by Michal Minczuk
Yesterday we were proud to join the launch of the LifeArc Centre for Rare Mitochondrial Diseases - a major step forward in mito research

We led a workshop on making complex science clear – because involving patients is key to success

#mitochondrialdisease #mitoresearch #patientvoice #raredisease
April 15, 2025 at 3:31 PM
Reposted by Michal Minczuk
Very full schedule at our #IMGCglasgow workshop last week, delivered by MitoCluster team @robpitceathly.bsky.social, Carlo Viscomi, @mitogene.bsky.social, and @jim-ca.bsky.social. A pleasure to attend, thanks for the invite @mrcmousenetwork.bsky.social & IMGS! 🧬

#mitochondria #MouseModels #ECR
April 15, 2025 at 10:09 AM
🚨 Join us for the @faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
April 12, 2025 at 1:42 PM
Reposted by Michal Minczuk
Clinically translatable mitochondrial #GeneTherapy in muscle using tandem mtZFN architecture.
By P. Nash, @mitogene.bsky.social & colleagues @mrc-mbu.bsky.social

🗞️ doi.org/10.1038/s443...

Read also related N&V by A. Ghifari & M. Ott 👉 doi.org/10.1038/s443...
April 11, 2025 at 2:36 PM
Great opportunity!
2x CRA posts extended until end of April. So you have another chance to work with #mito disease patients as part of the @lifearc.bsky.social centre for #rare #mito diseases! See links below to apply!
@eastgenomics.bsky.social @camneuro.bsky.social @cuhnhs.bsky.social
📢 We have not 1 but 3 clinical/patient-facing jobs working with #mitoCAMB on the #LifeArc #raredisease centre for #mito diseases.

1x pre/post-doctoral CRA;
1x post-doctoral CRA (with potential to become a 4 year ACL); 1x research coordinator

Join us! Links below.
April 11, 2025 at 9:37 AM
Huge congrats to Pavel Nash on publishing his PhD work! 🎉 We showcase a safer mtDNA gene therapy using a novel mtZFN architecture compatible with a single AAV. Thanks to the entire team! @mrc-mbu.bsky.social
@mbu-postdocs.bsky.social #MitochondrialDisease #mtDNA
www.embopress.org/doi/full/10....
Clinically translatable mitochondrial gene therapy in muscle using tandem mtZFN architecture | EMBO Molecular Medicine
imageimageEfficient mitochondrial gene therapy is achieved with a novel tandem zinc finger nuclease (mtZFN) architecture delivered via adeno-associated viral (AAV) vectors, significantly reducing mutation loads in muscle tissue and rescuing ...
www.embopress.org
April 9, 2025 at 7:10 PM
Exciting news from Pretzel Therapeutics! We’ve launched a Phase 1 trial for our POLG activator—PX578—targeting rare mitochondrial syndromes with potential for Parkinson’s & Alzheimer’s diseases.
Congratulations to the entire team—proud to be part of this journey!
www.pretzeltx.com/pretzel-ther...
Pretzel Therapeutics Initiates Phase 1 Clinical Study Evaluating PX578, Lead Therapeutic in its Bioenergetics Restoration Franchise » Pretzel Therapeutics
First-in-class approach to targeting mitochondrial DNA polymerase (POLG) with disease modifying potential across mitochondrial DNA depletion syndromes
www.pretzeltx.com
April 4, 2025 at 9:41 AM
Reposted by Michal Minczuk
Exciting News: Learn about the Speakers of Euromit 2026!
We are happy to announce the amazing speakers for Euromit 2026, the leading congress on mitochondrial pathology.🌍✨
📢 See the full list ! 👇
#euromit2026 #mitochondria #science #innovation #angers
March 20, 2025 at 2:26 PM
Reposted by Michal Minczuk
Looking forward to #IMGC2025 Glasgow next month!

MitoCluster will be delivering an #ECR Workshop on Mouse Models of #Mitochondrial DNA Disease, featuring cluster lead @robpitceathly.bsky.social and investigators Carlo Viscomi, @jim-ca.bsky.social, and @mitogene.bsky.social🐁
The programme is now finalised, and the abstracts are on the IMGS website. Looking forward to seeing people in Glasgow and sharing some great science!
hashtag#MouseGenetics hashtag#PreclinicalScience hashtag#PreclinicalResearch hashtag#MammalianGenetics www.imgs.org/2025-38th-im...
2025-38th IMGC Glasgow — International Mammalian Genome Society
The Abstract Submission for oral presentation consideration deadline was January 17, 2025. Abstracts will still be accepted, but for poster presentations only.
www.imgs.org
March 25, 2025 at 2:52 PM
Reposted by Michal Minczuk
🌍Euromit 2026 is coming to Angers!🌍

✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨

📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬
February 3, 2025 at 8:46 AM
REGISTRATION OPEN for @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair | June 1 - 5, 2025 | Nashville, Tennessee. Apply before it is too late: events.faseb.org/event/mitoch...
Please re-post!
March 6, 2025 at 12:46 AM
Reposted by Michal Minczuk
If you are interested in mitochondria, Nashville is the place to be June 1-5. Check out this FASEB meeting. Please RT. events.faseb.org/event/mitoch...
Mechanisms of Mitochondrial DNA Mutation and Repair
events.faseb.org
March 5, 2025 at 2:32 PM