Michael Grange
LightNews LightNews
banner
michaelgrange.bsky.social
Michael Grange
@michaelgrange.bsky.social
710 followers 120 following 21 posts
Group Leader at the Rosalind Franklin Institute. In situ imaging/cryo tomography of complex biological systems.
Posts Replies Media Videos
Reposted by Michael Grange
tbharat-lab.bsky.social
An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
Reposted by Michael Grange
maxrenner.bsky.social
Our new preprint is out 🥳🥳🥳

Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?

👇
November 3, 2025 at 12:26 PM
Reposted by Michael Grange
mpibp.bsky.social
Have you registered to the next EMBO Practical Course on In-situ structural biology by Cryo-FIB and Cryo-ET? 🧊 Join us in Frankfurt for hands-on training on cryo-techniques and networking with experts!

🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...
📍 Frankfurt | 📆 April 12–20, 2026
Orange and green poster of the In-situ structural biology by Cryo-FIB and Cryo-ET in Frankfurt am Main, with EMBO logo. The poster promotes childcare grants, travel grants and that this is a sustainable event.
October 23, 2025 at 9:10 AM
Reposted by Michael Grange
joedobbs.bsky.social
Check out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️

www.biorxiv.org/content/10.1...
#teamtomo
Figure 1 from the preprint
October 15, 2025 at 6:26 AM
Reposted by Michael Grange
lapassmore.bsky.social
We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM
September 27, 2025 at 11:07 AM
Reposted by Michael Grange
cellarchlab.com
Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with @profmattjohnson.bsky.social to dive into spinach chloroplasts with #CryoET ❄️🔬. Curious? ..Read on!

#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
1/🧵
September 25, 2025 at 6:00 PM
Reposted by Michael Grange
nexperion.net
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026
September 23, 2025 at 10:42 AM
Reposted by Michael Grange
kattoropova.bsky.social
The Dunn School PhD programme is live! 🎉

Two projects in our labs:
1) How the motor protein giant dynein-2 works
2) How signalling-essential membrane proteins get into cilia

Cryo-EM/ET, single mol & live-cell fluor microscopy, CRISPR-based genetic tools & more!

www.path.ox.ac.uk/study-with-u...
How to Apply - Dunn School
Here you can find more information on how to apply for our PhD programme, including deadlines and application requirements.
www.path.ox.ac.uk
September 8, 2025 at 6:40 PM
Reposted by Michael Grange
pombo-garcialab.bsky.social
🚨 We are hiring a #postdoc in Quantitative Cell Biology/Biochemistry. Join us if you are interested in using super-resolution STED & cryoET to uncover self-organization dynamics of epithelial cell interfaces & glycobiology collaboration with WuLab
zurl.co/aTGq7
About The Rosalind Franklin Institute - Rosalind Franklin Institute
The Rosalind Franklin Institute is a new national institute, announced in 2017 by the UK government, dedicated to bringing about transformative changes in life science through interdisciplinary resear...
zurl.co
September 6, 2025 at 12:11 PM
Reposted by Michael Grange
tbharat-lab.bsky.social
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging

Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social

www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
August 31, 2025 at 6:44 PM
Reposted by Michael Grange
jennysachweh.bsky.social
My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!

Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!

Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
The small GTPase Ran defines nuclear pore complex asymmetry
Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin build…
www.sciencedirect.com
August 18, 2025 at 4:26 PM
Reposted by Michael Grange
cmholab.bsky.social
Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH

A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo
Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug
Nature Structural & Molecular Biology - Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation...
rdcu.be
August 18, 2025 at 12:13 PM
Reposted by Michael Grange
sjorsscheres.bsky.social
Fantastic work by the group of @matteoall.bsky.social : a SUN5:Nesprin3 complex at the head:tail junction of sperm cells. 🤯 #teamtomo

www.biorxiv.org/content/10.1...
In-cell structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells
In eukaryotic cells, LINC complexes physically bridge the two nuclear membranes to cytoskeletal filaments, transmitting mechanical forces to the nucleus. Due to their dynamic and membrane-embedded nat...
www.biorxiv.org
August 5, 2025 at 6:14 AM
Reposted by Michael Grange
madic.bsky.social
New preprint: In situ Architecture of #Plasmodesmata.

Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.

🔗 doi.org/10.1101/2025...

🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM
July 26, 2025 at 3:38 PM
michaelgrange.bsky.social
And here it is now in print! www.cell.com/cell-reports...

With a front cover splash 😍
July 21, 2025 at 7:15 PM
Reposted by Michael Grange
thomsharp.bsky.social
We’re hiring a postdoc! 🔬

Join us in Bristol, UK to study in situ structural immunology using cryoFIB-SEM + cryoET on our new Hydra Bio system. ERC-funded, 3 years, studying phagocytosis to develop new immunotherapeutics.

Closing 29 July 2025.

Info + apply: www.bristol.ac.uk/jobs/find/de...
Details | Working at Bristol | University of Bristol
www.bristol.ac.uk
July 9, 2025 at 2:56 PM
Reposted by Michael Grange
centriolelab.bsky.social
🚨 New preprint!
Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM
www.biorxiv.org/content/10.1...
June 19, 2025 at 8:58 AM
Reposted by Michael Grange
cryoempapers.bsky.social
A generalizable and targeted molecular biopsy approach for in situ cryogenic electron tomography of vitreous brain tissue pubmed.ncbi.nlm.nih.gov/40527314/ #cryoem
June 18, 2025 at 11:54 PM
Reposted by Michael Grange
fitzpatricklab.bsky.social
New preprint from Daniel Du @fitzpatricklab.bsky.social shows #femtosecond light pulses can lens electron beams, promising higher contrast in #cryoET and better aberration correction in #cryoEM

tinyurl.com/257sw7j9

Experiments made possible by support from @cziscience.bsky.social #ImagingTheFuture
June 17, 2025 at 3:38 PM
michaelgrange.bsky.social
Proud to share our latest paper. doi.org/10.1016/j.cr...

Through the dedication of @glynnca.bsky.social and @cryingem.bsky.social we report a thorough method to image molecular organisation within hippocampus tissue.

Structural biology in tissue is well and truly here!

@rosfrankinst.bsky.social
June 17, 2025 at 10:59 AM
Reposted by Michael Grange
biorxivpreprint.bsky.social
Exploring shaped focused ion beams for lamella preparation https://www.biorxiv.org/content/10.1101/2025.04.01.646235v1
April 6, 2025 at 10:47 PM
Reposted by Michael Grange
lacarlson.bsky.social
Repost appreciated:

Open #PhDposition in structural virology in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET combined with #virology, #cellbiology, and #biophysics.

Deadline 4 May. More info: www.carlsonlab.se/join/
April 4, 2025 at 8:06 AM
michaelgrange.bsky.social
Check out our paper on Xenon milling of HPF samples, now online @naturecomms.bsky.social

rdcu.be/eczIb
rdcu.be
March 7, 2025 at 12:54 PM
Reposted by Michael Grange
simonemattei.bsky.social
Thanks to Instruct-ERIC, the @embl.org Imaging Centre is able to offer an advanced hands-on workshop on cryo-FIB-SEM methods. This is a great opportunity to exchange knowledge with our fantastic cryo-CLEM specialists! 21-25 July 2025. Apply here before May 12th: www.embl.org/about/info/i...
February 21, 2025 at 10:59 AM
michaelgrange.bsky.social
There is a postdoctoral position available in cryoET and FIB/SEM of Parkinson's disease available in at the Franklin!

See details here: opportunities.rfi.ac.uk/vacancy/post...

This work is in collaboration with our partners at MSD and their London Discovery Centre.

Please share!
December 20, 2024 at 3:28 PM