Mable Lam
@mablelam-phd.bsky.social
NINDS K99 Fellow in the Zuchero lab @ Stanford | myelin cell biology | Former Helen Hay Whitney | PhD in the Walter lab
@UCSF | she/her
@UCSF | she/her
Pinned
Mable Lam
@mablelam-phd.bsky.social
· May 27
We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines.
Learn more about these exceptional scientists:
www.leadingedgesymposium.org/fellows
Learn more about these exceptional scientists:
www.leadingedgesymposium.org/fellows
Honored to be a part of this fantastic community! 🎉
Reposted by Mable Lam
The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor.
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
November 5, 2025 at 5:48 PM
The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor.
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2.
www.leadingedgesymposium.org/apply/
Reposted by Mable Lam
In the desert of tools to manipulate oligodendrocytes in the brain, we built an OASIS. 🌿 Pun intended. I’m still in awe every time I spot an amazing-looking cell. The beauty of OL and myelin never fails me!
Hope this tool helps more people see it too.
Hope this tool helps more people see it too.
OASIS: in vivo AAV-mediated transduction and genome editing of adult oligodendrocytes https://www.biorxiv.org/content/10.1101/2025.10.20.683551v1
October 21, 2025 at 11:58 PM
In the desert of tools to manipulate oligodendrocytes in the brain, we built an OASIS. 🌿 Pun intended. I’m still in awe every time I spot an amazing-looking cell. The beauty of OL and myelin never fails me!
Hope this tool helps more people see it too.
Hope this tool helps more people see it too.
Reposted by Mable Lam
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Mable Lam
Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling
Stroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue…
www.sciencedirect.com
October 10, 2025 at 11:13 PM
Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Mable Lam
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Induction of menstruation in mice reveals the regulation of menstrual shedding
During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...
www.biorxiv.org
October 10, 2025 at 1:26 PM
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Reposted by Mable Lam
The Sosa Lab website is now live!
www.sosaneurolab.com
We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.
www.sosaneurolab.com
We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.
Sosa Lab
www.sosaneurolab.com
September 22, 2025 at 9:23 PM
The Sosa Lab website is now live!
www.sosaneurolab.com
We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.
www.sosaneurolab.com
We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.
Reposted by Mable Lam
Which track do I choose: On #FluorescenceFriday, a pair of newly formed oligodendrocytes encounter a field of neuronal axons. Later in development, they will wrap around and insulate subset of these axons
September 19, 2025 at 8:22 PM
Which track do I choose: On #FluorescenceFriday, a pair of newly formed oligodendrocytes encounter a field of neuronal axons. Later in development, they will wrap around and insulate subset of these axons
Reposted by Mable Lam
Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11
Read the thread below for a summary of our findings 🧵1/11
September 17, 2025 at 2:55 PM
Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11
Read the thread below for a summary of our findings 🧵1/11
Reposted by Mable Lam
Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
September 12, 2025 at 1:21 PM
Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
Reposted by Mable Lam
Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function
Myelination is essential for normal brain function, yet the mechanisms governing neuron-oligodendrocyte interactions that ensure proper myelination le…
www.sciencedirect.com
September 10, 2025 at 9:20 AM
Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Mable Lam
If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system
Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...
www.biorxiv.org
September 3, 2025 at 11:51 AM
If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mable Lam
Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD
Thanks to Nina and all of the team!
Thanks to Nina and all of the team!
Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function
Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...
rdcu.be
August 31, 2025 at 1:03 PM
Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD
Thanks to Nina and all of the team!
Thanks to Nina and all of the team!
Reposted by Mable Lam
Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh
🧵
www.sciencedirect.com/science/arti...
🧵
www.sciencedirect.com/science/arti...
Investigating morphogen and patterning dynamics with optogenetic control of morphogen production
Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…
www.sciencedirect.com
August 26, 2025 at 8:28 AM
Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh
🧵
www.sciencedirect.com/science/arti...
🧵
www.sciencedirect.com/science/arti...
Reposted by Mable Lam
Reposted by Mable Lam
Delighted to share this work on intracortical arbor development and selective synaptogenesis by corticothalamic neurons. This was a really fun collaboration with Alan and the Brown lab during my PhD.
Excited to share our new preprint from my graduate work, a collaboration between the Brown lab and @srirams433.bsky.social and others in the Kolodkin lab! Our study investigated how patterned excitatory connectivity is generated in the development of the cerebral cortex (1/7)
Cell-type-selective synaptogenesis during the development of excitatory connectivity in the mammalian neocortex
The function of mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased patterns of excitatory synaptic connections. A subtype of excitatory neurons, layer 6 c...
www.biorxiv.org
August 19, 2025 at 5:25 PM
Delighted to share this work on intracortical arbor development and selective synaptogenesis by corticothalamic neurons. This was a really fun collaboration with Alan and the Brown lab during my PhD.
Reposted by Mable Lam
Reposted by Mable Lam
Extremely excited to share that I’m joining Columbia University @columbiauniversity.bsky.social as an Assistant Professor!
We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky
thawanilab.org
We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky
thawanilab.org
The Thawani Lab at Columbia University
The Thawani Lab at Columbia University describing their research on mobile genome, cryo-electron microscopy and genome engineering
thawanilab.org
August 19, 2025 at 5:00 PM
Extremely excited to share that I’m joining Columbia University @columbiauniversity.bsky.social as an Assistant Professor!
We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky
thawanilab.org
We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky
thawanilab.org
🎉 Huge congrats to my advisor @bradzuchero.bsky.social and @ethanhugheslab.bsky.social for this McKnight award!
med.stanford.edu/neurosurgery...
med.stanford.edu/neurosurgery...
Stanford researcher awarded McKnight grant to uncover myelin's connection to Alzheimer's disease
Brad Zuchero, PhD, assistant professor of neurosurgery, is a recipient of the 2025 McKnight Neurobiology of Brain Disorders (NBD) Award for his research project “Does myelin dysfunction drive Alzheime...
med.stanford.edu
July 22, 2025 at 1:36 AM
🎉 Huge congrats to my advisor @bradzuchero.bsky.social and @ethanhugheslab.bsky.social for this McKnight award!
med.stanford.edu/neurosurgery...
med.stanford.edu/neurosurgery...
Reposted by Mable Lam
We had fun assembling images and describing approaches for imaging oligodendrocytes and myelin in vivo, in organotypic slices, and in fixed tissues. This work started in the lab of @jgrutzendler.bsky.social over 10 years ago and continues to keep us busy.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
July 18, 2025 at 6:15 PM
We had fun assembling images and describing approaches for imaging oligodendrocytes and myelin in vivo, in organotypic slices, and in fixed tissues. This work started in the lab of @jgrutzendler.bsky.social over 10 years ago and continues to keep us busy.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Reposted by Mable Lam
Was a lot of fun working on this piece with Ben Clayton for @annualreviews.bsky.social
Reactive astrocyte heterogeneity is a thoroughly exciting and complicated problem... lots of exciting discoveries in recent years.
www.annualreviews.org/content/jour...
Reactive astrocyte heterogeneity is a thoroughly exciting and complicated problem... lots of exciting discoveries in recent years.
www.annualreviews.org/content/jour...
July 18, 2025 at 7:31 PM
Was a lot of fun working on this piece with Ben Clayton for @annualreviews.bsky.social
Reactive astrocyte heterogeneity is a thoroughly exciting and complicated problem... lots of exciting discoveries in recent years.
www.annualreviews.org/content/jour...
Reactive astrocyte heterogeneity is a thoroughly exciting and complicated problem... lots of exciting discoveries in recent years.
www.annualreviews.org/content/jour...
Reposted by Mable Lam
The NYT is doing a great job on these infographics showing how taxpayer money is being blocked from reaching its intended recipients
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
June 30, 2025 at 11:42 PM
The NYT is doing a great job on these infographics showing how taxpayer money is being blocked from reaching its intended recipients
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Reposted by Mable Lam
TIL that one of the books removed from the Armed Forces Library because it "had DEI" in it is Ben Barres' autobiography. Remember that you can buy and should read this book because Ben was badass and an amazing scientist mitpress.mit.edu/978026253954...
June 27, 2025 at 8:55 AM
TIL that one of the books removed from the Armed Forces Library because it "had DEI" in it is Ben Barres' autobiography. Remember that you can buy and should read this book because Ben was badass and an amazing scientist mitpress.mit.edu/978026253954...
Reposted by Mable Lam
Being part of the myelin field has been the most rewarding aspect of my scientific career ❤️
Stanford research by Dr Barres changed our understanding of myelin—once seen as static insulation, now linked to learning & memory. Learn how @michellemonje.bsky.social, @erinmgibson.bsky.social, @bradzuchero.bsky.social & others continue to shape the field: neuroscience.stanford.edu/news/underst...
June 23, 2025 at 6:51 PM
Being part of the myelin field has been the most rewarding aspect of my scientific career ❤️
Reposted by Mable Lam
🖤 On #Juneteenth, we honor the fight for Black freedom — delayed, but never denied.
At #BlackInNeuro, we carry that legacy forward by creating space for Black excellence in neuroscience, year-round. ✨
Freedom is a journey — and we’re not done yet. ✊🏾
At #BlackInNeuro, we carry that legacy forward by creating space for Black excellence in neuroscience, year-round. ✨
Freedom is a journey — and we’re not done yet. ✊🏾
June 19, 2025 at 4:22 PM
🖤 On #Juneteenth, we honor the fight for Black freedom — delayed, but never denied.
At #BlackInNeuro, we carry that legacy forward by creating space for Black excellence in neuroscience, year-round. ✨
Freedom is a journey — and we’re not done yet. ✊🏾
At #BlackInNeuro, we carry that legacy forward by creating space for Black excellence in neuroscience, year-round. ✨
Freedom is a journey — and we’re not done yet. ✊🏾
Reposted by Mable Lam
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling: Cell www.cell.com/cell/fulltex...
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling
Midbrain cholinergic neuronal activity promotes the proliferation of both oligodendrocyte
precursor cells and diffuse midline glioma (DMG) cells in a circuit-dependent manner,
mediated by muscarinic M...
www.cell.com
June 20, 2025 at 2:03 AM
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling: Cell www.cell.com/cell/fulltex...