Sriram S
@srirams433.bsky.social
Post-doc in the Zuchero and Soltesz labs, Stanford Neurosurgery, studying neuron-oligodendrocyte interactions. Previously PhD in the Kolodkin lab @HopkinsNeuro
Pinned
Sriram S
@srirams433.bsky.social
· Aug 19
Excited to share our new preprint from my graduate work, a collaboration between the Brown lab and @srirams433.bsky.social and others in the Kolodkin lab! Our study investigated how patterned excitatory connectivity is generated in the development of the cerebral cortex (1/7)
Cell-type-selective synaptogenesis during the development of excitatory connectivity in the mammalian neocortex
The function of mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased patterns of excitatory synaptic connections. A subtype of excitatory neurons, layer 6 c...
www.biorxiv.org
Delighted to share this work on intracortical arbor development and selective synaptogenesis by corticothalamic neurons. This was a really fun collaboration with Alan and the Brown lab during my PhD.
Happy #FluorescenceFriday from this pair of white-matter oligodendrocytes!
November 15, 2025 at 12:01 AM
Happy #FluorescenceFriday from this pair of white-matter oligodendrocytes!
Reposted by Sriram S
Thread coming soon, but be the first to read the latest from @franziau.bsky.social!
Oligodendrocytes support functional development of subcortical premotor neurons and navigation https://www.biorxiv.org/content/10.1101/2025.11.01.686017v1
November 2, 2025 at 12:00 PM
Thread coming soon, but be the first to read the latest from @franziau.bsky.social!
Reposted by Sriram S
In the desert of tools to manipulate oligodendrocytes in the brain, we built an OASIS. 🌿 Pun intended. I’m still in awe every time I spot an amazing-looking cell. The beauty of OL and myelin never fails me!
Hope this tool helps more people see it too.
Hope this tool helps more people see it too.
OASIS: in vivo AAV-mediated transduction and genome editing of adult oligodendrocytes https://www.biorxiv.org/content/10.1101/2025.10.20.683551v1
October 21, 2025 at 11:58 PM
In the desert of tools to manipulate oligodendrocytes in the brain, we built an OASIS. 🌿 Pun intended. I’m still in awe every time I spot an amazing-looking cell. The beauty of OL and myelin never fails me!
Hope this tool helps more people see it too.
Hope this tool helps more people see it too.
New cell-type for #FluorescenceFriday: astrocytes in the cerebral cortex
October 4, 2025 at 12:51 AM
New cell-type for #FluorescenceFriday: astrocytes in the cerebral cortex
Which track do I choose: On #FluorescenceFriday, a pair of newly formed oligodendrocytes encounter a field of neuronal axons. Later in development, they will wrap around and insulate subset of these axons
September 19, 2025 at 8:22 PM
Which track do I choose: On #FluorescenceFriday, a pair of newly formed oligodendrocytes encounter a field of neuronal axons. Later in development, they will wrap around and insulate subset of these axons
Reposted by Sriram S
The hippocampus is one of the most studied brain areas because of its major role in fundamental brain functions including learning, memory, and spatial navigation.
In a new #ScienceReview, researchers focus on the role of overlooked areas and circuits within the hippocampus. https://scim.ag/3VKRbMM
In a new #ScienceReview, researchers focus on the role of overlooked areas and circuits within the hippocampus. https://scim.ag/3VKRbMM
September 12, 2025 at 4:51 PM
The hippocampus is one of the most studied brain areas because of its major role in fundamental brain functions including learning, memory, and spatial navigation.
In a new #ScienceReview, researchers focus on the role of overlooked areas and circuits within the hippocampus. https://scim.ag/3VKRbMM
In a new #ScienceReview, researchers focus on the role of overlooked areas and circuits within the hippocampus. https://scim.ag/3VKRbMM
Delighted to share this work on intracortical arbor development and selective synaptogenesis by corticothalamic neurons. This was a really fun collaboration with Alan and the Brown lab during my PhD.
Excited to share our new preprint from my graduate work, a collaboration between the Brown lab and @srirams433.bsky.social and others in the Kolodkin lab! Our study investigated how patterned excitatory connectivity is generated in the development of the cerebral cortex (1/7)
Cell-type-selective synaptogenesis during the development of excitatory connectivity in the mammalian neocortex
The function of mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased patterns of excitatory synaptic connections. A subtype of excitatory neurons, layer 6 c...
www.biorxiv.org
August 19, 2025 at 5:25 PM
Delighted to share this work on intracortical arbor development and selective synaptogenesis by corticothalamic neurons. This was a really fun collaboration with Alan and the Brown lab during my PhD.
Reposted by Sriram S
The Wu Lab at @JohnsHopkins is looking for a new postdoc fellow to study sleep and/or circadian-related behaviors in mice. If you're interested in, please contact us.
www.markwulab.net
www.markwulab.net
Wu Lab
www.markwulab.net
August 10, 2025 at 6:48 PM
The Wu Lab at @JohnsHopkins is looking for a new postdoc fellow to study sleep and/or circadian-related behaviors in mice. If you're interested in, please contact us.
www.markwulab.net
www.markwulab.net
Reposted by Sriram S
#JNeurosci: <a href="https://bsky.app/profile/did:plc:tew5jhl2vvoqzvmdop3iwlqx" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@srirams433.bsky.social Guzman-Clavel et al. uncover roles for Mef2c in cortical development: regulation of laminar subtype specification during embryogenesis & axon targeting in postnatal callosal neurons. @oneneuroinitiative.bsky.social
https://doi.org/10.1523/JNEUROSCI.0201-25.2025
https://doi.org/10.1523/JNEUROSCI.0201-25.2025
July 28, 2025 at 3:01 PM
#JNeurosci: <a href="https://bsky.app/profile/did:plc:tew5jhl2vvoqzvmdop3iwlqx" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@srirams433.bsky.social Guzman-Clavel et al. uncover roles for Mef2c in cortical development: regulation of laminar subtype specification during embryogenesis & axon targeting in postnatal callosal neurons. @oneneuroinitiative.bsky.social
https://doi.org/10.1523/JNEUROSCI.0201-25.2025
https://doi.org/10.1523/JNEUROSCI.0201-25.2025
Reposted by Sriram S
Reposted by Sriram S
Stanford research by Dr Barres changed our understanding of myelin—once seen as static insulation, now linked to learning & memory. Learn how @michellemonje.bsky.social, @erinmgibson.bsky.social, @bradzuchero.bsky.social & others continue to shape the field: neuroscience.stanford.edu/news/underst...
June 23, 2025 at 6:12 PM
Stanford research by Dr Barres changed our understanding of myelin—once seen as static insulation, now linked to learning & memory. Learn how @michellemonje.bsky.social, @erinmgibson.bsky.social, @bradzuchero.bsky.social & others continue to shape the field: neuroscience.stanford.edu/news/underst...
Celebratory #FluorescenceFriday this week, with the JNeurosci cover featuring an image from our article on how Mef2c controls intracortical projection targeting
May 24, 2025 at 12:07 AM
Celebratory #FluorescenceFriday this week, with the JNeurosci cover featuring an image from our article on how Mef2c controls intracortical projection targeting
Reposted by Sriram S
The winner of OneNeuro's April #FotoFriday #FluorescenceFriday
contest was submitted by Luis Guzman-Clavel at the Alex Kolodkin Lab.
For more information, see pubmed.ncbi.nlm.nih.gov/40228894/
View the complete gallery of OneNeuro BRAINART images here:
www.oneneurojhu.org/art/
contest was submitted by Luis Guzman-Clavel at the Alex Kolodkin Lab.
For more information, see pubmed.ncbi.nlm.nih.gov/40228894/
View the complete gallery of OneNeuro BRAINART images here:
www.oneneurojhu.org/art/
May 2, 2025 at 6:27 PM
The winner of OneNeuro's April #FotoFriday #FluorescenceFriday
contest was submitted by Luis Guzman-Clavel at the Alex Kolodkin Lab.
For more information, see pubmed.ncbi.nlm.nih.gov/40228894/
View the complete gallery of OneNeuro BRAINART images here:
www.oneneurojhu.org/art/
contest was submitted by Luis Guzman-Clavel at the Alex Kolodkin Lab.
For more information, see pubmed.ncbi.nlm.nih.gov/40228894/
View the complete gallery of OneNeuro BRAINART images here:
www.oneneurojhu.org/art/
Reposted by Sriram S
Our latest manuscript (7 years in the works) tackles the question of how diurnal ground squirrels evolved a cone-dominant retina, in contrast to the ancestral rod-dominant retina retained by virtually all other mammals./1
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.
Evolutionary adaptation to diurnal vision in ground squirrels has led to the development of a cone-dominant retina, in stark contrast to the rod-dominant retinas of most mammals. The molecular mechani...
www.biorxiv.org
April 29, 2025 at 11:06 AM
Our latest manuscript (7 years in the works) tackles the question of how diurnal ground squirrels evolved a cone-dominant retina, in contrast to the ancestral rod-dominant retina retained by virtually all other mammals./1
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sriram S
Our field has lost an amazing scientist, mentor, and old friend. Benny, along with Mike Hoffman, had a brilliant idea in the early 1980s. The first oncogenes were being cloned and they realized if we wanted to understand their roles in cancer, we needed to understand their normal function 1/n 🧪
April 16, 2025 at 3:45 PM
Our field has lost an amazing scientist, mentor, and old friend. Benny, along with Mike Hoffman, had a brilliant idea in the early 1980s. The first oncogenes were being cloned and they realized if we wanted to understand their roles in cancer, we needed to understand their normal function 1/n 🧪
Reposted by Sriram S
I am proud to share that our work of 4+ years has finally been published. We wondered if there are distinct behaviors that mark sleep in 🪰, where sleep has been defined as prolonged immobility.
🔗 www.science.org/doi/10.1126/...
🔗 www.science.org/doi/10.1126/...
FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep in Drosophila
A machine learning platform identifies and characterizes the dynamics of microbehaviors during fly sleep.
www.science.org
April 8, 2025 at 5:12 PM
I am proud to share that our work of 4+ years has finally been published. We wondered if there are distinct behaviors that mark sleep in 🪰, where sleep has been defined as prolonged immobility.
🔗 www.science.org/doi/10.1126/...
🔗 www.science.org/doi/10.1126/...
Bittersweet #FluorescenceFriday saying goodbye to the Kolodkin lab with one last image, this time from the retinal side side of the lab. Here's a collection of retinorecipient targets in the mouse brain. How many of them can you name?
March 14, 2025 at 5:41 PM
Bittersweet #FluorescenceFriday saying goodbye to the Kolodkin lab with one last image, this time from the retinal side side of the lab. Here's a collection of retinorecipient targets in the mouse brain. How many of them can you name?
Reposted by Sriram S
We're organizing the 4th iDISCO / TRISCO workshop at @rockefelleruniv.bsky.social in NYC!
April 14-19 - FREE - registration to kavlifellows@mail.rockefeller.edu. Deadline: March 1st.
We'll talk about brain mapping of cells, genes, axons, vasculature, light sheet microscopy, tissue clearing.
April 14-19 - FREE - registration to kavlifellows@mail.rockefeller.edu. Deadline: March 1st.
We'll talk about brain mapping of cells, genes, axons, vasculature, light sheet microscopy, tissue clearing.
February 7, 2025 at 1:47 PM
We're organizing the 4th iDISCO / TRISCO workshop at @rockefelleruniv.bsky.social in NYC!
April 14-19 - FREE - registration to kavlifellows@mail.rockefeller.edu. Deadline: March 1st.
We'll talk about brain mapping of cells, genes, axons, vasculature, light sheet microscopy, tissue clearing.
April 14-19 - FREE - registration to kavlifellows@mail.rockefeller.edu. Deadline: March 1st.
We'll talk about brain mapping of cells, genes, axons, vasculature, light sheet microscopy, tissue clearing.
'From thought to action'... axons from the sensory cortex (green) arrive in the motor region to synapse with target neurons (yellow). Can't wait to get back to more imaging after weeks of thesis writing #FluorescenceFriday
February 1, 2025 at 12:07 AM
'From thought to action'... axons from the sensory cortex (green) arrive in the motor region to synapse with target neurons (yellow). Can't wait to get back to more imaging after weeks of thesis writing #FluorescenceFriday
Happy to share our pre-print, “ Mef2c controls postnatal callosal axon targeting by regulating sensitivity to Ephrin Repulsion”. We found that the topography of interhemispheric connectivity in the cerebral cortex is disrupted upon Mef2c deletion.(1/n)
January 24, 2025 at 11:20 PM
Happy to share our pre-print, “ Mef2c controls postnatal callosal axon targeting by regulating sensitivity to Ephrin Repulsion”. We found that the topography of interhemispheric connectivity in the cerebral cortex is disrupted upon Mef2c deletion.(1/n)