David Schoppik
@schoppik.com
Studying how balance develops, functions, and fails at NYU Langone. http://www.schoppiklab.com .
"And worse I may be yet: the worst is not so long as we can say, 'This is the worst.’” -- King Lear (Act IV Scene I)
"And worse I may be yet: the worst is not so long as we can say, 'This is the worst.’” -- King Lear (Act IV Scene I)
Pinned
David Schoppik
@schoppik.com
· Nov 19
Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish
Most fish are inherently unstable and must swim to stabilize posture. How diurnal fish reduce activity at night while maintaining postural control remains unclear. We defined distinct locomotor strate...
doi.org
Like most animals, fish move less at night. Underwater, stable posture requires movement. Find out how fish don't fall down at night in: Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish from @yunluzhu.bsky.social
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Christmas morning puzzle! Keep small children busy for maybe a minute with just a rubber band and a mug.
December 25, 2025 at 2:14 PM
Christmas morning puzzle! Keep small children busy for maybe a minute with just a rubber band and a mug.
Reposted by David Schoppik
#JoyScrolling: ASL Theathre (an initiative in Florida)
Students performing "Wait for it" (@suzbrockmann.bsky.social watch it, it's lovely)
Students performing "Wait for it" (@suzbrockmann.bsky.social watch it, it's lovely)
Wait for It in ASL
YouTube video by ASL Theatre
www.youtube.com
December 22, 2025 at 3:44 AM
#JoyScrolling: ASL Theathre (an initiative in Florida)
Students performing "Wait for it" (@suzbrockmann.bsky.social watch it, it's lovely)
Students performing "Wait for it" (@suzbrockmann.bsky.social watch it, it's lovely)
Reposted by David Schoppik
Well it’s been quite a year 🫠 but I’m happy and tremendously grateful to close it out on a personal science high-note - Ill be going to my first ever Cosyne, and I officially received the NOA for my K99/R00 from NIDCD 🙏 thank you Santa ie hardworking NIH staff for the best possible holiday gift 🥹
December 22, 2025 at 7:17 PM
Well it’s been quite a year 🫠 but I’m happy and tremendously grateful to close it out on a personal science high-note - Ill be going to my first ever Cosyne, and I officially received the NOA for my K99/R00 from NIDCD 🙏 thank you Santa ie hardworking NIH staff for the best possible holiday gift 🥹
Reposted by David Schoppik
It’s the “season of love and giving”…but this year, doesn’t it seem more like a “season of fear and taking”? Like many of you, I’ve been saddened by the human impact of draconian government budget cuts and how angry many housed Americans are at unhoused Americans.
🧵 1 of 9
🧵 1 of 9
December 21, 2025 at 2:51 AM
It’s the “season of love and giving”…but this year, doesn’t it seem more like a “season of fear and taking”? Like many of you, I’ve been saddened by the human impact of draconian government budget cuts and how angry many housed Americans are at unhoused Americans.
🧵 1 of 9
🧵 1 of 9
Seems like a great way to illustrate the notion that if you just do 20 experiments one result should be significant?
Wow this is a seriously serious supplementary figure from @cellpress.bsky.social today. Panels A through UU.
I get that Cell likes to minimize the number of supplementary figures. But is this really what is happening here?
www.cell.com/cell/fulltex...
I get that Cell likes to minimize the number of supplementary figures. But is this really what is happening here?
www.cell.com/cell/fulltex...
December 17, 2025 at 3:15 PM
Seems like a great way to illustrate the notion that if you just do 20 experiments one result should be significant?
Reposted by David Schoppik
This is incredibly important. If you read one thing this week: marcusolang.substack.com/p/im-kenyan-...
I'm Kenyan. I Don't Write Like ChatGPT. ChatGPT Writes Like Me.
I'm calm. I'm calm. I promise.
marcusolang.substack.com
December 16, 2025 at 9:47 AM
This is incredibly important. If you read one thing this week: marcusolang.substack.com/p/im-kenyan-...
Reposted by David Schoppik
*First preprint from our lab* !!!!!
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️
December 15, 2025 at 6:26 PM
*First preprint from our lab* !!!!!
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️
How does the brain learn to anchor its internal sense of direction to the outside world? 🧭
led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman:
“Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6...
Thread ⬇️
Reposted by David Schoppik
December 14, 2025 at 10:41 PM
December 14, 2025 at 9:45 PM
Snow's over and the sun is out but we got a proper dusting this morning here in #NYC.
#photography #snow #blackandwhite
#photography #snow #blackandwhite
December 14, 2025 at 9:14 PM
Snow's over and the sun is out but we got a proper dusting this morning here in #NYC.
#photography #snow #blackandwhite
#photography #snow #blackandwhite
Reposted by David Schoppik
thrilled to inform you that in the proud populist tradition of opera, the family production of magic flute at the met includes papageno counting 1, 2, … 6-7… 3
uproarious applause and laughter
uproarious applause and laughter
December 14, 2025 at 8:41 PM
thrilled to inform you that in the proud populist tradition of opera, the family production of magic flute at the met includes papageno counting 1, 2, … 6-7… 3
uproarious applause and laughter
uproarious applause and laughter
Reposted by David Schoppik
Settings->Apps->Safari
Change Tabs from “Compact” to “Bottom”
You are welcome.
Change Tabs from “Compact” to “Bottom”
You are welcome.
December 14, 2025 at 2:33 AM
Settings->Apps->Safari
Change Tabs from “Compact” to “Bottom”
You are welcome.
Change Tabs from “Compact” to “Bottom”
You are welcome.
Reposted by David Schoppik
🎉 Excited to share our latest preprint📰 !
www.biorxiv.org/cgi/content/...
Many thanks to everyone involved in this project ! Using a zebrafish model 🐟 and iPSC-derived motor neurons 🔬 we show that restoring the calpastatin/calpain pathway preserves motoneuron survival and function in C9orf72 ALS!
www.biorxiv.org/cgi/content/...
Many thanks to everyone involved in this project ! Using a zebrafish model 🐟 and iPSC-derived motor neurons 🔬 we show that restoring the calpastatin/calpain pathway preserves motoneuron survival and function in C9orf72 ALS!
Therapeutic modulation of the calpastatin/calpain pathway restores calpain-mediated synaptic proteolysis and preserves motor neurons survival and function in C9orf72 ALS
A hexanucleotide repeat expansion (GGGGCC) in the C9orf72 gene is the most prevalent genetic cause of ALS, with early neuromuscular junction (NMJ) dysfunction being a key pathological feature. Current...
www.biorxiv.org
December 12, 2025 at 3:21 PM
🎉 Excited to share our latest preprint📰 !
www.biorxiv.org/cgi/content/...
Many thanks to everyone involved in this project ! Using a zebrafish model 🐟 and iPSC-derived motor neurons 🔬 we show that restoring the calpastatin/calpain pathway preserves motoneuron survival and function in C9orf72 ALS!
www.biorxiv.org/cgi/content/...
Many thanks to everyone involved in this project ! Using a zebrafish model 🐟 and iPSC-derived motor neurons 🔬 we show that restoring the calpastatin/calpain pathway preserves motoneuron survival and function in C9orf72 ALS!
Reposted by David Schoppik
The only professor party I have attended ended up with a car in a ditch, a divorce, an internal investigation, and said professor leaving the country and marrying a student. 10/10 would recommend
December 10, 2025 at 4:51 PM
The only professor party I have attended ended up with a car in a ditch, a divorce, an internal investigation, and said professor leaving the country and marrying a student. 10/10 would recommend
Sometimes the blue is just perfect when leaving work. #photography #nyc
December 9, 2025 at 10:47 PM
Sometimes the blue is just perfect when leaving work. #photography #nyc
Reposted by David Schoppik
How do neural circuits generate the walking rhythm?
Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg.
w @bingbrunton.bsky.social
www.biorxiv.org/content/10.1...
Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg.
w @bingbrunton.bsky.social
www.biorxiv.org/content/10.1...
December 9, 2025 at 5:50 PM
How do neural circuits generate the walking rhythm?
Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg.
w @bingbrunton.bsky.social
www.biorxiv.org/content/10.1...
Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each 🪰 leg.
w @bingbrunton.bsky.social
www.biorxiv.org/content/10.1...
Reposted by David Schoppik
Last night Adam Kampff, the glue, the light, the catalyst, the builder, the smile, left us. He and his work transformed the lives of many labs, scientists, students. He inspired and was generous to his last transformation, working tirelessly to set up a foundation to continue the work.Thank you!
December 9, 2025 at 3:37 PM
Last night Adam Kampff, the glue, the light, the catalyst, the builder, the smile, left us. He and his work transformed the lives of many labs, scientists, students. He inspired and was generous to his last transformation, working tirelessly to set up a foundation to continue the work.Thank you!
Reposted by David Schoppik
💼 💔 Academia’s toxic love language is playing “hard to get”
🧪 💓 Science is the beautiful pursuit of building knowledge
I wrote an essay for Nature Human Behaviour on treating academia as “just a job” www.nature.com/articles/s41...
What ideas would you add? 💡
#HigherEd #PhDLife #DiversityInSTEM
🧪 💓 Science is the beautiful pursuit of building knowledge
I wrote an essay for Nature Human Behaviour on treating academia as “just a job” www.nature.com/articles/s41...
What ideas would you add? 💡
#HigherEd #PhDLife #DiversityInSTEM
www.nature.com
December 5, 2025 at 10:24 AM
💼 💔 Academia’s toxic love language is playing “hard to get”
🧪 💓 Science is the beautiful pursuit of building knowledge
I wrote an essay for Nature Human Behaviour on treating academia as “just a job” www.nature.com/articles/s41...
What ideas would you add? 💡
#HigherEd #PhDLife #DiversityInSTEM
🧪 💓 Science is the beautiful pursuit of building knowledge
I wrote an essay for Nature Human Behaviour on treating academia as “just a job” www.nature.com/articles/s41...
What ideas would you add? 💡
#HigherEd #PhDLife #DiversityInSTEM
Reposted by David Schoppik
Pleased to say that Jonas Hartmann (bs-less) and I have finally released DySTrack (“diss track”) - Dynamic Sample Tracking.
It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems.
Preprint: www.biorxiv.org/content/10.6...
[1/6]
It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems.
Preprint: www.biorxiv.org/content/10.6...
[1/6]
December 8, 2025 at 9:48 AM
Pleased to say that Jonas Hartmann (bs-less) and I have finally released DySTrack (“diss track”) - Dynamic Sample Tracking.
It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems.
Preprint: www.biorxiv.org/content/10.6...
[1/6]
It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems.
Preprint: www.biorxiv.org/content/10.6...
[1/6]
Reposted by David Schoppik
I think everyone can relate to the importance of science for healthcare, and I’ve been sharing these slides for people to use and adapt with their own stories! youtu.be/BY_SFgi-Cig
Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25
YouTube video by Steve Lawson
youtu.be
December 7, 2025 at 2:38 PM
I think everyone can relate to the importance of science for healthcare, and I’ve been sharing these slides for people to use and adapt with their own stories! youtu.be/BY_SFgi-Cig
Reposted by David Schoppik
I think this early shot of O'Connell Bridge in Dublin is my favourite Martin Parr photo. All the artistry and all the comic love of the absurdity of everyday life is here.
December 7, 2025 at 8:58 PM
I think this early shot of O'Connell Bridge in Dublin is my favourite Martin Parr photo. All the artistry and all the comic love of the absurdity of everyday life is here.
Reposted by David Schoppik
Read yet another review today that ascribes GECIs' larger SNR vs GEVIs to their being evolved earlier (suggesting the GECIs are better optimized). This assumption is understandable but incorrect. GEVIs' photonic response per molecule per AP have been as good as GECIs since ASAP3.
December 6, 2025 at 12:36 AM
Read yet another review today that ascribes GECIs' larger SNR vs GEVIs to their being evolved earlier (suggesting the GECIs are better optimized). This assumption is understandable but incorrect. GEVIs' photonic response per molecule per AP have been as good as GECIs since ASAP3.
Reposted by David Schoppik
excited to embark on a new era @nsb-mbl.bsky.social w directors Lauren O'Connell (Stanford) + Bruce Carlson (WashU), new 6-week format for graduate students, postdocs & investigators. learn state-of-the-art methods & approach towards neural systems of behavior. deadline Feb 2. tinyurl.com/57476k4v
December 2, 2025 at 10:29 AM
excited to embark on a new era @nsb-mbl.bsky.social w directors Lauren O'Connell (Stanford) + Bruce Carlson (WashU), new 6-week format for graduate students, postdocs & investigators. learn state-of-the-art methods & approach towards neural systems of behavior. deadline Feb 2. tinyurl.com/57476k4v
Reposted by David Schoppik
when someone tells me not to use em dashes because AI uses em dashes
November 30, 2025 at 7:48 PM
when someone tells me not to use em dashes because AI uses em dashes
Reposted by David Schoppik
For the oculomotor nerds out there… we’re excited to share our paired papers on precerebellar circuitry!
These two studies look at how internuclear pathways talk to the cerebellum and what that means for eye movement control. 👀🧠 #neuroskyence #science
These two studies look at how internuclear pathways talk to the cerebellum and what that means for eye movement control. 👀🧠 #neuroskyence #science
November 30, 2025 at 3:00 PM
For the oculomotor nerds out there… we’re excited to share our paired papers on precerebellar circuitry!
These two studies look at how internuclear pathways talk to the cerebellum and what that means for eye movement control. 👀🧠 #neuroskyence #science
These two studies look at how internuclear pathways talk to the cerebellum and what that means for eye movement control. 👀🧠 #neuroskyence #science