Miguel Correa
@m-correa-m.bsky.social
Computational biologist @ Roche | Views my own
Reposted by Miguel Correa
OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇
October 28, 2025 at 6:30 PM
OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇
Reposted by Miguel Correa
Open position at the Swiss Institute of Bioinformatics:
We are looking for a Director of the Center of Pathogen Bioinformatics
apply.refline.ch/499599/0346/...
I am in the Center's steering board together with fantastic colleagues (Emma Hodcroft @firefoxx66.bsky.social, Richard Neher @neher.io, and
We are looking for a Director of the Center of Pathogen Bioinformatics
apply.refline.ch/499599/0346/...
I am in the Center's steering board together with fantastic colleagues (Emma Hodcroft @firefoxx66.bsky.social, Richard Neher @neher.io, and
Director, Center for Pathogen Bioinformatics
The Centre for Pathogen Bioinformatics (CPB) is a unit of SIB which offers expertise and services in pathogen bioinformatics, computational molecular epidemiology and related multi-site project manage...
apply.refline.ch
October 25, 2025 at 1:03 PM
Open position at the Swiss Institute of Bioinformatics:
We are looking for a Director of the Center of Pathogen Bioinformatics
apply.refline.ch/499599/0346/...
I am in the Center's steering board together with fantastic colleagues (Emma Hodcroft @firefoxx66.bsky.social, Richard Neher @neher.io, and
We are looking for a Director of the Center of Pathogen Bioinformatics
apply.refline.ch/499599/0346/...
I am in the Center's steering board together with fantastic colleagues (Emma Hodcroft @firefoxx66.bsky.social, Richard Neher @neher.io, and
Hot off the press! Our paper, “Global comparative structural analysis of responses to protein phosphorylation”, is now out in Nature Communications!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Global comparative structural analysis of responses to protein phosphorylation - Nature Communications
Phosphorylation is central to protein regulation, yet its structural mechanisms remain poorly understood. Here, the authors conduct a global, systematic analysis of phosphorylated versus non-phosphory...
www.nature.com
October 27, 2025 at 10:29 AM
Hot off the press! Our paper, “Global comparative structural analysis of responses to protein phosphorylation”, is now out in Nature Communications!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Miguel Correa
Excited to share my PhD research, now on bioRxiv! We report a proteo-transcriptomic reprogramming and resource reallocation in the aging brain.
Co–first author with Verena Kluever. Grateful to @forna.bsky.social for mentorship, and to @tatjanat.bsky.social, Carlos López Otín & all collaborators🧠
Co–first author with Verena Kluever. Grateful to @forna.bsky.social for mentorship, and to @tatjanat.bsky.social, Carlos López Otín & all collaborators🧠
August 20, 2025 at 8:45 AM
Excited to share my PhD research, now on bioRxiv! We report a proteo-transcriptomic reprogramming and resource reallocation in the aging brain.
Co–first author with Verena Kluever. Grateful to @forna.bsky.social for mentorship, and to @tatjanat.bsky.social, Carlos López Otín & all collaborators🧠
Co–first author with Verena Kluever. Grateful to @forna.bsky.social for mentorship, and to @tatjanat.bsky.social, Carlos López Otín & all collaborators🧠
Today in predatory journal spam: plagiarizing 15% of your manuscript is OK
May 2, 2025 at 7:17 AM
Today in predatory journal spam: plagiarizing 15% of your manuscript is OK
Good to know our paper on the protein-protein interaction network between phytoplasma effectors and host proteins is getting attention: it's a #TopViewedArticle in TPJ @theplantjournal.bsky.social
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Protein interaction mapping reveals widespread targeting of development‐related host transcription factors by phytoplasma effectors
This work shows that the effectors of phytoplasma, a globally economically important bacterial plant pathogen, have pervasive interactions with development-related host transcription factors, providi...
onlinelibrary.wiley.com
April 16, 2025 at 11:15 AM
Good to know our paper on the protein-protein interaction network between phytoplasma effectors and host proteins is getting attention: it's a #TopViewedArticle in TPJ @theplantjournal.bsky.social
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Reposted by Miguel Correa
If anyone has any tips for fellowships or grants or giftfunds our group can apply for (in the US), please send our way.
So far, we've not had much luck in raising funds... 💰 In this relatively popular area, so I feel like I'm doing something wrong 😅
So far, we've not had much luck in raising funds... 💰 In this relatively popular area, so I feel like I'm doing something wrong 😅
April 9, 2025 at 12:30 PM
If anyone has any tips for fellowships or grants or giftfunds our group can apply for (in the US), please send our way.
So far, we've not had much luck in raising funds... 💰 In this relatively popular area, so I feel like I'm doing something wrong 😅
So far, we've not had much luck in raising funds... 💰 In this relatively popular area, so I feel like I'm doing something wrong 😅
Reposted by Miguel Correa
A protein language model trained to predict subcellular localization for human proteins can generate de novo sequences with the desired localization and identify pathological mutations.
@itamarchinn.bsky.social @pgmikhael.bsky.social
www.science.org/doi/10.1126/...
@itamarchinn.bsky.social @pgmikhael.bsky.social
www.science.org/doi/10.1126/...
February 10, 2025 at 10:28 PM
A protein language model trained to predict subcellular localization for human proteins can generate de novo sequences with the desired localization and identify pathological mutations.
@itamarchinn.bsky.social @pgmikhael.bsky.social
www.science.org/doi/10.1126/...
@itamarchinn.bsky.social @pgmikhael.bsky.social
www.science.org/doi/10.1126/...
Reposted by Miguel Correa
At ALLOX @alloxbio.bsky.social in Barcelona we now have 3 computational positions available!
📌Structural Bioinformatics Scientist 👉 tinyurl.com/3rs46j4t
📌Platform Bioinformatician 👉 tinyurl.com/nyvazbke
📌Computational Chemist 👉 tinyurl.com/5n6vpem3
Apply or repost to help us spread the word 🙏
📌Structural Bioinformatics Scientist 👉 tinyurl.com/3rs46j4t
📌Platform Bioinformatician 👉 tinyurl.com/nyvazbke
📌Computational Chemist 👉 tinyurl.com/5n6vpem3
Apply or repost to help us spread the word 🙏
January 30, 2025 at 2:43 PM
At ALLOX @alloxbio.bsky.social in Barcelona we now have 3 computational positions available!
📌Structural Bioinformatics Scientist 👉 tinyurl.com/3rs46j4t
📌Platform Bioinformatician 👉 tinyurl.com/nyvazbke
📌Computational Chemist 👉 tinyurl.com/5n6vpem3
Apply or repost to help us spread the word 🙏
📌Structural Bioinformatics Scientist 👉 tinyurl.com/3rs46j4t
📌Platform Bioinformatician 👉 tinyurl.com/nyvazbke
📌Computational Chemist 👉 tinyurl.com/5n6vpem3
Apply or repost to help us spread the word 🙏
Reposted by Miguel Correa
Looking forward to the monthly on-line seminars organized by the Protein Modules Community @pmc-modularity.bsky.social and talks on SLiMs, systems biology, signaling, computational biology and much more. First talks by Dr Gogl @teamgogl.bsky.social and Dr Dionne @gingraslab.bsky.social.
Join us for our new online seminar series, featuring two talks on protein modules every month! The first session kicks off at 6pm CET Feb 10 with Dr. Gergő Gógl and Dr. Ugo Dionne.
Register to attend: tinyurl.com/register-pmc-seminar
Register to attend: tinyurl.com/register-pmc-seminar
January 15, 2025 at 5:59 PM
Looking forward to the monthly on-line seminars organized by the Protein Modules Community @pmc-modularity.bsky.social and talks on SLiMs, systems biology, signaling, computational biology and much more. First talks by Dr Gogl @teamgogl.bsky.social and Dr Dionne @gingraslab.bsky.social.
Reposted by Miguel Correa
Long Covid: The never-ending pandemic
in the magazine of @snsf-ch.bsky.social
www.horizons-mag.ch/2024/12/02/t...
in the magazine of @snsf-ch.bsky.social
www.horizons-mag.ch/2024/12/02/t...
The never-ending pandemic
Horizons - Issue 143
www.horizons-mag.ch
January 16, 2025 at 1:48 PM
Long Covid: The never-ending pandemic
in the magazine of @snsf-ch.bsky.social
www.horizons-mag.ch/2024/12/02/t...
in the magazine of @snsf-ch.bsky.social
www.horizons-mag.ch/2024/12/02/t...
Reposted by Miguel Correa
Deep learning methods aid in de novo design of proteins to neutralize lethal snake venom toxins in vitro and protect mice from a lethal neurotoxin challenge. www.nature.com/articles/s41... #NBThighlight
De novo designed proteins neutralize lethal snake venom toxins - Nature
Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible an...
www.nature.com
January 16, 2025 at 9:46 AM
Deep learning methods aid in de novo design of proteins to neutralize lethal snake venom toxins in vitro and protect mice from a lethal neurotoxin challenge. www.nature.com/articles/s41... #NBThighlight
Reposted by Miguel Correa
The Nobel Prize-winning chemist, Martin Karplus, has passed away. A pioneer in the theory and computation of the dynamics of macromolecules. 🧪 #ChemSky
January 2, 2025 at 6:21 PM
The Nobel Prize-winning chemist, Martin Karplus, has passed away. A pioneer in the theory and computation of the dynamics of macromolecules. 🧪 #ChemSky
Reposted by Miguel Correa
Are PDB models biased in terms of how well they explain the underlying experimental data and are modeled?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Modeling Bias Toward Binding Sites in PDB Structural Models
The protein data bank (PDB) is one of the richest databases in biology. The structural models deposited have provided insights into protein folds, relationships to evolution, energy functions of struc...
www.biorxiv.org
December 16, 2024 at 3:14 PM
Are PDB models biased in terms of how well they explain the underlying experimental data and are modeled?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Miguel Correa
#compchem Good read: Allosteric Communication Mediated by Protein Contact Clusters: A Dynamical Model #compchemsky pubs.acs.org/doi/10.1021/...
Allosteric Communication Mediated by Protein Contact Clusters: A Dynamical Model
Describing the puzzling phenomenon of long-range communication between distant protein sites, allostery is of paramount importance in biomolecular regulation and signal transduction. It is commonly as...
pubs.acs.org
November 23, 2024 at 7:09 AM
#compchem Good read: Allosteric Communication Mediated by Protein Contact Clusters: A Dynamical Model #compchemsky pubs.acs.org/doi/10.1021/...
So many easy choices, but I'll go for this
December 12, 2024 at 7:41 PM
So many easy choices, but I'll go for this
Reposted by Miguel Correa
How much of computational biology is doing detective work trying to figure out why some program won't run?
November 23, 2024 at 2:52 AM
How much of computational biology is doing detective work trying to figure out why some program won't run?
For those around Zurich, I'll be at the Zurich Seminar in #Bioinformatics this Thursday to talk about my work on the impact of phosphorylation on protein structure:
compbiozurich.org/news/2024/20...
compbiozurich.org/news/2024/20...
Global comparative structural analysis of responses to protein phosphorylation<br/>Miguel Correa, FGCZ - CompbioZurich
Zurich Seminars in Bioinformatics
compbiozurich.org
December 3, 2024 at 10:32 AM
For those around Zurich, I'll be at the Zurich Seminar in #Bioinformatics this Thursday to talk about my work on the impact of phosphorylation on protein structure:
compbiozurich.org/news/2024/20...
compbiozurich.org/news/2024/20...
Reposted by Miguel Correa
Here's a first:
I'm hiring a PhD student.
If you have (or know someone who has) a strong background and interest in computational (bio)chemistry or computer science (especially 3D computer vision), let's work together 😊
www.wur.nl/nl/vacature/...
I'm hiring a PhD student.
If you have (or know someone who has) a strong background and interest in computational (bio)chemistry or computer science (especially 3D computer vision), let's work together 😊
www.wur.nl/nl/vacature/...
PhD student - Machine learning in bio- and cheminformatics
www.wur.nl
December 2, 2024 at 5:51 PM
Here's a first:
I'm hiring a PhD student.
If you have (or know someone who has) a strong background and interest in computational (bio)chemistry or computer science (especially 3D computer vision), let's work together 😊
www.wur.nl/nl/vacature/...
I'm hiring a PhD student.
If you have (or know someone who has) a strong background and interest in computational (bio)chemistry or computer science (especially 3D computer vision), let's work together 😊
www.wur.nl/nl/vacature/...
Dear hivemind, in the absence of a fresh CAFA publication: what predictor(s) do people consider to be the state-of-the-art in protein function prediction nowadays? #bioinformatics #bioml #protein
December 2, 2024 at 5:01 PM
Dear hivemind, in the absence of a fresh CAFA publication: what predictor(s) do people consider to be the state-of-the-art in protein function prediction nowadays? #bioinformatics #bioml #protein
Reposted by Miguel Correa
#CASP16 program is posted (so you can guess the "winners". Congratulations to Yang and Kihara who seems to have done well in RNA+Proteins. Also congratulations to AF3-server (i.e. me) who was selected to talk (i.e. most people did worse than the server). predictioncenter.org/casp16/doc/C... .
predictioncenter.org
November 28, 2024 at 7:39 AM
#CASP16 program is posted (so you can guess the "winners". Congratulations to Yang and Kihara who seems to have done well in RNA+Proteins. Also congratulations to AF3-server (i.e. me) who was selected to talk (i.e. most people did worse than the server). predictioncenter.org/casp16/doc/C... .