Lucía Luengo-Gutiérrez
@lucialugut.bsky.social
🧬 Biotech @usal | 🧠 Neuroscience @Imperial | Currently on my PhD journey @ Mitochondrial Biology Unit, Cambridge ⚡️🔋
Reposted by Lucía Luengo-Gutiérrez
Great two days in York with the MRC National Mouse Genetics Network. Always a pleasure to be invited to share MitoCluster's work, thank you!
@mrcmousenetwork.bsky.social @jellevda.bsky.social @lauragreaves.bsky.social @robpitceathly.bsky.social
@mrcmousenetwork.bsky.social @jellevda.bsky.social @lauragreaves.bsky.social @robpitceathly.bsky.social
November 14, 2025 at 5:22 PM
Great two days in York with the MRC National Mouse Genetics Network. Always a pleasure to be invited to share MitoCluster's work, thank you!
@mrcmousenetwork.bsky.social @jellevda.bsky.social @lauragreaves.bsky.social @robpitceathly.bsky.social
@mrcmousenetwork.bsky.social @jellevda.bsky.social @lauragreaves.bsky.social @robpitceathly.bsky.social
Reposted by Lucía Luengo-Gutiérrez
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 10, 2025 at 8:45 AM
How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.
www.science.org/doi/10.1126/...
Reposted by Lucía Luengo-Gutiérrez
Congratulations to @lucialugut.bsky.social who passed her PhD with flying colours last week; and with no thesis corrections ☺️🎓👏
October 8, 2025 at 4:10 PM
Congratulations to @lucialugut.bsky.social who passed her PhD with flying colours last week; and with no thesis corrections ☺️🎓👏
Reposted by Lucía Luengo-Gutiérrez
This is amazing news!! @camneurodept.bsky.social @mrc-mbu.bsky.social @jellevda.bsky.social @ritahorvath.bsky.social @mito-news.bsky.social
📢 BREAKING NEWS!
The first ever treatment for a mitochondrial disease has been approved for use by NHS England! Idebenone is now available for LHON patients
A huge milestone for the mito community! 💥
www.thelilyfoundation.org.uk/news/first-e...
@mitocamb.bsky.social
The first ever treatment for a mitochondrial disease has been approved for use by NHS England! Idebenone is now available for LHON patients
A huge milestone for the mito community! 💥
www.thelilyfoundation.org.uk/news/first-e...
@mitocamb.bsky.social
August 7, 2025 at 11:34 AM
Thanks Michal & team!
On Monday, I was beyond honoured to receive a CSAR award for my PhD project - I’m truly grateful to the committee for the recognition
On Monday, I was beyond honoured to receive a CSAR award for my PhD project - I’m truly grateful to the committee for the recognition
Massive congratulations to @lucialugut.bsky.social on receiving the prestigious 2025 CSAR Award! 🎉 Lucia's groundbreaking work in modeling and correcting mtDNA mutations paves the way for innovative future therapies for mitochondrial diseases. @mrc-mbu.bsky.social www.csar.org.uk/student-awar...
July 2, 2025 at 6:33 PM
Thanks Michal & team!
On Monday, I was beyond honoured to receive a CSAR award for my PhD project - I’m truly grateful to the committee for the recognition
On Monday, I was beyond honoured to receive a CSAR award for my PhD project - I’m truly grateful to the committee for the recognition
Reposted by Lucía Luengo-Gutiérrez
Massive congratulations to @lucialugut.bsky.social on receiving the prestigious 2025 CSAR Award! 🎉 Lucia's groundbreaking work in modeling and correcting mtDNA mutations paves the way for innovative future therapies for mitochondrial diseases. @mrc-mbu.bsky.social www.csar.org.uk/student-awar...
July 2, 2025 at 1:44 PM
Massive congratulations to @lucialugut.bsky.social on receiving the prestigious 2025 CSAR Award! 🎉 Lucia's groundbreaking work in modeling and correcting mtDNA mutations paves the way for innovative future therapies for mitochondrial diseases. @mrc-mbu.bsky.social www.csar.org.uk/student-awar...
Reposted by Lucía Luengo-Gutiérrez
Yesterday we were proud to join the launch of the LifeArc Centre for Rare Mitochondrial Diseases - a major step forward in mito research
We led a workshop on making complex science clear – because involving patients is key to success
#mitochondrialdisease #mitoresearch #patientvoice #raredisease
We led a workshop on making complex science clear – because involving patients is key to success
#mitochondrialdisease #mitoresearch #patientvoice #raredisease
April 15, 2025 at 3:31 PM
Yesterday we were proud to join the launch of the LifeArc Centre for Rare Mitochondrial Diseases - a major step forward in mito research
We led a workshop on making complex science clear – because involving patients is key to success
#mitochondrialdisease #mitoresearch #patientvoice #raredisease
We led a workshop on making complex science clear – because involving patients is key to success
#mitochondrialdisease #mitoresearch #patientvoice #raredisease
Reposted by Lucía Luengo-Gutiérrez
Engineering mtDNA deletions by reconstituting end joining in human mitochondria: Cell www.cell.com/cell/fulltex...
Engineering mtDNA deletions by reconstituting end joining in human mitochondria
Combined expression of a mitochondrially targeted endonuclease and end-joining machinery
enables formation of mtDNA deletions with a broad range of heteroplasmy.
www.cell.com
March 10, 2025 at 3:05 PM
Engineering mtDNA deletions by reconstituting end joining in human mitochondria: Cell www.cell.com/cell/fulltex...
Reposted by Lucía Luengo-Gutiérrez
Hypothalamic deep brain stimulation augments walking after spinal cord injury. Yes, this is wild. I wonder if there is anything the hypothalamus can't do. #neuroscience 🩺
Cho et al., Nat Med
www.nature.com/articles/s41...
Cho et al., Nat Med
www.nature.com/articles/s41...
Hypothalamic deep brain stimulation augments walking after spinal cord injury - Nature Medicine
Whole-brain anatomical and activity surveys identify the lateral hypothalamus as a key driver of recovery from spinal cord injury, leading to a deep brain stimulation therapy that augments the recover...
www.nature.com
December 2, 2024 at 8:44 PM
Hypothalamic deep brain stimulation augments walking after spinal cord injury. Yes, this is wild. I wonder if there is anything the hypothalamus can't do. #neuroscience 🩺
Cho et al., Nat Med
www.nature.com/articles/s41...
Cho et al., Nat Med
www.nature.com/articles/s41...
Reposted by Lucía Luengo-Gutiérrez
Check this out!! Awesome discovery by the labs of Carmelo Bellardita in Copenhagen Univ and Simone di Giovanni in London on the physiological role of macrophages in muscle spindles on proprioceptor afferents - implication in sensorimotor control of movement
www.nature.com/articles/s41....
www.nature.com/articles/s41....
Macrophages excite muscle spindles with glutamate to bolster locomotion - Nature
A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component, the muscle s...
www.nature.com
December 4, 2024 at 6:36 PM
Check this out!! Awesome discovery by the labs of Carmelo Bellardita in Copenhagen Univ and Simone di Giovanni in London on the physiological role of macrophages in muscle spindles on proprioceptor afferents - implication in sensorimotor control of movement
www.nature.com/articles/s41....
www.nature.com/articles/s41....
Reposted by Lucía Luengo-Gutiérrez
Proud to announce the publication of our latest paper!
Huge thanks to all our collaborators for making this work possible. #Science #Mitochondria #Research #MitochondrialDisease #RareDiseases
www.embopress.org/doi/full/10....
Huge thanks to all our collaborators for making this work possible. #Science #Mitochondria #Research #MitochondrialDisease #RareDiseases
www.embopress.org/doi/full/10....
November 20, 2024 at 3:29 PM
Proud to announce the publication of our latest paper!
Huge thanks to all our collaborators for making this work possible. #Science #Mitochondria #Research #MitochondrialDisease #RareDiseases
www.embopress.org/doi/full/10....
Huge thanks to all our collaborators for making this work possible. #Science #Mitochondria #Research #MitochondrialDisease #RareDiseases
www.embopress.org/doi/full/10....