Lindsey Van Haute
@lindseyvanhaute.bsky.social
Next generation sequencing geek and mitochondria lover
https://www.nextgenseqanalysis.com
Check out my YouTube channel: https://www.youtube.com/@SimpleScienceLVH
#RNA,#DNA,#mitochondria,#NGS
#RNAseq,#Genomics,#bioinformatics,#equality
https://www.nextgenseqanalysis.com
Check out my YouTube channel: https://www.youtube.com/@SimpleScienceLVH
#RNA,#DNA,#mitochondria,#NGS
#RNAseq,#Genomics,#bioinformatics,#equality
Pinned
I thought connecting current and past members of MBU Mitochondrial Biology Unit Cambridge would be useful.
Please note that this is a work in progress and that more people will be added.
🔄 Anyone missing? Additions welcome!
go.bsky.app/9ATZngh
Please note that this is a work in progress and that more people will be added.
🔄 Anyone missing? Additions welcome!
go.bsky.app/9ATZngh
Reposted by Lindsey Van Haute
What factors contribute the most to PhD satisfaction? Stipends that are more than just a living wage? Manageable hours? A supportive team? These all matter, and are often in short supply. Another factor often overlooked is supportive supervision.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
What makes PhD students happy? Good supervision
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.
www.nature.com
November 4, 2025 at 1:14 PM
What factors contribute the most to PhD satisfaction? Stipends that are more than just a living wage? Manageable hours? A supportive team? These all matter, and are often in short supply. Another factor often overlooked is supportive supervision.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Higher education is being reshaped by powerful forces — from AI to mental health to decolonization. Six scholars offer fresh ideas for how universities can truly evolve.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Universities must move with the times: how six scholars tackle AI, mental health and more
Societies are evolving, and so must higher education. Researchers describe initiatives that can help to create stimulating and nurturing environments fit for today’s learning landscape.
www.nature.com
October 5, 2025 at 5:19 PM
Higher education is being reshaped by powerful forces — from AI to mental health to decolonization. Six scholars offer fresh ideas for how universities can truly evolve.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
The rise in applications indicates a “huge increase in the amount and cost of work for academics completing these applications”. “[Researchers] must be spending less time either teaching or doing research, and spending more time on writing these grants”.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
The grant lottery: award rates at UK national funding agency fall below 20%
Application volume is outpacing available funding, intensifying competition and worsening pressure on the peer-review system. But those who win grants are now getting more.
www.nature.com
September 2, 2025 at 10:53 AM
The rise in applications indicates a “huge increase in the amount and cost of work for academics completing these applications”. “[Researchers] must be spending less time either teaching or doing research, and spending more time on writing these grants”.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
P-hacking
Removing outliers, using alternative statistical methods and running extra experiments are some methods that could be used to change the P-value. Be careful not to fall in this trap! Stay sceptical! Null results are a normal part of science.
www.nature.com/articles/d41...
Removing outliers, using alternative statistical methods and running extra experiments are some methods that could be used to change the P-value. Be careful not to fall in this trap! Stay sceptical! Null results are a normal part of science.
www.nature.com/articles/d41...
P hacking — Five ways it could happen to you
Some data practices can lead to statistically dubious findings. Here’s how to avoid them.
www.nature.com
May 15, 2025 at 8:05 AM
P-hacking
Removing outliers, using alternative statistical methods and running extra experiments are some methods that could be used to change the P-value. Be careful not to fall in this trap! Stay sceptical! Null results are a normal part of science.
www.nature.com/articles/d41...
Removing outliers, using alternative statistical methods and running extra experiments are some methods that could be used to change the P-value. Be careful not to fall in this trap! Stay sceptical! Null results are a normal part of science.
www.nature.com/articles/d41...
Reposted by Lindsey Van Haute
It was fantastic to have @labliston.bsky.social give a talk at the @mrc-mbu.bsky.social on building a positive research culture. Valuable for all investigators/group leaders regardless of career stage, check out the resources below:
listonlab.uk/careers/
listonlab.uk/careers/
Translational Immunology - Careers
Becoming a Scientist
listonlab.uk
April 30, 2025 at 4:19 PM
It was fantastic to have @labliston.bsky.social give a talk at the @mrc-mbu.bsky.social on building a positive research culture. Valuable for all investigators/group leaders regardless of career stage, check out the resources below:
listonlab.uk/careers/
listonlab.uk/careers/
Stem cells were initially touted as a cure-all, but aside from a few anecdotal studies, this has not been proven true. Is it finally going to happen?
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Japan’s big bet on stem-cell therapies might soon pay off with medical breakthroughs
Induced pluripotent stem cells are being tested to treat blindness, paralysis, Parkinson’s disease and more. Approvals might be around the corner.
www.nature.com
April 17, 2025 at 8:07 AM
Stem cells were initially touted as a cure-all, but aside from a few anecdotal studies, this has not been proven true. Is it finally going to happen?
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Lindsey Van Haute
Clinically translatable mitochondrial #GeneTherapy in muscle using tandem mtZFN architecture.
By P. Nash, @mitogene.bsky.social & colleagues @mrc-mbu.bsky.social
🗞️ doi.org/10.1038/s443...
Read also related N&V by A. Ghifari & M. Ott 👉 doi.org/10.1038/s443...
By P. Nash, @mitogene.bsky.social & colleagues @mrc-mbu.bsky.social
🗞️ doi.org/10.1038/s443...
Read also related N&V by A. Ghifari & M. Ott 👉 doi.org/10.1038/s443...
April 11, 2025 at 2:36 PM
Clinically translatable mitochondrial #GeneTherapy in muscle using tandem mtZFN architecture.
By P. Nash, @mitogene.bsky.social & colleagues @mrc-mbu.bsky.social
🗞️ doi.org/10.1038/s443...
Read also related N&V by A. Ghifari & M. Ott 👉 doi.org/10.1038/s443...
By P. Nash, @mitogene.bsky.social & colleagues @mrc-mbu.bsky.social
🗞️ doi.org/10.1038/s443...
Read also related N&V by A. Ghifari & M. Ott 👉 doi.org/10.1038/s443...
Congratulations, Pavel!
Proud to have been involved in this project.
Proud to have been involved in this project.
Huge congrats to Pavel Nash on publishing his PhD work! 🎉 We showcase a safer mtDNA gene therapy using a novel mtZFN architecture compatible with a single AAV. Thanks to the entire team! @mrc-mbu.bsky.social
@mbu-postdocs.bsky.social #MitochondrialDisease #mtDNA
www.embopress.org/doi/full/10....
@mbu-postdocs.bsky.social #MitochondrialDisease #mtDNA
www.embopress.org/doi/full/10....
Clinically translatable mitochondrial gene therapy in muscle using tandem mtZFN architecture | EMBO Molecular Medicine
imageimageEfficient mitochondrial gene therapy is achieved with a novel tandem zinc finger nuclease (mtZFN) architecture delivered via adeno-associated viral (AAV) vectors, significantly reducing mutation loads in muscle tissue and rescuing ...
www.embopress.org
April 9, 2025 at 9:21 PM
Congratulations, Pavel!
Proud to have been involved in this project.
Proud to have been involved in this project.
Reposting since it's been a while since I posted this, and new MBU members might have joined.
I thought connecting current and past members of MBU Mitochondrial Biology Unit Cambridge would be useful.
Please note that this is a work in progress and that more people will be added.
🔄 Anyone missing? Additions welcome!
go.bsky.app/9ATZngh
Please note that this is a work in progress and that more people will be added.
🔄 Anyone missing? Additions welcome!
go.bsky.app/9ATZngh
March 28, 2025 at 11:10 AM
Reposting since it's been a while since I posted this, and new MBU members might have joined.
Mitochondria differ in type and density in different parts of the brain. For example, the evolutionarily oldest brain regions have a lower density of mitochondria than newer regions.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
First map of human brain mitochondria is ‘groundbreaking’ achievement
Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.
www.nature.com
March 27, 2025 at 9:21 AM
Mitochondria differ in type and density in different parts of the brain. For example, the evolutionarily oldest brain regions have a lower density of mitochondria than newer regions.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Shared first authorship, but who gets to be first? According to this study, there is no disadvantage to sharing credit.
Weakness of the study: The test name was a gender-neutral European name. Can someone please repeat this study with female/non-European names?
www.nature.com/articles/d41...
Weakness of the study: The test name was a gender-neutral European name. Can someone please repeat this study with female/non-European names?
www.nature.com/articles/d41...
Does sharing first authorship on a paper carry a penalty? What the research says
Study dispels myth that order of names in a paper’s author list dictates perception of success.
www.nature.com
March 25, 2025 at 10:51 AM
Shared first authorship, but who gets to be first? According to this study, there is no disadvantage to sharing credit.
Weakness of the study: The test name was a gender-neutral European name. Can someone please repeat this study with female/non-European names?
www.nature.com/articles/d41...
Weakness of the study: The test name was a gender-neutral European name. Can someone please repeat this study with female/non-European names?
www.nature.com/articles/d41...
Reposted by Lindsey Van Haute
In-cell architecture of the mitochondrial respiratory chain | Science www.science.org/doi/10.1126/...
In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
www.science.org
March 21, 2025 at 9:33 AM
In-cell architecture of the mitochondrial respiratory chain | Science www.science.org/doi/10.1126/...
“These findings will need to be confirmed in vivo.“
Animal research can be extremely valuable, but isn't it time to encourage novel alternative non-animal models if they are available? Shouldn't funders encourage research to establish such alternative models more?
www.nature.com/articles/d41...
Animal research can be extremely valuable, but isn't it time to encourage novel alternative non-animal models if they are available? Shouldn't funders encourage research to establish such alternative models more?
www.nature.com/articles/d41...
How ‘animal methods bias’ is affecting research careers
Some early-career researchers report feeling pressure to use animal models to meet journal and grant requirements, even in disciplines and projects that don’t require them.
www.nature.com
March 21, 2025 at 8:39 AM
“These findings will need to be confirmed in vivo.“
Animal research can be extremely valuable, but isn't it time to encourage novel alternative non-animal models if they are available? Shouldn't funders encourage research to establish such alternative models more?
www.nature.com/articles/d41...
Animal research can be extremely valuable, but isn't it time to encourage novel alternative non-animal models if they are available? Shouldn't funders encourage research to establish such alternative models more?
www.nature.com/articles/d41...
It is often said that the first responsibility of any government is the safety and protection of its people. Vaccines save lives, and casting doubt on their safety could have dangerous and far-reaching consequences.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Vaccines save lives. Leaders must champion them
Attacks on vaccines and the cancellation of research into what causes vaccine hesitancy puts people in harm’s way.
www.nature.com
March 19, 2025 at 10:43 AM
It is often said that the first responsibility of any government is the safety and protection of its people. Vaccines save lives, and casting doubt on their safety could have dangerous and far-reaching consequences.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Lindsey Van Haute
Can internet use become addictive?
A #SciencePerspective discusses the addictive potential of the #internet and how it can be best conceptualized and evaluated. scim.ag/3R5Npv1 #BrainAwarenessWeek
A #SciencePerspective discusses the addictive potential of the #internet and how it can be best conceptualized and evaluated. scim.ag/3R5Npv1 #BrainAwarenessWeek
March 16, 2025 at 2:07 PM
Can internet use become addictive?
A #SciencePerspective discusses the addictive potential of the #internet and how it can be best conceptualized and evaluated. scim.ag/3R5Npv1 #BrainAwarenessWeek
A #SciencePerspective discusses the addictive potential of the #internet and how it can be best conceptualized and evaluated. scim.ag/3R5Npv1 #BrainAwarenessWeek
Reposted by Lindsey Van Haute
Conference alert: Machines acting on DNA and RNA
Madrid, May 28-30
Abstract deadline: April 24
Organised by @cniostopcancer.bsky.social. Come to share your research with experts in the molecular mechanisms of DNA & RNA machines. See the list of speakers below.
Please repost.
Madrid, May 28-30
Abstract deadline: April 24
Organised by @cniostopcancer.bsky.social. Come to share your research with experts in the molecular mechanisms of DNA & RNA machines. See the list of speakers below.
Please repost.
March 15, 2025 at 7:48 PM
Conference alert: Machines acting on DNA and RNA
Madrid, May 28-30
Abstract deadline: April 24
Organised by @cniostopcancer.bsky.social. Come to share your research with experts in the molecular mechanisms of DNA & RNA machines. See the list of speakers below.
Please repost.
Madrid, May 28-30
Abstract deadline: April 24
Organised by @cniostopcancer.bsky.social. Come to share your research with experts in the molecular mechanisms of DNA & RNA machines. See the list of speakers below.
Please repost.
Reposted by Lindsey Van Haute
Thought that only purine nucleotides could inhibit mitochondrial thermogenesis in brown adipose tissue? Edmund Kunji and coworkers @mitocarriers.bsky.social @mrc-mbu.bsky.social show that pyrimidines bind and inhibit UCP1 in similar manner
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
March 3, 2025 at 5:25 PM
Thought that only purine nucleotides could inhibit mitochondrial thermogenesis in brown adipose tissue? Edmund Kunji and coworkers @mitocarriers.bsky.social @mrc-mbu.bsky.social show that pyrimidines bind and inhibit UCP1 in similar manner
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Today is World Kidney Day. Are you sure your kidneys are OK? Do the quick test in the link and read about the risks.
www.worldkidneyday.org/2025-campaign/
www.worldkidneyday.org/2025-campaign/
2025 campaign - World Kidney Day 2025
World Kidney Day – 13 March 2025 Are Your Kidneys OK?Detect early, protectkidney health Are Your Kidneys OK? Take this quiz! Are Your Kidneys OK? Detect early, protect kidney health Chronic kidney dis...
www.worldkidneyday.org
March 13, 2025 at 10:05 AM
Today is World Kidney Day. Are you sure your kidneys are OK? Do the quick test in the link and read about the risks.
www.worldkidneyday.org/2025-campaign/
www.worldkidneyday.org/2025-campaign/
Alcohol raises the risk of at least seven types of cancer, including breast, liver, and esophageal cancer. Yet, many drinkers remain unaware.
Is there truly a “safe” amount of alcohol? Would a cancer warning label be helpful?
htps://www.nature.com/articles/d41586-025-00729-5
Is there truly a “safe” amount of alcohol? Would a cancer warning label be helpful?
htps://www.nature.com/articles/d41586-025-00729-5
Alcohol and cancer risk: what you need to know
Experts weigh in on the risks of moderate drinking — and how people should assess them.
www.nature.com
March 12, 2025 at 9:22 AM
Alcohol raises the risk of at least seven types of cancer, including breast, liver, and esophageal cancer. Yet, many drinkers remain unaware.
Is there truly a “safe” amount of alcohol? Would a cancer warning label be helpful?
htps://www.nature.com/articles/d41586-025-00729-5
Is there truly a “safe” amount of alcohol? Would a cancer warning label be helpful?
htps://www.nature.com/articles/d41586-025-00729-5